LeishMANIAdb
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Dual-specificity kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dual-specificity kinase
Gene product:
dual-specificity protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X6S4_LEIDO
TriTrypDb:
LdBPK_331930.1 , LdCL_330026000 , LDHU3_33.2830
Length:
958

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005856 cytoskeleton 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X6S4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6S4

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009987 cellular process 1 6
GO:0016310 phosphorylation 5 6
GO:0019538 protein metabolic process 3 6
GO:0036211 protein modification process 4 6
GO:0043170 macromolecule metabolic process 3 6
GO:0043412 macromolecule modification 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0071704 organic substance metabolic process 2 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018107 peptidyl-threonine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0018210 peptidyl-threonine modification 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 6
GO:0003824 catalytic activity 1 6
GO:0004672 protein kinase activity 3 6
GO:0004712 protein serine/threonine/tyrosine kinase activity 4 6
GO:0005488 binding 1 6
GO:0005524 ATP binding 5 6
GO:0016301 kinase activity 4 6
GO:0016740 transferase activity 2 6
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 6
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 6
GO:0017076 purine nucleotide binding 4 6
GO:0030554 adenyl nucleotide binding 5 6
GO:0032553 ribonucleotide binding 3 6
GO:0032555 purine ribonucleotide binding 4 6
GO:0032559 adenyl ribonucleotide binding 5 6
GO:0035639 purine ribonucleoside triphosphate binding 4 6
GO:0036094 small molecule binding 2 6
GO:0043167 ion binding 2 6
GO:0043168 anion binding 3 6
GO:0097159 organic cyclic compound binding 2 6
GO:0097367 carbohydrate derivative binding 2 6
GO:0140096 catalytic activity, acting on a protein 2 6
GO:1901265 nucleoside phosphate binding 3 6
GO:1901363 heterocyclic compound binding 2 6
GO:0004674 protein serine/threonine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 102 106 PF00656 0.382
CLV_C14_Caspase3-7 731 735 PF00656 0.694
CLV_NRD_NRD_1 117 119 PF00675 0.437
CLV_NRD_NRD_1 315 317 PF00675 0.432
CLV_NRD_NRD_1 32 34 PF00675 0.514
CLV_NRD_NRD_1 521 523 PF00675 0.754
CLV_NRD_NRD_1 533 535 PF00675 0.661
CLV_NRD_NRD_1 722 724 PF00675 0.704
CLV_NRD_NRD_1 756 758 PF00675 0.767
CLV_NRD_NRD_1 863 865 PF00675 0.600
CLV_PCSK_FUR_1 313 317 PF00082 0.437
CLV_PCSK_FUR_1 531 535 PF00082 0.772
CLV_PCSK_KEX2_1 313 315 PF00082 0.437
CLV_PCSK_KEX2_1 369 371 PF00082 0.416
CLV_PCSK_KEX2_1 521 523 PF00082 0.754
CLV_PCSK_KEX2_1 533 535 PF00082 0.661
CLV_PCSK_KEX2_1 722 724 PF00082 0.704
CLV_PCSK_KEX2_1 756 758 PF00082 0.767
CLV_PCSK_KEX2_1 863 865 PF00082 0.693
CLV_PCSK_KEX2_1 901 903 PF00082 0.656
CLV_PCSK_KEX2_1 953 955 PF00082 0.714
CLV_PCSK_PC1ET2_1 369 371 PF00082 0.430
CLV_PCSK_PC1ET2_1 901 903 PF00082 0.603
CLV_PCSK_PC1ET2_1 953 955 PF00082 0.714
CLV_PCSK_PC7_1 529 535 PF00082 0.774
CLV_PCSK_SKI1_1 118 122 PF00082 0.535
CLV_PCSK_SKI1_1 316 320 PF00082 0.437
CLV_PCSK_SKI1_1 360 364 PF00082 0.437
CLV_PCSK_SKI1_1 889 893 PF00082 0.573
CLV_PCSK_SKI1_1 922 926 PF00082 0.746
DEG_SPOP_SBC_1 429 433 PF00917 0.599
DEG_SPOP_SBC_1 843 847 PF00917 0.627
DOC_CKS1_1 852 857 PF01111 0.644
DOC_CYCLIN_yClb5_NLxxxL_5 164 173 PF00134 0.437
DOC_CYCLIN_yCln2_LP_2 557 563 PF00134 0.733
DOC_CYCLIN_yCln2_LP_2 912 915 PF00134 0.751
DOC_MAPK_FxFP_2 386 389 PF00069 0.583
DOC_MAPK_gen_1 686 694 PF00069 0.584
DOC_MAPK_gen_1 753 763 PF00069 0.764
DOC_MAPK_gen_1 828 836 PF00069 0.800
DOC_MAPK_HePTP_8 244 256 PF00069 0.437
DOC_MAPK_MEF2A_6 192 199 PF00069 0.392
DOC_MAPK_MEF2A_6 247 256 PF00069 0.437
DOC_PP1_RVXF_1 260 267 PF00149 0.382
DOC_PP2B_LxvP_1 299 302 PF13499 0.437
DOC_PP2B_LxvP_1 557 560 PF13499 0.698
DOC_PP2B_LxvP_1 912 915 PF13499 0.751
DOC_PP4_FxxP_1 386 389 PF00568 0.583
DOC_USP7_MATH_1 20 24 PF00917 0.467
DOC_USP7_MATH_1 389 393 PF00917 0.675
DOC_USP7_MATH_1 409 413 PF00917 0.727
DOC_USP7_MATH_1 429 433 PF00917 0.573
DOC_USP7_MATH_1 449 453 PF00917 0.621
DOC_USP7_MATH_1 470 474 PF00917 0.653
DOC_USP7_MATH_1 497 501 PF00917 0.813
DOC_USP7_MATH_1 551 555 PF00917 0.783
DOC_USP7_MATH_1 563 567 PF00917 0.666
DOC_USP7_MATH_1 578 582 PF00917 0.560
DOC_USP7_MATH_1 585 589 PF00917 0.649
DOC_USP7_MATH_1 646 650 PF00917 0.725
DOC_USP7_MATH_1 703 707 PF00917 0.669
DOC_USP7_MATH_1 741 745 PF00917 0.723
DOC_USP7_MATH_1 820 824 PF00917 0.678
DOC_USP7_MATH_1 838 842 PF00917 0.568
DOC_USP7_MATH_1 844 848 PF00917 0.679
DOC_USP7_MATH_1 853 857 PF00917 0.596
DOC_USP7_MATH_1 884 888 PF00917 0.701
DOC_WW_Pin1_4 447 452 PF00397 0.671
DOC_WW_Pin1_4 52 57 PF00397 0.596
DOC_WW_Pin1_4 547 552 PF00397 0.705
DOC_WW_Pin1_4 581 586 PF00397 0.733
DOC_WW_Pin1_4 636 641 PF00397 0.675
DOC_WW_Pin1_4 642 647 PF00397 0.666
DOC_WW_Pin1_4 737 742 PF00397 0.773
DOC_WW_Pin1_4 744 749 PF00397 0.690
DOC_WW_Pin1_4 802 807 PF00397 0.762
DOC_WW_Pin1_4 839 844 PF00397 0.824
DOC_WW_Pin1_4 851 856 PF00397 0.683
DOC_WW_Pin1_4 941 946 PF00397 0.751
LIG_14-3-3_CanoR_1 147 154 PF00244 0.421
LIG_14-3-3_CanoR_1 155 164 PF00244 0.370
LIG_14-3-3_CanoR_1 508 514 PF00244 0.678
LIG_14-3-3_CanoR_1 531 541 PF00244 0.773
LIG_14-3-3_CanoR_1 609 616 PF00244 0.669
LIG_14-3-3_CanoR_1 622 630 PF00244 0.551
LIG_14-3-3_CanoR_1 709 719 PF00244 0.744
LIG_14-3-3_CanoR_1 736 741 PF00244 0.690
LIG_14-3-3_CanoR_1 802 806 PF00244 0.667
LIG_14-3-3_CanoR_1 863 873 PF00244 0.681
LIG_14-3-3_CanoR_1 886 892 PF00244 0.647
LIG_14-3-3_CanoR_1 916 926 PF00244 0.750
LIG_Actin_WH2_2 608 624 PF00022 0.666
LIG_APCC_ABBA_1 794 799 PF00400 0.759
LIG_BRCT_BRCA1_1 231 235 PF00533 0.382
LIG_BRCT_BRCA1_1 90 94 PF00533 0.437
LIG_deltaCOP1_diTrp_1 265 269 PF00928 0.437
LIG_EVH1_1 464 468 PF00568 0.601
LIG_EVH1_2 302 306 PF00568 0.437
LIG_FHA_1 180 186 PF00498 0.382
LIG_FHA_1 671 677 PF00498 0.715
LIG_FHA_1 689 695 PF00498 0.620
LIG_FHA_1 852 858 PF00498 0.712
LIG_FHA_1 944 950 PF00498 0.725
LIG_FHA_2 27 33 PF00498 0.518
LIG_Integrin_isoDGR_2 58 60 PF01839 0.591
LIG_LIR_Apic_2 246 252 PF02991 0.437
LIG_LIR_Apic_2 297 301 PF02991 0.437
LIG_LIR_Apic_2 385 389 PF02991 0.567
LIG_LIR_Apic_2 787 791 PF02991 0.651
LIG_LIR_Apic_2 899 903 PF02991 0.702
LIG_LIR_Gen_1 161 170 PF02991 0.437
LIG_LIR_Gen_1 352 363 PF02991 0.432
LIG_LIR_Nem_3 161 165 PF02991 0.511
LIG_LIR_Nem_3 265 269 PF02991 0.437
LIG_LIR_Nem_3 352 358 PF02991 0.437
LIG_LIR_Nem_3 91 97 PF02991 0.437
LIG_MYND_1 855 859 PF01753 0.765
LIG_Pex14_2 358 362 PF04695 0.437
LIG_Pex14_2 94 98 PF04695 0.437
LIG_REV1ctd_RIR_1 316 324 PF16727 0.382
LIG_SH2_CRK 143 147 PF00017 0.437
LIG_SH2_CRK 241 245 PF00017 0.354
LIG_SH2_CRK 788 792 PF00017 0.649
LIG_SH2_SRC 682 685 PF00017 0.646
LIG_SH2_SRC 774 777 PF00017 0.701
LIG_SH2_STAP1 260 264 PF00017 0.382
LIG_SH2_STAP1 759 763 PF00017 0.707
LIG_SH2_STAT3 44 47 PF00017 0.492
LIG_SH2_STAT5 172 175 PF00017 0.456
LIG_SH2_STAT5 241 244 PF00017 0.528
LIG_SH2_STAT5 298 301 PF00017 0.437
LIG_SH2_STAT5 44 47 PF00017 0.436
LIG_SH2_STAT5 71 74 PF00017 0.502
LIG_SH2_STAT5 861 864 PF00017 0.638
LIG_SH3_2 421 426 PF14604 0.707
LIG_SH3_2 911 916 PF14604 0.699
LIG_SH3_3 278 284 PF00018 0.437
LIG_SH3_3 415 421 PF00018 0.686
LIG_SH3_3 432 438 PF00018 0.588
LIG_SH3_3 455 461 PF00018 0.747
LIG_SH3_3 462 468 PF00018 0.644
LIG_SH3_3 511 517 PF00018 0.803
LIG_SH3_3 538 544 PF00018 0.868
LIG_SH3_3 770 776 PF00018 0.692
LIG_SH3_3 849 855 PF00018 0.708
LIG_SH3_3 908 914 PF00018 0.694
LIG_SH3_3 935 941 PF00018 0.742
LIG_SH3_3 944 950 PF00018 0.678
LIG_SUMO_SIM_anti_2 182 188 PF11976 0.382
LIG_SUMO_SIM_anti_2 691 696 PF11976 0.633
LIG_SUMO_SIM_par_1 193 198 PF11976 0.437
LIG_SUMO_SIM_par_1 226 232 PF11976 0.382
LIG_SUMO_SIM_par_1 690 696 PF11976 0.579
LIG_TRAF2_1 124 127 PF00917 0.437
LIG_TYR_ITIM 160 165 PF00017 0.437
LIG_TYR_ITIM 37 42 PF00017 0.528
LIG_WRC_WIRS_1 21 26 PF05994 0.482
LIG_WRC_WIRS_1 355 360 PF05994 0.437
LIG_WW_3 371 375 PF00397 0.382
LIG_WW_3 913 917 PF00397 0.755
MOD_CDK_SPK_2 744 749 PF00069 0.717
MOD_CDK_SPxxK_3 636 643 PF00069 0.639
MOD_CDK_SPxxK_3 851 858 PF00069 0.757
MOD_CK1_1 399 405 PF00069 0.723
MOD_CK1_1 430 436 PF00069 0.759
MOD_CK1_1 487 493 PF00069 0.608
MOD_CK1_1 498 504 PF00069 0.635
MOD_CK1_1 581 587 PF00069 0.718
MOD_CK1_1 651 657 PF00069 0.674
MOD_CK1_1 744 750 PF00069 0.759
MOD_CK1_1 829 835 PF00069 0.773
MOD_CK1_1 842 848 PF00069 0.675
MOD_CK1_1 887 893 PF00069 0.637
MOD_CK2_1 13 19 PF00069 0.549
MOD_CK2_1 26 32 PF00069 0.355
MOD_CK2_1 302 308 PF00069 0.465
MOD_CK2_1 563 569 PF00069 0.759
MOD_Cter_Amidation 720 723 PF01082 0.680
MOD_DYRK1A_RPxSP_1 802 806 PF00069 0.667
MOD_GlcNHglycan 15 18 PF01048 0.451
MOD_GlcNHglycan 231 234 PF01048 0.467
MOD_GlcNHglycan 310 313 PF01048 0.495
MOD_GlcNHglycan 407 410 PF01048 0.747
MOD_GlcNHglycan 451 454 PF01048 0.684
MOD_GlcNHglycan 480 483 PF01048 0.702
MOD_GlcNHglycan 496 500 PF01048 0.605
MOD_GlcNHglycan 523 526 PF01048 0.761
MOD_GlcNHglycan 564 569 PF01048 0.724
MOD_GlcNHglycan 580 583 PF01048 0.583
MOD_GlcNHglycan 587 590 PF01048 0.663
MOD_GlcNHglycan 616 619 PF01048 0.582
MOD_GlcNHglycan 623 626 PF01048 0.578
MOD_GlcNHglycan 666 669 PF01048 0.691
MOD_GlcNHglycan 696 700 PF01048 0.635
MOD_GlcNHglycan 725 728 PF01048 0.828
MOD_GlcNHglycan 846 849 PF01048 0.786
MOD_GlcNHglycan 9 12 PF01048 0.658
MOD_GlcNHglycan 90 93 PF01048 0.487
MOD_GlcNHglycan 955 958 PF01048 0.699
MOD_GSK3_1 181 188 PF00069 0.382
MOD_GSK3_1 239 246 PF00069 0.412
MOD_GSK3_1 405 412 PF00069 0.682
MOD_GSK3_1 424 431 PF00069 0.671
MOD_GSK3_1 466 473 PF00069 0.722
MOD_GSK3_1 487 494 PF00069 0.612
MOD_GSK3_1 547 554 PF00069 0.735
MOD_GSK3_1 580 587 PF00069 0.717
MOD_GSK3_1 610 617 PF00069 0.678
MOD_GSK3_1 642 649 PF00069 0.767
MOD_GSK3_1 684 691 PF00069 0.732
MOD_GSK3_1 710 717 PF00069 0.723
MOD_GSK3_1 732 739 PF00069 0.742
MOD_GSK3_1 764 771 PF00069 0.706
MOD_GSK3_1 838 845 PF00069 0.783
MOD_GSK3_1 847 854 PF00069 0.669
MOD_GSK3_1 864 871 PF00069 0.553
MOD_GSK3_1 939 946 PF00069 0.729
MOD_N-GLC_1 389 394 PF02516 0.551
MOD_N-GLC_1 405 410 PF02516 0.663
MOD_N-GLC_1 551 556 PF02516 0.750
MOD_N-GLC_1 646 651 PF02516 0.707
MOD_NEK2_1 104 109 PF00069 0.437
MOD_NEK2_1 181 186 PF00069 0.395
MOD_NEK2_1 621 626 PF00069 0.719
MOD_NEK2_1 7 12 PF00069 0.586
MOD_NEK2_2 327 332 PF00069 0.354
MOD_NEK2_2 409 414 PF00069 0.727
MOD_PIKK_1 714 720 PF00454 0.690
MOD_PIKK_1 829 835 PF00454 0.710
MOD_PIKK_1 865 871 PF00454 0.690
MOD_PIKK_1 884 890 PF00454 0.527
MOD_PIKK_1 917 923 PF00454 0.611
MOD_PK_1 697 703 PF00069 0.539
MOD_PK_1 757 763 PF00069 0.707
MOD_PKA_1 521 527 PF00069 0.752
MOD_PKA_1 533 539 PF00069 0.663
MOD_PKA_2 146 152 PF00069 0.474
MOD_PKA_2 327 333 PF00069 0.382
MOD_PKA_2 507 513 PF00069 0.705
MOD_PKA_2 521 527 PF00069 0.628
MOD_PKA_2 532 538 PF00069 0.673
MOD_PKA_2 594 600 PF00069 0.710
MOD_PKA_2 621 627 PF00069 0.637
MOD_PKA_2 801 807 PF00069 0.697
MOD_PKA_2 838 844 PF00069 0.699
MOD_PKA_2 865 871 PF00069 0.773
MOD_PKA_2 915 921 PF00069 0.710
MOD_PKB_1 531 539 PF00069 0.773
MOD_Plk_1 104 110 PF00069 0.437
MOD_Plk_1 396 402 PF00069 0.657
MOD_Plk_1 757 763 PF00069 0.707
MOD_Plk_1 829 835 PF00069 0.735
MOD_Plk_4 104 110 PF00069 0.437
MOD_Plk_4 181 187 PF00069 0.398
MOD_Plk_4 195 201 PF00069 0.310
MOD_Plk_4 220 226 PF00069 0.392
MOD_Plk_4 239 245 PF00069 0.256
MOD_Plk_4 302 308 PF00069 0.382
MOD_Plk_4 354 360 PF00069 0.501
MOD_Plk_4 697 703 PF00069 0.567
MOD_Plk_4 868 874 PF00069 0.715
MOD_ProDKin_1 447 453 PF00069 0.672
MOD_ProDKin_1 52 58 PF00069 0.609
MOD_ProDKin_1 547 553 PF00069 0.704
MOD_ProDKin_1 581 587 PF00069 0.736
MOD_ProDKin_1 636 642 PF00069 0.675
MOD_ProDKin_1 737 743 PF00069 0.776
MOD_ProDKin_1 744 750 PF00069 0.690
MOD_ProDKin_1 802 808 PF00069 0.765
MOD_ProDKin_1 839 845 PF00069 0.823
MOD_ProDKin_1 851 857 PF00069 0.685
MOD_ProDKin_1 941 947 PF00069 0.747
MOD_SUMO_for_1 210 213 PF00179 0.437
MOD_SUMO_for_1 425 428 PF00179 0.702
MOD_SUMO_rev_2 136 142 PF00179 0.437
MOD_SUMO_rev_2 203 212 PF00179 0.437
MOD_SUMO_rev_2 232 240 PF00179 0.437
MOD_SUMO_rev_2 392 396 PF00179 0.709
MOD_SUMO_rev_2 639 645 PF00179 0.713
TRG_DiLeu_BaEn_2 350 356 PF01217 0.437
TRG_DiLeu_BaEn_4 393 399 PF01217 0.669
TRG_DiLeu_BaLyEn_6 813 818 PF01217 0.657
TRG_ENDOCYTIC_2 143 146 PF00928 0.437
TRG_ENDOCYTIC_2 162 165 PF00928 0.437
TRG_ENDOCYTIC_2 170 173 PF00928 0.342
TRG_ENDOCYTIC_2 241 244 PF00928 0.410
TRG_ENDOCYTIC_2 39 42 PF00928 0.519
TRG_ENDOCYTIC_2 83 86 PF00928 0.437
TRG_ER_diArg_1 313 316 PF00400 0.437
TRG_ER_diArg_1 325 328 PF00400 0.295
TRG_ER_diArg_1 531 534 PF00400 0.774
TRG_ER_diArg_1 863 866 PF00400 0.698
TRG_NES_CRM1_1 102 117 PF08389 0.382
TRG_Pf-PMV_PEXEL_1 609 614 PF00026 0.670
TRG_Pf-PMV_PEXEL_1 922 927 PF00026 0.706

Homologs

Protein Taxonomy Sequence identity Coverage
A4HLP3 Leishmania braziliensis 70% 100%
A4I978 Leishmania infantum 100% 100%
E9B419 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q405 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS