Derlin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Derlin

Gene product:

Der1-like family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6X1_LEIDO

TriTrypDb:

LdBPK_331900.1 , LdCL_330025700 , LDHU3_33.2800

Length:

215

Annotations

LeishMANIAdb annotations

Conserved eukaryotic protein, homologous to animal derlins. Probably involved in ER quality control.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0000151	ubiquitin ligase complex	3	1
GO:0000153	cytoplasmic ubiquitin ligase complex	4	1
GO:0000835	ER ubiquitin ligase complex	3	1
GO:0000836	Hrd1p ubiquitin ligase complex	4	1
GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3S7X6X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6X1

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	10
GO:0050896	response to stimulus	1	10
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0030968	endoplasmic reticulum unfolded protein response	3	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051787	misfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	107	113	PF00089	0.461
CLV_NRD_NRD_1	90	92	PF00675	0.284
CLV_PCSK_KEX2_1	90	92	PF00082	0.309
CLV_PCSK_SKI1_1	54	58	PF00082	0.466
DEG_APCC_DBOX_1	89	97	PF00400	0.567
DEG_Nend_UBRbox_3	1	3	PF02207	0.679
DOC_CDC14_PxL_1	114	122	PF14671	0.420
DOC_MAPK_gen_1	90	98	PF00069	0.539
DOC_MAPK_HePTP_8	131	143	PF00069	0.370
DOC_MAPK_MEF2A_6	10	18	PF00069	0.551
DOC_MAPK_MEF2A_6	134	143	PF00069	0.501
DOC_MAPK_MEF2A_6	152	161	PF00069	0.236
DOC_MAPK_MEF2A_6	91	100	PF00069	0.482
DOC_PP4_FxxP_1	145	148	PF00568	0.461
DOC_PP4_FxxP_1	207	210	PF00568	0.705
DOC_WW_Pin1_4	192	197	PF00397	0.710
DOC_WW_Pin1_4	39	44	PF00397	0.284
DOC_WW_Pin1_4	9	14	PF00397	0.667
LIG_14-3-3_CanoR_1	110	118	PF00244	0.401
LIG_14-3-3_CterR_2	212	215	PF00244	0.721
LIG_Actin_RPEL_3	83	102	PF02755	0.511
LIG_Actin_WH2_2	94	112	PF00022	0.420
LIG_BRCT_BRCA1_1	132	136	PF00533	0.430
LIG_BRCT_BRCA1_1	43	47	PF00533	0.339
LIG_eIF4E_1	130	136	PF01652	0.315
LIG_eIF4E_1	95	101	PF01652	0.420
LIG_FHA_1	13	19	PF00498	0.301
LIG_FHA_1	167	173	PF00498	0.384
LIG_FHA_1	55	61	PF00498	0.337
LIG_GBD_Chelix_1	17	25	PF00786	0.364
LIG_HCF-1_HBM_1	49	52	PF13415	0.367
LIG_LIR_Apic_2	204	210	PF02991	0.707
LIG_LIR_Gen_1	133	144	PF02991	0.548
LIG_LIR_Gen_1	57	67	PF02991	0.367
LIG_LIR_Gen_1	72	83	PF02991	0.340
LIG_LIR_Gen_1	94	102	PF02991	0.375
LIG_LIR_LC3C_4	15	18	PF02991	0.364
LIG_LIR_Nem_3	186	191	PF02991	0.470
LIG_LIR_Nem_3	49	55	PF02991	0.279
LIG_LIR_Nem_3	57	62	PF02991	0.260
LIG_LIR_Nem_3	72	78	PF02991	0.349
LIG_LIR_Nem_3	94	100	PF02991	0.394
LIG_Pex14_2	184	188	PF04695	0.506
LIG_Pex14_2	203	207	PF04695	0.646
LIG_PTB_Apo_2	113	120	PF02174	0.384
LIG_PTB_Apo_2	55	62	PF02174	0.334
LIG_PTB_Phospho_1	113	119	PF10480	0.384
LIG_PTB_Phospho_1	55	61	PF10480	0.337
LIG_SH2_PTP2	95	98	PF00017	0.461
LIG_SH2_SRC	82	85	PF00017	0.567
LIG_SH2_STAT5	119	122	PF00017	0.339
LIG_SH2_STAT5	130	133	PF00017	0.307
LIG_SH2_STAT5	183	186	PF00017	0.337
LIG_SH2_STAT5	38	41	PF00017	0.325
LIG_SH2_STAT5	61	64	PF00017	0.316
LIG_SH2_STAT5	77	80	PF00017	0.377
LIG_SH2_STAT5	82	85	PF00017	0.478
LIG_SH2_STAT5	95	98	PF00017	0.244
LIG_SH3_3	112	118	PF00018	0.386
LIG_SH3_3	144	150	PF00018	0.424
LIG_SH3_3	30	36	PF00018	0.420
LIG_SUMO_SIM_anti_2	11	18	PF11976	0.524
LIG_SUMO_SIM_anti_2	29	35	PF11976	0.403
LIG_TYR_ITIM	93	98	PF00017	0.537
MOD_CDC14_SPxK_1	195	198	PF00782	0.710
MOD_CDK_SPxK_1	192	198	PF00069	0.712
MOD_CK1_1	166	172	PF00069	0.420
MOD_CK2_1	26	32	PF00069	0.441
MOD_CK2_1	78	84	PF00069	0.512
MOD_GlcNHglycan	165	168	PF01048	0.382
MOD_GlcNHglycan	65	68	PF01048	0.461
MOD_GSK3_1	126	133	PF00069	0.401
MOD_GSK3_1	78	85	PF00069	0.487
MOD_NEK2_1	109	114	PF00069	0.410
MOD_NEK2_1	123	128	PF00069	0.262
MOD_NEK2_1	78	83	PF00069	0.537
MOD_PIKK_1	82	88	PF00454	0.414
MOD_PK_1	110	116	PF00069	0.420
MOD_PKA_2	109	115	PF00069	0.401
MOD_PKA_2	189	195	PF00069	0.617
MOD_Plk_4	102	108	PF00069	0.371
MOD_Plk_4	110	116	PF00069	0.308
MOD_Plk_4	118	124	PF00069	0.233
MOD_Plk_4	126	132	PF00069	0.310
MOD_Plk_4	160	166	PF00069	0.392
MOD_Plk_4	41	47	PF00069	0.299
MOD_Plk_4	78	84	PF00069	0.545
MOD_ProDKin_1	192	198	PF00069	0.712
MOD_ProDKin_1	39	45	PF00069	0.284
MOD_ProDKin_1	9	15	PF00069	0.667
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.378
TRG_ENDOCYTIC_2	38	41	PF00928	0.337
TRG_ENDOCYTIC_2	52	55	PF00928	0.131
TRG_ENDOCYTIC_2	95	98	PF00928	0.390
TRG_ER_diArg_1	90	92	PF00400	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV02	Leptomonas seymouri	26%	84%
A0A0N1PDU1	Leptomonas seymouri	52%	100%
A0A0S4IV51	Bodo saltans	24%	87%
A0A0S4KDZ1	Bodo saltans	35%	100%
A0A1X0NMT1	Trypanosomatidae	27%	84%
A0A1X0P505	Trypanosomatidae	45%	100%
A0A3S5H750	Leishmania donovani	28%	85%
A0A422N3D3	Trypanosoma rangeli	44%	100%
A4H9X0	Leishmania braziliensis	28%	85%
A4HLP0	Leishmania braziliensis	90%	100%
A4I975	Leishmania infantum	100%	100%
E9AGR5	Leishmania infantum	28%	85%
E9ARW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	85%
E9B416	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q06397	Oryza sativa subsp. japonica	26%	89%
Q0P5E4	Bos taurus	28%	93%
Q21997	Caenorhabditis elegans	26%	91%
Q4G2J3	Zea mays	26%	86%
Q4G2J4	Zea mays	28%	86%
Q4G2J5	Zea mays	26%	88%
Q4G2J6	Zea mays	27%	88%
Q4Q408	Leishmania major	98%	100%
Q54IC9	Dictyostelium discoideum	24%	89%
Q54NN1	Dictyostelium discoideum	27%	85%
Q5R9W3	Pongo abelii	29%	86%
Q5RC74	Pongo abelii	31%	90%
Q71SS4	Bos taurus	29%	86%
Q851X7	Oryza sativa subsp. japonica	26%	86%
Q8BNI4	Mus musculus	31%	90%
Q8VZ96	Arabidopsis thaliana	27%	88%
Q8VZU9	Arabidopsis thaliana	29%	81%
Q93561	Caenorhabditis elegans	27%	88%
Q96Q80	Homo sapiens	31%	91%
Q99J56	Mus musculus	28%	86%
Q9BUN8	Homo sapiens	29%	86%
Q9D8K3	Mus musculus	31%	94%
Q9GZP9	Homo sapiens	31%	90%
Q9VQ57	Drosophila melanogaster	30%	88%
Q9Y7Y0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	96%
Q9ZS88	Arabidopsis thaliana	27%	88%
V5BIJ4	Trypanosoma cruzi	29%	85%