Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X6W7_LEIDO

TriTrypDb:

LdBPK_331950.1 , LdCL_330026300 , LDHU3_33.2860

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6W7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.734
CLV_C14_Caspase3-7	189	193	PF00656	0.513
CLV_C14_Caspase3-7	227	231	PF00656	0.452
CLV_NRD_NRD_1	32	34	PF00675	0.497
CLV_PCSK_KEX2_1	25	27	PF00082	0.558
CLV_PCSK_KEX2_1	32	34	PF00082	0.495
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.433
CLV_PCSK_SKI1_1	226	230	PF00082	0.542
CLV_PCSK_SKI1_1	32	36	PF00082	0.504
CLV_PCSK_SKI1_1	9	13	PF00082	0.538
DEG_SCF_FBW7_1	177	182	PF00400	0.524
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.514
DOC_MAPK_gen_1	195	202	PF00069	0.631
DOC_PP2B_LxvP_1	138	141	PF13499	0.501
DOC_PP4_FxxP_1	145	148	PF00568	0.523
DOC_USP7_MATH_1	86	90	PF00917	0.693
DOC_USP7_MATH_1	97	101	PF00917	0.802
DOC_WW_Pin1_4	144	149	PF00397	0.508
DOC_WW_Pin1_4	175	180	PF00397	0.654
DOC_WW_Pin1_4	73	78	PF00397	0.761
LIG_APCC_ABBA_1	200	205	PF00400	0.532
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_eIF4E_1	210	216	PF01652	0.539
LIG_FHA_1	180	186	PF00498	0.548
LIG_FHA_2	225	231	PF00498	0.487
LIG_FHA_2	236	242	PF00498	0.452
LIG_LIR_Apic_2	143	148	PF02991	0.522
LIG_LIR_Gen_1	155	164	PF02991	0.534
LIG_LIR_Nem_3	155	161	PF02991	0.481
LIG_SH2_CRK	52	56	PF00017	0.465
LIG_SH3_3	102	108	PF00018	0.824
LIG_SUMO_SIM_anti_2	184	189	PF11976	0.619
LIG_SUMO_SIM_par_1	181	186	PF11976	0.633
LIG_SUMO_SIM_par_1	233	238	PF11976	0.397
LIG_TRAF2_1	238	241	PF00917	0.573
LIG_UBA3_1	130	139	PF00899	0.487
LIG_WRC_WIRS_1	248	253	PF05994	0.639
MOD_CDC14_SPxK_1	147	150	PF00782	0.510
MOD_CDK_SPxK_1	144	150	PF00069	0.503
MOD_CK1_1	201	207	PF00069	0.657
MOD_CK1_1	217	223	PF00069	0.374
MOD_CK1_1	247	253	PF00069	0.558
MOD_CK1_1	89	95	PF00069	0.695
MOD_CK2_1	235	241	PF00069	0.564
MOD_GlcNHglycan	1	4	PF01048	0.589
MOD_GlcNHglycan	164	168	PF01048	0.682
MOD_GlcNHglycan	61	64	PF01048	0.526
MOD_GlcNHglycan	67	70	PF01048	0.595
MOD_GlcNHglycan	88	91	PF01048	0.637
MOD_GlcNHglycan	92	95	PF01048	0.680
MOD_GSK3_1	140	147	PF00069	0.515
MOD_GSK3_1	152	159	PF00069	0.515
MOD_GSK3_1	175	182	PF00069	0.682
MOD_GSK3_1	214	221	PF00069	0.518
MOD_GSK3_1	73	80	PF00069	0.647
MOD_GSK3_1	85	92	PF00069	0.699
MOD_N-GLC_1	172	177	PF02516	0.797
MOD_N-GLC_1	241	246	PF02516	0.636
MOD_NEK2_1	156	161	PF00069	0.630
MOD_NEK2_1	183	188	PF00069	0.504
MOD_NEK2_2	198	203	PF00069	0.508
MOD_PKA_2	41	47	PF00069	0.506
MOD_Plk_1	217	223	PF00069	0.638
MOD_Plk_2-3	111	117	PF00069	0.749
MOD_Plk_4	152	158	PF00069	0.511
MOD_Plk_4	183	189	PF00069	0.513
MOD_Plk_4	198	204	PF00069	0.550
MOD_Plk_4	244	250	PF00069	0.570
MOD_ProDKin_1	144	150	PF00069	0.503
MOD_ProDKin_1	175	181	PF00069	0.643
MOD_ProDKin_1	73	79	PF00069	0.764
MOD_SUMO_for_1	24	27	PF00179	0.512
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.516
TRG_ENDOCYTIC_2	157	160	PF00928	0.514
TRG_ENDOCYTIC_2	52	55	PF00928	0.465
TRG_ER_diArg_1	31	33	PF00400	0.501
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P841	Leptomonas seymouri	59%	100%
A4HLP6	Leishmania braziliensis	74%	98%
A4I947	Leishmania infantum	100%	100%
E9B421	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q403	Leishmania major	91%	100%