RNA editing complex protein MP46

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing complex protein MP46

Species:

Leishmania donovani

UniProt:

A0A3S7X6X4_LEIDO

TriTrypDb:

LdBPK_332090.1 , LdCL_330027800 , LDHU3_33.3010

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X6X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6X4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.562
CLV_NRD_NRD_1	148	150	PF00675	0.516
CLV_NRD_NRD_1	347	349	PF00675	0.619
CLV_NRD_NRD_1	469	471	PF00675	0.583
CLV_NRD_NRD_1	76	78	PF00675	0.459
CLV_NRD_NRD_1	82	84	PF00675	0.373
CLV_PCSK_KEX2_1	148	150	PF00082	0.499
CLV_PCSK_KEX2_1	346	348	PF00082	0.617
CLV_PCSK_KEX2_1	471	473	PF00082	0.593
CLV_PCSK_KEX2_1	81	83	PF00082	0.393
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.617
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.691
CLV_PCSK_PC7_1	77	83	PF00082	0.517
CLV_PCSK_SKI1_1	149	153	PF00082	0.494
CLV_PCSK_SKI1_1	96	100	PF00082	0.423
DEG_SCF_FBW7_1	20	27	PF00400	0.546
DOC_CKS1_1	483	488	PF01111	0.645
DOC_CYCLIN_yClb1_LxF_4	476	481	PF00134	0.652
DOC_CYCLIN_yClb5_NLxxxL_5	315	322	PF00134	0.491
DOC_MAPK_RevD_3	64	78	PF00069	0.546
DOC_PP4_FxxP_1	47	50	PF00568	0.476
DOC_SPAK_OSR1_1	45	49	PF12202	0.519
DOC_USP7_MATH_1	204	208	PF00917	0.560
DOC_USP7_MATH_1	219	223	PF00917	0.723
DOC_USP7_MATH_1	24	28	PF00917	0.467
DOC_USP7_MATH_1	251	255	PF00917	0.741
DOC_USP7_MATH_1	385	389	PF00917	0.746
DOC_USP7_MATH_1	50	54	PF00917	0.645
DOC_WW_Pin1_4	107	112	PF00397	0.654
DOC_WW_Pin1_4	199	204	PF00397	0.460
DOC_WW_Pin1_4	20	25	PF00397	0.539
DOC_WW_Pin1_4	242	247	PF00397	0.733
DOC_WW_Pin1_4	256	261	PF00397	0.490
DOC_WW_Pin1_4	388	393	PF00397	0.623
DOC_WW_Pin1_4	437	442	PF00397	0.712
DOC_WW_Pin1_4	445	450	PF00397	0.621
DOC_WW_Pin1_4	482	487	PF00397	0.704
LIG_14-3-3_CanoR_1	265	269	PF00244	0.518
LIG_14-3-3_CanoR_1	292	297	PF00244	0.486
LIG_14-3-3_CanoR_1	347	356	PF00244	0.645
LIG_14-3-3_CanoR_1	361	368	PF00244	0.700
LIG_14-3-3_CanoR_1	393	400	PF00244	0.624
LIG_Actin_WH2_2	53	71	PF00022	0.569
LIG_Actin_WH2_2	84	102	PF00022	0.439
LIG_BIR_II_1	1	5	PF00653	0.485
LIG_BRCT_BRCA1_1	132	136	PF00533	0.461
LIG_BRCT_BRCA1_1	447	451	PF00533	0.584
LIG_deltaCOP1_diTrp_1	474	481	PF00928	0.669
LIG_FHA_1	1	7	PF00498	0.554
LIG_FHA_1	126	132	PF00498	0.593
LIG_FHA_1	175	181	PF00498	0.476
LIG_FHA_1	208	214	PF00498	0.650
LIG_FHA_1	357	363	PF00498	0.503
LIG_FHA_1	381	387	PF00498	0.735
LIG_FHA_1	464	470	PF00498	0.550
LIG_FHA_1	483	489	PF00498	0.782
LIG_FHA_2	161	167	PF00498	0.496
LIG_FHA_2	371	377	PF00498	0.590
LIG_FHA_2	422	428	PF00498	0.565
LIG_FHA_2	445	451	PF00498	0.706
LIG_LIR_Apic_2	363	368	PF02991	0.524
LIG_LIR_Gen_1	448	455	PF02991	0.676
LIG_LIR_Gen_1	474	483	PF02991	0.713
LIG_LIR_Nem_3	410	415	PF02991	0.646
LIG_LIR_Nem_3	448	454	PF02991	0.692
LIG_LIR_Nem_3	459	465	PF02991	0.526
LIG_LIR_Nem_3	474	479	PF02991	0.619
LIG_NRBOX	188	194	PF00104	0.487
LIG_NRP_CendR_1	492	495	PF00754	0.722
LIG_SH2_STAT5	173	176	PF00017	0.421
LIG_SH2_STAT5	25	28	PF00017	0.505
LIG_SH2_STAT5	275	278	PF00017	0.427
LIG_SH2_STAT5	380	383	PF00017	0.638
LIG_SH2_STAT5	412	415	PF00017	0.588
LIG_SH2_STAT5	445	448	PF00017	0.678
LIG_SH3_3	101	107	PF00018	0.503
LIG_SH3_3	258	264	PF00018	0.619
LIG_SH3_3	384	390	PF00018	0.704
LIG_SH3_3	433	439	PF00018	0.655
LIG_SH3_3	477	483	PF00018	0.652
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.489
LIG_SUMO_SIM_anti_2	450	459	PF11976	0.693
LIG_SUMO_SIM_par_1	127	134	PF11976	0.437
MOD_CDK_SPK_2	388	393	PF00069	0.664
MOD_CDK_SPxK_1	107	113	PF00069	0.562
MOD_CDK_SPxxK_3	482	489	PF00069	0.709
MOD_CK1_1	102	108	PF00069	0.484
MOD_CK1_1	12	18	PF00069	0.591
MOD_CK1_1	125	131	PF00069	0.562
MOD_CK1_1	169	175	PF00069	0.453
MOD_CK1_1	199	205	PF00069	0.526
MOD_CK1_1	207	213	PF00069	0.571
MOD_CK1_1	229	235	PF00069	0.740
MOD_CK1_1	239	245	PF00069	0.715
MOD_CK1_1	295	301	PF00069	0.465
MOD_CK1_1	372	378	PF00069	0.651
MOD_CK1_1	388	394	PF00069	0.620
MOD_CK1_1	396	402	PF00069	0.559
MOD_CK1_1	437	443	PF00069	0.760
MOD_CK2_1	160	166	PF00069	0.505
MOD_CK2_1	185	191	PF00069	0.483
MOD_CK2_1	24	30	PF00069	0.574
MOD_CK2_1	370	376	PF00069	0.736
MOD_CK2_1	419	425	PF00069	0.641
MOD_CK2_1	444	450	PF00069	0.644
MOD_CK2_1	481	487	PF00069	0.715
MOD_Cter_Amidation	79	82	PF01082	0.455
MOD_GlcNHglycan	124	127	PF01048	0.653
MOD_GlcNHglycan	221	224	PF01048	0.712
MOD_GlcNHglycan	253	256	PF01048	0.538
MOD_GlcNHglycan	362	365	PF01048	0.675
MOD_GlcNHglycan	401	404	PF01048	0.618
MOD_GlcNHglycan	421	424	PF01048	0.489
MOD_GlcNHglycan	436	439	PF01048	0.744
MOD_GSK3_1	102	109	PF00069	0.547
MOD_GSK3_1	169	176	PF00069	0.418
MOD_GSK3_1	20	27	PF00069	0.468
MOD_GSK3_1	236	243	PF00069	0.732
MOD_GSK3_1	356	363	PF00069	0.510
MOD_GSK3_1	437	444	PF00069	0.734
MOD_GSK3_1	450	457	PF00069	0.739
MOD_GSK3_1	5	12	PF00069	0.572
MOD_N-GLC_1	204	209	PF02516	0.640
MOD_N-GLC_1	354	359	PF02516	0.583
MOD_NEK2_1	174	179	PF00069	0.446
MOD_NEK2_1	228	233	PF00069	0.659
MOD_NEK2_1	356	361	PF00069	0.522
MOD_NEK2_1	408	413	PF00069	0.643
MOD_NEK2_1	488	493	PF00069	0.660
MOD_NEK2_1	99	104	PF00069	0.427
MOD_PIKK_1	12	18	PF00454	0.481
MOD_PIKK_1	393	399	PF00454	0.630
MOD_PK_1	292	298	PF00069	0.481
MOD_PK_1	52	58	PF00069	0.590
MOD_PKA_2	119	125	PF00069	0.414
MOD_PKA_2	264	270	PF00069	0.509
MOD_PKA_2	349	355	PF00069	0.585
MOD_PKA_2	360	366	PF00069	0.657
MOD_PKA_2	99	105	PF00069	0.385
MOD_Plk_1	185	191	PF00069	0.483
MOD_Plk_1	370	376	PF00069	0.634
MOD_Plk_2-3	185	191	PF00069	0.483
MOD_Plk_2-3	221	227	PF00069	0.631
MOD_Plk_4	166	172	PF00069	0.373
MOD_Plk_4	185	191	PF00069	0.558
MOD_Plk_4	332	338	PF00069	0.495
MOD_Plk_4	408	414	PF00069	0.606
MOD_Plk_4	52	58	PF00069	0.617
MOD_ProDKin_1	107	113	PF00069	0.661
MOD_ProDKin_1	199	205	PF00069	0.471
MOD_ProDKin_1	20	26	PF00069	0.546
MOD_ProDKin_1	242	248	PF00069	0.734
MOD_ProDKin_1	256	262	PF00069	0.486
MOD_ProDKin_1	388	394	PF00069	0.649
MOD_ProDKin_1	437	443	PF00069	0.712
MOD_ProDKin_1	445	451	PF00069	0.620
MOD_ProDKin_1	482	488	PF00069	0.707
MOD_SUMO_rev_2	267	274	PF00179	0.462
MOD_SUMO_rev_2	484	491	PF00179	0.713
MOD_SUMO_rev_2	61	71	PF00179	0.564
MOD_SUMO_rev_2	72	79	PF00179	0.535
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.497
TRG_ENDOCYTIC_2	412	415	PF00928	0.688
TRG_ER_diArg_1	147	149	PF00400	0.491
TRG_ER_diArg_1	347	350	PF00400	0.565
TRG_ER_diArg_1	469	472	PF00400	0.645
TRG_ER_diArg_1	81	83	PF00400	0.393
TRG_NLS_MonoExtC_3	345	350	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7J1	Leptomonas seymouri	43%	79%
A0A3R7JYR8	Trypanosoma rangeli	37%	100%
A4HLQ9	Leishmania braziliensis	74%	99%
A4I959	Leishmania infantum	100%	100%
D0A6B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B435	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3Z0	Leishmania major	90%	100%
V5BYM8	Trypanosoma cruzi	38%	100%