Derlin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Derlin

Gene product:

Der1-like family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6X1_LEIDO

TriTrypDb:

LdBPK_331900.1 , LdCL_330025700 , LDHU3_33.2800

Length:

215

Annotations

LeishMANIAdb annotations

Conserved eukaryotic protein, homologous to animal derlins. Probably involved in ER quality control.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000153	cytoplasmic ubiquitin ligase complex	4	1
GO:0000835	ER ubiquitin ligase complex	3	1
GO:0000836	Hrd1p ubiquitin ligase complex	4	1
GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex	5	1
GO:0005789	endoplasmic reticulum membrane	4	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

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Expansion

Sequence features

A0A3S7X6X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6X1

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	10
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051787	misfolded protein binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	107	113	PF00089	0.461
CLV_NRD_NRD_1	90	92	PF00675	0.284
CLV_PCSK_KEX2_1	90	92	PF00082	0.309
CLV_PCSK_SKI1_1	54	58	PF00082	0.466
DEG_APCC_DBOX_1	89	97	PF00400	0.567
DEG_Nend_UBRbox_3	1	3	PF02207	0.679
DOC_CDC14_PxL_1	114	122	PF14671	0.420
DOC_MAPK_gen_1	90	98	PF00069	0.539
DOC_MAPK_HePTP_8	131	143	PF00069	0.370
DOC_MAPK_MEF2A_6	10	18	PF00069	0.551

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV02	Leptomonas seymouri	26%	84%
A0A0N1PDU1	Leptomonas seymouri	52%	100%
A0A0S4IV51	Bodo saltans	24%	87%
A0A0S4KDZ1	Bodo saltans	35%	100%
A0A1X0NMT1	Trypanosomatidae	27%	84%
A0A1X0P505	Trypanosomatidae	45%	100%
A0A3S5H750	Leishmania donovani	28%	85%
A0A422N3D3	Trypanosoma rangeli	44%	100%
A4H9X0	Leishmania braziliensis	28%	85%
A4HLP0	Leishmania braziliensis	90%	100%

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