Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6V6_LEIDO

TriTrypDb:

LdBPK_332250.1 , LdCL_330029500 , LDHU3_33.3240

Length:

920

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6V6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	94	100	PF00089	0.540
CLV_NRD_NRD_1	142	144	PF00675	0.632
CLV_NRD_NRD_1	311	313	PF00675	0.513
CLV_NRD_NRD_1	562	564	PF00675	0.557
CLV_NRD_NRD_1	705	707	PF00675	0.545
CLV_NRD_NRD_1	883	885	PF00675	0.673
CLV_PCSK_KEX2_1	132	134	PF00082	0.643
CLV_PCSK_KEX2_1	562	564	PF00082	0.557
CLV_PCSK_KEX2_1	705	707	PF00082	0.545
CLV_PCSK_KEX2_1	882	884	PF00082	0.675
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.622
CLV_PCSK_SKI1_1	273	277	PF00082	0.393
CLV_PCSK_SKI1_1	585	589	PF00082	0.359
DEG_Nend_Nbox_1	1	3	PF02207	0.614
DEG_SCF_FBW7_1	723	729	PF00400	0.623
DEG_SPOP_SBC_1	431	435	PF00917	0.647
DEG_SPOP_SBC_1	567	571	PF00917	0.616
DOC_CKS1_1	723	728	PF01111	0.666
DOC_CKS1_1	857	862	PF01111	0.667
DOC_CKS1_1	87	92	PF01111	0.650
DOC_CKS1_1	909	914	PF01111	0.629
DOC_CYCLIN_yCln2_LP_2	446	452	PF00134	0.616
DOC_CYCLIN_yCln2_LP_2	896	902	PF00134	0.630
DOC_MAPK_FxFP_2	831	834	PF00069	0.647
DOC_MAPK_MEF2A_6	696	703	PF00069	0.495
DOC_PP1_RVXF_1	546	552	PF00149	0.483
DOC_PP1_RVXF_1	583	589	PF00149	0.388
DOC_PP2B_LxvP_1	470	473	PF13499	0.623
DOC_PP2B_LxvP_1	476	479	PF13499	0.645
DOC_PP2B_LxvP_1	896	899	PF13499	0.633
DOC_PP4_FxxP_1	535	538	PF00568	0.599
DOC_PP4_FxxP_1	783	786	PF00568	0.590
DOC_PP4_FxxP_1	831	834	PF00568	0.647
DOC_PP4_MxPP_1	450	453	PF00568	0.594
DOC_PP4_MxPP_1	827	830	PF00568	0.640
DOC_USP7_MATH_1	264	268	PF00917	0.614
DOC_USP7_MATH_1	419	423	PF00917	0.643
DOC_USP7_MATH_1	431	435	PF00917	0.628
DOC_USP7_MATH_1	453	457	PF00917	0.681
DOC_USP7_MATH_1	502	506	PF00917	0.622
DOC_USP7_MATH_1	568	572	PF00917	0.692
DOC_USP7_MATH_1	576	580	PF00917	0.662
DOC_USP7_MATH_1	627	631	PF00917	0.717
DOC_USP7_MATH_1	786	790	PF00917	0.604
DOC_USP7_MATH_1	900	904	PF00917	0.612
DOC_USP7_MATH_2	593	599	PF00917	0.404
DOC_WW_Pin1_4	238	243	PF00397	0.697
DOC_WW_Pin1_4	250	255	PF00397	0.591
DOC_WW_Pin1_4	266	271	PF00397	0.473
DOC_WW_Pin1_4	301	306	PF00397	0.464
DOC_WW_Pin1_4	354	359	PF00397	0.402
DOC_WW_Pin1_4	427	432	PF00397	0.584
DOC_WW_Pin1_4	465	470	PF00397	0.614
DOC_WW_Pin1_4	479	484	PF00397	0.704
DOC_WW_Pin1_4	519	524	PF00397	0.645
DOC_WW_Pin1_4	533	538	PF00397	0.536
DOC_WW_Pin1_4	561	566	PF00397	0.585
DOC_WW_Pin1_4	719	724	PF00397	0.671
DOC_WW_Pin1_4	750	755	PF00397	0.730
DOC_WW_Pin1_4	808	813	PF00397	0.680
DOC_WW_Pin1_4	856	861	PF00397	0.665
DOC_WW_Pin1_4	86	91	PF00397	0.587
DOC_WW_Pin1_4	908	913	PF00397	0.646
LIG_14-3-3_CanoR_1	135	145	PF00244	0.666
LIG_14-3-3_CanoR_1	288	294	PF00244	0.368
LIG_14-3-3_CanoR_1	391	396	PF00244	0.537
LIG_14-3-3_CanoR_1	504	512	PF00244	0.674
LIG_14-3-3_CanoR_1	548	552	PF00244	0.457
LIG_14-3-3_CanoR_1	668	678	PF00244	0.455
LIG_14-3-3_CanoR_1	689	695	PF00244	0.448
LIG_BRCT_BRCA1_1	291	295	PF00533	0.357
LIG_BRCT_BRCA1_1	601	605	PF00533	0.360
LIG_EVH1_2	829	833	PF00568	0.628
LIG_FHA_1	523	529	PF00498	0.615
LIG_FHA_1	623	629	PF00498	0.573
LIG_FHA_1	649	655	PF00498	0.432
LIG_FHA_1	834	840	PF00498	0.576
LIG_FHA_2	103	109	PF00498	0.654
LIG_FHA_2	146	152	PF00498	0.551
LIG_FHA_2	37	43	PF00498	0.590
LIG_FHA_2	836	842	PF00498	0.546
LIG_Integrin_isoDGR_2	316	318	PF01839	0.581
LIG_LIR_Apic_2	175	181	PF02991	0.432
LIG_LIR_Apic_2	352	358	PF02991	0.410
LIG_LIR_Apic_2	841	847	PF02991	0.547
LIG_LIR_Apic_2	86	90	PF02991	0.609
LIG_LIR_Gen_1	602	613	PF02991	0.382
LIG_LIR_Gen_1	89	98	PF02991	0.590
LIG_LIR_Nem_3	174	180	PF02991	0.507
LIG_LIR_Nem_3	550	554	PF02991	0.445
LIG_LIR_Nem_3	851	857	PF02991	0.622
LIG_LIR_Nem_3	89	95	PF02991	0.586
LIG_LYPXL_yS_3	745	748	PF13949	0.657
LIG_MAD2	585	593	PF02301	0.344
LIG_NRBOX	158	164	PF00104	0.547
LIG_Pex14_2	777	781	PF04695	0.606
LIG_PTAP_UEV_1	564	569	PF05743	0.616
LIG_Rb_LxCxE_1	342	365	PF01857	0.436
LIG_SH2_CRK	178	182	PF00017	0.469
LIG_SH2_CRK	454	458	PF00017	0.667
LIG_SH2_CRK	462	466	PF00017	0.568
LIG_SH2_CRK	752	756	PF00017	0.580
LIG_SH2_CRK	844	848	PF00017	0.537
LIG_SH2_NCK_1	281	285	PF00017	0.422
LIG_SH2_NCK_1	38	42	PF00017	0.589
LIG_SH2_PTP2	355	358	PF00017	0.404
LIG_SH2_STAT5	158	161	PF00017	0.546
LIG_SH2_STAT5	348	351	PF00017	0.398
LIG_SH2_STAT5	355	358	PF00017	0.404
LIG_SH2_STAT5	38	41	PF00017	0.593
LIG_SH2_STAT5	481	484	PF00017	0.680
LIG_SH2_STAT5	554	557	PF00017	0.511
LIG_SH2_STAT5	600	603	PF00017	0.377
LIG_SH2_STAT5	728	731	PF00017	0.649
LIG_SH2_STAT5	87	90	PF00017	0.651
LIG_SH2_STAT6	91	95	PF00017	0.609
LIG_SH3_1	562	568	PF00018	0.558
LIG_SH3_3	377	383	PF00018	0.543
LIG_SH3_3	446	452	PF00018	0.739
LIG_SH3_3	454	460	PF00018	0.630
LIG_SH3_3	562	568	PF00018	0.612
LIG_SH3_3	626	632	PF00018	0.679
LIG_SH3_3	720	726	PF00018	0.661
LIG_SH3_3	740	746	PF00018	0.618
LIG_SH3_3	748	754	PF00018	0.561
LIG_SH3_3	758	764	PF00018	0.484
LIG_SH3_3	794	800	PF00018	0.645
LIG_SH3_3	816	822	PF00018	0.677
LIG_SH3_3	826	832	PF00018	0.635
LIG_SH3_3	854	860	PF00018	0.659
LIG_SH3_3	896	902	PF00018	0.663
LIG_SH3_3	906	912	PF00018	0.632
LIG_SUMO_SIM_par_1	371	376	PF11976	0.484
LIG_SUMO_SIM_par_1	385	390	PF11976	0.427
LIG_SUMO_SIM_par_1	835	841	PF11976	0.606
LIG_TRFH_1	92	96	PF08558	0.589
LIG_TYR_ITIM	279	284	PF00017	0.406
LIG_UBA3_1	162	168	PF00899	0.555
LIG_UBA3_1	362	370	PF00899	0.459
LIG_WW_1	451	454	PF00397	0.595
LIG_WW_1	459	462	PF00397	0.599
LIG_WW_1	478	481	PF00397	0.670
MOD_CDK_SPK_2	238	243	PF00069	0.653
MOD_CDK_SPxxK_3	266	273	PF00069	0.542
MOD_CK1_1	214	220	PF00069	0.689
MOD_CK1_1	238	244	PF00069	0.687
MOD_CK1_1	266	272	PF00069	0.541
MOD_CK1_1	304	310	PF00069	0.472
MOD_CK1_1	37	43	PF00069	0.614
MOD_CK1_1	404	410	PF00069	0.632
MOD_CK1_1	434	440	PF00069	0.811
MOD_CK1_1	484	490	PF00069	0.586
MOD_CK1_1	500	506	PF00069	0.744
MOD_CK1_1	518	524	PF00069	0.485
MOD_CK1_1	606	612	PF00069	0.467
MOD_CK1_1	648	654	PF00069	0.481
MOD_CK1_1	691	697	PF00069	0.526
MOD_CK1_1	708	714	PF00069	0.509
MOD_CK1_1	717	723	PF00069	0.644
MOD_CK1_1	784	790	PF00069	0.606
MOD_CK2_1	145	151	PF00069	0.691
MOD_CK2_1	220	226	PF00069	0.626
MOD_CK2_1	36	42	PF00069	0.707
MOD_CK2_1	71	77	PF00069	0.572
MOD_CK2_1	891	897	PF00069	0.707
MOD_Cter_Amidation	141	144	PF01082	0.613
MOD_Cter_Amidation	880	883	PF01082	0.678
MOD_DYRK1A_RPxSP_1	250	254	PF00069	0.659
MOD_GlcNHglycan	140	143	PF01048	0.638
MOD_GlcNHglycan	196	199	PF01048	0.688
MOD_GlcNHglycan	213	216	PF01048	0.623
MOD_GlcNHglycan	222	225	PF01048	0.600
MOD_GlcNHglycan	226	230	PF01048	0.567
MOD_GlcNHglycan	231	236	PF01048	0.531
MOD_GlcNHglycan	237	240	PF01048	0.567
MOD_GlcNHglycan	285	288	PF01048	0.403
MOD_GlcNHglycan	39	42	PF01048	0.734
MOD_GlcNHglycan	403	407	PF01048	0.648
MOD_GlcNHglycan	421	424	PF01048	0.651
MOD_GlcNHglycan	513	516	PF01048	0.625
MOD_GlcNHglycan	517	520	PF01048	0.590
MOD_GlcNHglycan	570	573	PF01048	0.696
MOD_GlcNHglycan	574	577	PF01048	0.625
MOD_GlcNHglycan	579	582	PF01048	0.537
MOD_GlcNHglycan	629	632	PF01048	0.673
MOD_GlcNHglycan	637	640	PF01048	0.647
MOD_GlcNHglycan	65	69	PF01048	0.658
MOD_GlcNHglycan	680	683	PF01048	0.439
MOD_GlcNHglycan	684	688	PF01048	0.416
MOD_GlcNHglycan	707	710	PF01048	0.643
MOD_GlcNHglycan	716	719	PF01048	0.654
MOD_GlcNHglycan	731	734	PF01048	0.645
MOD_GlcNHglycan	739	742	PF01048	0.705
MOD_GlcNHglycan	788	791	PF01048	0.585
MOD_GlcNHglycan	8	11	PF01048	0.730
MOD_GlcNHglycan	876	879	PF01048	0.670
MOD_GlcNHglycan	886	890	PF01048	0.663
MOD_GSK3_1	190	197	PF00069	0.641
MOD_GSK3_1	214	221	PF00069	0.671
MOD_GSK3_1	231	238	PF00069	0.745
MOD_GSK3_1	250	257	PF00069	0.632
MOD_GSK3_1	30	37	PF00069	0.623
MOD_GSK3_1	321	328	PF00069	0.458
MOD_GSK3_1	402	409	PF00069	0.710
MOD_GSK3_1	427	434	PF00069	0.717
MOD_GSK3_1	437	444	PF00069	0.607
MOD_GSK3_1	477	484	PF00069	0.682
MOD_GSK3_1	500	507	PF00069	0.738
MOD_GSK3_1	511	518	PF00069	0.555
MOD_GSK3_1	533	540	PF00069	0.544
MOD_GSK3_1	563	570	PF00069	0.663
MOD_GSK3_1	572	579	PF00069	0.599
MOD_GSK3_1	591	598	PF00069	0.365
MOD_GSK3_1	599	606	PF00069	0.350
MOD_GSK3_1	608	615	PF00069	0.360
MOD_GSK3_1	722	729	PF00069	0.710
MOD_GSK3_1	781	788	PF00069	0.555
MOD_GSK3_1	913	920	PF00069	0.656
MOD_N-GLC_1	136	141	PF02516	0.646
MOD_N-GLC_1	440	445	PF02516	0.685
MOD_N-GLC_1	643	648	PF02516	0.547
MOD_N-GLC_1	823	828	PF02516	0.655
MOD_NEK2_1	190	195	PF00069	0.655
MOD_NEK2_1	56	61	PF00069	0.776
MOD_NEK2_1	608	613	PF00069	0.390
MOD_NEK2_1	645	650	PF00069	0.559
MOD_NEK2_1	670	675	PF00069	0.480
MOD_NEK2_1	737	742	PF00069	0.567
MOD_NEK2_1	913	918	PF00069	0.650
MOD_NEK2_2	325	330	PF00069	0.395
MOD_PIKK_1	172	178	PF00454	0.466
MOD_PIKK_1	441	447	PF00454	0.591
MOD_PIKK_1	522	528	PF00454	0.585
MOD_PKA_1	705	711	PF00069	0.577
MOD_PKA_2	311	317	PF00069	0.545
MOD_PKA_2	401	407	PF00069	0.664
MOD_PKA_2	503	509	PF00069	0.672
MOD_PKA_2	547	553	PF00069	0.471
MOD_PKA_2	688	694	PF00069	0.448
MOD_PKA_2	705	711	PF00069	0.615
MOD_PKB_1	133	141	PF00069	0.668
MOD_Plk_1	145	151	PF00069	0.558
MOD_Plk_1	683	689	PF00069	0.415
MOD_Plk_1	691	697	PF00069	0.549
MOD_Plk_1	823	829	PF00069	0.654
MOD_Plk_2-3	104	110	PF00069	0.651
MOD_Plk_4	158	164	PF00069	0.571
MOD_Plk_4	289	295	PF00069	0.361
MOD_Plk_4	304	310	PF00069	0.407
MOD_Plk_4	325	331	PF00069	0.416
MOD_Plk_4	506	512	PF00069	0.633
MOD_Plk_4	599	605	PF00069	0.313
MOD_Plk_4	83	89	PF00069	0.597
MOD_ProDKin_1	238	244	PF00069	0.696
MOD_ProDKin_1	250	256	PF00069	0.589
MOD_ProDKin_1	266	272	PF00069	0.454
MOD_ProDKin_1	301	307	PF00069	0.462
MOD_ProDKin_1	354	360	PF00069	0.404
MOD_ProDKin_1	427	433	PF00069	0.585
MOD_ProDKin_1	465	471	PF00069	0.614
MOD_ProDKin_1	479	485	PF00069	0.705
MOD_ProDKin_1	519	525	PF00069	0.649
MOD_ProDKin_1	533	539	PF00069	0.534
MOD_ProDKin_1	561	567	PF00069	0.585
MOD_ProDKin_1	719	725	PF00069	0.672
MOD_ProDKin_1	750	756	PF00069	0.731
MOD_ProDKin_1	808	814	PF00069	0.682
MOD_ProDKin_1	856	862	PF00069	0.666
MOD_ProDKin_1	86	92	PF00069	0.586
MOD_ProDKin_1	908	914	PF00069	0.648
TRG_DiLeu_BaEn_4	154	160	PF01217	0.500
TRG_DiLeu_BaLyEn_6	524	529	PF01217	0.602
TRG_ENDOCYTIC_2	281	284	PF00928	0.413
TRG_ENDOCYTIC_2	454	457	PF00928	0.697
TRG_ENDOCYTIC_2	462	465	PF00928	0.664
TRG_ENDOCYTIC_2	745	748	PF00928	0.628
TRG_ENDOCYTIC_2	92	95	PF00928	0.589
TRG_ER_diArg_1	705	707	PF00400	0.506
TRG_ER_diArg_1	882	884	PF00400	0.675
TRG_ER_FFAT_2	32	43	PF00635	0.580
TRG_NLS_MonoExtN_4	131	136	PF00514	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N1	Leptomonas seymouri	45%	100%
A4HLS5	Leishmania braziliensis	71%	100%
A4I984	Leishmania infantum	99%	100%
E9B451	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q9GRN4	Leishmania major	90%	100%