Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6Y8_LEIDO

TriTrypDb:

LdBPK_332260.1 , LdCL_330029600 , LDHU3_33.3260

Length:

960

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	10
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10
GO:0099512	supramolecular fiber	4	10
GO:0099513	polymeric cytoskeletal fiber	5	10
GO:0110165	cellular anatomical entity	1	10
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X6Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6Y8

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0016787	hydrolase activity	2	5
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.335
CLV_C14_Caspase3-7	538	542	PF00656	0.618
CLV_C14_Caspase3-7	734	738	PF00656	0.698
CLV_C14_Caspase3-7	744	748	PF00656	0.670
CLV_C14_Caspase3-7	845	849	PF00656	0.740
CLV_NRD_NRD_1	170	172	PF00675	0.335
CLV_NRD_NRD_1	195	197	PF00675	0.402
CLV_NRD_NRD_1	248	250	PF00675	0.480
CLV_NRD_NRD_1	415	417	PF00675	0.512
CLV_NRD_NRD_1	428	430	PF00675	0.435
CLV_NRD_NRD_1	479	481	PF00675	0.547
CLV_NRD_NRD_1	583	585	PF00675	0.609
CLV_NRD_NRD_1	645	647	PF00675	0.606
CLV_NRD_NRD_1	649	651	PF00675	0.582
CLV_NRD_NRD_1	654	656	PF00675	0.533
CLV_NRD_NRD_1	729	731	PF00675	0.669
CLV_NRD_NRD_1	755	757	PF00675	0.701
CLV_NRD_NRD_1	800	802	PF00675	0.775
CLV_NRD_NRD_1	803	805	PF00675	0.773
CLV_NRD_NRD_1	840	842	PF00675	0.660
CLV_NRD_NRD_1	931	933	PF00675	0.665
CLV_PCSK_FUR_1	727	731	PF00082	0.730
CLV_PCSK_KEX2_1	104	106	PF00082	0.447
CLV_PCSK_KEX2_1	195	197	PF00082	0.402
CLV_PCSK_KEX2_1	248	250	PF00082	0.335
CLV_PCSK_KEX2_1	417	419	PF00082	0.510
CLV_PCSK_KEX2_1	479	481	PF00082	0.547
CLV_PCSK_KEX2_1	583	585	PF00082	0.585
CLV_PCSK_KEX2_1	592	594	PF00082	0.654
CLV_PCSK_KEX2_1	645	647	PF00082	0.606
CLV_PCSK_KEX2_1	649	651	PF00082	0.582
CLV_PCSK_KEX2_1	654	656	PF00082	0.533
CLV_PCSK_KEX2_1	729	731	PF00082	0.659
CLV_PCSK_KEX2_1	755	757	PF00082	0.717
CLV_PCSK_KEX2_1	799	801	PF00082	0.760
CLV_PCSK_KEX2_1	840	842	PF00082	0.639
CLV_PCSK_KEX2_1	931	933	PF00082	0.659
CLV_PCSK_KEX2_1	935	937	PF00082	0.676
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.447
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.515
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.772
CLV_PCSK_PC1ET2_1	935	937	PF00082	0.804
CLV_PCSK_PC7_1	645	651	PF00082	0.659
CLV_PCSK_PC7_1	931	937	PF00082	0.807
CLV_PCSK_SKI1_1	125	129	PF00082	0.335
CLV_PCSK_SKI1_1	233	237	PF00082	0.335
CLV_PCSK_SKI1_1	255	259	PF00082	0.335
CLV_PCSK_SKI1_1	298	302	PF00082	0.355
CLV_PCSK_SKI1_1	432	436	PF00082	0.504
CLV_PCSK_SKI1_1	555	559	PF00082	0.634
CLV_PCSK_SKI1_1	619	623	PF00082	0.614
CLV_PCSK_SKI1_1	65	69	PF00082	0.335
CLV_PCSK_SKI1_1	740	744	PF00082	0.563
CLV_PCSK_SKI1_1	932	936	PF00082	0.813
CLV_PCSK_SKI1_1	95	99	PF00082	0.338
DEG_APCC_DBOX_1	529	537	PF00400	0.725
DEG_APCC_DBOX_1	561	569	PF00400	0.600
DEG_APCC_DBOX_1	649	657	PF00400	0.691
DEG_APCC_KENBOX_2	867	871	PF00400	0.757
DEG_SPOP_SBC_1	792	796	PF00917	0.762
DOC_CYCLIN_RxL_1	230	237	PF00134	0.335
DOC_CYCLIN_RxL_1	95	102	PF00134	0.355
DOC_MAPK_gen_1	198	206	PF00069	0.308
DOC_MAPK_gen_1	301	310	PF00069	0.454
DOC_MAPK_gen_1	462	471	PF00069	0.493
DOC_MAPK_gen_1	654	662	PF00069	0.691
DOC_MAPK_gen_1	95	103	PF00069	0.355
DOC_MAPK_MEF2A_6	184	191	PF00069	0.335
DOC_MAPK_MEF2A_6	301	310	PF00069	0.461
DOC_MAPK_MEF2A_6	464	473	PF00069	0.496
DOC_MAPK_MEF2A_6	95	103	PF00069	0.355
DOC_PP2B_LxvP_1	310	313	PF13499	0.532
DOC_USP7_MATH_1	42	46	PF00917	0.447
DOC_USP7_MATH_1	495	499	PF00917	0.503
DOC_USP7_MATH_1	604	608	PF00917	0.632
DOC_USP7_MATH_1	844	848	PF00917	0.721
DOC_USP7_MATH_1	874	878	PF00917	0.743
DOC_USP7_MATH_1	880	884	PF00917	0.686
DOC_USP7_MATH_1	949	953	PF00917	0.729
DOC_WW_Pin1_4	104	109	PF00397	0.408
DOC_WW_Pin1_4	596	601	PF00397	0.699
DOC_WW_Pin1_4	670	675	PF00397	0.697
DOC_WW_Pin1_4	920	925	PF00397	0.787
DOC_WW_Pin1_4	955	960	PF00397	0.668
LIG_14-3-3_CanoR_1	198	204	PF00244	0.325
LIG_14-3-3_CanoR_1	217	225	PF00244	0.424
LIG_14-3-3_CanoR_1	233	239	PF00244	0.335
LIG_14-3-3_CanoR_1	294	302	PF00244	0.335
LIG_14-3-3_CanoR_1	441	451	PF00244	0.523
LIG_14-3-3_CanoR_1	593	599	PF00244	0.724
LIG_14-3-3_CanoR_1	619	626	PF00244	0.497
LIG_14-3-3_CanoR_1	727	735	PF00244	0.715
LIG_14-3-3_CanoR_1	787	793	PF00244	0.778
LIG_14-3-3_CanoR_1	841	847	PF00244	0.732
LIG_BIR_II_1	1	5	PF00653	0.420
LIG_BRCT_BRCA1_1	698	702	PF00533	0.673
LIG_Clathr_ClatBox_1	472	476	PF01394	0.637
LIG_eIF4E_1	230	236	PF01652	0.434
LIG_FHA_1	188	194	PF00498	0.355
LIG_FHA_1	218	224	PF00498	0.406
LIG_FHA_1	258	264	PF00498	0.329
LIG_FHA_1	271	277	PF00498	0.296
LIG_FHA_1	31	37	PF00498	0.355
LIG_FHA_1	546	552	PF00498	0.523
LIG_FHA_1	719	725	PF00498	0.711
LIG_FHA_2	154	160	PF00498	0.378
LIG_FHA_2	568	574	PF00498	0.641
LIG_FHA_2	620	626	PF00498	0.507
LIG_FHA_2	843	849	PF00498	0.731
LIG_HP1_1	306	310	PF01393	0.589
LIG_LIR_Apic_2	810	816	PF02991	0.745
LIG_LIR_Apic_2	869	874	PF02991	0.755
LIG_LIR_Gen_1	155	165	PF02991	0.348
LIG_LIR_Nem_3	155	160	PF02991	0.348
LIG_LIR_Nem_3	455	459	PF02991	0.477
LIG_LIR_Nem_3	616	621	PF02991	0.705
LIG_NRBOX	258	264	PF00104	0.480
LIG_PCNA_yPIPBox_3	121	132	PF02747	0.355
LIG_PCNA_yPIPBox_3	855	868	PF02747	0.692
LIG_PTB_Apo_2	35	42	PF02174	0.480
LIG_PTB_Phospho_1	35	41	PF10480	0.480
LIG_REV1ctd_RIR_1	144	154	PF16727	0.480
LIG_SH2_CRK	37	41	PF00017	0.335
LIG_SH2_CRK	618	622	PF00017	0.674
LIG_SH2_CRK	789	793	PF00017	0.595
LIG_SH2_CRK	890	894	PF00017	0.702
LIG_SH2_GRB2like	230	233	PF00017	0.434
LIG_SH2_NCK_1	116	120	PF00017	0.447
LIG_SH2_NCK_1	26	30	PF00017	0.447
LIG_SH2_NCK_1	37	41	PF00017	0.447
LIG_SH2_NCK_1	890	894	PF00017	0.702
LIG_SH2_SRC	735	738	PF00017	0.696
LIG_SH2_STAP1	116	120	PF00017	0.447
LIG_SH2_STAP1	485	489	PF00017	0.500
LIG_SH2_STAP1	890	894	PF00017	0.791
LIG_SH2_STAT3	361	364	PF00017	0.636
LIG_SH2_STAT3	395	398	PF00017	0.611
LIG_SH2_STAT3	814	817	PF00017	0.568
LIG_SH2_STAT5	116	119	PF00017	0.339
LIG_SH2_STAT5	230	233	PF00017	0.434
LIG_SH2_STAT5	251	254	PF00017	0.335
LIG_SH2_STAT5	349	352	PF00017	0.586
LIG_SH2_STAT5	35	38	PF00017	0.335
LIG_SH3_2	250	255	PF14604	0.408
LIG_SH3_3	247	253	PF00018	0.408
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.480
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.479
LIG_SUMO_SIM_par_1	150	156	PF11976	0.447
LIG_SUMO_SIM_par_1	535	541	PF11976	0.695
LIG_TRAF2_1	407	410	PF00917	0.610
LIG_TRAF2_1	707	710	PF00917	0.767
LIG_TRAF2_1	902	905	PF00917	0.690
LIG_TYR_ITIM	483	488	PF00017	0.598
LIG_UBA3_1	745	750	PF00899	0.676
LIG_UBA3_1	99	104	PF00899	0.355
LIG_WRC_WIRS_1	154	159	PF05994	0.480
LIG_WRC_WIRS_1	188	193	PF05994	0.335
MOD_CDK_SPxxK_3	104	111	PF00069	0.480
MOD_CDK_SPxxK_3	596	603	PF00069	0.646
MOD_CK1_1	182	188	PF00069	0.335
MOD_CK1_1	20	26	PF00069	0.438
MOD_CK1_1	234	240	PF00069	0.335
MOD_CK1_1	270	276	PF00069	0.355
MOD_CK1_1	356	362	PF00069	0.573
MOD_CK1_1	371	377	PF00069	0.569
MOD_CK1_1	43	49	PF00069	0.337
MOD_CK1_1	446	452	PF00069	0.553
MOD_CK1_1	518	524	PF00069	0.532
MOD_CK1_1	607	613	PF00069	0.703
MOD_CK1_1	663	669	PF00069	0.730
MOD_CK1_1	670	676	PF00069	0.678
MOD_CK1_1	696	702	PF00069	0.749
MOD_CK1_1	731	737	PF00069	0.678
MOD_CK1_1	77	83	PF00069	0.335
MOD_CK1_1	791	797	PF00069	0.784
MOD_CK1_1	954	960	PF00069	0.644
MOD_CK2_1	16	22	PF00069	0.435
MOD_CK2_1	221	227	PF00069	0.355
MOD_CK2_1	404	410	PF00069	0.601
MOD_CK2_1	42	48	PF00069	0.480
MOD_CK2_1	421	427	PF00069	0.511
MOD_CK2_1	567	573	PF00069	0.591
MOD_CK2_1	619	625	PF00069	0.622
MOD_CK2_1	791	797	PF00069	0.797
MOD_CK2_1	829	835	PF00069	0.816
MOD_CK2_1	854	860	PF00069	0.683
MOD_Cter_Amidation	727	730	PF01082	0.721
MOD_Cter_Amidation	802	805	PF01082	0.787
MOD_GlcNHglycan	19	22	PF01048	0.450
MOD_GlcNHglycan	213	216	PF01048	0.335
MOD_GlcNHglycan	269	272	PF01048	0.355
MOD_GlcNHglycan	333	336	PF01048	0.637
MOD_GlcNHglycan	506	509	PF01048	0.658
MOD_GlcNHglycan	515	518	PF01048	0.661
MOD_GlcNHglycan	520	523	PF01048	0.686
MOD_GlcNHglycan	594	597	PF01048	0.706
MOD_GlcNHglycan	675	678	PF01048	0.698
MOD_GlcNHglycan	731	734	PF01048	0.709
MOD_GlcNHglycan	76	79	PF01048	0.335
MOD_GlcNHglycan	831	834	PF01048	0.717
MOD_GlcNHglycan	848	851	PF01048	0.814
MOD_GlcNHglycan	876	879	PF01048	0.716
MOD_GSK3_1	16	23	PF00069	0.442
MOD_GSK3_1	209	216	PF00069	0.366
MOD_GSK3_1	217	224	PF00069	0.335
MOD_GSK3_1	289	296	PF00069	0.335
MOD_GSK3_1	314	321	PF00069	0.620
MOD_GSK3_1	349	356	PF00069	0.526
MOD_GSK3_1	42	49	PF00069	0.355
MOD_GSK3_1	421	428	PF00069	0.577
MOD_GSK3_1	439	446	PF00069	0.602
MOD_GSK3_1	588	595	PF00069	0.652
MOD_GSK3_1	656	663	PF00069	0.681
MOD_GSK3_1	741	748	PF00069	0.672
MOD_GSK3_1	762	769	PF00069	0.709
MOD_GSK3_1	788	795	PF00069	0.790
MOD_GSK3_1	842	849	PF00069	0.716
MOD_GSK3_1	850	857	PF00069	0.680
MOD_GSK3_1	874	881	PF00069	0.573
MOD_GSK3_1	914	921	PF00069	0.770
MOD_GSK3_1	949	956	PF00069	0.655
MOD_N-GLC_1	120	125	PF02516	0.335
MOD_N-GLC_1	231	236	PF02516	0.335
MOD_N-GLC_1	43	48	PF02516	0.345
MOD_N-GLC_1	604	609	PF02516	0.751
MOD_N-GLC_1	65	70	PF02516	0.438
MOD_N-GLC_1	696	701	PF02516	0.767
MOD_N-GLC_1	854	859	PF02516	0.661
MOD_N-GLC_1	869	874	PF02516	0.700
MOD_NEK2_1	103	108	PF00069	0.480
MOD_NEK2_1	25	30	PF00069	0.335
MOD_NEK2_1	262	267	PF00069	0.400
MOD_NEK2_1	286	291	PF00069	0.403
MOD_NEK2_1	293	298	PF00069	0.335
MOD_NEK2_1	343	348	PF00069	0.623
MOD_NEK2_1	513	518	PF00069	0.623
MOD_NEK2_1	660	665	PF00069	0.720
MOD_NEK2_1	686	691	PF00069	0.776
MOD_NEK2_1	702	707	PF00069	0.703
MOD_NEK2_2	120	125	PF00069	0.346
MOD_NEK2_2	545	550	PF00069	0.691
MOD_PIKK_1	293	299	PF00454	0.335
MOD_PIKK_1	360	366	PF00454	0.516
MOD_PIKK_1	696	702	PF00454	0.727
MOD_PIKK_1	772	778	PF00454	0.781
MOD_PKA_1	592	598	PF00069	0.638
MOD_PKA_1	649	655	PF00069	0.650
MOD_PKA_1	729	735	PF00069	0.721
MOD_PKA_2	293	299	PF00069	0.335
MOD_PKA_2	343	349	PF00069	0.715
MOD_PKA_2	404	410	PF00069	0.570
MOD_PKA_2	592	598	PF00069	0.751
MOD_PKA_2	649	655	PF00069	0.598
MOD_PKA_2	656	662	PF00069	0.571
MOD_PKA_2	663	669	PF00069	0.611
MOD_PKA_2	728	734	PF00069	0.720
MOD_PKA_2	9	15	PF00069	0.573
MOD_PKB_1	727	735	PF00069	0.722
MOD_Plk_1	120	126	PF00069	0.335
MOD_Plk_1	231	237	PF00069	0.335
MOD_Plk_1	286	292	PF00069	0.335
MOD_Plk_1	46	52	PF00069	0.354
MOD_Plk_1	65	71	PF00069	0.216
MOD_Plk_1	807	813	PF00069	0.757
MOD_Plk_1	854	860	PF00069	0.639
MOD_Plk_2-3	153	159	PF00069	0.447
MOD_Plk_2-3	221	227	PF00069	0.331
MOD_Plk_2-3	421	427	PF00069	0.569
MOD_Plk_2-3	854	860	PF00069	0.639
MOD_Plk_4	199	205	PF00069	0.447
MOD_Plk_4	20	26	PF00069	0.444
MOD_Plk_4	343	349	PF00069	0.600
MOD_Plk_4	353	359	PF00069	0.473
MOD_Plk_4	46	52	PF00069	0.354
MOD_Plk_4	532	538	PF00069	0.722
MOD_Plk_4	65	71	PF00069	0.216
MOD_Plk_4	741	747	PF00069	0.672
MOD_Plk_4	79	85	PF00069	0.335
MOD_ProDKin_1	104	110	PF00069	0.408
MOD_ProDKin_1	596	602	PF00069	0.697
MOD_ProDKin_1	670	676	PF00069	0.697
MOD_ProDKin_1	920	926	PF00069	0.790
MOD_SUMO_for_1	434	437	PF00179	0.567
MOD_SUMO_rev_2	142	152	PF00179	0.312
MOD_SUMO_rev_2	563	571	PF00179	0.679
MOD_SUMO_rev_2	634	640	PF00179	0.571
TRG_DiLeu_BaEn_1	468	473	PF01217	0.646
TRG_DiLeu_BaEn_1	636	641	PF01217	0.568
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.480
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.493
TRG_ENDOCYTIC_2	116	119	PF00928	0.447
TRG_ENDOCYTIC_2	37	40	PF00928	0.335
TRG_ENDOCYTIC_2	485	488	PF00928	0.596
TRG_ENDOCYTIC_2	618	621	PF00928	0.677
TRG_ENDOCYTIC_2	789	792	PF00928	0.599
TRG_ENDOCYTIC_2	890	893	PF00928	0.734
TRG_ER_diArg_1	195	198	PF00400	0.363
TRG_ER_diArg_1	248	250	PF00400	0.480
TRG_ER_diArg_1	402	405	PF00400	0.558
TRG_ER_diArg_1	479	482	PF00400	0.540
TRG_ER_diArg_1	648	650	PF00400	0.611
TRG_ER_diArg_1	653	655	PF00400	0.559
TRG_ER_diArg_1	7	10	PF00400	0.389
TRG_ER_diArg_1	727	730	PF00400	0.655
TRG_ER_diArg_1	799	801	PF00400	0.773
TRG_NLS_MonoExtC_3	931	936	PF00514	0.733
TRG_NLS_MonoExtN_4	931	936	PF00514	0.733
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYU7	Leptomonas seymouri	68%	97%
A0A1X0P4H8	Trypanosomatidae	52%	100%
A0A422NI32	Trypanosoma rangeli	54%	100%
A4HLS6	Leishmania braziliensis	84%	100%
A4I985	Leishmania infantum	100%	100%
D0A6A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B452	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q9GRN3	Leishmania major	94%	100%
V5BTV0	Trypanosoma cruzi	54%	100%