LeishMANIAdb
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Cysteine desulfurase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cysteine desulfurase
Gene product:
thiamine biosynthesis-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7X6Q8_LEIDO
TriTrypDb:
LdBPK_331780.1 , LdCL_330024500 , LDHU3_33.2640
Length:
795

Annotations

Annotations by Jardim et al.

Coenzyme/cofactor biosynthesis, Thiamine biosynthesis-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6Q8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6Q8

Function

Biological processes
Term Name Level Count
GO:0006790 sulfur compound metabolic process 3 8
GO:0008152 metabolic process 1 8
GO:0009987 cellular process 1 8
GO:0016043 cellular component organization 3 8
GO:0016226 iron-sulfur cluster assembly 4 8
GO:0022607 cellular component assembly 4 8
GO:0031163 metallo-sulfur cluster assembly 5 8
GO:0044237 cellular metabolic process 2 8
GO:0044571 [2Fe-2S] cluster assembly 5 8
GO:0071840 cellular component organization or biogenesis 2 8
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 8
GO:0003824 catalytic activity 1 8
GO:0004652 obsolete polynucleotide adenylyltransferase activity 6 8
GO:0004810 CCA tRNA nucleotidyltransferase activity 8 8
GO:0005488 binding 1 8
GO:0005524 ATP binding 5 8
GO:0016740 transferase activity 2 8
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 8
GO:0016779 nucleotidyltransferase activity 4 8
GO:0016782 transferase activity, transferring sulphur-containing groups 3 8
GO:0016783 sulfurtransferase activity 4 8
GO:0017076 purine nucleotide binding 4 8
GO:0019842 vitamin binding 3 8
GO:0030170 pyridoxal phosphate binding 4 8
GO:0030554 adenyl nucleotide binding 5 8
GO:0031071 cysteine desulfurase activity 5 8
GO:0032553 ribonucleotide binding 3 8
GO:0032555 purine ribonucleotide binding 4 8
GO:0032559 adenyl ribonucleotide binding 5 8
GO:0035639 purine ribonucleoside triphosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0043169 cation binding 3 8
GO:0046872 metal ion binding 4 8
GO:0051536 iron-sulfur cluster binding 3 8
GO:0051540 metal cluster binding 2 8
GO:0070279 vitamin B6 binding 3 8
GO:0070566 adenylyltransferase activity 5 8
GO:0097159 organic cyclic compound binding 2 8
GO:0097367 carbohydrate derivative binding 2 8
GO:1901265 nucleoside phosphate binding 3 8
GO:1901363 heterocyclic compound binding 2 8
GO:1990817 poly(A) RNA polymerase activity 7 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 16 20 PF00656 0.494
CLV_C14_Caspase3-7 614 618 PF00656 0.502
CLV_C14_Caspase3-7 773 777 PF00656 0.480
CLV_NRD_NRD_1 139 141 PF00675 0.440
CLV_NRD_NRD_1 152 154 PF00675 0.318
CLV_NRD_NRD_1 170 172 PF00675 0.421
CLV_NRD_NRD_1 201 203 PF00675 0.632
CLV_NRD_NRD_1 270 272 PF00675 0.292
CLV_NRD_NRD_1 371 373 PF00675 0.308
CLV_NRD_NRD_1 403 405 PF00675 0.469
CLV_NRD_NRD_1 411 413 PF00675 0.466
CLV_NRD_NRD_1 701 703 PF00675 0.259
CLV_NRD_NRD_1 71 73 PF00675 0.449
CLV_NRD_NRD_1 85 87 PF00675 0.501
CLV_PCSK_KEX2_1 113 115 PF00082 0.462
CLV_PCSK_KEX2_1 141 143 PF00082 0.391
CLV_PCSK_KEX2_1 152 154 PF00082 0.364
CLV_PCSK_KEX2_1 270 272 PF00082 0.298
CLV_PCSK_KEX2_1 403 405 PF00082 0.469
CLV_PCSK_KEX2_1 411 413 PF00082 0.466
CLV_PCSK_KEX2_1 701 703 PF00082 0.259
CLV_PCSK_KEX2_1 71 73 PF00082 0.408
CLV_PCSK_KEX2_1 85 87 PF00082 0.501
CLV_PCSK_PC1ET2_1 113 115 PF00082 0.460
CLV_PCSK_PC1ET2_1 141 143 PF00082 0.391
CLV_PCSK_PC7_1 67 73 PF00082 0.476
CLV_PCSK_SKI1_1 152 156 PF00082 0.377
CLV_PCSK_SKI1_1 207 211 PF00082 0.501
CLV_PCSK_SKI1_1 242 246 PF00082 0.302
CLV_PCSK_SKI1_1 411 415 PF00082 0.466
CLV_PCSK_SKI1_1 419 423 PF00082 0.418
CLV_PCSK_SKI1_1 585 589 PF00082 0.476
CLV_PCSK_SKI1_1 638 642 PF00082 0.302
CLV_PCSK_SKI1_1 785 789 PF00082 0.383
DEG_APCC_DBOX_1 139 147 PF00400 0.417
DEG_APCC_DBOX_1 411 419 PF00400 0.473
DEG_APCC_DBOX_1 513 521 PF00400 0.502
DEG_ODPH_VHL_1 356 368 PF01847 0.502
DEG_SCF_FBW7_1 754 761 PF00400 0.508
DOC_CDC14_PxL_1 56 64 PF14671 0.413
DOC_CKS1_1 219 224 PF01111 0.437
DOC_MAPK_gen_1 140 146 PF00069 0.364
DOC_MAPK_gen_1 411 420 PF00069 0.457
DOC_MAPK_gen_1 785 793 PF00069 0.322
DOC_MAPK_MEF2A_6 140 148 PF00069 0.563
DOC_MAPK_MEF2A_6 353 362 PF00069 0.502
DOC_MAPK_RevD_3 127 142 PF00069 0.402
DOC_MAPK_RevD_3 57 72 PF00069 0.465
DOC_PP1_RVXF_1 603 609 PF00149 0.502
DOC_PP1_RVXF_1 763 769 PF00149 0.459
DOC_PP2B_PxIxI_1 357 363 PF00149 0.508
DOC_USP7_MATH_1 41 45 PF00917 0.565
DOC_USP7_MATH_1 760 764 PF00917 0.502
DOC_USP7_UBL2_3 177 181 PF12436 0.469
DOC_WW_Pin1_4 19 24 PF00397 0.597
DOC_WW_Pin1_4 218 223 PF00397 0.409
DOC_WW_Pin1_4 233 238 PF00397 0.416
DOC_WW_Pin1_4 447 452 PF00397 0.621
DOC_WW_Pin1_4 754 759 PF00397 0.508
LIG_14-3-3_CanoR_1 275 280 PF00244 0.485
LIG_14-3-3_CanoR_1 372 378 PF00244 0.502
LIG_14-3-3_CanoR_1 403 407 PF00244 0.449
LIG_14-3-3_CanoR_1 412 421 PF00244 0.448
LIG_14-3-3_CanoR_1 676 681 PF00244 0.483
LIG_14-3-3_CanoR_1 72 81 PF00244 0.476
LIG_14-3-3_CanoR_1 726 733 PF00244 0.528
LIG_14-3-3_CanoR_1 765 769 PF00244 0.459
LIG_14-3-3_CanoR_1 779 788 PF00244 0.358
LIG_Actin_WH2_2 119 137 PF00022 0.406
LIG_BRCT_BRCA1_1 432 436 PF00533 0.426
LIG_Clathr_ClatBox_1 603 607 PF01394 0.502
LIG_FHA_1 122 128 PF00498 0.346
LIG_FHA_1 260 266 PF00498 0.492
LIG_FHA_1 578 584 PF00498 0.383
LIG_FHA_1 657 663 PF00498 0.496
LIG_FHA_1 687 693 PF00498 0.526
LIG_FHA_1 719 725 PF00498 0.502
LIG_FHA_1 741 747 PF00498 0.459
LIG_FHA_1 759 765 PF00498 0.459
LIG_FHA_2 164 170 PF00498 0.482
LIG_FHA_2 586 592 PF00498 0.482
LIG_FHA_2 747 753 PF00498 0.502
LIG_FHA_2 771 777 PF00498 0.459
LIG_FHA_2 90 96 PF00498 0.524
LIG_IRF3_LxIS_1 123 128 PF10401 0.399
LIG_LIR_Gen_1 284 293 PF02991 0.441
LIG_LIR_Gen_1 748 759 PF02991 0.461
LIG_LIR_Gen_1 767 774 PF02991 0.502
LIG_LIR_Gen_1 95 103 PF02991 0.403
LIG_LIR_Nem_3 284 290 PF02991 0.441
LIG_LIR_Nem_3 307 313 PF02991 0.486
LIG_LIR_Nem_3 345 351 PF02991 0.459
LIG_LIR_Nem_3 433 439 PF02991 0.471
LIG_LIR_Nem_3 44 50 PF02991 0.498
LIG_LIR_Nem_3 607 611 PF02991 0.502
LIG_LIR_Nem_3 748 754 PF02991 0.461
LIG_LIR_Nem_3 767 771 PF02991 0.502
LIG_LIR_Nem_3 95 100 PF02991 0.394
LIG_LYPXL_S_1 347 351 PF13949 0.302
LIG_LYPXL_yS_3 348 351 PF13949 0.480
LIG_MYND_3 59 63 PF01753 0.444
LIG_PCNA_yPIPBox_3 172 186 PF02747 0.447
LIG_SH2_CRK 545 549 PF00017 0.529
LIG_SH2_CRK 751 755 PF00017 0.502
LIG_SH2_GRB2like 718 721 PF00017 0.508
LIG_SH2_PTP2 287 290 PF00017 0.502
LIG_SH2_PTP2 97 100 PF00017 0.376
LIG_SH2_SRC 287 290 PF00017 0.502
LIG_SH2_STAT3 438 441 PF00017 0.511
LIG_SH2_STAT5 133 136 PF00017 0.499
LIG_SH2_STAT5 287 290 PF00017 0.502
LIG_SH2_STAT5 409 412 PF00017 0.339
LIG_SH2_STAT5 47 50 PF00017 0.456
LIG_SH2_STAT5 471 474 PF00017 0.502
LIG_SH2_STAT5 636 639 PF00017 0.459
LIG_SH2_STAT5 708 711 PF00017 0.532
LIG_SH2_STAT5 97 100 PF00017 0.376
LIG_SH3_3 216 222 PF00018 0.455
LIG_SH3_3 352 358 PF00018 0.465
LIG_SH3_3 441 447 PF00018 0.458
LIG_SH3_3 54 60 PF00018 0.466
LIG_SH3_3 545 551 PF00018 0.582
LIG_SH3_3 8 14 PF00018 0.638
LIG_SUMO_SIM_anti_2 121 128 PF11976 0.423
LIG_SUMO_SIM_anti_2 790 795 PF11976 0.355
LIG_SUMO_SIM_par_1 123 128 PF11976 0.352
LIG_SUMO_SIM_par_1 225 231 PF11976 0.534
LIG_TRAF2_1 195 198 PF00917 0.502
LIG_TRAF2_1 380 383 PF00917 0.502
LIG_TYR_ITSM 344 351 PF00017 0.480
LIG_UBA3_1 182 191 PF00899 0.496
LIG_WRC_WIRS_1 374 379 PF05994 0.459
LIG_WW_1 715 718 PF00397 0.459
MOD_CDK_SPxxK_3 218 225 PF00069 0.437
MOD_CK1_1 434 440 PF00069 0.450
MOD_CK1_1 532 538 PF00069 0.502
MOD_CK1_1 553 559 PF00069 0.442
MOD_CK1_1 647 653 PF00069 0.508
MOD_CK1_1 725 731 PF00069 0.502
MOD_CK1_1 767 773 PF00069 0.502
MOD_CK2_1 125 131 PF00069 0.354
MOD_CK2_1 163 169 PF00069 0.465
MOD_CK2_1 261 267 PF00069 0.490
MOD_CK2_1 377 383 PF00069 0.502
MOD_CK2_1 499 505 PF00069 0.502
MOD_CK2_1 553 559 PF00069 0.432
MOD_CK2_1 585 591 PF00069 0.480
MOD_CK2_1 89 95 PF00069 0.530
MOD_Cter_Amidation 111 114 PF01082 0.448
MOD_Cter_Amidation 401 404 PF01082 0.451
MOD_Cter_Amidation 69 72 PF01082 0.487
MOD_GlcNHglycan 135 138 PF01048 0.494
MOD_GlcNHglycan 212 215 PF01048 0.543
MOD_GlcNHglycan 230 233 PF01048 0.207
MOD_GlcNHglycan 331 334 PF01048 0.302
MOD_GlcNHglycan 394 397 PF01048 0.527
MOD_GlcNHglycan 441 444 PF01048 0.529
MOD_GlcNHglycan 501 504 PF01048 0.259
MOD_GlcNHglycan 531 534 PF01048 0.302
MOD_GlcNHglycan 646 649 PF01048 0.376
MOD_GlcNHglycan 704 708 PF01048 0.261
MOD_GlcNHglycan 738 741 PF01048 0.278
MOD_GlcNHglycan 781 784 PF01048 0.407
MOD_GSK3_1 121 128 PF00069 0.355
MOD_GSK3_1 255 262 PF00069 0.508
MOD_GSK3_1 288 295 PF00069 0.502
MOD_GSK3_1 313 320 PF00069 0.505
MOD_GSK3_1 343 350 PF00069 0.502
MOD_GSK3_1 373 380 PF00069 0.459
MOD_GSK3_1 430 437 PF00069 0.437
MOD_GSK3_1 495 502 PF00069 0.459
MOD_GSK3_1 528 535 PF00069 0.485
MOD_GSK3_1 550 557 PF00069 0.468
MOD_GSK3_1 607 614 PF00069 0.475
MOD_GSK3_1 615 622 PF00069 0.452
MOD_GSK3_1 718 725 PF00069 0.501
MOD_GSK3_1 736 743 PF00069 0.393
MOD_GSK3_1 746 753 PF00069 0.459
MOD_GSK3_1 754 761 PF00069 0.459
MOD_N-GLC_1 19 24 PF02516 0.473
MOD_N-GLC_1 256 261 PF02516 0.292
MOD_N-GLC_1 304 309 PF02516 0.259
MOD_N-GLC_1 342 347 PF02516 0.259
MOD_N-GLC_1 447 452 PF02516 0.639
MOD_N-GLC_1 585 590 PF02516 0.472
MOD_N-GLC_1 746 751 PF02516 0.259
MOD_NEK2_1 125 130 PF00069 0.343
MOD_NEK2_1 147 152 PF00069 0.431
MOD_NEK2_1 210 215 PF00069 0.416
MOD_NEK2_1 255 260 PF00069 0.502
MOD_NEK2_1 313 318 PF00069 0.462
MOD_NEK2_1 321 326 PF00069 0.455
MOD_NEK2_1 377 382 PF00069 0.459
MOD_NEK2_1 392 397 PF00069 0.567
MOD_NEK2_1 499 504 PF00069 0.485
MOD_NEK2_1 674 679 PF00069 0.500
MOD_NEK2_2 337 342 PF00069 0.502
MOD_NEK2_2 760 765 PF00069 0.502
MOD_PIKK_1 193 199 PF00454 0.527
MOD_PIKK_1 292 298 PF00454 0.519
MOD_PIKK_1 335 341 PF00454 0.459
MOD_PIKK_1 512 518 PF00454 0.494
MOD_PIKK_1 597 603 PF00454 0.502
MOD_PIKK_1 647 653 PF00454 0.502
MOD_PK_1 275 281 PF00069 0.469
MOD_PKA_2 274 280 PF00069 0.488
MOD_PKA_2 402 408 PF00069 0.454
MOD_PKA_2 725 731 PF00069 0.528
MOD_PKA_2 764 770 PF00069 0.459
MOD_Plk_1 288 294 PF00069 0.495
MOD_Plk_1 304 310 PF00069 0.409
MOD_Plk_1 321 327 PF00069 0.459
MOD_Plk_1 342 348 PF00069 0.459
MOD_Plk_1 377 383 PF00069 0.459
MOD_Plk_1 434 440 PF00069 0.450
MOD_Plk_1 746 752 PF00069 0.502
MOD_Plk_2-3 261 267 PF00069 0.502
MOD_Plk_2-3 459 465 PF00069 0.574
MOD_Plk_2-3 579 585 PF00069 0.382
MOD_Plk_2-3 607 613 PF00069 0.502
MOD_Plk_4 121 127 PF00069 0.360
MOD_Plk_4 163 169 PF00069 0.437
MOD_Plk_4 261 267 PF00069 0.502
MOD_Plk_4 343 349 PF00069 0.459
MOD_Plk_4 565 571 PF00069 0.466
MOD_Plk_4 683 689 PF00069 0.419
MOD_Plk_4 746 752 PF00069 0.502
MOD_ProDKin_1 19 25 PF00069 0.587
MOD_ProDKin_1 218 224 PF00069 0.414
MOD_ProDKin_1 233 239 PF00069 0.416
MOD_ProDKin_1 447 453 PF00069 0.626
MOD_ProDKin_1 754 760 PF00069 0.508
MOD_SUMO_rev_2 3 11 PF00179 0.639
MOD_SUMO_rev_2 423 430 PF00179 0.390
MOD_SUMO_rev_2 52 57 PF00179 0.453
TRG_DiLeu_BaEn_1 121 126 PF01217 0.448
TRG_DiLeu_BaEn_1 178 183 PF01217 0.443
TRG_DiLeu_BaEn_1 683 688 PF01217 0.485
TRG_DiLeu_BaLyEn_6 355 360 PF01217 0.502
TRG_ENDOCYTIC_2 241 244 PF00928 0.459
TRG_ENDOCYTIC_2 287 290 PF00928 0.502
TRG_ENDOCYTIC_2 310 313 PF00928 0.459
TRG_ENDOCYTIC_2 348 351 PF00928 0.459
TRG_ENDOCYTIC_2 545 548 PF00928 0.530
TRG_ENDOCYTIC_2 751 754 PF00928 0.459
TRG_ENDOCYTIC_2 97 100 PF00928 0.376
TRG_ER_diArg_1 140 143 PF00400 0.415
TRG_ER_diArg_1 151 153 PF00400 0.324
TRG_ER_diArg_1 270 272 PF00400 0.498
TRG_ER_diArg_1 410 412 PF00400 0.474
TRG_ER_diArg_1 71 73 PF00400 0.449
TRG_NES_CRM1_1 274 289 PF08389 0.502
TRG_Pf-PMV_PEXEL_1 145 149 PF00026 0.391
TRG_Pf-PMV_PEXEL_1 270 274 PF00026 0.279
TRG_Pf-PMV_PEXEL_1 786 790 PF00026 0.304

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM59 Leptomonas seymouri 82% 100%
A0A0S4JKY0 Bodo saltans 43% 85%
A4HLM9 Leishmania braziliensis 91% 100%
A4I940 Leishmania infantum 100% 100%
E9B405 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4Q419 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS