Presenilin_enhancer-2_subunit_of_gamma_secretase_ putative/Pfam:PF10251

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Presenilin enhancer-2 subunit of gamma secretase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6Y2_LEIDO

TriTrypDb:

LdBPK_332120.1 , LdCL_330028100 , LDHU3_33.3050

Length:

115

Annotations

LeishMANIAdb annotations

Homologous to animal gamma-secretase subunits.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0032991	protein-containing complex	1	1
GO:0070765	gamma-secretase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0098797	plasma membrane protein complex	3	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3S7X6Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6Y2

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	12
GO:0007166	cell surface receptor signaling pathway	3	12
GO:0007219	Notch signaling pathway	4	12
GO:0009987	cellular process	1	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008233	peptidase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_FUR_1	54	58	PF00082	0.278
CLV_PCSK_KEX2_1	56	58	PF00082	0.273
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.257
DEG_Nend_Nbox_1	1	3	PF02207	0.398
DOC_CDC14_PxL_1	24	32	PF14671	0.266
DOC_PP1_RVXF_1	19	25	PF00149	0.374
DOC_PP4_FxxP_1	25	28	PF00568	0.411
DOC_PP4_FxxP_1	75	78	PF00568	0.425
DOC_USP7_MATH_1	111	115	PF00917	0.442
DOC_WW_Pin1_4	78	83	PF00397	0.333
LIG_14-3-3_CanoR_1	4	10	PF00244	0.402
LIG_14-3-3_CanoR_1	57	61	PF00244	0.495
LIG_AP2alpha_1	89	93	PF02296	0.381
LIG_APCC_ABBA_1	86	91	PF00400	0.421
LIG_BRCT_BRCA1_1	69	73	PF00533	0.426
LIG_FHA_1	78	84	PF00498	0.339
LIG_GSK3_LRP6_1	78	83	PF00069	0.295
LIG_LIR_Gen_1	70	79	PF02991	0.353
LIG_LIR_Nem_3	70	76	PF02991	0.326
LIG_LIR_Nem_3	92	98	PF02991	0.414
LIG_Pex14_2	25	29	PF04695	0.285
LIG_Pex14_2	89	93	PF04695	0.377
LIG_REV1ctd_RIR_1	35	43	PF16727	0.411
LIG_SH2_STAT5	51	54	PF00017	0.431
LIG_SH2_STAT5	97	100	PF00017	0.391
LIG_SH3_3	73	79	PF00018	0.368
LIG_SH3_3	82	88	PF00018	0.321
MOD_GlcNHglycan	13	16	PF01048	0.559
MOD_GlcNHglycan	60	63	PF01048	0.370
MOD_N-GLC_1	100	105	PF02516	0.675
MOD_NEK2_1	89	94	PF00069	0.438
MOD_PK_1	56	62	PF00069	0.478
MOD_PKA_1	56	62	PF00069	0.478
MOD_PKA_2	3	9	PF00069	0.345
MOD_PKA_2	56	62	PF00069	0.535
MOD_Plk_4	67	73	PF00069	0.468
MOD_ProDKin_1	78	84	PF00069	0.329
TRG_ENDOCYTIC_2	19	22	PF00928	0.307
TRG_ENDOCYTIC_2	97	100	PF00928	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P831	Leptomonas seymouri	57%	92%
A0A0S4J486	Bodo saltans	39%	100%
A0A0S4J7I6	Bodo saltans	38%	100%
A0A1X0P406	Trypanosomatidae	39%	100%
A0A3R7NE49	Trypanosoma rangeli	40%	100%
A4HLR2	Leishmania braziliensis	76%	100%
A4I962	Leishmania infantum	100%	100%
D0A696	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B438	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q3Y7	Leishmania major	93%	100%