Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6Z4_LEIDO

TriTrypDb:

LdBPK_332150.1 , LdCL_330028400 , LDHU3_33.3120

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X6Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6Z4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	640	644	PF00656	0.513
CLV_NRD_NRD_1	303	305	PF00675	0.571
CLV_NRD_NRD_1	605	607	PF00675	0.467
CLV_NRD_NRD_1	778	780	PF00675	0.702
CLV_PCSK_KEX2_1	303	305	PF00082	0.571
CLV_PCSK_KEX2_1	778	780	PF00082	0.702
CLV_PCSK_SKI1_1	149	153	PF00082	0.429
CLV_PCSK_SKI1_1	543	547	PF00082	0.467
CLV_PCSK_SKI1_1	592	596	PF00082	0.453
CLV_PCSK_SKI1_1	803	807	PF00082	0.611
DEG_SPOP_SBC_1	310	314	PF00917	0.730
DEG_SPOP_SBC_1	399	403	PF00917	0.619
DOC_CDC14_PxL_1	374	382	PF14671	0.572
DOC_CYCLIN_RxL_1	146	155	PF00134	0.565
DOC_MAPK_DCC_7	592	601	PF00069	0.577
DOC_MAPK_gen_1	606	613	PF00069	0.679
DOC_MAPK_MEF2A_6	457	464	PF00069	0.522
DOC_MAPK_MEF2A_6	55	64	PF00069	0.606
DOC_MAPK_MEF2A_6	592	601	PF00069	0.648
DOC_PP1_RVXF_1	459	465	PF00149	0.523
DOC_PP2B_LxvP_1	354	357	PF13499	0.713
DOC_PP2B_LxvP_1	562	565	PF13499	0.706
DOC_PP2B_LxvP_1	7	10	PF13499	0.843
DOC_PP4_FxxP_1	271	274	PF00568	0.689
DOC_USP7_MATH_1	128	132	PF00917	0.700
DOC_USP7_MATH_1	133	137	PF00917	0.683
DOC_USP7_MATH_1	147	151	PF00917	0.567
DOC_USP7_MATH_1	242	246	PF00917	0.662
DOC_USP7_MATH_1	28	32	PF00917	0.717
DOC_USP7_MATH_1	399	403	PF00917	0.677
DOC_USP7_MATH_1	406	410	PF00917	0.565
DOC_USP7_MATH_1	485	489	PF00917	0.652
DOC_USP7_MATH_1	498	502	PF00917	0.581
DOC_USP7_MATH_1	51	55	PF00917	0.725
DOC_USP7_MATH_1	518	522	PF00917	0.442
DOC_USP7_MATH_1	631	635	PF00917	0.398
DOC_USP7_MATH_1	637	641	PF00917	0.448
DOC_WW_Pin1_4	24	29	PF00397	0.745
DOC_WW_Pin1_4	270	275	PF00397	0.722
DOC_WW_Pin1_4	332	337	PF00397	0.773
DOC_WW_Pin1_4	494	499	PF00397	0.659
DOC_WW_Pin1_4	564	569	PF00397	0.587
DOC_WW_Pin1_4	580	585	PF00397	0.618
DOC_WW_Pin1_4	592	597	PF00397	0.559
DOC_WW_Pin1_4	605	610	PF00397	0.590
DOC_WW_Pin1_4	726	731	PF00397	0.404
DOC_WW_Pin1_4	77	82	PF00397	0.659
LIG_14-3-3_CanoR_1	118	125	PF00244	0.765
LIG_14-3-3_CanoR_1	132	142	PF00244	0.665
LIG_14-3-3_CanoR_1	265	274	PF00244	0.783
LIG_14-3-3_CanoR_1	382	388	PF00244	0.620
LIG_14-3-3_CanoR_1	398	407	PF00244	0.540
LIG_14-3-3_CanoR_1	543	548	PF00244	0.681
LIG_14-3-3_CanoR_1	749	756	PF00244	0.491
LIG_Actin_WH2_2	698	715	PF00022	0.387
LIG_Actin_WH2_2	797	815	PF00022	0.325
LIG_BIR_III_4	197	201	PF00653	0.551
LIG_BRCT_BRCA1_1	267	271	PF00533	0.678
LIG_BRCT_BRCA1_1	487	491	PF00533	0.608
LIG_BRCT_BRCA1_1	625	629	PF00533	0.410
LIG_CtBP_PxDLS_1	426	430	PF00389	0.588
LIG_EH1_1	160	168	PF00400	0.671
LIG_eIF4E_1	146	152	PF01652	0.547
LIG_eIF4E_1	655	661	PF01652	0.433
LIG_EVH1_1	562	566	PF00568	0.639
LIG_FHA_1	137	143	PF00498	0.612
LIG_FHA_1	153	159	PF00498	0.494
LIG_FHA_1	162	168	PF00498	0.549
LIG_FHA_1	177	183	PF00498	0.543
LIG_FHA_1	194	200	PF00498	0.529
LIG_FHA_1	228	234	PF00498	0.574
LIG_FHA_1	283	289	PF00498	0.768
LIG_FHA_1	437	443	PF00498	0.644
LIG_FHA_1	474	480	PF00498	0.661
LIG_FHA_1	529	535	PF00498	0.592
LIG_FHA_1	540	546	PF00498	0.596
LIG_FHA_1	593	599	PF00498	0.570
LIG_FHA_1	676	682	PF00498	0.345
LIG_FHA_1	78	84	PF00498	0.603
LIG_FHA_1	91	97	PF00498	0.577
LIG_FHA_2	357	363	PF00498	0.692
LIG_FHA_2	461	467	PF00498	0.653
LIG_FHA_2	491	497	PF00498	0.755
LIG_FHA_2	749	755	PF00498	0.387
LIG_FHA_2	758	764	PF00498	0.391
LIG_GBD_Chelix_1	506	514	PF00786	0.366
LIG_LIR_Apic_2	268	274	PF02991	0.681
LIG_LIR_Gen_1	172	180	PF02991	0.536
LIG_LIR_Gen_1	40	48	PF02991	0.603
LIG_LIR_Gen_1	541	551	PF02991	0.698
LIG_LIR_Gen_1	614	625	PF02991	0.410
LIG_LIR_Gen_1	653	663	PF02991	0.446
LIG_LIR_Nem_3	40	44	PF02991	0.584
LIG_LIR_Nem_3	416	421	PF02991	0.566
LIG_LIR_Nem_3	541	547	PF02991	0.665
LIG_LIR_Nem_3	626	632	PF02991	0.410
LIG_LIR_Nem_3	653	658	PF02991	0.445
LIG_MLH1_MIPbox_1	625	629	PF16413	0.410
LIG_NRBOX	657	663	PF00104	0.342
LIG_PCNA_yPIPBox_3	606	617	PF02747	0.629
LIG_PDZ_Class_1	812	817	PF00595	0.518
LIG_Pex14_2	628	632	PF04695	0.410
LIG_Pex14_2	98	102	PF04695	0.597
LIG_PTB_Apo_2	321	328	PF02174	0.759
LIG_PTB_Apo_2	621	628	PF02174	0.410
LIG_PTB_Apo_2	680	687	PF02174	0.386
LIG_PTB_Phospho_1	621	627	PF10480	0.410
LIG_PTB_Phospho_1	680	686	PF10480	0.387
LIG_SH2_CRK	655	659	PF00017	0.444
LIG_SH2_GRB2like	686	689	PF00017	0.409
LIG_SH2_NCK_1	686	690	PF00017	0.403
LIG_SH2_PTP2	544	547	PF00017	0.662
LIG_SH2_STAP1	646	650	PF00017	0.417
LIG_SH2_STAP1	746	750	PF00017	0.356
LIG_SH2_STAT3	750	753	PF00017	0.489
LIG_SH2_STAT5	114	117	PF00017	0.707
LIG_SH2_STAT5	527	530	PF00017	0.656
LIG_SH2_STAT5	544	547	PF00017	0.484
LIG_SH2_STAT5	617	620	PF00017	0.410
LIG_SH2_STAT5	627	630	PF00017	0.410
LIG_SH2_STAT5	665	668	PF00017	0.389
LIG_SH2_STAT5	686	689	PF00017	0.401
LIG_SH2_STAT5	746	749	PF00017	0.403
LIG_SH2_STAT5	750	753	PF00017	0.420
LIG_SH3_3	164	170	PF00018	0.613
LIG_SH3_3	544	550	PF00018	0.660
LIG_SH3_3	560	566	PF00018	0.608
LIG_SH3_3	581	587	PF00018	0.654
LIG_SH3_3	591	597	PF00018	0.648
LIG_SH3_3	731	737	PF00018	0.402
LIG_SUMO_SIM_anti_2	500	508	PF11976	0.681
LIG_SUMO_SIM_anti_2	700	706	PF11976	0.384
LIG_SUMO_SIM_par_1	154	160	PF11976	0.568
LIG_TRAF2_1	360	363	PF00917	0.804
LIG_TRAF2_1	497	500	PF00917	0.752
LIG_TRAF2_1	761	764	PF00917	0.498
LIG_TRFH_1	352	356	PF08558	0.648
LIG_TYR_ITSM	540	547	PF00017	0.474
LIG_UBA3_1	601	607	PF00899	0.566
LIG_UBA3_1	62	67	PF00899	0.472
LIG_WW_3	355	359	PF00397	0.663
MOD_CDC14_SPxK_1	729	732	PF00782	0.514
MOD_CDK_SPxK_1	726	732	PF00069	0.501
MOD_CDK_SPxxK_3	270	277	PF00069	0.611
MOD_CK1_1	117	123	PF00069	0.654
MOD_CK1_1	136	142	PF00069	0.422
MOD_CK1_1	269	275	PF00069	0.801
MOD_CK1_1	330	336	PF00069	0.738
MOD_CK1_1	623	629	PF00069	0.477
MOD_CK1_1	653	659	PF00069	0.504
MOD_CK1_1	73	79	PF00069	0.659
MOD_CK1_1	745	751	PF00069	0.595
MOD_CK1_1	788	794	PF00069	0.520
MOD_CK2_1	117	123	PF00069	0.550
MOD_CK2_1	356	362	PF00069	0.718
MOD_CK2_1	421	427	PF00069	0.471
MOD_CK2_1	494	500	PF00069	0.706
MOD_CK2_1	51	57	PF00069	0.537
MOD_CK2_1	757	763	PF00069	0.555
MOD_CMANNOS	223	226	PF00535	0.452
MOD_DYRK1A_RPxSP_1	592	596	PF00069	0.461
MOD_GlcNHglycan	126	129	PF01048	0.711
MOD_GlcNHglycan	135	138	PF01048	0.572
MOD_GlcNHglycan	2	5	PF01048	0.724
MOD_GlcNHglycan	213	217	PF01048	0.469
MOD_GlcNHglycan	244	247	PF01048	0.579
MOD_GlcNHglycan	268	271	PF01048	0.795
MOD_GlcNHglycan	279	282	PF01048	0.630
MOD_GlcNHglycan	290	293	PF01048	0.640
MOD_GlcNHglycan	30	33	PF01048	0.786
MOD_GlcNHglycan	332	335	PF01048	0.695
MOD_GlcNHglycan	341	344	PF01048	0.744
MOD_GlcNHglycan	547	550	PF01048	0.582
MOD_GlcNHglycan	814	817	PF01048	0.582
MOD_GSK3_1	124	131	PF00069	0.703
MOD_GSK3_1	133	140	PF00069	0.696
MOD_GSK3_1	157	164	PF00069	0.397
MOD_GSK3_1	238	245	PF00069	0.582
MOD_GSK3_1	24	31	PF00069	0.691
MOD_GSK3_1	265	272	PF00069	0.790
MOD_GSK3_1	273	280	PF00069	0.686
MOD_GSK3_1	335	342	PF00069	0.728
MOD_GSK3_1	444	451	PF00069	0.594
MOD_GSK3_1	490	497	PF00069	0.558
MOD_GSK3_1	539	546	PF00069	0.531
MOD_GSK3_1	650	657	PF00069	0.463
MOD_GSK3_1	671	678	PF00069	0.455
MOD_GSK3_1	69	76	PF00069	0.598
MOD_GSK3_1	744	751	PF00069	0.443
MOD_GSK3_1	785	792	PF00069	0.545
MOD_LATS_1	309	315	PF00433	0.672
MOD_N-GLC_1	137	142	PF02516	0.565
MOD_N-GLC_1	266	271	PF02516	0.594
MOD_N-GLC_1	623	628	PF02516	0.410
MOD_N-GLC_1	682	687	PF02516	0.472
MOD_N-GLC_1	723	728	PF02516	0.466
MOD_N-GLC_2	366	368	PF02516	0.439
MOD_N-GLC_2	443	445	PF02516	0.583
MOD_N-GLC_2	697	699	PF02516	0.494
MOD_N-GLC_2	717	719	PF02516	0.202
MOD_NEK2_1	152	157	PF00069	0.419
MOD_NEK2_1	176	181	PF00069	0.554
MOD_NEK2_1	266	271	PF00069	0.794
MOD_NEK2_1	327	332	PF00069	0.801
MOD_NEK2_1	339	344	PF00069	0.560
MOD_NEK2_1	421	426	PF00069	0.482
MOD_NEK2_1	490	495	PF00069	0.678
MOD_NEK2_1	505	510	PF00069	0.313
MOD_NEK2_1	528	533	PF00069	0.436
MOD_NEK2_1	558	563	PF00069	0.702
MOD_NEK2_1	590	595	PF00069	0.429
MOD_NEK2_1	611	616	PF00069	0.484
MOD_NEK2_1	620	625	PF00069	0.410
MOD_NEK2_1	654	659	PF00069	0.546
MOD_NEK2_1	70	75	PF00069	0.521
MOD_NEK2_1	723	728	PF00069	0.466
MOD_NEK2_1	739	744	PF00069	0.495
MOD_NEK2_1	812	817	PF00069	0.555
MOD_NEK2_1	91	96	PF00069	0.466
MOD_PIKK_1	39	45	PF00454	0.520
MOD_PIKK_1	485	491	PF00454	0.482
MOD_PKA_1	304	310	PF00069	0.725
MOD_PKA_2	117	123	PF00069	0.555
MOD_PKA_2	193	199	PF00069	0.538
MOD_PKA_2	288	294	PF00069	0.757
MOD_PKA_2	381	387	PF00069	0.467
MOD_PKA_2	748	754	PF00069	0.515
MOD_PKB_1	263	271	PF00069	0.681
MOD_Plk_1	137	143	PF00069	0.610
MOD_Plk_1	255	261	PF00069	0.795
MOD_Plk_1	39	45	PF00069	0.555
MOD_Plk_1	499	505	PF00069	0.635
MOD_Plk_1	623	629	PF00069	0.410
MOD_Plk_1	671	677	PF00069	0.396
MOD_Plk_1	682	688	PF00069	0.420
MOD_Plk_1	700	706	PF00069	0.464
MOD_Plk_2-3	169	175	PF00069	0.592
MOD_Plk_2-3	448	454	PF00069	0.472
MOD_Plk_4	137	143	PF00069	0.476
MOD_Plk_4	152	158	PF00069	0.418
MOD_Plk_4	255	261	PF00069	0.584
MOD_Plk_4	335	341	PF00069	0.665
MOD_Plk_4	406	412	PF00069	0.469
MOD_Plk_4	413	419	PF00069	0.432
MOD_Plk_4	437	443	PF00069	0.464
MOD_Plk_4	460	466	PF00069	0.549
MOD_Plk_4	529	535	PF00069	0.378
MOD_Plk_4	623	629	PF00069	0.368
MOD_Plk_4	650	656	PF00069	0.566
MOD_Plk_4	700	706	PF00069	0.412
MOD_Plk_4	739	745	PF00069	0.517
MOD_Plk_4	91	97	PF00069	0.440
MOD_ProDKin_1	24	30	PF00069	0.688
MOD_ProDKin_1	270	276	PF00069	0.659
MOD_ProDKin_1	332	338	PF00069	0.728
MOD_ProDKin_1	494	500	PF00069	0.566
MOD_ProDKin_1	564	570	PF00069	0.460
MOD_ProDKin_1	580	586	PF00069	0.387
MOD_ProDKin_1	592	598	PF00069	0.424
MOD_ProDKin_1	605	611	PF00069	0.465
MOD_ProDKin_1	726	732	PF00069	0.489
MOD_ProDKin_1	77	83	PF00069	0.559
TRG_DiLeu_BaEn_1	204	209	PF01217	0.580
TRG_DiLeu_BaEn_4	362	368	PF01217	0.625
TRG_DiLeu_BaEn_4	427	433	PF01217	0.535
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.592
TRG_DiLeu_BaLyEn_6	597	602	PF01217	0.438
TRG_DiLeu_LyEn_5	204	209	PF01217	0.580
TRG_ENDOCYTIC_2	418	421	PF00928	0.440
TRG_ENDOCYTIC_2	544	547	PF00928	0.573
TRG_ENDOCYTIC_2	617	620	PF00928	0.410
TRG_ENDOCYTIC_2	655	658	PF00928	0.551
TRG_ER_diArg_1	260	263	PF00400	0.744
TRG_ER_diArg_1	302	304	PF00400	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8G1	Leptomonas seymouri	46%	75%
A4HLR5	Leishmania braziliensis	70%	100%
A4I941	Leishmania infantum	100%	100%
E9B441	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q3Y4	Leishmania major	92%	100%