LeishMANIAdb
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Macrophage migration inhibitory factor-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Macrophage migration inhibitory factor-like protein
Gene product:
macrophage migration inhibitory factor-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7X6W1_LEIDO
TriTrypDb:
LdBPK_331850.1 , LdCL_330025300 , LDHU3_33.2740
Length:
113

Annotations

Annotations by Jardim et al.

Glycosylation, Macrophage migration inhibitory factor-like MIF2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
TermNameLevelCount
GO:0005615 extracellular space 2 2
GO:0110165 cellular anatomical entity 1 2
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Expansion

Sequence features

A0A3S7X6W1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6W1

PDB structure(s): 3b64_A , 3fwt_A , 3fwu_A , 4nwr_1 , 4nwr_3 , 4nwr_5 , 4nwr_7 , 4nwr_9 , 4nwr_AB , 4nwr_AD , 4nwr_AF , 4nwr_AH , 4nwr_AJ , 4nwr_AL , 4nwr_AN , 4nwr_AP , 4nwr_AR , 4nwr_AT , 4nwr_AV , 4nwr_AX , 4nwr_AZ , 4nwr_b , 4nwr_BB , 4nwr_BD , 4nwr_BF , 4nwr_BH , 4nwr_d , 4nwr_f , 4nwr_h , 4nwr_j , 4nwr_l , 4nwr_n , 4nwr_p , 4nwr_r , 4nwr_t , 4nwr_v , 4nwr_x , 4nwr_z

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 2
GO:0016853 isomerase activity 2 2
GO:0016860 intramolecular oxidoreductase activity 3 2
GO:0016862 intramolecular oxidoreductase activity, interconverting keto- and enol-groups 4 2
GO:0050178 phenylpyruvate tautomerase activity 5 2
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_PCSK_KEX2_1 16 18 PF00082 0.476
CLV_PCSK_PC1ET2_1 16 18 PF00082 0.476
CLV_PCSK_SKI1_1 75 79 PF00082 0.426
DEG_SCF_FBW7_1 76 82 PF00400 0.297
DOC_CKS1_1 76 81 PF01111 0.382
DOC_WW_Pin1_4 44 49 PF00397 0.404
DOC_WW_Pin1_4 75 80 PF00397 0.351
LIG_14-3-3_CanoR_1 17 27 PF00244 0.468
LIG_FHA_1 76 82 PF00498 0.404
LIG_LIR_Nem_3 21 27 PF02991 0.445
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I920 Leptomonas seymouri 65% 100%
A0A3S7X6S3 Leishmania donovani 60% 100%
A4I970 Leishmania infantum 60% 100%
A4I971 Leishmania infantum 100% 100%
A9JSE7 Xenopus tropicalis 26% 98%
E9B411 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 100%
E9B412 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
P81529 Trichinella spiralis 27% 99%
Q4Q412 Leishmania major 94% 100%
Q4Q413 Leishmania major 59% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS