Nucleoporin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Nucleoporin

Gene product:

Nucleoporin NUP59

Species:

Leishmania donovani

UniProt:

A0A3S7X6X9_LEIDO

TriTrypDb:

LdBPK_332500.1 , LdCL_330032000 , LDHU3_33.3580

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.448
CLV_NRD_NRD_1	362	364	PF00675	0.591
CLV_NRD_NRD_1	399	401	PF00675	0.571
CLV_NRD_NRD_1	90	92	PF00675	0.538
CLV_PCSK_KEX2_1	173	175	PF00082	0.421
CLV_PCSK_KEX2_1	190	192	PF00082	0.411
CLV_PCSK_KEX2_1	21	23	PF00082	0.620
CLV_PCSK_KEX2_1	29	31	PF00082	0.553
CLV_PCSK_KEX2_1	364	366	PF00082	0.432
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.486
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.596
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.526
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.391
CLV_PCSK_SKI1_1	174	178	PF00082	0.432
CLV_PCSK_SKI1_1	29	33	PF00082	0.497
CLV_PCSK_SKI1_1	364	368	PF00082	0.411
CLV_PCSK_SKI1_1	390	394	PF00082	0.550
CLV_PCSK_SKI1_1	409	413	PF00082	0.245
CLV_PCSK_SKI1_1	515	519	PF00082	0.470
CLV_PCSK_SKI1_1	91	95	PF00082	0.483
DEG_APCC_DBOX_1	362	370	PF00400	0.561
DEG_SPOP_SBC_1	229	233	PF00917	0.592
DEG_SPOP_SBC_1	331	335	PF00917	0.721
DOC_CYCLIN_RxL_1	158	166	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.566
DOC_PIKK_1	57	65	PF02985	0.439
DOC_PP1_RVXF_1	144	150	PF00149	0.619
DOC_PP1_RVXF_1	513	520	PF00149	0.594
DOC_PP4_FxxP_1	75	78	PF00568	0.635
DOC_USP7_MATH_1	178	182	PF00917	0.557
DOC_USP7_MATH_1	197	201	PF00917	0.631
DOC_USP7_MATH_1	217	221	PF00917	0.599
DOC_USP7_MATH_1	246	250	PF00917	0.668
DOC_USP7_MATH_1	254	258	PF00917	0.684
DOC_USP7_MATH_1	284	288	PF00917	0.705
DOC_USP7_MATH_1	3	7	PF00917	0.620
DOC_USP7_MATH_1	331	335	PF00917	0.728
DOC_USP7_MATH_1	340	344	PF00917	0.722
DOC_USP7_MATH_1	440	444	PF00917	0.550
DOC_USP7_MATH_1	457	461	PF00917	0.281
DOC_USP7_MATH_1	498	502	PF00917	0.539
DOC_USP7_MATH_1	509	513	PF00917	0.460
DOC_USP7_UBL2_3	29	33	PF12436	0.622
DOC_USP7_UBL2_3	518	522	PF12436	0.491
DOC_WW_Pin1_4	207	212	PF00397	0.724
DOC_WW_Pin1_4	240	245	PF00397	0.547
DOC_WW_Pin1_4	259	264	PF00397	0.621
DOC_WW_Pin1_4	312	317	PF00397	0.735
DOC_WW_Pin1_4	98	103	PF00397	0.427
LIG_14-3-3_CanoR_1	363	373	PF00244	0.451
LIG_14-3-3_CanoR_1	73	78	PF00244	0.495
LIG_14-3-3_CanoR_1	97	102	PF00244	0.521
LIG_Actin_WH2_2	471	487	PF00022	0.383
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	209	213	PF00533	0.638
LIG_BRCT_BRCA1_1	291	295	PF00533	0.576
LIG_BRCT_BRCA1_1	308	312	PF00533	0.680
LIG_BRCT_BRCA1_1	459	463	PF00533	0.372
LIG_deltaCOP1_diTrp_1	428	437	PF00928	0.477
LIG_deltaCOP1_diTrp_1	86	90	PF00928	0.550
LIG_EH_1	555	559	PF12763	0.531
LIG_FHA_1	203	209	PF00498	0.754
LIG_FHA_1	351	357	PF00498	0.567
LIG_FHA_1	387	393	PF00498	0.474
LIG_FHA_1	440	446	PF00498	0.447
LIG_FHA_1	66	72	PF00498	0.474
LIG_FHA_2	505	511	PF00498	0.590
LIG_LIR_Apic_2	74	78	PF02991	0.629
LIG_LIR_Gen_1	460	471	PF02991	0.358
LIG_LIR_Gen_1	86	94	PF02991	0.460
LIG_LIR_Nem_3	460	466	PF02991	0.377
LIG_LIR_Nem_3	512	517	PF02991	0.443
LIG_LIR_Nem_3	86	90	PF02991	0.459
LIG_OCRL_FandH_1	462	474	PF00620	0.429
LIG_PALB2_WD40_1	100	108	PF16756	0.423
LIG_PCNA_yPIPBox_3	33	45	PF02747	0.581
LIG_Pex14_2	265	269	PF04695	0.653
LIG_Pex14_2	293	297	PF04695	0.579
LIG_PTB_Apo_2	411	418	PF02174	0.350
LIG_PTB_Apo_2	465	472	PF02174	0.321
LIG_PTB_Phospho_1	465	471	PF10480	0.318
LIG_SH2_CRK	471	475	PF00017	0.346
LIG_SH2_NCK_1	151	155	PF00017	0.665
LIG_SH2_NCK_1	471	475	PF00017	0.346
LIG_SH2_SRC	128	131	PF00017	0.591
LIG_SH2_STAP1	471	475	PF00017	0.472
LIG_SH2_STAT5	128	131	PF00017	0.541
LIG_SH2_STAT5	143	146	PF00017	0.356
LIG_SH3_3	144	150	PF00018	0.619
LIG_SH3_3	301	307	PF00018	0.692
LIG_SH3_3	325	331	PF00018	0.703
LIG_SH3_3	543	549	PF00018	0.533
LIG_SUMO_SIM_par_1	480	487	PF11976	0.435
LIG_UBA3_1	357	364	PF00899	0.442
LIG_UBA3_1	412	419	PF00899	0.392
LIG_UBA3_1	499	504	PF00899	0.445
LIG_WRPW_2	528	531	PF00400	0.538
LIG_WW_2	328	331	PF00397	0.617
MOD_CDK_SPK_2	98	103	PF00069	0.415
MOD_CK1_1	218	224	PF00069	0.566
MOD_CK1_1	257	263	PF00069	0.685
MOD_CK1_1	285	291	PF00069	0.659
MOD_CK1_1	315	321	PF00069	0.757
MOD_CK1_1	535	541	PF00069	0.528
MOD_CK2_1	149	155	PF00069	0.530
MOD_CK2_1	272	278	PF00069	0.689
MOD_CK2_1	504	510	PF00069	0.584
MOD_GlcNHglycan	114	117	PF01048	0.475
MOD_GlcNHglycan	17	20	PF01048	0.503
MOD_GlcNHglycan	195	198	PF01048	0.627
MOD_GlcNHglycan	199	202	PF01048	0.634
MOD_GlcNHglycan	217	220	PF01048	0.642
MOD_GlcNHglycan	233	236	PF01048	0.709
MOD_GlcNHglycan	244	247	PF01048	0.696
MOD_GlcNHglycan	248	251	PF01048	0.696
MOD_GlcNHglycan	256	259	PF01048	0.706
MOD_GlcNHglycan	284	287	PF01048	0.725
MOD_GlcNHglycan	341	345	PF01048	0.722
MOD_GlcNHglycan	374	377	PF01048	0.448
MOD_GlcNHglycan	442	445	PF01048	0.462
MOD_GlcNHglycan	510	514	PF01048	0.490
MOD_GlcNHglycan	534	537	PF01048	0.534
MOD_GlcNHglycan	6	9	PF01048	0.594
MOD_GSK3_1	11	18	PF00069	0.615
MOD_GSK3_1	193	200	PF00069	0.715
MOD_GSK3_1	215	222	PF00069	0.607
MOD_GSK3_1	236	243	PF00069	0.681
MOD_GSK3_1	246	253	PF00069	0.644
MOD_GSK3_1	285	292	PF00069	0.683
MOD_GSK3_1	451	458	PF00069	0.315
MOD_GSK3_1	73	80	PF00069	0.585
MOD_GSK3_1	93	100	PF00069	0.604
MOD_N-GLC_1	97	102	PF02516	0.352
MOD_N-GLC_2	432	434	PF02516	0.433
MOD_NEK2_1	215	220	PF00069	0.645
MOD_NEK2_1	293	298	PF00069	0.613
MOD_NEK2_1	386	391	PF00069	0.568
MOD_NEK2_1	462	467	PF00069	0.379
MOD_NEK2_1	484	489	PF00069	0.341
MOD_NEK2_1	65	70	PF00069	0.465
MOD_PIKK_1	315	321	PF00454	0.706
MOD_PIKK_1	498	504	PF00454	0.537
MOD_PIKK_1	73	79	PF00454	0.586
MOD_PKA_1	11	17	PF00069	0.600
MOD_PKA_1	364	370	PF00069	0.445
MOD_PKA_1	4	10	PF00069	0.637
MOD_PKA_2	364	370	PF00069	0.445
MOD_PKA_2	484	490	PF00069	0.548
MOD_PKB_1	449	457	PF00069	0.315
MOD_Plk_1	504	510	PF00069	0.407
MOD_Plk_2-3	121	127	PF00069	0.506
MOD_ProDKin_1	207	213	PF00069	0.724
MOD_ProDKin_1	240	246	PF00069	0.546
MOD_ProDKin_1	259	265	PF00069	0.623
MOD_ProDKin_1	312	318	PF00069	0.735
MOD_ProDKin_1	98	104	PF00069	0.424
MOD_SUMO_rev_2	341	348	PF00179	0.708
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.558
TRG_DiLeu_BaLyEn_6	512	517	PF01217	0.456
TRG_ENDOCYTIC_2	471	474	PF00928	0.377
TRG_ER_diArg_1	172	174	PF00400	0.458
TRG_ER_diArg_1	363	366	PF00400	0.567
TRG_NLS_Bipartite_1	173	194	PF00514	0.424
TRG_NLS_MonoExtC_3	362	368	PF00514	0.416
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8T0	Leptomonas seymouri	64%	100%
A0A0S4J4Z2	Bodo saltans	39%	100%
A0A1X0P580	Trypanosomatidae	46%	100%
A0A3R7NSX9	Trypanosoma rangeli	50%	100%
A4HHX8	Leishmania braziliensis	78%	100%
D0A676	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AHQ5	Leishmania infantum	99%	100%
E9B476	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q3V0	Leishmania major	92%	100%
V5BYJ7	Trypanosoma cruzi	46%	100%