LeishMANIAdb
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Kinesin motor domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Kinesin motor domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X6W4_LEIDO
TriTrypDb:
LdBPK_332400.1 * , LdCL_330031000 , LDHU3_33.3440
Length:
1047

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005576 extracellular region 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X6W4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6W4

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006810 transport 3 1
GO:0006869 lipid transport 5 1
GO:0008152 metabolic process 1 1
GO:0019538 protein metabolic process 3 1
GO:0042157 lipoprotein metabolic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0071702 organic substance transport 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0008289 lipid binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 23 27 PF00656 0.581
CLV_C14_Caspase3-7 51 55 PF00656 0.525
CLV_NRD_NRD_1 1012 1014 PF00675 0.451
CLV_PCSK_FUR_1 1033 1037 PF00082 0.487
CLV_PCSK_KEX2_1 1011 1013 PF00082 0.475
CLV_PCSK_KEX2_1 1035 1037 PF00082 0.487
CLV_PCSK_PC1ET2_1 1035 1037 PF00082 0.487
CLV_PCSK_PC7_1 1008 1014 PF00082 0.437
CLV_PCSK_SKI1_1 983 987 PF00082 0.403
DEG_APCC_DBOX_1 100 108 PF00400 0.416
DEG_SPOP_SBC_1 45 49 PF00917 0.557
DOC_CYCLIN_RxL_1 117 125 PF00134 0.481
DOC_MAPK_MEF2A_6 8 16 PF00069 0.514
DOC_USP7_MATH_1 111 115 PF00917 0.529
DOC_USP7_MATH_1 141 145 PF00917 0.438
DOC_USP7_MATH_1 180 184 PF00917 0.506
DOC_USP7_MATH_1 219 223 PF00917 0.499
DOC_USP7_MATH_1 258 262 PF00917 0.478
DOC_USP7_MATH_1 28 32 PF00917 0.677
DOC_USP7_MATH_1 297 301 PF00917 0.477
DOC_USP7_MATH_1 336 340 PF00917 0.440
DOC_USP7_MATH_1 375 379 PF00917 0.459
DOC_USP7_MATH_1 414 418 PF00917 0.497
DOC_USP7_MATH_1 453 457 PF00917 0.457
DOC_USP7_MATH_1 492 496 PF00917 0.481
DOC_USP7_MATH_1 531 535 PF00917 0.534
DOC_USP7_MATH_1 570 574 PF00917 0.502
DOC_USP7_MATH_1 609 613 PF00917 0.485
DOC_USP7_MATH_1 648 652 PF00917 0.412
DOC_USP7_MATH_1 687 691 PF00917 0.488
DOC_USP7_MATH_1 726 730 PF00917 0.486
DOC_USP7_MATH_1 765 769 PF00917 0.505
DOC_USP7_MATH_1 804 808 PF00917 0.499
DOC_USP7_MATH_1 843 847 PF00917 0.497
DOC_USP7_MATH_1 882 886 PF00917 0.504
DOC_USP7_MATH_1 973 977 PF00917 0.397
DOC_USP7_UBL2_3 945 949 PF12436 0.476
DOC_WW_Pin1_4 8 13 PF00397 0.602
LIG_14-3-3_CanoR_1 1036 1041 PF00244 0.476
LIG_14-3-3_CanoR_1 39 46 PF00244 0.573
LIG_14-3-3_CanoR_1 84 89 PF00244 0.404
LIG_BIR_II_1 1 5 PF00653 0.475
LIG_CaM_IQ_9 957 973 PF13499 0.383
LIG_FHA_1 1018 1024 PF00498 0.439
LIG_FHA_1 117 123 PF00498 0.506
LIG_FHA_2 111 117 PF00498 0.511
LIG_FHA_2 51 57 PF00498 0.624
LIG_GBD_Chelix_1 956 964 PF00786 0.409
LIG_LIR_Gen_1 56 66 PF02991 0.459
LIG_LIR_Nem_3 56 61 PF02991 0.600
LIG_NRBOX 1018 1024 PF00104 0.439
LIG_SH2_CRK 58 62 PF00017 0.465
LIG_SH2_GRB2like 58 61 PF00017 0.462
LIG_SH2_STAT5 33 36 PF00017 0.571
LIG_SH3_3 11 17 PF00018 0.623
LIG_SH3_3 927 933 PF00018 0.443
LIG_SUMO_SIM_anti_2 96 101 PF11976 0.398
LIG_TRAF2_1 1024 1027 PF00917 0.507
LIG_UBA3_1 72 78 PF00899 0.384
MOD_CAAXbox 1044 1047 PF01239 0.474
MOD_CK1_1 29 35 PF00069 0.581
MOD_CK1_1 38 44 PF00069 0.604
MOD_CK1_1 47 53 PF00069 0.650
MOD_CK2_1 110 116 PF00069 0.539
MOD_CK2_1 141 147 PF00069 0.467
MOD_CK2_1 180 186 PF00069 0.512
MOD_CK2_1 219 225 PF00069 0.515
MOD_CK2_1 258 264 PF00069 0.531
MOD_CK2_1 297 303 PF00069 0.515
MOD_CK2_1 336 342 PF00069 0.452
MOD_CK2_1 375 381 PF00069 0.469
MOD_CK2_1 414 420 PF00069 0.536
MOD_CK2_1 453 459 PF00069 0.668
MOD_CK2_1 492 498 PF00069 0.488
MOD_CK2_1 50 56 PF00069 0.496
MOD_CK2_1 531 537 PF00069 0.551
MOD_CK2_1 570 576 PF00069 0.509
MOD_CK2_1 609 615 PF00069 0.497
MOD_CK2_1 648 654 PF00069 0.425
MOD_CK2_1 687 693 PF00069 0.493
MOD_CK2_1 726 732 PF00069 0.534
MOD_CK2_1 765 771 PF00069 0.519
MOD_CK2_1 804 810 PF00069 0.684
MOD_CK2_1 843 849 PF00069 0.535
MOD_CK2_1 882 888 PF00069 0.495
MOD_GlcNHglycan 1 4 PF01048 0.542
MOD_GlcNHglycan 1027 1030 PF01048 0.473
MOD_GlcNHglycan 144 147 PF01048 0.479
MOD_GlcNHglycan 183 186 PF01048 0.475
MOD_GlcNHglycan 222 225 PF01048 0.469
MOD_GlcNHglycan 26 29 PF01048 0.614
MOD_GlcNHglycan 261 264 PF01048 0.448
MOD_GlcNHglycan 300 303 PF01048 0.494
MOD_GlcNHglycan 339 342 PF01048 0.428
MOD_GlcNHglycan 378 381 PF01048 0.461
MOD_GlcNHglycan 41 44 PF01048 0.563
MOD_GlcNHglycan 417 420 PF01048 0.466
MOD_GlcNHglycan 456 459 PF01048 0.449
MOD_GlcNHglycan 495 498 PF01048 0.467
MOD_GlcNHglycan 50 53 PF01048 0.448
MOD_GlcNHglycan 534 537 PF01048 0.516
MOD_GlcNHglycan 573 576 PF01048 0.506
MOD_GlcNHglycan 612 615 PF01048 0.423
MOD_GlcNHglycan 651 654 PF01048 0.418
MOD_GlcNHglycan 690 693 PF01048 0.460
MOD_GlcNHglycan 729 732 PF01048 0.476
MOD_GlcNHglycan 768 771 PF01048 0.479
MOD_GlcNHglycan 807 810 PF01048 0.472
MOD_GlcNHglycan 846 849 PF01048 0.466
MOD_GlcNHglycan 885 888 PF01048 0.473
MOD_GSK3_1 1025 1032 PF00069 0.505
MOD_GSK3_1 20 27 PF00069 0.623
MOD_GSK3_1 28 35 PF00069 0.622
MOD_GSK3_1 37 44 PF00069 0.615
MOD_GSK3_1 46 53 PF00069 0.717
MOD_LATS_1 37 43 PF00433 0.567
MOD_N-GLC_1 24 29 PF02516 0.530
MOD_NEK2_1 82 87 PF00069 0.464
MOD_NEK2_1 918 923 PF00069 0.380
MOD_NEK2_1 934 939 PF00069 0.416
MOD_NEK2_1 960 965 PF00069 0.372
MOD_PIKK_1 26 32 PF00454 0.583
MOD_PKA_2 38 44 PF00069 0.564
MOD_PKA_2 83 89 PF00069 0.455
MOD_Plk_1 20 26 PF00069 0.520
MOD_Plk_1 918 924 PF00069 0.382
MOD_Plk_2-3 20 26 PF00069 0.490
MOD_Plk_4 41 47 PF00069 0.687
MOD_ProDKin_1 8 14 PF00069 0.603
MOD_SUMO_for_1 107 110 PF00179 0.417
MOD_SUMO_for_1 61 64 PF00179 0.451
MOD_SUMO_rev_2 980 987 PF00179 0.380
TRG_DiLeu_BaEn_1 1018 1023 PF01217 0.504
TRG_ENDOCYTIC_2 58 61 PF00928 0.462
TRG_ENDOCYTIC_2 79 82 PF00928 0.418
TRG_ER_diArg_1 1010 1013 PF00400 0.491
TRG_ER_diArg_1 975 978 PF00400 0.412
TRG_NLS_MonoExtN_4 1033 1039 PF00514 0.481
TRG_Pf-PMV_PEXEL_1 120 125 PF00026 0.508

Homologs

Protein Taxonomy Sequence identity Coverage
A4H3R9 Leishmania braziliensis 33% 89%
A4HBI8 Leishmania braziliensis 34% 100%
A4HLU0 Leishmania braziliensis 62% 85%
D0A687 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9B466 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS