Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6V4_LEIDO

TriTrypDb:

LdBPK_331760.1 , LdCL_330024300 , LDHU3_33.2620

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6V4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.601
CLV_C14_Caspase3-7	190	194	PF00656	0.628
CLV_C14_Caspase3-7	46	50	PF00656	0.625
CLV_NRD_NRD_1	137	139	PF00675	0.603
CLV_NRD_NRD_1	186	188	PF00675	0.569
CLV_PCSK_KEX2_1	137	139	PF00082	0.642
CLV_PCSK_KEX2_1	186	188	PF00082	0.569
CLV_PCSK_KEX2_1	99	101	PF00082	0.667
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.628
CLV_PCSK_SKI1_1	160	164	PF00082	0.578
DEG_Nend_UBRbox_3	1	3	PF02207	0.668
DOC_PP4_FxxP_1	58	61	PF00568	0.709
DOC_USP7_MATH_1	109	113	PF00917	0.635
DOC_USP7_MATH_1	144	148	PF00917	0.698
DOC_USP7_MATH_1	173	177	PF00917	0.569
DOC_USP7_MATH_1	98	102	PF00917	0.583
DOC_WW_Pin1_4	105	110	PF00397	0.629
LIG_14-3-3_CanoR_1	186	192	PF00244	0.634
LIG_APCC_ABBA_1	149	154	PF00400	0.696
LIG_DLG_GKlike_1	187	195	PF00625	0.624
LIG_FHA_1	106	112	PF00498	0.719
LIG_FHA_1	11	17	PF00498	0.603
LIG_FHA_1	37	43	PF00498	0.651
LIG_LIR_Gen_1	121	132	PF02991	0.672
LIG_LIR_Gen_1	161	170	PF02991	0.575
LIG_LIR_Gen_1	180	189	PF02991	0.360
LIG_LIR_Gen_1	32	41	PF02991	0.620
LIG_LIR_Nem_3	121	127	PF02991	0.745
LIG_LIR_Nem_3	161	165	PF02991	0.708
LIG_LIR_Nem_3	32	36	PF02991	0.574
LIG_SH2_NCK_1	191	195	PF00017	0.622
LIG_SH2_PTP2	68	71	PF00017	0.487
LIG_SH2_SRC	191	194	PF00017	0.625
LIG_SH2_STAT5	102	105	PF00017	0.564
LIG_SH2_STAT5	107	110	PF00017	0.568
LIG_SH2_STAT5	124	127	PF00017	0.599
LIG_SH2_STAT5	68	71	PF00017	0.487
LIG_SH3_3	129	135	PF00018	0.612
LIG_TYR_ITIM	66	71	PF00017	0.598
MOD_CK1_1	118	124	PF00069	0.525
MOD_CK2_1	144	150	PF00069	0.702
MOD_GlcNHglycan	117	120	PF01048	0.612
MOD_GlcNHglycan	146	149	PF01048	0.708
MOD_GSK3_1	105	112	PF00069	0.739
MOD_GSK3_1	173	180	PF00069	0.537
MOD_GSK3_1	56	63	PF00069	0.577
MOD_NEK2_1	10	15	PF00069	0.632
MOD_NEK2_1	143	148	PF00069	0.673
MOD_NEK2_1	185	190	PF00069	0.625
MOD_NEK2_1	36	41	PF00069	0.659
MOD_PIKK_1	138	144	PF00454	0.555
MOD_PKA_2	185	191	PF00069	0.679
MOD_Plk_1	138	144	PF00069	0.680
MOD_Plk_1	195	201	PF00069	0.604
MOD_Plk_4	37	43	PF00069	0.648
MOD_Plk_4	51	57	PF00069	0.566
MOD_ProDKin_1	105	111	PF00069	0.632
TRG_ENDOCYTIC_2	124	127	PF00928	0.672
TRG_ENDOCYTIC_2	68	71	PF00928	0.585
TRG_ER_diArg_1	185	187	PF00400	0.534
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU1	Leptomonas seymouri	55%	99%
A0A3R7KFM1	Trypanosoma rangeli	26%	94%
A4HLM7	Leishmania braziliensis	83%	100%
A4I938	Leishmania infantum	99%	100%
C9ZIV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B403	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q421	Leishmania major	94%	100%