LeishMANIAdb
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Derlin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Derlin
Gene product:
Der1-like family, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X6X1_LEIDO
TriTrypDb:
LdBPK_331900.1 , LdCL_330025700 , LDHU3_33.2800
Length:
215

Annotations

LeishMANIAdb annotations

Conserved eukaryotic protein, homologous to animal derlins. Probably involved in ER quality control.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
TermNameLevelCount
GO:0000151 ubiquitin ligase complex 3 1
GO:0000153 cytoplasmic ubiquitin ligase complex 4 1
GO:0000835 ER ubiquitin ligase complex 3 1
GO:0000836 Hrd1p ubiquitin ligase complex 4 1
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex 5 1
GO:0005789 endoplasmic reticulum membrane 4 9
GO:0016020 membrane 2 9
GO:0031090 organelle membrane 3 9
GO:0032991 protein-containing complex 1 1
GO:0098796 membrane protein complex 2 1
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Expansion

Sequence features

A0A3S7X6X1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6X1

Function

Biological processes
TermNameLevelCount
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 10
GO:0007165 signal transduction 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010033 response to organic substance 3 1
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Molecular functions
TermNameLevelCount
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0051787 misfolded protein binding 3 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_MEL_PAP_1 107 113 PF00089 0.461
CLV_NRD_NRD_1 90 92 PF00675 0.284
CLV_PCSK_KEX2_1 90 92 PF00082 0.309
CLV_PCSK_SKI1_1 54 58 PF00082 0.466
DEG_APCC_DBOX_1 89 97 PF00400 0.567
DEG_Nend_UBRbox_3 1 3 PF02207 0.679
DOC_CDC14_PxL_1 114 122 PF14671 0.420
DOC_MAPK_gen_1 90 98 PF00069 0.539
DOC_MAPK_HePTP_8 131 143 PF00069 0.370
DOC_MAPK_MEF2A_6 10 18 PF00069 0.551
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HV02 Leptomonas seymouri 26% 84%
A0A0N1PDU1 Leptomonas seymouri 52% 100%
A0A0S4IV51 Bodo saltans 24% 87%
A0A0S4KDZ1 Bodo saltans 35% 100%
A0A1X0NMT1 Trypanosomatidae 27% 84%
A0A1X0P505 Trypanosomatidae 45% 100%
A0A3S5H750 Leishmania donovani 28% 85%
A0A422N3D3 Trypanosoma rangeli 44% 100%
A4H9X0 Leishmania braziliensis 28% 85%
A4HLP0 Leishmania braziliensis 90% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS