Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6R5_LEIDO

TriTrypDb:

LdBPK_331300.1 , LdCL_330019200 , LDHU3_33.1950

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	8
GO:0032991	protein-containing complex	1	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:1990904	ribonucleoprotein complex	2	8
GO:0035869	ciliary transition zone	2	2

Expansion

Sequence features

A0A3S7X6R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6R5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.462
CLV_C14_Caspase3-7	427	431	PF00656	0.540
CLV_C14_Caspase3-7	551	555	PF00656	0.596
CLV_NRD_NRD_1	178	180	PF00675	0.566
CLV_NRD_NRD_1	456	458	PF00675	0.502
CLV_NRD_NRD_1	57	59	PF00675	0.542
CLV_NRD_NRD_1	789	791	PF00675	0.660
CLV_NRD_NRD_1	809	811	PF00675	0.453
CLV_PCSK_FUR_1	806	810	PF00082	0.557
CLV_PCSK_KEX2_1	103	105	PF00082	0.611
CLV_PCSK_KEX2_1	456	458	PF00082	0.493
CLV_PCSK_KEX2_1	479	481	PF00082	0.606
CLV_PCSK_KEX2_1	57	59	PF00082	0.542
CLV_PCSK_KEX2_1	789	791	PF00082	0.798
CLV_PCSK_KEX2_1	805	807	PF00082	0.473
CLV_PCSK_KEX2_1	808	810	PF00082	0.462
CLV_PCSK_KEX2_1	847	849	PF00082	0.626
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.611
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.518
CLV_PCSK_PC1ET2_1	805	807	PF00082	0.550
CLV_PCSK_PC1ET2_1	847	849	PF00082	0.626
CLV_PCSK_PC7_1	475	481	PF00082	0.488
CLV_PCSK_SKI1_1	123	127	PF00082	0.422
CLV_PCSK_SKI1_1	475	479	PF00082	0.441
CLV_PCSK_SKI1_1	847	851	PF00082	0.645
CLV_PCSK_SKI1_1	854	858	PF00082	0.591
CLV_Separin_Metazoa	54	58	PF03568	0.566
DEG_APCC_DBOX_1	500	508	PF00400	0.535
DEG_APCC_DBOX_1	809	817	PF00400	0.659
DEG_SPOP_SBC_1	593	597	PF00917	0.642
DEG_SPOP_SBC_1	860	864	PF00917	0.613
DOC_CYCLIN_RxL_1	117	130	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.569
DOC_CYCLIN_yCln2_LP_2	567	573	PF00134	0.641
DOC_CYCLIN_yCln2_LP_2	588	594	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	612	618	PF00134	0.588
DOC_MAPK_DCC_7	808	818	PF00069	0.661
DOC_MAPK_gen_1	808	818	PF00069	0.661
DOC_MAPK_MEF2A_6	501	508	PF00069	0.544
DOC_MAPK_MEF2A_6	809	818	PF00069	0.662
DOC_MAPK_NFAT4_5	501	509	PF00069	0.550
DOC_PP1_RVXF_1	360	367	PF00149	0.492
DOC_PP2B_LxvP_1	126	129	PF13499	0.467
DOC_PP2B_LxvP_1	20	23	PF13499	0.614
DOC_PP2B_LxvP_1	506	509	PF13499	0.611
DOC_PP2B_LxvP_1	571	574	PF13499	0.664
DOC_PP2B_LxvP_1	588	591	PF13499	0.616
DOC_PP2B_LxvP_1	610	613	PF13499	0.716
DOC_SPAK_OSR1_1	362	366	PF12202	0.478
DOC_USP7_MATH_1	155	159	PF00917	0.601
DOC_USP7_MATH_1	184	188	PF00917	0.466
DOC_USP7_MATH_1	237	241	PF00917	0.556
DOC_USP7_MATH_1	383	387	PF00917	0.533
DOC_USP7_MATH_1	563	567	PF00917	0.647
DOC_USP7_MATH_1	594	598	PF00917	0.711
DOC_USP7_MATH_1	61	65	PF00917	0.554
DOC_USP7_MATH_1	678	682	PF00917	0.506
DOC_USP7_MATH_1	689	693	PF00917	0.468
DOC_USP7_MATH_1	71	75	PF00917	0.558
DOC_USP7_MATH_1	762	766	PF00917	0.597
DOC_USP7_MATH_1	794	798	PF00917	0.642
DOC_WW_Pin1_4	400	405	PF00397	0.571
DOC_WW_Pin1_4	528	533	PF00397	0.721
DOC_WW_Pin1_4	742	747	PF00397	0.488
DOC_WW_Pin1_4	766	771	PF00397	0.555
DOC_WW_Pin1_4	792	797	PF00397	0.647
DOC_WW_Pin1_4	827	832	PF00397	0.648
LIG_14-3-3_CanoR_1	104	108	PF00244	0.572
LIG_14-3-3_CanoR_1	179	188	PF00244	0.449
LIG_14-3-3_CanoR_1	216	223	PF00244	0.300
LIG_14-3-3_CanoR_1	309	314	PF00244	0.487
LIG_14-3-3_CanoR_1	342	350	PF00244	0.525
LIG_14-3-3_CanoR_1	409	413	PF00244	0.497
LIG_14-3-3_CanoR_1	438	444	PF00244	0.554
LIG_14-3-3_CanoR_1	86	92	PF00244	0.591
LIG_BIR_III_4	284	288	PF00653	0.430
LIG_BRCT_BRCA1_1	440	444	PF00533	0.552
LIG_deltaCOP1_diTrp_1	34	40	PF00928	0.480
LIG_EVH1_1	610	614	PF00568	0.723
LIG_FHA_1	169	175	PF00498	0.523
LIG_FHA_1	180	186	PF00498	0.373
LIG_FHA_1	244	250	PF00498	0.550
LIG_FHA_1	326	332	PF00498	0.489
LIG_FHA_1	414	420	PF00498	0.547
LIG_FHA_1	50	56	PF00498	0.567
LIG_FHA_1	522	528	PF00498	0.627
LIG_FHA_1	529	535	PF00498	0.732
LIG_FHA_1	573	579	PF00498	0.630
LIG_FHA_1	594	600	PF00498	0.653
LIG_FHA_1	653	659	PF00498	0.747
LIG_FHA_1	798	804	PF00498	0.631
LIG_FHA_1	855	861	PF00498	0.677
LIG_FHA_2	29	35	PF00498	0.502
LIG_FHA_2	37	43	PF00498	0.368
LIG_FHA_2	498	504	PF00498	0.580
LIG_FHA_2	521	527	PF00498	0.695
LIG_FHA_2	549	555	PF00498	0.598
LIG_FHA_2	831	837	PF00498	0.698
LIG_LIR_Gen_1	34	45	PF02991	0.644
LIG_LIR_Gen_1	380	390	PF02991	0.703
LIG_LIR_LC3C_4	17	22	PF02991	0.636
LIG_LIR_Nem_3	190	194	PF02991	0.472
LIG_LIR_Nem_3	34	40	PF02991	0.480
LIG_LIR_Nem_3	402	408	PF02991	0.570
LIG_MAD2	18	26	PF02301	0.540
LIG_NRBOX	173	179	PF00104	0.494
LIG_SH2_SRC	194	197	PF00017	0.417
LIG_SH2_SRC	232	235	PF00017	0.550
LIG_SH2_STAP1	214	218	PF00017	0.401
LIG_SH2_STAT5	194	197	PF00017	0.495
LIG_SH2_STAT5	262	265	PF00017	0.460
LIG_SH2_STAT5	530	533	PF00017	0.635
LIG_SH2_STAT5	786	789	PF00017	0.658
LIG_SH3_3	19	25	PF00018	0.589
LIG_SH3_3	351	357	PF00018	0.617
LIG_SH3_3	567	573	PF00018	0.706
LIG_SH3_3	598	604	PF00018	0.675
LIG_SH3_3	605	611	PF00018	0.665
LIG_SH3_3	626	632	PF00018	0.798
LIG_SH3_3	639	645	PF00018	0.757
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.626
LIG_SUMO_SIM_anti_2	173	179	PF11976	0.404
LIG_SUMO_SIM_par_1	124	130	PF11976	0.530
LIG_SUMO_SIM_par_1	25	31	PF11976	0.471
LIG_UBA3_1	174	180	PF00899	0.487
MOD_CDK_SPxK_1	400	406	PF00069	0.573
MOD_CDK_SPxxK_3	792	799	PF00069	0.648
MOD_CK1_1	158	164	PF00069	0.631
MOD_CK1_1	170	176	PF00069	0.481
MOD_CK1_1	28	34	PF00069	0.550
MOD_CK1_1	322	328	PF00069	0.460
MOD_CK1_1	400	406	PF00069	0.573
MOD_CK1_1	547	553	PF00069	0.717
MOD_CK1_1	565	571	PF00069	0.549
MOD_CK1_1	634	640	PF00069	0.813
MOD_CK1_1	643	649	PF00069	0.611
MOD_CK1_1	69	75	PF00069	0.648
MOD_CK1_1	797	803	PF00069	0.627
MOD_CK1_1	8	14	PF00069	0.652
MOD_CK1_1	81	87	PF00069	0.540
MOD_CK1_1	830	836	PF00069	0.649
MOD_CK2_1	184	190	PF00069	0.428
MOD_CK2_1	194	200	PF00069	0.322
MOD_CK2_1	349	355	PF00069	0.427
MOD_CK2_1	38	44	PF00069	0.455
MOD_CK2_1	383	389	PF00069	0.562
MOD_CK2_1	444	450	PF00069	0.684
MOD_CK2_1	497	503	PF00069	0.456
MOD_CK2_1	830	836	PF00069	0.699
MOD_CK2_1	840	846	PF00069	0.583
MOD_DYRK1A_RPxSP_1	827	831	PF00069	0.606
MOD_GlcNHglycan	117	120	PF01048	0.613
MOD_GlcNHglycan	157	160	PF01048	0.668
MOD_GlcNHglycan	196	199	PF01048	0.418
MOD_GlcNHglycan	239	242	PF01048	0.330
MOD_GlcNHglycan	266	269	PF01048	0.579
MOD_GlcNHglycan	281	284	PF01048	0.490
MOD_GlcNHglycan	285	288	PF01048	0.546
MOD_GlcNHglycan	306	309	PF01048	0.570
MOD_GlcNHglycan	321	324	PF01048	0.413
MOD_GlcNHglycan	335	338	PF01048	0.539
MOD_GlcNHglycan	351	354	PF01048	0.492
MOD_GlcNHglycan	368	371	PF01048	0.414
MOD_GlcNHglycan	385	388	PF01048	0.517
MOD_GlcNHglycan	399	402	PF01048	0.451
MOD_GlcNHglycan	516	519	PF01048	0.592
MOD_GlcNHglycan	535	538	PF01048	0.695
MOD_GlcNHglycan	541	544	PF01048	0.678
MOD_GlcNHglycan	580	583	PF01048	0.770
MOD_GlcNHglycan	585	588	PF01048	0.628
MOD_GlcNHglycan	605	608	PF01048	0.734
MOD_GlcNHglycan	63	66	PF01048	0.668
MOD_GlcNHglycan	633	636	PF01048	0.810
MOD_GlcNHglycan	68	71	PF01048	0.487
MOD_GlcNHglycan	73	76	PF01048	0.592
MOD_GlcNHglycan	749	752	PF01048	0.690
MOD_GlcNHglycan	763	767	PF01048	0.669
MOD_GlcNHglycan	840	843	PF01048	0.654
MOD_GlcNHglycan	87	90	PF01048	0.625
MOD_GlcNHglycan	98	101	PF01048	0.612
MOD_GSK3_1	103	110	PF00069	0.671
MOD_GSK3_1	163	170	PF00069	0.599
MOD_GSK3_1	179	186	PF00069	0.580
MOD_GSK3_1	239	246	PF00069	0.567
MOD_GSK3_1	253	260	PF00069	0.369
MOD_GSK3_1	279	286	PF00069	0.574
MOD_GSK3_1	321	328	PF00069	0.468
MOD_GSK3_1	393	400	PF00069	0.591
MOD_GSK3_1	544	551	PF00069	0.757
MOD_GSK3_1	574	581	PF00069	0.670
MOD_GSK3_1	762	769	PF00069	0.581
MOD_GSK3_1	794	801	PF00069	0.634
MOD_GSK3_1	81	88	PF00069	0.690
MOD_GSK3_1	823	830	PF00069	0.669
MOD_GSK3_1	836	843	PF00069	0.597
MOD_GSK3_1	850	857	PF00069	0.552
MOD_GSK3_1	862	869	PF00069	0.552
MOD_N-GLC_2	143	145	PF02516	0.460
MOD_NEK2_1	139	144	PF00069	0.521
MOD_NEK2_1	217	222	PF00069	0.404
MOD_NEK2_1	257	262	PF00069	0.458
MOD_NEK2_1	408	413	PF00069	0.483
MOD_NEK2_1	444	449	PF00069	0.578
MOD_NEK2_1	497	502	PF00069	0.467
MOD_NEK2_1	538	543	PF00069	0.755
MOD_NEK2_1	592	597	PF00069	0.548
MOD_NEK2_1	776	781	PF00069	0.621
MOD_NEK2_1	79	84	PF00069	0.611
MOD_NEK2_2	253	258	PF00069	0.402
MOD_PIKK_1	262	268	PF00454	0.435
MOD_PIKK_1	413	419	PF00454	0.516
MOD_PKA_1	103	109	PF00069	0.599
MOD_PKA_1	179	185	PF00069	0.458
MOD_PKA_1	847	853	PF00069	0.629
MOD_PKA_2	103	109	PF00069	0.498
MOD_PKA_2	167	173	PF00069	0.546
MOD_PKA_2	257	263	PF00069	0.530
MOD_PKA_2	341	347	PF00069	0.466
MOD_PKA_2	408	414	PF00069	0.513
MOD_PKA_2	47	53	PF00069	0.649
MOD_PKA_2	776	782	PF00069	0.643
MOD_PKA_2	798	804	PF00069	0.631
MOD_PKA_2	847	853	PF00069	0.620
MOD_PKA_2	85	91	PF00069	0.590
MOD_PKB_1	823	831	PF00069	0.652
MOD_Plk_1	243	249	PF00069	0.549
MOD_Plk_2-3	393	399	PF00069	0.530
MOD_Plk_4	170	176	PF00069	0.481
MOD_Plk_4	393	399	PF00069	0.576
MOD_Plk_4	439	445	PF00069	0.660
MOD_Plk_4	855	861	PF00069	0.635
MOD_ProDKin_1	400	406	PF00069	0.573
MOD_ProDKin_1	528	534	PF00069	0.724
MOD_ProDKin_1	742	748	PF00069	0.488
MOD_ProDKin_1	766	772	PF00069	0.553
MOD_ProDKin_1	792	798	PF00069	0.647
MOD_ProDKin_1	827	833	PF00069	0.650
MOD_SUMO_for_1	804	807	PF00179	0.625
MOD_SUMO_for_1	816	819	PF00179	0.584
MOD_SUMO_rev_2	830	839	PF00179	0.676
TRG_DiLeu_BaEn_1	234	239	PF01217	0.621
TRG_DiLeu_BaEn_1	503	508	PF01217	0.554
TRG_ENDOCYTIC_2	214	217	PF00928	0.408
TRG_ENDOCYTIC_2	382	385	PF00928	0.556
TRG_ENDOCYTIC_2	405	408	PF00928	0.602
TRG_ER_diArg_1	456	458	PF00400	0.476
TRG_ER_diArg_1	468	471	PF00400	0.403
TRG_ER_diArg_1	56	58	PF00400	0.622
TRG_ER_diArg_1	789	791	PF00400	0.660
TRG_ER_diArg_1	808	810	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P0X2	Trypanosomatidae	31%	100%
A4HLH8	Leishmania braziliensis	29%	95%
A4HLH9	Leishmania braziliensis	75%	100%
A4I8Y9	Leishmania infantum	97%	99%
E9B3V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q466	Leishmania major	92%	100%
Q4Q467	Leishmania major	31%	100%