Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6X8_LEIDO

TriTrypDb:

LdBPK_331990.1 , LdCL_330026700 , LDHU3_33.2900

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7X6X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6X8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	461	465	PF00656	0.513
CLV_MEL_PAP_1	546	552	PF00089	0.603
CLV_NRD_NRD_1	153	155	PF00675	0.719
CLV_NRD_NRD_1	189	191	PF00675	0.676
CLV_NRD_NRD_1	304	306	PF00675	0.675
CLV_NRD_NRD_1	426	428	PF00675	0.737
CLV_NRD_NRD_1	480	482	PF00675	0.703
CLV_NRD_NRD_1	548	550	PF00675	0.479
CLV_NRD_NRD_1	65	67	PF00675	0.734
CLV_PCSK_KEX2_1	153	155	PF00082	0.789
CLV_PCSK_KEX2_1	189	191	PF00082	0.732
CLV_PCSK_KEX2_1	304	306	PF00082	0.675
CLV_PCSK_KEX2_1	426	428	PF00082	0.741
CLV_PCSK_KEX2_1	480	482	PF00082	0.703
CLV_PCSK_KEX2_1	548	550	PF00082	0.479
CLV_PCSK_KEX2_1	65	67	PF00082	0.734
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.741
CLV_PCSK_PC7_1	422	428	PF00082	0.785
CLV_PCSK_SKI1_1	128	132	PF00082	0.588
CLV_PCSK_SKI1_1	193	197	PF00082	0.649
CLV_PCSK_SKI1_1	480	484	PF00082	0.685
DEG_SPOP_SBC_1	332	336	PF00917	0.629
DEG_SPOP_SBC_1	449	453	PF00917	0.566
DEG_SPOP_SBC_1	76	80	PF00917	0.564
DEG_SPOP_SBC_1	88	92	PF00917	0.336
DOC_CYCLIN_RxL_1	477	486	PF00134	0.407
DOC_MAPK_gen_1	128	136	PF00069	0.421
DOC_MAPK_MEF2A_6	369	376	PF00069	0.591
DOC_MAPK_RevD_3	536	549	PF00069	0.436
DOC_PP4_FxxP_1	358	361	PF00568	0.442
DOC_USP7_MATH_1	165	169	PF00917	0.394
DOC_USP7_MATH_1	217	221	PF00917	0.584
DOC_USP7_MATH_1	244	248	PF00917	0.576
DOC_USP7_MATH_1	286	290	PF00917	0.574
DOC_USP7_MATH_1	328	332	PF00917	0.575
DOC_USP7_MATH_1	338	342	PF00917	0.556
DOC_USP7_MATH_1	398	402	PF00917	0.535
DOC_USP7_MATH_1	4	8	PF00917	0.492
DOC_USP7_MATH_1	441	445	PF00917	0.593
DOC_USP7_MATH_1	449	453	PF00917	0.627
DOC_USP7_MATH_1	499	503	PF00917	0.574
DOC_USP7_MATH_1	77	81	PF00917	0.595
DOC_USP7_MATH_1	88	92	PF00917	0.354
DOC_USP7_MATH_1	9	13	PF00917	0.486
DOC_USP7_UBL2_3	365	369	PF12436	0.489
DOC_USP7_UBL2_3	426	430	PF12436	0.579
DOC_USP7_UBL2_3	99	103	PF12436	0.532
DOC_WW_Pin1_4	112	117	PF00397	0.450
DOC_WW_Pin1_4	238	243	PF00397	0.629
DOC_WW_Pin1_4	313	318	PF00397	0.450
DOC_WW_Pin1_4	444	449	PF00397	0.648
DOC_WW_Pin1_4	470	475	PF00397	0.590
DOC_WW_Pin1_4	97	102	PF00397	0.426
LIG_14-3-3_CanoR_1	189	193	PF00244	0.462
LIG_14-3-3_CanoR_1	262	271	PF00244	0.476
LIG_14-3-3_CanoR_1	28	33	PF00244	0.461
LIG_14-3-3_CanoR_1	305	315	PF00244	0.410
LIG_14-3-3_CanoR_1	330	340	PF00244	0.480
LIG_14-3-3_CanoR_1	429	437	PF00244	0.491
LIG_14-3-3_CanoR_1	548	553	PF00244	0.685
LIG_14-3-3_CanoR_1	65	71	PF00244	0.555
LIG_Actin_WH2_2	142	158	PF00022	0.457
LIG_Actin_WH2_2	90	107	PF00022	0.502
LIG_BRCT_BRCA1_1	132	136	PF00533	0.460
LIG_deltaCOP1_diTrp_1	178	185	PF00928	0.410
LIG_eIF4E_1	525	531	PF01652	0.556
LIG_FHA_1	265	271	PF00498	0.466
LIG_FHA_1	307	313	PF00498	0.420
LIG_FHA_1	411	417	PF00498	0.549
LIG_FHA_1	88	94	PF00498	0.376
LIG_FHA_2	31	37	PF00498	0.462
LIG_FHA_2	456	462	PF00498	0.633
LIG_Integrin_RGD_1	19	21	PF01839	0.761
LIG_LIR_Gen_1	169	176	PF02991	0.434
LIG_LIR_Gen_1	291	302	PF02991	0.516
LIG_LIR_Nem_3	133	139	PF02991	0.457
LIG_LIR_Nem_3	169	175	PF02991	0.464
LIG_LIR_Nem_3	291	297	PF02991	0.529
LIG_LIR_Nem_3	354	360	PF02991	0.449
LIG_PDZ_Class_1	548	553	PF00595	0.685
LIG_SH2_NCK_1	325	329	PF00017	0.501
LIG_SH2_STAP1	525	529	PF00017	0.560
LIG_SH2_STAT3	106	109	PF00017	0.461
LIG_SH2_STAT5	106	109	PF00017	0.500
LIG_SH2_STAT5	357	360	PF00017	0.444
LIG_SH3_3	236	242	PF00018	0.569
LIG_SH3_3	373	379	PF00018	0.572
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.457
LIG_SUMO_SIM_par_1	172	179	PF11976	0.318
LIG_SUMO_SIM_par_1	90	98	PF11976	0.430
LIG_TYR_ITIM	355	360	PF00017	0.656
LIG_WRC_WIRS_1	29	34	PF05994	0.545
MOD_CDK_SPK_2	313	318	PF00069	0.557
MOD_CDK_SPxK_1	97	103	PF00069	0.515
MOD_CK1_1	115	121	PF00069	0.537
MOD_CK1_1	188	194	PF00069	0.567
MOD_CK1_1	248	254	PF00069	0.657
MOD_CK1_1	331	337	PF00069	0.806
MOD_CK1_1	387	393	PF00069	0.748
MOD_CK1_1	401	407	PF00069	0.618
MOD_CK1_1	411	417	PF00069	0.683
MOD_CK1_1	418	424	PF00069	0.761
MOD_CK1_1	444	450	PF00069	0.835
MOD_CK1_1	452	458	PF00069	0.721
MOD_CK1_1	78	84	PF00069	0.726
MOD_CK2_1	188	194	PF00069	0.591
MOD_CK2_1	197	203	PF00069	0.520
MOD_CK2_1	286	292	PF00069	0.615
MOD_CK2_1	30	36	PF00069	0.549
MOD_CK2_1	418	424	PF00069	0.818
MOD_CK2_1	455	461	PF00069	0.781
MOD_Cter_Amidation	424	427	PF01082	0.735
MOD_GlcNHglycan	11	14	PF01048	0.660
MOD_GlcNHglycan	247	250	PF01048	0.703
MOD_GlcNHglycan	329	333	PF01048	0.745
MOD_GlcNHglycan	347	350	PF01048	0.541
MOD_GlcNHglycan	392	396	PF01048	0.803
MOD_GlcNHglycan	403	406	PF01048	0.623
MOD_GlcNHglycan	409	413	PF01048	0.554
MOD_GlcNHglycan	432	435	PF01048	0.757
MOD_GlcNHglycan	440	444	PF01048	0.679
MOD_GlcNHglycan	501	504	PF01048	0.761
MOD_GlcNHglycan	525	528	PF01048	0.759
MOD_GlcNHglycan	531	534	PF01048	0.371
MOD_GlcNHglycan	6	9	PF01048	0.630
MOD_GlcNHglycan	85	88	PF01048	0.748
MOD_GSK3_1	115	122	PF00069	0.551
MOD_GSK3_1	197	204	PF00069	0.587
MOD_GSK3_1	217	224	PF00069	0.487
MOD_GSK3_1	244	251	PF00069	0.667
MOD_GSK3_1	328	335	PF00069	0.783
MOD_GSK3_1	338	345	PF00069	0.668
MOD_GSK3_1	364	371	PF00069	0.681
MOD_GSK3_1	384	391	PF00069	0.498
MOD_GSK3_1	407	414	PF00069	0.736
MOD_GSK3_1	439	446	PF00069	0.762
MOD_GSK3_1	448	455	PF00069	0.704
MOD_GSK3_1	75	82	PF00069	0.737
MOD_GSK3_1	83	90	PF00069	0.544
MOD_N-GLC_1	207	212	PF02516	0.787
MOD_NEK2_1	185	190	PF00069	0.584
MOD_NEK2_1	273	278	PF00069	0.457
MOD_NEK2_1	30	35	PF00069	0.597
MOD_NEK2_1	364	369	PF00069	0.697
MOD_NEK2_1	483	488	PF00069	0.578
MOD_NEK2_1	494	499	PF00069	0.635
MOD_PIKK_1	197	203	PF00454	0.578
MOD_PIKK_1	264	270	PF00454	0.568
MOD_PKA_1	430	436	PF00069	0.717
MOD_PKA_1	65	71	PF00069	0.722
MOD_PKA_2	188	194	PF00069	0.567
MOD_PKA_2	398	404	PF00069	0.745
MOD_PKA_2	64	70	PF00069	0.685
MOD_Plk_1	178	184	PF00069	0.507
MOD_Plk_1	292	298	PF00069	0.649
MOD_Plk_4	115	121	PF00069	0.514
MOD_Plk_4	22	28	PF00069	0.629
MOD_Plk_4	275	281	PF00069	0.499
MOD_Plk_4	89	95	PF00069	0.449
MOD_ProDKin_1	112	118	PF00069	0.555
MOD_ProDKin_1	238	244	PF00069	0.810
MOD_ProDKin_1	313	319	PF00069	0.550
MOD_ProDKin_1	444	450	PF00069	0.835
MOD_ProDKin_1	470	476	PF00069	0.747
MOD_ProDKin_1	97	103	PF00069	0.523
MOD_SUMO_rev_2	188	198	PF00179	0.567
TRG_DiLeu_BaEn_1	36	41	PF01217	0.537
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.607
TRG_ENDOCYTIC_2	357	360	PF00928	0.549
TRG_ER_diArg_1	153	156	PF00400	0.752
TRG_ER_diArg_1	256	259	PF00400	0.657
TRG_ER_diArg_1	303	305	PF00400	0.597
TRG_ER_diArg_1	479	481	PF00400	0.639
TRG_ER_diArg_1	547	549	PF00400	0.596
TRG_ER_diArg_1	64	66	PF00400	0.622
TRG_NLS_MonoCore_2	425	430	PF00514	0.728
TRG_NLS_MonoExtC_3	425	430	PF00514	0.738
TRG_NLS_MonoExtN_4	426	433	PF00514	0.732
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I907	Leptomonas seymouri	42%	89%
A4HLQ0	Leishmania braziliensis	69%	100%
A4I950	Leishmania infantum	99%	100%
E9B425	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q3Z9	Leishmania major	90%	100%