LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X6T2_LEIDO
TriTrypDb:
LdBPK_331640.1 , LdCL_330023000 , LDHU3_33.2480
Length:
327

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6T2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6T2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 209 211 PF00675 0.497
CLV_NRD_NRD_1 47 49 PF00675 0.556
CLV_PCSK_KEX2_1 46 48 PF00082 0.549
CLV_PCSK_SKI1_1 301 305 PF00082 0.542
CLV_PCSK_SKI1_1 38 42 PF00082 0.641
DEG_Nend_UBRbox_1 1 4 PF02207 0.713
DEG_SCF_FBW7_1 168 175 PF00400 0.648
DEG_SPOP_SBC_1 167 171 PF00917 0.744
DEG_SPOP_SBC_1 172 176 PF00917 0.641
DEG_SPOP_SBC_1 84 88 PF00917 0.772
DOC_CDC14_PxL_1 178 186 PF14671 0.445
DOC_MAPK_gen_1 210 217 PF00069 0.561
DOC_MAPK_gen_1 246 256 PF00069 0.727
DOC_USP7_MATH_1 160 164 PF00917 0.771
DOC_USP7_MATH_1 166 170 PF00917 0.718
DOC_USP7_MATH_1 172 176 PF00917 0.758
DOC_USP7_MATH_1 258 262 PF00917 0.692
DOC_USP7_MATH_1 79 83 PF00917 0.810
DOC_WW_Pin1_4 168 173 PF00397 0.679
DOC_WW_Pin1_4 272 277 PF00397 0.727
DOC_WW_Pin1_4 69 74 PF00397 0.807
DOC_WW_Pin1_4 90 95 PF00397 0.641
LIG_14-3-3_CanoR_1 126 133 PF00244 0.513
LIG_14-3-3_CanoR_1 148 156 PF00244 0.678
LIG_14-3-3_CanoR_1 214 218 PF00244 0.498
LIG_14-3-3_CanoR_1 249 257 PF00244 0.620
LIG_14-3-3_CanoR_1 307 316 PF00244 0.617
LIG_Actin_WH2_2 181 199 PF00022 0.604
LIG_BIR_III_4 295 299 PF00653 0.643
LIG_BRCT_BRCA1_1 174 178 PF00533 0.629
LIG_BRCT_BRCA1_1 273 277 PF00533 0.776
LIG_FHA_1 278 284 PF00498 0.541
LIG_FHA_1 85 91 PF00498 0.662
LIG_FHA_2 11 17 PF00498 0.508
LIG_FHA_2 178 184 PF00498 0.672
LIG_FHA_2 230 236 PF00498 0.676
LIG_FHA_2 64 70 PF00498 0.793
LIG_LIR_Apic_2 313 318 PF02991 0.646
LIG_LIR_Gen_1 22 31 PF02991 0.517
LIG_LIR_Gen_1 59 65 PF02991 0.666
LIG_LIR_Nem_3 22 28 PF02991 0.521
LIG_LIR_Nem_3 261 267 PF02991 0.662
LIG_MLH1_MIPbox_1 174 178 PF16413 0.727
LIG_PCNA_PIPBox_1 18 27 PF02747 0.562
LIG_PCNA_yPIPBox_3 114 126 PF02747 0.614
LIG_PCNA_yPIPBox_3 15 25 PF02747 0.403
LIG_SH2_STAT5 177 180 PF00017 0.622
LIG_SH2_STAT5 25 28 PF00017 0.524
LIG_SH2_STAT5 315 318 PF00017 0.564
LIG_SH3_2 287 292 PF14604 0.722
LIG_SH3_3 153 159 PF00018 0.713
LIG_SH3_3 284 290 PF00018 0.752
LIG_SUMO_SIM_anti_2 212 219 PF11976 0.370
LIG_UBA3_1 205 211 PF00899 0.616
LIG_WRC_WIRS_1 11 16 PF05994 0.513
LIG_WRC_WIRS_1 300 305 PF05994 0.616
MOD_CDK_SPxxK_3 272 279 PF00069 0.602
MOD_CK1_1 102 108 PF00069 0.554
MOD_CK1_1 125 131 PF00069 0.515
MOD_CK1_1 233 239 PF00069 0.599
MOD_CK1_1 272 278 PF00069 0.666
MOD_CK1_1 89 95 PF00069 0.590
MOD_CK2_1 10 16 PF00069 0.513
MOD_CK2_1 177 183 PF00069 0.687
MOD_CK2_1 26 32 PF00069 0.510
MOD_CK2_1 263 269 PF00069 0.696
MOD_CK2_1 299 305 PF00069 0.622
MOD_CK2_1 63 69 PF00069 0.789
MOD_GlcNHglycan 101 104 PF01048 0.599
MOD_GlcNHglycan 160 163 PF01048 0.758
MOD_GlcNHglycan 220 223 PF01048 0.551
MOD_GlcNHglycan 224 227 PF01048 0.575
MOD_GlcNHglycan 232 235 PF01048 0.517
MOD_GlcNHglycan 271 274 PF01048 0.703
MOD_GlcNHglycan 28 31 PF01048 0.483
MOD_GSK3_1 167 174 PF00069 0.754
MOD_GSK3_1 19 26 PF00069 0.535
MOD_GSK3_1 218 225 PF00069 0.530
MOD_GSK3_1 229 236 PF00069 0.677
MOD_GSK3_1 248 255 PF00069 0.454
MOD_GSK3_1 259 266 PF00069 0.562
MOD_GSK3_1 268 275 PF00069 0.654
MOD_GSK3_1 307 314 PF00069 0.580
MOD_GSK3_1 65 72 PF00069 0.698
MOD_GSK3_1 75 82 PF00069 0.744
MOD_GSK3_1 85 92 PF00069 0.620
MOD_NEK2_1 101 106 PF00069 0.509
MOD_NEK2_1 20 25 PF00069 0.427
MOD_NEK2_1 218 223 PF00069 0.483
MOD_NEK2_1 228 233 PF00069 0.619
MOD_NEK2_1 259 264 PF00069 0.689
MOD_NEK2_1 277 282 PF00069 0.523
MOD_NEK2_2 10 15 PF00069 0.512
MOD_PIKK_1 125 131 PF00454 0.515
MOD_PIKK_1 33 39 PF00454 0.520
MOD_PK_1 197 203 PF00069 0.493
MOD_PKA_1 210 216 PF00069 0.390
MOD_PKA_2 125 131 PF00069 0.515
MOD_PKA_2 147 153 PF00069 0.653
MOD_PKA_2 213 219 PF00069 0.589
MOD_PKA_2 248 254 PF00069 0.656
MOD_Plk_1 182 188 PF00069 0.619
MOD_Plk_2-3 65 71 PF00069 0.711
MOD_Plk_4 173 179 PF00069 0.634
MOD_Plk_4 197 203 PF00069 0.482
MOD_Plk_4 20 26 PF00069 0.551
MOD_Plk_4 213 219 PF00069 0.557
MOD_Plk_4 252 258 PF00069 0.719
MOD_Plk_4 299 305 PF00069 0.492
MOD_Plk_4 311 317 PF00069 0.584
MOD_Plk_4 86 92 PF00069 0.542
MOD_ProDKin_1 168 174 PF00069 0.679
MOD_ProDKin_1 272 278 PF00069 0.727
MOD_ProDKin_1 69 75 PF00069 0.812
MOD_ProDKin_1 90 96 PF00069 0.630
TRG_DiLeu_BaEn_1 16 21 PF01217 0.509
TRG_DiLeu_BaEn_1 252 257 PF01217 0.649
TRG_DiLeu_BaEn_1 319 324 PF01217 0.573
TRG_ENDOCYTIC_2 25 28 PF00928 0.621
TRG_ER_diArg_1 46 48 PF00400 0.553

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2U9 Leptomonas seymouri 47% 99%
A4HLL5 Leishmania braziliensis 79% 100%
A4I926 Leishmania infantum 99% 100%
E9B3Z1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q433 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS