Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7X6Q5_LEIDO

TriTrypDb:

LdBPK_331200.1 , LdCL_330018200 , LDHU3_33.1840

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7X6Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6Q5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.417
CLV_NRD_NRD_1	392	394	PF00675	0.469
CLV_NRD_NRD_1	399	401	PF00675	0.565
CLV_NRD_NRD_1	421	423	PF00675	0.517
CLV_PCSK_FUR_1	397	401	PF00082	0.452
CLV_PCSK_KEX2_1	397	399	PF00082	0.441
CLV_PCSK_PC7_1	393	399	PF00082	0.371
CLV_PCSK_SKI1_1	56	60	PF00082	0.614
DOC_ANK_TNKS_1	398	405	PF00023	0.677
DOC_MAPK_DCC_7	82	90	PF00069	0.378
DOC_MAPK_RevD_3	379	394	PF00069	0.388
DOC_PP4_MxPP_1	320	323	PF00568	0.386
DOC_SPAK_OSR1_1	200	204	PF12202	0.466
DOC_USP7_MATH_1	238	242	PF00917	0.454
DOC_USP7_MATH_1	243	247	PF00917	0.441
DOC_USP7_MATH_1	274	278	PF00917	0.483
DOC_USP7_MATH_1	302	306	PF00917	0.411
DOC_USP7_MATH_1	417	421	PF00917	0.708
DOC_USP7_MATH_1	76	80	PF00917	0.455
DOC_USP7_UBL2_3	204	208	PF12436	0.405
DOC_WW_Pin1_4	279	284	PF00397	0.380
DOC_WW_Pin1_4	298	303	PF00397	0.500
DOC_WW_Pin1_4	318	323	PF00397	0.249
LIG_14-3-3_CanoR_1	393	401	PF00244	0.579
LIG_Actin_WH2_2	377	395	PF00022	0.388
LIG_BRCT_BRCA1_1	144	148	PF00533	0.397
LIG_BRCT_BRCA1_1	154	158	PF00533	0.405
LIG_BRCT_BRCA1_1	253	257	PF00533	0.349
LIG_deltaCOP1_diTrp_1	134	142	PF00928	0.413
LIG_FHA_1	17	23	PF00498	0.484
LIG_FHA_1	172	178	PF00498	0.452
LIG_FHA_1	184	190	PF00498	0.315
LIG_FHA_1	208	214	PF00498	0.394
LIG_FHA_1	290	296	PF00498	0.467
LIG_FHA_1	87	93	PF00498	0.436
LIG_FHA_2	49	55	PF00498	0.462
LIG_FHA_2	57	63	PF00498	0.484
LIG_HCF-1_HBM_1	261	264	PF13415	0.388
LIG_LIR_Gen_1	261	271	PF02991	0.396
LIG_LIR_Gen_1	363	374	PF02991	0.322
LIG_LIR_Nem_3	155	161	PF02991	0.407
LIG_LIR_Nem_3	261	267	PF02991	0.395
LIG_LIR_Nem_3	305	309	PF02991	0.344
LIG_LIR_Nem_3	363	369	PF02991	0.322
LIG_PCNA_APIM_2	198	204	PF02747	0.467
LIG_PCNA_yPIPBox_3	311	320	PF02747	0.471
LIG_Pex14_2	376	380	PF04695	0.461
LIG_SH2_CRK	154	158	PF00017	0.397
LIG_SH2_CRK	199	203	PF00017	0.385
LIG_SH2_PTP2	366	369	PF00017	0.388
LIG_SH2_STAP1	154	158	PF00017	0.397
LIG_SH2_STAT5	325	328	PF00017	0.388
LIG_SH2_STAT5	366	369	PF00017	0.479
LIG_SH3_3	1	7	PF00018	0.494
LIG_SH3_3	220	226	PF00018	0.401
LIG_SUMO_SIM_anti_2	370	376	PF11976	0.388
LIG_SUMO_SIM_par_1	176	181	PF11976	0.470
LIG_SUMO_SIM_par_1	209	217	PF11976	0.407
LIG_SUMO_SIM_par_1	383	388	PF11976	0.314
LIG_SUMO_SIM_par_1	88	94	PF11976	0.440
LIG_TRAF2_1	52	55	PF00917	0.405
LIG_Vh1_VBS_1	371	389	PF01044	0.351
LIG_WW_1	322	325	PF00397	0.397
LIG_WW_2	225	228	PF00397	0.412
LIG_WW_3	321	325	PF00397	0.390
MOD_CAAXbox	429	432	PF01239	0.710
MOD_CDC14_SPxK_1	321	324	PF00782	0.482
MOD_CDK_SPxK_1	318	324	PF00069	0.486
MOD_CK1_1	113	119	PF00069	0.471
MOD_CK1_1	171	177	PF00069	0.428
MOD_CK1_1	183	189	PF00069	0.397
MOD_CK1_1	410	416	PF00069	0.724
MOD_CK2_1	48	54	PF00069	0.459
MOD_GlcNHglycan	122	125	PF01048	0.742
MOD_GlcNHglycan	144	147	PF01048	0.621
MOD_GlcNHglycan	192	195	PF01048	0.544
MOD_GlcNHglycan	240	243	PF01048	0.657
MOD_GlcNHglycan	245	248	PF01048	0.638
MOD_GlcNHglycan	276	279	PF01048	0.612
MOD_GlcNHglycan	30	33	PF01048	0.610
MOD_GlcNHglycan	332	335	PF01048	0.637
MOD_GlcNHglycan	363	366	PF01048	0.722
MOD_GlcNHglycan	79	82	PF01048	0.668
MOD_GSK3_1	113	120	PF00069	0.475
MOD_GSK3_1	126	133	PF00069	0.433
MOD_GSK3_1	140	147	PF00069	0.384
MOD_GSK3_1	176	183	PF00069	0.388
MOD_GSK3_1	203	210	PF00069	0.375
MOD_GSK3_1	248	255	PF00069	0.398
MOD_GSK3_1	289	296	PF00069	0.398
MOD_GSK3_1	298	305	PF00069	0.418
MOD_GSK3_1	338	345	PF00069	0.460
MOD_GSK3_1	35	42	PF00069	0.437
MOD_N-GLC_1	293	298	PF02516	0.493
MOD_N-GLC_1	346	351	PF02516	0.788
MOD_NEK2_1	178	183	PF00069	0.421
MOD_NEK2_1	185	190	PF00069	0.364
MOD_NEK2_1	212	217	PF00069	0.420
MOD_NEK2_1	250	255	PF00069	0.356
MOD_NEK2_1	407	412	PF00069	0.728
MOD_NEK2_1	64	69	PF00069	0.442
MOD_NEK2_1	77	82	PF00069	0.373
MOD_PKA_2	392	398	PF00069	0.561
MOD_Plk_1	293	299	PF00069	0.300
MOD_Plk_4	152	158	PF00069	0.359
MOD_Plk_4	185	191	PF00069	0.421
MOD_Plk_4	207	213	PF00069	0.378
MOD_Plk_4	367	373	PF00069	0.429
MOD_Plk_4	385	391	PF00069	0.425
MOD_Plk_4	86	92	PF00069	0.387
MOD_Plk_4	99	105	PF00069	0.401
MOD_ProDKin_1	279	285	PF00069	0.382
MOD_ProDKin_1	298	304	PF00069	0.496
MOD_ProDKin_1	318	324	PF00069	0.250
MOD_SUMO_for_1	33	36	PF00179	0.475
MOD_SUMO_rev_2	420	425	PF00179	0.710
MOD_SUMO_rev_2	50	58	PF00179	0.422
TRG_ENDOCYTIC_2	154	157	PF00928	0.399
TRG_ENDOCYTIC_2	199	202	PF00928	0.387
TRG_ENDOCYTIC_2	264	267	PF00928	0.383
TRG_ENDOCYTIC_2	306	309	PF00928	0.374
TRG_ENDOCYTIC_2	366	369	PF00928	0.463
TRG_ER_diArg_1	397	400	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8J7	Leptomonas seymouri	53%	89%
A4HLG8	Leishmania braziliensis	71%	100%
A4HLG9	Leishmania braziliensis	71%	100%
A4I8X9	Leishmania infantum	99%	100%
E9B3U8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q476	Leishmania major	91%	100%