Pre-mRNA-splicing factor CWC15

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6R7_LEIDO

TriTrypDb:

LdBPK_331380.1 , LdCL_330020100 , LDHU3_33.2070

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7X6R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6R7

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.735
CLV_NRD_NRD_1	118	120	PF00675	0.565
CLV_NRD_NRD_1	19	21	PF00675	0.578
CLV_NRD_NRD_1	29	31	PF00675	0.619
CLV_PCSK_FUR_1	116	120	PF00082	0.556
CLV_PCSK_KEX2_1	118	120	PF00082	0.561
CLV_PCSK_KEX2_1	17	19	PF00082	0.568
CLV_PCSK_KEX2_1	189	191	PF00082	0.554
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.568
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.554
CLV_PCSK_SKI1_1	108	112	PF00082	0.584
CLV_PCSK_SKI1_1	212	216	PF00082	0.585
CLV_PCSK_SKI1_1	76	80	PF00082	0.660
DEG_SPOP_SBC_1	56	60	PF00917	0.552
DEG_SPOP_SBC_1	80	84	PF00917	0.640
DOC_USP7_MATH_1	11	15	PF00917	0.613
DOC_USP7_MATH_1	135	139	PF00917	0.687
DOC_USP7_MATH_1	151	155	PF00917	0.639
DOC_USP7_MATH_1	56	60	PF00917	0.659
DOC_USP7_MATH_1	70	74	PF00917	0.650
DOC_USP7_MATH_1	80	84	PF00917	0.639
DOC_USP7_UBL2_3	189	193	PF12436	0.581
DOC_USP7_UBL2_3	212	216	PF12436	0.460
DOC_USP7_UBL2_3	72	76	PF12436	0.633
DOC_WW_Pin1_4	147	152	PF00397	0.748
LIG_Actin_WH2_2	54	69	PF00022	0.495
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BRCT_BRCA1_1	203	207	PF00533	0.552
LIG_eIF4E_1	166	172	PF01652	0.553
LIG_FHA_1	58	64	PF00498	0.668
LIG_FHA_2	183	189	PF00498	0.629
LIG_Integrin_RGD_1	35	37	PF01839	0.537
LIG_LIR_Nem_3	204	210	PF02991	0.514
LIG_Pex14_2	210	214	PF04695	0.533
LIG_REV1ctd_RIR_1	212	216	PF16727	0.554
LIG_SH2_STAP1	166	170	PF00017	0.645
LIG_SUMO_SIM_par_1	58	64	PF11976	0.504
MOD_CK1_1	130	136	PF00069	0.718
MOD_CK1_1	149	155	PF00069	0.665
MOD_CK1_1	181	187	PF00069	0.553
MOD_CK1_1	82	88	PF00069	0.633
MOD_CK1_1	89	95	PF00069	0.568
MOD_CK2_1	182	188	PF00069	0.605
MOD_CK2_1	90	96	PF00069	0.624
MOD_GlcNHglycan	1	4	PF01048	0.648
MOD_GlcNHglycan	130	133	PF01048	0.662
MOD_GlcNHglycan	137	140	PF01048	0.593
MOD_GlcNHglycan	151	154	PF01048	0.565
MOD_GlcNHglycan	63	66	PF01048	0.649
MOD_GlcNHglycan	68	71	PF01048	0.673
MOD_GlcNHglycan	73	76	PF01048	0.658
MOD_GSK3_1	123	130	PF00069	0.557
MOD_GSK3_1	131	138	PF00069	0.655
MOD_GSK3_1	145	152	PF00069	0.607
MOD_GSK3_1	178	185	PF00069	0.655
MOD_GSK3_1	20	27	PF00069	0.699
MOD_GSK3_1	57	64	PF00069	0.646
MOD_GSK3_1	66	73	PF00069	0.636
MOD_GSK3_1	79	86	PF00069	0.604
MOD_N-GLC_1	198	203	PF02516	0.534
MOD_NEK2_1	66	71	PF00069	0.597
MOD_NEK2_1	79	84	PF00069	0.635
MOD_PIKK_1	198	204	PF00454	0.584
MOD_PIKK_1	20	26	PF00454	0.643
MOD_PK_1	193	199	PF00069	0.608
MOD_PKA_2	66	72	PF00069	0.540
MOD_PKA_2	80	86	PF00069	0.692
MOD_PKB_1	18	26	PF00069	0.638
MOD_Plk_4	11	17	PF00069	0.582
MOD_Plk_4	193	199	PF00069	0.726
MOD_ProDKin_1	147	153	PF00069	0.746
TRG_ER_diArg_1	116	119	PF00400	0.523
TRG_ER_diArg_1	172	175	PF00400	0.579
TRG_ER_diArg_1	18	20	PF00400	0.578
TRG_NLS_MonoCore_2	16	21	PF00514	0.574
TRG_NLS_MonoExtC_3	16	22	PF00514	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U6	Leptomonas seymouri	47%	100%
A4HLI7	Leishmania braziliensis	76%	99%
A4I8Z7	Leishmania infantum	95%	98%
D0A4Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B3W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4Q458	Leishmania major	89%	99%
V5BLV0	Trypanosoma cruzi	29%	100%