Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6Z0_LEIDO

TriTrypDb:

LdBPK_332080.1 , LdCL_330027700 , LDHU3_33.3000

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6Z0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.642
CLV_C14_Caspase3-7	273	277	PF00656	0.651
CLV_C14_Caspase3-7	432	436	PF00656	0.660
CLV_C14_Caspase3-7	93	97	PF00656	0.742
CLV_PCSK_KEX2_1	227	229	PF00082	0.681
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.681
CLV_PCSK_SKI1_1	129	133	PF00082	0.780
CLV_PCSK_SKI1_1	384	388	PF00082	0.588
CLV_PCSK_SKI1_1	458	462	PF00082	0.673
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DEG_SCF_FBW7_1	362	368	PF00400	0.758
DEG_SPOP_SBC_1	155	159	PF00917	0.601
DEG_SPOP_SBC_1	270	274	PF00917	0.660
DEG_SPOP_SBC_1	365	369	PF00917	0.794
DEG_SPOP_SBC_1	430	434	PF00917	0.700
DOC_CKS1_1	348	353	PF01111	0.854
DOC_CKS1_1	362	367	PF01111	0.637
DOC_MAPK_DCC_7	129	137	PF00069	0.737
DOC_MAPK_FxFP_2	137	140	PF00069	0.800
DOC_MAPK_MEF2A_6	129	137	PF00069	0.737
DOC_PP1_RVXF_1	70	76	PF00149	0.734
DOC_PP2B_LxvP_1	521	524	PF13499	0.730
DOC_PP4_FxxP_1	137	140	PF00568	0.800
DOC_PP4_FxxP_1	153	156	PF00568	0.542
DOC_SPAK_OSR1_1	191	195	PF12202	0.625
DOC_USP7_MATH_1	109	113	PF00917	0.764
DOC_USP7_MATH_1	156	160	PF00917	0.740
DOC_USP7_MATH_1	21	25	PF00917	0.733
DOC_USP7_MATH_1	234	238	PF00917	0.782
DOC_USP7_MATH_1	251	255	PF00917	0.522
DOC_USP7_MATH_1	27	31	PF00917	0.689
DOC_USP7_MATH_1	270	274	PF00917	0.553
DOC_USP7_MATH_1	300	304	PF00917	0.752
DOC_USP7_MATH_1	318	322	PF00917	0.566
DOC_USP7_MATH_1	329	333	PF00917	0.713
DOC_USP7_MATH_1	334	338	PF00917	0.663
DOC_USP7_MATH_1	365	369	PF00917	0.709
DOC_USP7_MATH_1	430	434	PF00917	0.700
DOC_USP7_MATH_1	465	469	PF00917	0.596
DOC_USP7_MATH_1	524	528	PF00917	0.772
DOC_USP7_MATH_2	230	236	PF00917	0.821
DOC_WW_Pin1_4	170	175	PF00397	0.754
DOC_WW_Pin1_4	23	28	PF00397	0.640
DOC_WW_Pin1_4	283	288	PF00397	0.744
DOC_WW_Pin1_4	347	352	PF00397	0.818
DOC_WW_Pin1_4	361	366	PF00397	0.637
DOC_WW_Pin1_4	426	431	PF00397	0.745
DOC_WW_Pin1_4	488	493	PF00397	0.704
LIG_14-3-3_CanoR_1	266	270	PF00244	0.759
LIG_14-3-3_CanoR_1	288	296	PF00244	0.636
LIG_14-3-3_CanoR_1	335	339	PF00244	0.777
LIG_14-3-3_CanoR_1	458	464	PF00244	0.730
LIG_14-3-3_CanoR_1	525	533	PF00244	0.727
LIG_Actin_WH2_2	459	474	PF00022	0.504
LIG_BIR_III_2	313	317	PF00653	0.797
LIG_BIR_III_4	108	112	PF00653	0.635
LIG_BIR_III_4	96	100	PF00653	0.786
LIG_BRCT_BRCA1_1	78	82	PF00533	0.718
LIG_eIF4E_1	488	494	PF01652	0.606
LIG_FHA_1	266	272	PF00498	0.763
LIG_FHA_1	447	453	PF00498	0.691
LIG_FHA_1	465	471	PF00498	0.440
LIG_FHA_1	489	495	PF00498	0.704
LIG_FHA_2	410	416	PF00498	0.721
LIG_Integrin_RGD_1	100	102	PF01839	0.750
LIG_LIR_Apic_2	152	156	PF02991	0.663
LIG_LIR_Gen_1	76	82	PF02991	0.721
LIG_LIR_Nem_3	76	80	PF02991	0.722
LIG_MLH1_MIPbox_1	78	82	PF16413	0.718
LIG_NRBOX	255	261	PF00104	0.627
LIG_NRBOX	503	509	PF00104	0.704
LIG_Pex14_2	77	81	PF04695	0.719
LIG_Rb_LxCxE_1	407	425	PF01857	0.727
LIG_SH2_CRK	172	176	PF00017	0.863
LIG_SH2_NCK_1	172	176	PF00017	0.863
LIG_SH2_SRC	90	93	PF00017	0.751
LIG_SH2_STAT5	115	118	PF00017	0.792
LIG_SH3_3	176	182	PF00018	0.805
LIG_SH3_3	198	204	PF00018	0.769
LIG_SH3_3	207	213	PF00018	0.661
LIG_SH3_3	323	329	PF00018	0.784
LIG_SH3_3	345	351	PF00018	0.855
LIG_SH3_3	353	359	PF00018	0.728
LIG_SH3_3	367	373	PF00018	0.603
LIG_SH3_3	411	417	PF00018	0.618
LIG_SH3_3	491	497	PF00018	0.688
LIG_SH3_3	53	59	PF00018	0.632
LIG_SUMO_SIM_par_1	499	505	PF11976	0.679
LIG_TRAF2_1	417	420	PF00917	0.630
LIG_TRAF2_1	512	515	PF00917	0.562
LIG_TRAF2_1	6	9	PF00917	0.735
LIG_WRC_WIRS_1	423	428	PF05994	0.629
LIG_WRC_WIRS_1	77	82	PF05994	0.720
LIG_WW_3	324	328	PF00397	0.780
MOD_CDK_SPK_2	283	288	PF00069	0.646
MOD_CDK_SPK_2	352	357	PF00069	0.793
MOD_CDK_SPxK_1	366	372	PF00069	0.765
MOD_CK1_1	264	270	PF00069	0.857
MOD_CK1_1	272	278	PF00069	0.724
MOD_CK1_1	291	297	PF00069	0.522
MOD_CK1_1	31	37	PF00069	0.780
MOD_CK1_1	366	372	PF00069	0.800
MOD_CK1_1	425	431	PF00069	0.786
MOD_CK1_1	456	462	PF00069	0.740
MOD_CK2_1	272	278	PF00069	0.702
MOD_CK2_1	409	415	PF00069	0.785
MOD_GlcNHglycan	119	122	PF01048	0.700
MOD_GlcNHglycan	163	166	PF01048	0.820
MOD_GlcNHglycan	19	22	PF01048	0.730
MOD_GlcNHglycan	236	239	PF01048	0.761
MOD_GlcNHglycan	30	33	PF01048	0.634
MOD_GlcNHglycan	320	323	PF01048	0.668
MOD_GlcNHglycan	454	458	PF01048	0.584
MOD_GlcNHglycan	535	538	PF01048	0.810
MOD_GlcNHglycan	86	89	PF01048	0.741
MOD_GlcNHglycan	91	95	PF01048	0.711
MOD_GSK3_1	109	116	PF00069	0.647
MOD_GSK3_1	17	24	PF00069	0.730
MOD_GSK3_1	261	268	PF00069	0.805
MOD_GSK3_1	27	34	PF00069	0.640
MOD_GSK3_1	329	336	PF00069	0.812
MOD_GSK3_1	361	368	PF00069	0.860
MOD_GSK3_1	385	392	PF00069	0.765
MOD_GSK3_1	421	428	PF00069	0.761
MOD_GSK3_1	446	453	PF00069	0.711
MOD_N-GLC_1	36	41	PF02516	0.777
MOD_N-GLC_1	62	67	PF02516	0.716
MOD_N-GLC_2	293	295	PF02516	0.782
MOD_NEK2_1	17	22	PF00069	0.732
MOD_NEK2_1	421	426	PF00069	0.780
MOD_PIKK_1	113	119	PF00454	0.645
MOD_PIKK_1	261	267	PF00454	0.844
MOD_PKA_2	109	115	PF00069	0.777
MOD_PKA_2	117	123	PF00069	0.697
MOD_PKA_2	265	271	PF00069	0.826
MOD_PKA_2	334	340	PF00069	0.773
MOD_PKA_2	450	456	PF00069	0.743
MOD_PKA_2	524	530	PF00069	0.770
MOD_Plk_1	241	247	PF00069	0.690
MOD_Plk_1	301	307	PF00069	0.775
MOD_Plk_1	384	390	PF00069	0.789
MOD_Plk_2-3	62	68	PF00069	0.615
MOD_Plk_4	149	155	PF00069	0.812
MOD_Plk_4	206	212	PF00069	0.845
MOD_Plk_4	76	82	PF00069	0.721
MOD_ProDKin_1	170	176	PF00069	0.756
MOD_ProDKin_1	23	29	PF00069	0.643
MOD_ProDKin_1	283	289	PF00069	0.744
MOD_ProDKin_1	347	353	PF00069	0.817
MOD_ProDKin_1	361	367	PF00069	0.636
MOD_ProDKin_1	426	432	PF00069	0.738
MOD_ProDKin_1	488	494	PF00069	0.699
MOD_SUMO_rev_2	511	517	PF00179	0.670
MOD_SUMO_rev_2	62	70	PF00179	0.652
TRG_DiLeu_BaEn_1	374	379	PF01217	0.786
TRG_ENDOCYTIC_2	2	5	PF00928	0.761

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HLQ8	Leishmania braziliensis	63%	100%
A4I958	Leishmania infantum	100%	100%
E9B434	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q3Z1	Leishmania major	86%	100%