DNA polymerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA polymerase

Gene product:

DNA polymerase delta catalytic subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6W2_LEIDO

TriTrypDb:

LdBPK_331790.1 , LdCL_330024700 , LDHU3_33.2660

Length:

1032

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0032991	protein-containing complex	1	1
GO:0042575	DNA polymerase complex	3	1
GO:0043625	delta DNA polymerase complex	3	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3S7X6W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6W2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006261	DNA-templated DNA replication	6	1
GO:0006281	DNA repair	5	1
GO:0006287	base-excision repair, gap-filling	5	1
GO:0006297	nucleotide-excision repair, DNA gap filling	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0045004	DNA replication proofreading	6	1
GO:0045005	DNA-templated DNA replication maintenance of fidelity	5	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003887	DNA-directed DNA polymerase activity	5	12
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0034061	DNA polymerase activity	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051539	4 iron, 4 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0008296	3'-5'-DNA exonuclease activity	7	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	751	755	PF00656	0.246
CLV_MEL_PAP_1	1022	1028	PF00089	0.348
CLV_NRD_NRD_1	1008	1010	PF00675	0.246
CLV_NRD_NRD_1	120	122	PF00675	0.305
CLV_NRD_NRD_1	248	250	PF00675	0.280
CLV_NRD_NRD_1	435	437	PF00675	0.305
CLV_NRD_NRD_1	489	491	PF00675	0.291
CLV_NRD_NRD_1	595	597	PF00675	0.246
CLV_NRD_NRD_1	762	764	PF00675	0.257
CLV_PCSK_KEX2_1	120	122	PF00082	0.264
CLV_PCSK_KEX2_1	434	436	PF00082	0.307
CLV_PCSK_KEX2_1	737	739	PF00082	0.270
CLV_PCSK_KEX2_1	762	764	PF00082	0.257
CLV_PCSK_KEX2_1	970	972	PF00082	0.246
CLV_PCSK_PC1ET2_1	737	739	PF00082	0.246
CLV_PCSK_PC1ET2_1	970	972	PF00082	0.246
CLV_PCSK_SKI1_1	149	153	PF00082	0.246
CLV_PCSK_SKI1_1	250	254	PF00082	0.246
CLV_PCSK_SKI1_1	280	284	PF00082	0.246
CLV_PCSK_SKI1_1	443	447	PF00082	0.318
CLV_PCSK_SKI1_1	578	582	PF00082	0.286
CLV_PCSK_SKI1_1	685	689	PF00082	0.305
CLV_PCSK_SKI1_1	718	722	PF00082	0.303
CLV_PCSK_SKI1_1	857	861	PF00082	0.283
CLV_PCSK_SKI1_1	932	936	PF00082	0.439
DOC_CYCLIN_RxL_1	144	154	PF00134	0.261
DOC_CYCLIN_yClb1_LxF_4	719	724	PF00134	0.246
DOC_CYCLIN_yClb5_NLxxxL_5	660	668	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.375
DOC_CYCLIN_yCln2_LP_2	552	558	PF00134	0.311
DOC_MAPK_DCC_7	127	137	PF00069	0.391
DOC_MAPK_DCC_7	48	57	PF00069	0.411
DOC_MAPK_FxFP_2	329	332	PF00069	0.246
DOC_MAPK_gen_1	120	126	PF00069	0.391
DOC_MAPK_gen_1	46	54	PF00069	0.494
DOC_MAPK_gen_1	490	499	PF00069	0.261
DOC_MAPK_gen_1	695	704	PF00069	0.280
DOC_MAPK_JIP1_4	718	724	PF00069	0.269
DOC_MAPK_MEF2A_6	10	17	PF00069	0.496
DOC_MAPK_MEF2A_6	443	451	PF00069	0.276
DOC_MAPK_MEF2A_6	48	57	PF00069	0.342
DOC_MAPK_MEF2A_6	726	734	PF00069	0.246
DOC_MAPK_RevD_3	582	597	PF00069	0.246
DOC_PP1_RVXF_1	22	29	PF00149	0.335
DOC_PP1_RVXF_1	719	725	PF00149	0.246
DOC_PP2B_LxvP_1	15	18	PF13499	0.357
DOC_PP2B_LxvP_1	497	500	PF13499	0.305
DOC_PP2B_LxvP_1	891	894	PF13499	0.261
DOC_PP2B_PxIxI_1	259	265	PF00149	0.246
DOC_PP2B_PxIxI_1	538	544	PF00149	0.261
DOC_PP4_FxxP_1	202	205	PF00568	0.245
DOC_PP4_FxxP_1	253	256	PF00568	0.261
DOC_PP4_FxxP_1	329	332	PF00568	0.246
DOC_PP4_FxxP_1	716	719	PF00568	0.246
DOC_SPAK_OSR1_1	1025	1029	PF12202	0.357
DOC_SPAK_OSR1_1	181	185	PF12202	0.246
DOC_USP7_MATH_1	607	611	PF00917	0.263
DOC_USP7_MATH_1	88	92	PF00917	0.353
DOC_USP7_MATH_2	40	46	PF00917	0.463
DOC_USP7_UBL2_3	1010	1014	PF12436	0.339
DOC_USP7_UBL2_3	364	368	PF12436	0.280
DOC_USP7_UBL2_3	491	495	PF12436	0.280
DOC_USP7_UBL2_3	691	695	PF12436	0.311
DOC_USP7_UBL2_3	752	756	PF12436	0.246
DOC_USP7_UBL2_3	814	818	PF12436	0.246
DOC_USP7_UBL2_3	966	970	PF12436	0.246
DOC_WW_Pin1_4	201	206	PF00397	0.305
DOC_WW_Pin1_4	566	571	PF00397	0.246
LIG_14-3-3_CanoR_1	120	124	PF00244	0.305
LIG_14-3-3_CanoR_1	149	157	PF00244	0.261
LIG_14-3-3_CanoR_1	167	173	PF00244	0.217
LIG_14-3-3_CanoR_1	399	404	PF00244	0.246
LIG_14-3-3_CanoR_1	46	55	PF00244	0.486
LIG_14-3-3_CanoR_1	568	576	PF00244	0.389
LIG_Actin_WH2_2	328	344	PF00022	0.391
LIG_Actin_WH2_2	608	626	PF00022	0.246
LIG_APCC_ABBAyCdc20_2	249	255	PF00400	0.280
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BIR_III_4	754	758	PF00653	0.246
LIG_BRCT_BRCA1_1	343	347	PF00533	0.311
LIG_BRCT_BRCA1_1	406	410	PF00533	0.347
LIG_BRCT_BRCA1_1	571	575	PF00533	0.311
LIG_BRCT_BRCA1_1	712	716	PF00533	0.268
LIG_BRCT_BRCA1_1	90	94	PF00533	0.329
LIG_BRCT_BRCA1_2	571	577	PF00533	0.311
LIG_BRCT_BRCA1_2	712	718	PF00533	0.286
LIG_eIF4E_1	728	734	PF01652	0.246
LIG_FHA_1	208	214	PF00498	0.286
LIG_FHA_1	277	283	PF00498	0.249
LIG_FHA_1	569	575	PF00498	0.469
LIG_FHA_1	659	665	PF00498	0.265
LIG_FHA_1	677	683	PF00498	0.351
LIG_FHA_1	913	919	PF00498	0.381
LIG_FHA_2	299	305	PF00498	0.261
LIG_FHA_2	514	520	PF00498	0.272
LIG_FHA_2	743	749	PF00498	0.304
LIG_FHA_2	794	800	PF00498	0.246
LIG_FHA_2	844	850	PF00498	0.340
LIG_Integrin_isoDGR_2	617	619	PF01839	0.246
LIG_IRF3_LxIS_1	641	647	PF10401	0.391
LIG_IRF3_LxIS_1	801	808	PF10401	0.246
LIG_LIR_Apic_2	713	719	PF02991	0.246
LIG_LIR_Gen_1	166	177	PF02991	0.343
LIG_LIR_Gen_1	191	201	PF02991	0.391
LIG_LIR_Gen_1	230	239	PF02991	0.305
LIG_LIR_Gen_1	25	32	PF02991	0.322
LIG_LIR_Gen_1	374	380	PF02991	0.246
LIG_LIR_Gen_1	531	542	PF02991	0.246
LIG_LIR_Gen_1	63	72	PF02991	0.299
LIG_LIR_Gen_1	723	732	PF02991	0.246
LIG_LIR_Gen_1	747	758	PF02991	0.246
LIG_LIR_Gen_1	75	84	PF02991	0.213
LIG_LIR_Nem_3	1024	1029	PF02991	0.353
LIG_LIR_Nem_3	166	172	PF02991	0.288
LIG_LIR_Nem_3	191	196	PF02991	0.391
LIG_LIR_Nem_3	197	201	PF02991	0.391
LIG_LIR_Nem_3	230	234	PF02991	0.305
LIG_LIR_Nem_3	25	31	PF02991	0.164
LIG_LIR_Nem_3	330	334	PF02991	0.302
LIG_LIR_Nem_3	374	378	PF02991	0.246
LIG_LIR_Nem_3	444	449	PF02991	0.349
LIG_LIR_Nem_3	531	537	PF02991	0.246
LIG_LIR_Nem_3	579	584	PF02991	0.261
LIG_LIR_Nem_3	610	616	PF02991	0.246
LIG_LIR_Nem_3	63	68	PF02991	0.299
LIG_LIR_Nem_3	7	12	PF02991	0.362
LIG_LIR_Nem_3	723	727	PF02991	0.246
LIG_LIR_Nem_3	747	753	PF02991	0.246
LIG_LIR_Nem_3	75	80	PF02991	0.213
LIG_LIR_Nem_3	962	967	PF02991	0.246
LIG_LIR_Nem_3	975	981	PF02991	0.246
LIG_LYPXL_S_1	537	541	PF13949	0.246
LIG_LYPXL_yS_3	538	541	PF13949	0.246
LIG_MYND_3	641	645	PF01753	0.246
LIG_NRBOX	147	153	PF00104	0.261
LIG_NRBOX	588	594	PF00104	0.261
LIG_PCNA_yPIPBox_3	478	488	PF02747	0.261
LIG_Pex14_2	178	182	PF04695	0.246
LIG_PTB_Apo_2	325	332	PF02174	0.261
LIG_PTB_Apo_2	369	376	PF02174	0.246
LIG_PTB_Phospho_1	369	375	PF10480	0.246
LIG_SH2_CRK	525	529	PF00017	0.261
LIG_SH2_CRK	549	553	PF00017	0.246
LIG_SH2_CRK	613	617	PF00017	0.246
LIG_SH2_CRK	739	743	PF00017	0.246
LIG_SH2_CRK	964	968	PF00017	0.246
LIG_SH2_NCK_1	974	978	PF00017	0.246
LIG_SH2_PTP2	853	856	PF00017	0.261
LIG_SH2_SRC	853	856	PF00017	0.261
LIG_SH2_SRC	886	889	PF00017	0.246
LIG_SH2_STAP1	299	303	PF00017	0.311
LIG_SH2_STAP1	549	553	PF00017	0.246
LIG_SH2_STAP1	974	978	PF00017	0.246
LIG_SH2_STAT3	653	656	PF00017	0.340
LIG_SH2_STAT5	125	128	PF00017	0.363
LIG_SH2_STAT5	21	24	PF00017	0.348
LIG_SH2_STAT5	231	234	PF00017	0.280
LIG_SH2_STAT5	333	336	PF00017	0.268
LIG_SH2_STAT5	375	378	PF00017	0.248
LIG_SH2_STAT5	440	443	PF00017	0.332
LIG_SH2_STAT5	504	507	PF00017	0.391
LIG_SH2_STAT5	728	731	PF00017	0.261
LIG_SH2_STAT5	77	80	PF00017	0.261
LIG_SH2_STAT5	853	856	PF00017	0.261
LIG_SH2_STAT5	873	876	PF00017	0.125
LIG_SH2_STAT5	886	889	PF00017	0.246
LIG_SH3_3	10	16	PF00018	0.279
LIG_SH3_3	136	142	PF00018	0.246
LIG_SH3_3	154	160	PF00018	0.246
LIG_SH3_3	173	179	PF00018	0.135
LIG_SH3_3	514	520	PF00018	0.246
LIG_SH3_3	724	730	PF00018	0.246
LIG_SH3_5	227	231	PF00018	0.391
LIG_SUMO_SIM_par_1	238	243	PF11976	0.246
LIG_TYR_ITIM	547	552	PF00017	0.246
LIG_TYR_ITIM	611	616	PF00017	0.246
LIG_TYR_ITIM	851	856	PF00017	0.261
LIG_UBA3_1	282	286	PF00899	0.261
LIG_WRC_WIRS_1	169	174	PF05994	0.280
MOD_CDC14_SPxK_1	204	207	PF00782	0.360
MOD_CDK_SPxK_1	201	207	PF00069	0.360
MOD_CK1_1	103	109	PF00069	0.401
MOD_CK1_1	150	156	PF00069	0.376
MOD_CK1_1	298	304	PF00069	0.268
MOD_CK1_1	4	10	PF00069	0.520
MOD_CK1_1	402	408	PF00069	0.340
MOD_CK1_1	421	427	PF00069	0.395
MOD_CK1_1	569	575	PF00069	0.395
MOD_CK1_1	626	632	PF00069	0.290
MOD_CK1_1	785	791	PF00069	0.275
MOD_CK1_1	843	849	PF00069	0.380
MOD_CK1_1	921	927	PF00069	0.449
MOD_CK2_1	298	304	PF00069	0.225
MOD_CK2_1	690	696	PF00069	0.280
MOD_CK2_1	785	791	PF00069	0.239
MOD_CK2_1	814	820	PF00069	0.261
MOD_Cter_Amidation	247	250	PF01082	0.246
MOD_GlcNHglycan	3	6	PF01048	0.563
MOD_GlcNHglycan	625	628	PF01048	0.248
MOD_GlcNHglycan	645	649	PF01048	0.125
MOD_GlcNHglycan	773	776	PF01048	0.275
MOD_GlcNHglycan	787	790	PF01048	0.288
MOD_GlcNHglycan	842	845	PF01048	0.281
MOD_GlcNHglycan	920	923	PF01048	0.420
MOD_GSK3_1	188	195	PF00069	0.330
MOD_GSK3_1	201	208	PF00069	0.198
MOD_GSK3_1	272	279	PF00069	0.309
MOD_GSK3_1	4	11	PF00069	0.464
MOD_GSK3_1	498	505	PF00069	0.280
MOD_GSK3_1	533	540	PF00069	0.267
MOD_GSK3_1	644	651	PF00069	0.246
MOD_GSK3_1	685	692	PF00069	0.370
MOD_GSK3_1	810	817	PF00069	0.264
MOD_GSK3_1	976	983	PF00069	0.261
MOD_N-GLC_1	103	108	PF02516	0.350
MOD_N-GLC_2	266	268	PF02516	0.261
MOD_N-GLC_2	325	327	PF02516	0.305
MOD_N-GLC_2	546	548	PF02516	0.246
MOD_NEK2_1	1	6	PF00069	0.592
MOD_NEK2_1	108	113	PF00069	0.335
MOD_NEK2_1	194	199	PF00069	0.311
MOD_NEK2_1	278	283	PF00069	0.261
MOD_NEK2_1	547	552	PF00069	0.250
MOD_NEK2_1	623	628	PF00069	0.283
MOD_NEK2_1	644	649	PF00069	0.249
MOD_NEK2_1	742	747	PF00069	0.246
MOD_NEK2_1	8	13	PF00069	0.316
MOD_NEK2_1	805	810	PF00069	0.246
MOD_NEK2_2	757	762	PF00069	0.255
MOD_PIKK_1	404	410	PF00454	0.344
MOD_PIKK_1	88	94	PF00454	0.305
MOD_PIKK_1	880	886	PF00454	0.246
MOD_PIKK_1	976	982	PF00454	0.249
MOD_PK_1	238	244	PF00069	0.251
MOD_PKA_2	119	125	PF00069	0.261
MOD_PKA_2	336	342	PF00069	0.317
MOD_PKA_2	465	471	PF00069	0.276
MOD_PKA_2	47	53	PF00069	0.496
MOD_Plk_1	103	109	PF00069	0.321
MOD_Plk_1	355	361	PF00069	0.260
MOD_Plk_1	376	382	PF00069	0.308
MOD_Plk_2-3	513	519	PF00069	0.261
MOD_Plk_2-3	690	696	PF00069	0.305
MOD_Plk_4	108	114	PF00069	0.288
MOD_Plk_4	17	23	PF00069	0.470
MOD_Plk_4	278	284	PF00069	0.391
MOD_Plk_4	308	314	PF00069	0.409
MOD_Plk_4	4	10	PF00069	0.506
MOD_Plk_4	418	424	PF00069	0.358
MOD_Plk_4	513	519	PF00069	0.246
MOD_Plk_4	533	539	PF00069	0.125
MOD_Plk_4	548	554	PF00069	0.246
MOD_Plk_4	626	632	PF00069	0.246
MOD_Plk_4	678	684	PF00069	0.291
MOD_Plk_4	904	910	PF00069	0.357
MOD_ProDKin_1	201	207	PF00069	0.305
MOD_ProDKin_1	566	572	PF00069	0.246
MOD_SUMO_for_1	576	579	PF00179	0.239
MOD_SUMO_for_1	720	723	PF00179	0.261
MOD_SUMO_rev_2	356	365	PF00179	0.261
MOD_SUMO_rev_2	610	616	PF00179	0.266
MOD_SUMO_rev_2	748	758	PF00179	0.248
TRG_DiLeu_BaEn_1	1018	1023	PF01217	0.338
TRG_DiLeu_BaEn_1	302	307	PF01217	0.301
TRG_ENDOCYTIC_2	198	201	PF00928	0.323
TRG_ENDOCYTIC_2	231	234	PF00928	0.280
TRG_ENDOCYTIC_2	375	378	PF00928	0.246
TRG_ENDOCYTIC_2	538	541	PF00928	0.246
TRG_ENDOCYTIC_2	549	552	PF00928	0.246
TRG_ENDOCYTIC_2	613	616	PF00928	0.246
TRG_ENDOCYTIC_2	731	734	PF00928	0.250
TRG_ENDOCYTIC_2	739	742	PF00928	0.253
TRG_ENDOCYTIC_2	77	80	PF00928	0.272
TRG_ENDOCYTIC_2	853	856	PF00928	0.261
TRG_ENDOCYTIC_2	964	967	PF00928	0.246
TRG_ENDOCYTIC_2	974	977	PF00928	0.246
TRG_ENDOCYTIC_2	978	981	PF00928	0.246
TRG_ER_diArg_1	434	436	PF00400	0.318
TRG_ER_diArg_1	761	763	PF00400	0.246
TRG_ER_diArg_1	836	839	PF00400	0.247
TRG_NLS_MonoExtN_4	491	498	PF00514	0.311
TRG_Pf-PMV_PEXEL_1	1014	1018	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.280
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.261
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.246
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.267
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	673	678	PF00026	0.256
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P846	Leptomonas seymouri	90%	100%
A0A0N1I597	Leptomonas seymouri	26%	77%
A0A0S4J863	Bodo saltans	73%	95%
A0A1X0P2A8	Trypanosomatidae	81%	100%
A0A3S5H6Z2	Leishmania donovani	26%	77%
A0A422N236	Trypanosoma rangeli	79%	100%
A4HLN0	Leishmania braziliensis	95%	100%
A4HX52	Leishmania infantum	25%	77%
A4I965	Leishmania infantum	100%	100%
A7U6F2	Pyramimonas orientalis virus	30%	86%
C9ZIW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9AQW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	77%
E9B406	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O00874	Leishmania donovani	26%	77%
O05706	Saccharolobus shibatae	22%	100%
O29753	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	26%	100%
O36363	Alcelaphine herpesvirus 1 (strain C500)	31%	100%
O48901	Glycine max	53%	95%
O54747	Rattus norvegicus	54%	94%
O70736	Red sea bream iridovirus	25%	100%
O71121	Rhesus cytomegalovirus (strain 68-1)	29%	100%
O89042	Rattus norvegicus	26%	71%
O93746	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	27%	100%
P03198	Epstein-Barr virus (strain B95-8)	33%	100%
P04292	Human herpesvirus 1 (strain KOS)	29%	84%
P04293	Human herpesvirus 1 (strain 17)	29%	84%
P07917	Human herpesvirus 1 (strain Angelotti)	29%	84%
P07918	Human herpesvirus 2 (strain 186)	28%	83%
P09252	Varicella-zoster virus (strain Dumas)	27%	86%
P09854	Human herpesvirus 1 (strain SC16)	29%	84%
P09884	Homo sapiens	26%	71%
P0C971	African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)	23%	86%
P0C972	African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)	23%	86%
P0C973	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	23%	86%
P0C974	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	23%	86%
P0CL76	Pyrococcus abyssi	30%	100%
P0CL77	Pyrococcus abyssi (strain GE5 / Orsay)	30%	100%
P13382	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	70%
P14284	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	69%
P15436	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	94%
P24907	Saimiriine herpesvirus 2 (strain 11)	31%	100%
P26019	Drosophila melanogaster	24%	69%
P26811	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	25%	100%
P27172	Murid herpesvirus 1 (strain Smith)	28%	94%
P28040	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	73%
P28339	Bos taurus	53%	93%
P28340	Homo sapiens	54%	93%
P28857	Human herpesvirus 6A (strain Uganda-1102)	29%	100%
P28858	Equine herpesvirus 1 (strain Ab4p)	28%	85%
P30315	Plasmodium falciparum (isolate K1 / Thailand)	44%	94%
P30316	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	95%
P30320	Paramecium bursaria Chlorella virus NY2A	31%	100%
P30321	Paramecium bursaria Chlorella virus 1	32%	100%
P33609	Mus musculus	26%	70%
P42489	African swine fever virus (strain Badajoz 1971 Vero-adapted)	23%	85%
P43139	African swine fever virus (isolate Pig/Portugal/Lis 60/1960)	23%	83%
P46588	Candida albicans	50%	99%
P52025	Methanococcus voltae	24%	100%
P52342	Human herpesvirus 7 (strain JI)	29%	100%
P52367	Equine herpesvirus 2 (strain 86/87)	30%	100%
P52431	Mus musculus	54%	93%
P54358	Drosophila melanogaster	50%	95%
P56689	Thermococcus gorgonarius	29%	100%
P61875	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	28%	100%
P61876	Pyrococcus woesei	28%	100%
P89453	Human herpesvirus 2 (strain HG52)	28%	83%
P90829	Caenorhabditis elegans	48%	95%
P95690	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	24%	100%
P95979	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	20%	100%
P97283	Mesocricetus auratus	54%	94%
Q196U0	Invertebrate iridescent virus 3	26%	90%
Q1HVC1	Epstein-Barr virus (strain AG876)	33%	100%
Q2HRD0	Human herpesvirus 8 type P (isolate GK18)	31%	100%
Q38087	Escherichia phage RB69	23%	100%
Q3KSP1	Epstein-Barr virus (strain GD1)	33%	100%
Q4JQU7	Varicella-zoster virus (strain Oka vaccine)	27%	86%
Q4Q418	Leishmania major	98%	100%
Q4QEL1	Leishmania major	25%	77%
Q54N97	Dictyostelium discoideum	46%	93%
Q69025	Guinea pig cytomegalovirus (strain 22122)	30%	92%
Q6S6P1	Equine herpesvirus 1 (strain V592)	28%	85%
Q6UDK1	Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997)	29%	95%
Q83948	Orgyia pseudotsugata multicapsid polyhedrosis virus	22%	100%
Q9DE46	Xenopus laevis	25%	71%
Q9DKT8	Elephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998)	31%	99%
Q9E6N9	Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987)	26%	85%
Q9HH06	Pyrococcus glycovorans	29%	100%
Q9LRE6	Oryza sativa subsp. japonica	52%	93%
Q9LVN7	Arabidopsis thaliana	53%	94%
Q9P6L6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	70%
Q9QJ32	Human herpesvirus 6B (strain Z29)	29%	100%
V5B2M9	Trypanosoma cruzi	26%	77%
V5BH96	Trypanosoma cruzi	80%	100%