Dual-specificity kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual-specificity protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6S4_LEIDO

TriTrypDb:

LdBPK_331930.1 , LdCL_330026000 , LDHU3_33.2830

Length:

958

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Previous1Next

Expansion

Sequence features

A0A3S7X6S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6S4

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6

Previous1 2 3Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.382
CLV_C14_Caspase3-7	731	735	PF00656	0.694
CLV_NRD_NRD_1	117	119	PF00675	0.437
CLV_NRD_NRD_1	315	317	PF00675	0.432
CLV_NRD_NRD_1	32	34	PF00675	0.514
CLV_NRD_NRD_1	521	523	PF00675	0.754
CLV_NRD_NRD_1	533	535	PF00675	0.661
CLV_NRD_NRD_1	722	724	PF00675	0.704
CLV_NRD_NRD_1	756	758	PF00675	0.767
CLV_NRD_NRD_1	863	865	PF00675	0.600

Previous1 2 3 4 5…30Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A4HLP3	Leishmania braziliensis	70%	100%
A4I978	Leishmania infantum	100%	100%
E9B419	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q405	Leishmania major	92%	100%

Previous1Next