Macrophage migration inhibitory factor-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

macrophage migration inhibitory factor-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X6S3_LEIDO

TriTrypDb:

LdBPK_331840.1 , LdCL_330025200 , LDHU3_33.2730

Length:

113

Annotations

Annotations by Jardim et al.

Glycosylation, Macrophage migration inhibitory factor-like MIF1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005615	extracellular space	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7X6S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6S3

PDB structure(s): 3b64_A , 3fwt_A , 3fwu_A , 4nwr_1 , 4nwr_3 , 4nwr_5 , 4nwr_7 , 4nwr_9 , 4nwr_AB , 4nwr_AD , 4nwr_AF , 4nwr_AH , 4nwr_AJ , 4nwr_AL , 4nwr_AN , 4nwr_AP , 4nwr_AR , 4nwr_AT , 4nwr_AV , 4nwr_AX , 4nwr_AZ , 4nwr_b , 4nwr_BB , 4nwr_BD , 4nwr_BF , 4nwr_BH , 4nwr_d , 4nwr_f , 4nwr_h , 4nwr_j , 4nwr_l , 4nwr_n , 4nwr_p , 4nwr_r , 4nwr_t , 4nwr_v , 4nwr_x , 4nwr_z

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016853	isomerase activity	2	2
GO:0016860	intramolecular oxidoreductase activity	3	2
GO:0016862	intramolecular oxidoreductase activity, interconverting keto- and enol-groups	4	2
GO:0050178	phenylpyruvate tautomerase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	16	18	PF00082	0.570
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.570
CLV_PCSK_SKI1_1	25	29	PF00082	0.463
DEG_APCC_DBOX_1	16	24	PF00400	0.491
DOC_CKS1_1	8	13	PF01111	0.464
DOC_MAPK_JIP1_4	34	40	PF00069	0.419
DOC_WW_Pin1_4	44	49	PF00397	0.485
DOC_WW_Pin1_4	7	12	PF00397	0.459
DOC_WW_Pin1_4	99	104	PF00397	0.421
LIG_CtBP_PxDLS_1	35	39	PF00389	0.419
LIG_FHA_1	26	32	PF00498	0.419
LIG_FHA_1	53	59	PF00498	0.477
LIG_FHA_1	76	82	PF00498	0.440
LIG_FHA_2	40	46	PF00498	0.406
LIG_FHA_2	8	14	PF00498	0.501
LIG_LIR_Nem_3	94	100	PF02991	0.582
LIG_PDZ_Class_1	108	113	PF00595	0.463
LIG_Pex14_2	97	101	PF04695	0.419
LIG_SH2_CRK	24	28	PF00017	0.582
LIG_SH2_PTP2	60	63	PF00017	0.520
LIG_SH2_STAT5	100	103	PF00017	0.491
LIG_SH2_STAT5	60	63	PF00017	0.541
LIG_SH3_2	71	76	PF14604	0.425
LIG_SH3_3	5	11	PF00018	0.572
LIG_SH3_3	68	74	PF00018	0.453
LIG_TYR_ITIM	58	63	PF00017	0.357
LIG_WRC_WIRS_1	4	9	PF05994	0.467
LIG_WRC_WIRS_1	40	45	PF05994	0.511
MOD_CK1_1	79	85	PF00069	0.419
MOD_CK2_1	69	75	PF00069	0.476
MOD_GSK3_1	3	10	PF00069	0.475
MOD_GSK3_1	39	46	PF00069	0.572
MOD_GSK3_1	75	82	PF00069	0.449
MOD_N-GLC_1	108	113	PF02516	0.463
MOD_NEK2_1	43	48	PF00069	0.489
MOD_PK_1	76	82	PF00069	0.419
MOD_Plk_4	3	9	PF00069	0.629
MOD_Plk_4	76	82	PF00069	0.419
MOD_ProDKin_1	44	50	PF00069	0.485
MOD_ProDKin_1	7	13	PF00069	0.463
MOD_ProDKin_1	99	105	PF00069	0.421
TRG_ENDOCYTIC_2	24	27	PF00928	0.637
TRG_ENDOCYTIC_2	60	63	PF00928	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I920	Leptomonas seymouri	57%	100%
A0A3S7X6W1	Leishmania donovani	60%	100%
A4I970	Leishmania infantum	100%	100%
A4I971	Leishmania infantum	60%	100%
E9B411	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B412	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q02960	Gallus gallus	31%	98%
Q4Q412	Leishmania major	59%	100%
Q4Q413	Leishmania major	99%	100%