Macrophage migration inhibitory factor-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

macrophage migration inhibitory factor-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X6W1_LEIDO

TriTrypDb:

LdBPK_331850.1 , LdCL_330025300 , LDHU3_33.2740

Length:

113

Annotations

Annotations by Jardim et al.

Glycosylation, Macrophage migration inhibitory factor-like MIF2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005615	extracellular space	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7X6W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6W1

PDB structure(s): 3b64_A , 3fwt_A , 3fwu_A , 4nwr_1 , 4nwr_3 , 4nwr_5 , 4nwr_7 , 4nwr_9 , 4nwr_AB , 4nwr_AD , 4nwr_AF , 4nwr_AH , 4nwr_AJ , 4nwr_AL , 4nwr_AN , 4nwr_AP , 4nwr_AR , 4nwr_AT , 4nwr_AV , 4nwr_AX , 4nwr_AZ , 4nwr_b , 4nwr_BB , 4nwr_BD , 4nwr_BF , 4nwr_BH , 4nwr_d , 4nwr_f , 4nwr_h , 4nwr_j , 4nwr_l , 4nwr_n , 4nwr_p , 4nwr_r , 4nwr_t , 4nwr_v , 4nwr_x , 4nwr_z

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016853	isomerase activity	2	2
GO:0016860	intramolecular oxidoreductase activity	3	2
GO:0016862	intramolecular oxidoreductase activity, interconverting keto- and enol-groups	4	2
GO:0050178	phenylpyruvate tautomerase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	16	18	PF00082	0.476
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.476
CLV_PCSK_SKI1_1	75	79	PF00082	0.426
DEG_SCF_FBW7_1	76	82	PF00400	0.297
DOC_CKS1_1	76	81	PF01111	0.382
DOC_WW_Pin1_4	44	49	PF00397	0.404
DOC_WW_Pin1_4	75	80	PF00397	0.351
LIG_14-3-3_CanoR_1	17	27	PF00244	0.468
LIG_FHA_1	76	82	PF00498	0.404
LIG_LIR_Nem_3	21	27	PF02991	0.445
LIG_LIR_Nem_3	64	69	PF02991	0.415
LIG_LIR_Nem_3	94	100	PF02991	0.552
LIG_SH2_CRK	24	28	PF00017	0.564
LIG_SH2_PTP2	60	63	PF00017	0.456
LIG_SH2_SRC	69	72	PF00017	0.363
LIG_SH2_STAT5	60	63	PF00017	0.456
LIG_SH2_STAT5	97	100	PF00017	0.398
LIG_SH3_3	68	74	PF00018	0.404
LIG_SUMO_SIM_par_1	6	11	PF11976	0.435
LIG_TYR_ITSM	20	27	PF00017	0.399
MOD_CDK_SPK_2	75	80	PF00069	0.382
MOD_CK1_1	44	50	PF00069	0.382
MOD_GlcNHglycan	81	84	PF01048	0.340
MOD_GSK3_1	47	54	PF00069	0.382
MOD_GSK3_1	75	82	PF00069	0.382
MOD_N-GLC_1	18	23	PF02516	0.415
MOD_NEK2_1	3	8	PF00069	0.396
MOD_NEK2_1	38	43	PF00069	0.374
MOD_NEK2_1	51	56	PF00069	0.391
MOD_NEK2_1	99	104	PF00069	0.386
MOD_PKA_2	79	85	PF00069	0.299
MOD_Plk_4	3	9	PF00069	0.541
MOD_ProDKin_1	44	50	PF00069	0.404
MOD_ProDKin_1	75	81	PF00069	0.351
MOD_SUMO_rev_2	9	18	PF00179	0.459
TRG_ENDOCYTIC_2	24	27	PF00928	0.653
TRG_ENDOCYTIC_2	60	63	PF00928	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I920	Leptomonas seymouri	65%	100%
A0A3S7X6S3	Leishmania donovani	60%	100%
A4I970	Leishmania infantum	60%	100%
A4I971	Leishmania infantum	100%	100%
A9JSE7	Xenopus tropicalis	26%	98%
E9B411	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9B412	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P81529	Trichinella spiralis	27%	99%
Q4Q412	Leishmania major	94%	100%
Q4Q413	Leishmania major	59%	100%
Q76BK2	Xenopus laevis	29%	98%