PRA1 family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

PRA1 family protein

Gene product:

PRA1 family protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6T0_LEIDO

TriTrypDb:

LdBPK_331610.1 , LdCL_330022700 , LDHU3_33.2450

Length:

181

Annotations

LeishMANIAdb annotations

A small protein consisting of 2+2 helical bundles, very conserved in Eukaryota. Might have an N-terminal transit signal.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X6T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6T0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.258
CLV_PCSK_KEX2_1	169	171	PF00082	0.329
CLV_PCSK_SKI1_1	123	127	PF00082	0.291
DOC_PP4_FxxP_1	40	43	PF00568	0.435
DOC_WW_Pin1_4	39	44	PF00397	0.467
LIG_14-3-3_CanoR_1	97	106	PF00244	0.522
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BRCT_BRCA1_1	148	152	PF00533	0.286
LIG_BRCT_BRCA1_1	31	35	PF00533	0.484
LIG_EH1_1	63	71	PF00400	0.275
LIG_eIF4E_1	64	70	PF01652	0.300
LIG_FHA_1	45	51	PF00498	0.525
LIG_FHA_1	89	95	PF00498	0.333
LIG_LIR_Apic_2	37	43	PF02991	0.470
LIG_LIR_Gen_1	128	139	PF02991	0.449
LIG_LIR_Gen_1	175	181	PF02991	0.634
LIG_LIR_Gen_1	72	82	PF02991	0.310
LIG_LIR_Gen_1	91	101	PF02991	0.323
LIG_LIR_Nem_3	128	134	PF02991	0.440
LIG_LIR_Nem_3	149	155	PF02991	0.284
LIG_LIR_Nem_3	175	181	PF02991	0.634
LIG_LIR_Nem_3	72	77	PF02991	0.347
LIG_LIR_Nem_3	91	96	PF02991	0.407
LIG_MLH1_MIPbox_1	31	35	PF16413	0.484
LIG_PCNA_yPIPBox_3	18	26	PF02747	0.603
LIG_PDZ_Class_3	176	181	PF00595	0.650
LIG_Pex14_1	31	35	PF04695	0.435
LIG_Pex14_2	35	39	PF04695	0.525
LIG_PTB_Apo_2	119	126	PF02174	0.520
LIG_PTB_Apo_2	76	83	PF02174	0.279
LIG_SH2_CRK	85	89	PF00017	0.340
LIG_SH2_GRB2like	61	64	PF00017	0.435
LIG_SH2_PTP2	74	77	PF00017	0.310
LIG_SH2_STAP1	61	65	PF00017	0.491
LIG_SH2_STAP1	85	89	PF00017	0.397
LIG_SH2_STAT5	119	122	PF00017	0.486
LIG_SH2_STAT5	131	134	PF00017	0.214
LIG_SH2_STAT5	143	146	PF00017	0.316
LIG_SH2_STAT5	59	62	PF00017	0.458
LIG_SH2_STAT5	64	67	PF00017	0.284
LIG_SH2_STAT5	74	77	PF00017	0.264
LIG_SH2_STAT5	93	96	PF00017	0.179
LIG_SUMO_SIM_anti_2	72	79	PF11976	0.299
LIG_SUMO_SIM_par_1	86	91	PF11976	0.302
LIG_TRAF2_1	111	114	PF00917	0.525
LIG_TYR_ITSM	89	96	PF00017	0.333
LIG_WRC_WIRS_1	156	161	PF05994	0.427
MOD_CK1_1	146	152	PF00069	0.270
MOD_CK1_1	2	8	PF00069	0.591
MOD_CK1_1	44	50	PF00069	0.531
MOD_CK2_1	109	115	PF00069	0.525
MOD_GlcNHglycan	145	148	PF01048	0.514
MOD_GlcNHglycan	175	178	PF01048	0.469
MOD_GlcNHglycan	43	46	PF01048	0.293
MOD_GlcNHglycan	99	102	PF01048	0.314
MOD_GSK3_1	142	149	PF00069	0.326
MOD_GSK3_1	155	162	PF00069	0.349
MOD_GSK3_1	35	42	PF00069	0.488
MOD_GSK3_1	65	72	PF00069	0.379
MOD_NEK2_1	125	130	PF00069	0.493
MOD_NEK2_1	142	147	PF00069	0.176
MOD_NEK2_1	154	159	PF00069	0.252
MOD_NEK2_1	34	39	PF00069	0.510
MOD_NEK2_1	65	70	PF00069	0.334
MOD_NEK2_1	88	93	PF00069	0.385
MOD_NEK2_1	95	100	PF00069	0.315
MOD_NEK2_2	164	169	PF00069	0.529
MOD_PIKK_1	125	131	PF00454	0.467
MOD_Plk_1	2	8	PF00069	0.611
MOD_Plk_1	35	41	PF00069	0.519
MOD_Plk_4	146	152	PF00069	0.278
MOD_Plk_4	35	41	PF00069	0.525
MOD_Plk_4	65	71	PF00069	0.315
MOD_Plk_4	88	94	PF00069	0.449
MOD_ProDKin_1	39	45	PF00069	0.467
TRG_ENDOCYTIC_2	131	134	PF00928	0.300
TRG_ENDOCYTIC_2	64	67	PF00928	0.279
TRG_ENDOCYTIC_2	74	77	PF00928	0.279
TRG_ENDOCYTIC_2	85	88	PF00928	0.299
TRG_ENDOCYTIC_2	93	96	PF00928	0.299
TRG_ER_diArg_1	168	170	PF00400	0.525
TRG_ER_diArg_1	96	99	PF00400	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K1	Leptomonas seymouri	74%	76%
A0A0S4JEM7	Bodo saltans	35%	87%
A0A1X0P0Z7	Trypanosomatidae	40%	86%
A0A3Q8IK58	Leishmania donovani	26%	100%
A0A3R7ML24	Trypanosoma rangeli	39%	88%
A4HLL2	Leishmania braziliensis	26%	100%
A4HLL3	Leishmania braziliensis	88%	100%
A4I924	Leishmania infantum	99%	100%
D0A528	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	85%
E9AHN5	Leishmania infantum	26%	100%
E9B3Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O80915	Arabidopsis thaliana	23%	82%
P93829	Arabidopsis thaliana	30%	99%
Q4Q435	Leishmania major	97%	100%
Q4Q436	Leishmania major	26%	100%
Q9C889	Arabidopsis thaliana	30%	96%
Q9FLB6	Arabidopsis thaliana	30%	83%