HEAT repeat-containing protein 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6Q1_LEIDO

TriTrypDb:

LdBPK_331720.1 , LdCL_330023900 , LDHU3_33.2580

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.403
CLV_C14_Caspase3-7	803	807	PF00656	0.362
CLV_MEL_PAP_1	282	288	PF00089	0.328
CLV_NRD_NRD_1	279	281	PF00675	0.334
CLV_NRD_NRD_1	304	306	PF00675	0.446
CLV_NRD_NRD_1	375	377	PF00675	0.345
CLV_NRD_NRD_1	719	721	PF00675	0.290
CLV_PCSK_KEX2_1	18	20	PF00082	0.337
CLV_PCSK_KEX2_1	304	306	PF00082	0.449
CLV_PCSK_KEX2_1	867	869	PF00082	0.376
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.337
CLV_PCSK_PC1ET2_1	867	869	PF00082	0.376
CLV_PCSK_SKI1_1	104	108	PF00082	0.285
CLV_PCSK_SKI1_1	163	167	PF00082	0.377
CLV_PCSK_SKI1_1	174	178	PF00082	0.285
CLV_PCSK_SKI1_1	280	284	PF00082	0.330
CLV_PCSK_SKI1_1	304	308	PF00082	0.433
CLV_PCSK_SKI1_1	352	356	PF00082	0.372
CLV_PCSK_SKI1_1	360	364	PF00082	0.349
CLV_PCSK_SKI1_1	622	626	PF00082	0.261
CLV_PCSK_SKI1_1	675	679	PF00082	0.375
CLV_PCSK_SKI1_1	843	847	PF00082	0.365
CLV_PCSK_SKI1_1	882	886	PF00082	0.484
CLV_Separin_Metazoa	233	237	PF03568	0.386
CLV_Separin_Metazoa	698	702	PF03568	0.317
DEG_APCC_DBOX_1	103	111	PF00400	0.295
DEG_APCC_DBOX_1	279	287	PF00400	0.325
DEG_APCC_DBOX_1	351	359	PF00400	0.395
DEG_Nend_UBRbox_2	1	3	PF02207	0.381
DEG_SCF_FBW7_1	508	513	PF00400	0.407
DEG_SPOP_SBC_1	519	523	PF00917	0.370
DEG_SPOP_SBC_1	749	753	PF00917	0.386
DOC_CKS1_1	168	173	PF01111	0.315
DOC_MAPK_gen_1	376	383	PF00069	0.278
DOC_MAPK_gen_1	460	468	PF00069	0.516
DOC_MAPK_gen_1	570	579	PF00069	0.391
DOC_MAPK_gen_1	843	849	PF00069	0.350
DOC_MAPK_HePTP_8	583	595	PF00069	0.461
DOC_MAPK_MEF2A_6	259	268	PF00069	0.280
DOC_MAPK_MEF2A_6	376	383	PF00069	0.280
DOC_MAPK_MEF2A_6	586	595	PF00069	0.475
DOC_PP1_RVXF_1	307	314	PF00149	0.419
DOC_PP1_RVXF_1	380	386	PF00149	0.282
DOC_PP1_RVXF_1	620	626	PF00149	0.317
DOC_PP2B_PxIxI_1	873	879	PF00149	0.471
DOC_PP4_FxxP_1	139	142	PF00568	0.444
DOC_PP4_FxxP_1	324	327	PF00568	0.415
DOC_PP4_FxxP_1	431	434	PF00568	0.278
DOC_USP7_MATH_1	219	223	PF00917	0.412
DOC_USP7_MATH_1	510	514	PF00917	0.523
DOC_USP7_MATH_1	97	101	PF00917	0.408
DOC_USP7_MATH_2	451	457	PF00917	0.518
DOC_USP7_UBL2_3	148	152	PF12436	0.427
DOC_USP7_UBL2_3	460	464	PF12436	0.499
DOC_WW_Pin1_4	167	172	PF00397	0.398
DOC_WW_Pin1_4	506	511	PF00397	0.418
DOC_WW_Pin1_4	553	558	PF00397	0.350
DOC_WW_Pin1_4	824	829	PF00397	0.434
DOC_WW_Pin1_4	870	875	PF00397	0.384
LIG_14-3-3_CanoR_1	304	309	PF00244	0.436
LIG_14-3-3_CanoR_1	401	410	PF00244	0.422
LIG_14-3-3_CanoR_1	462	467	PF00244	0.418
LIG_14-3-3_CanoR_1	584	593	PF00244	0.337
LIG_14-3-3_CanoR_1	660	668	PF00244	0.394
LIG_14-3-3_CanoR_1	675	680	PF00244	0.246
LIG_14-3-3_CanoR_1	809	816	PF00244	0.454
LIG_Actin_WH2_2	161	179	PF00022	0.385
LIG_AP2alpha_1	139	143	PF02296	0.417
LIG_AP2alpha_2	141	143	PF02296	0.441
LIG_APCC_ABBA_1	845	850	PF00400	0.346
LIG_APCC_ABBAyCdc20_2	844	850	PF00400	0.346
LIG_BIR_III_4	473	477	PF00653	0.474
LIG_BRCT_BRCA1_1	221	225	PF00533	0.408
LIG_BRCT_BRCA1_1	320	324	PF00533	0.409
LIG_Clathr_ClatBox_1	132	136	PF01394	0.358
LIG_Clathr_ClatBox_1	798	802	PF01394	0.352
LIG_Clathr_ClatBox_1	846	850	PF01394	0.350
LIG_deltaCOP1_diTrp_1	366	371	PF00928	0.336
LIG_deltaCOP1_diTrp_1	822	829	PF00928	0.392
LIG_eIF4E_1	127	133	PF01652	0.370
LIG_eIF4E_1	260	266	PF01652	0.303
LIG_FHA_1	193	199	PF00498	0.347
LIG_FHA_1	341	347	PF00498	0.450
LIG_FHA_1	397	403	PF00498	0.403
LIG_FHA_1	420	426	PF00498	0.454
LIG_FHA_1	463	469	PF00498	0.398
LIG_FHA_1	482	488	PF00498	0.465
LIG_FHA_1	512	518	PF00498	0.402
LIG_FHA_1	520	526	PF00498	0.437
LIG_FHA_1	533	539	PF00498	0.315
LIG_FHA_1	607	613	PF00498	0.476
LIG_FHA_1	66	72	PF00498	0.374
LIG_FHA_1	669	675	PF00498	0.362
LIG_FHA_1	694	700	PF00498	0.511
LIG_FHA_1	713	719	PF00498	0.251
LIG_FHA_1	750	756	PF00498	0.399
LIG_FHA_1	815	821	PF00498	0.484
LIG_FHA_1	853	859	PF00498	0.492
LIG_FHA_2	305	311	PF00498	0.416
LIG_FHA_2	361	367	PF00498	0.349
LIG_FHA_2	467	473	PF00498	0.582
LIG_FHA_2	519	525	PF00498	0.341
LIG_FHA_2	676	682	PF00498	0.365
LIG_FHA_2	810	816	PF00498	0.400
LIG_LIR_Apic_2	136	142	PF02991	0.433
LIG_LIR_Apic_2	321	327	PF02991	0.418
LIG_LIR_Apic_2	366	370	PF02991	0.374
LIG_LIR_Apic_2	81	85	PF02991	0.300
LIG_LIR_Gen_1	129	139	PF02991	0.299
LIG_LIR_Gen_1	269	279	PF02991	0.328
LIG_LIR_Gen_1	40	50	PF02991	0.346
LIG_LIR_Gen_1	450	458	PF02991	0.549
LIG_LIR_Gen_1	634	643	PF02991	0.352
LIG_LIR_Nem_3	129	134	PF02991	0.296
LIG_LIR_Nem_3	141	146	PF02991	0.295
LIG_LIR_Nem_3	269	275	PF02991	0.320
LIG_LIR_Nem_3	328	334	PF02991	0.353
LIG_LIR_Nem_3	40	46	PF02991	0.372
LIG_LIR_Nem_3	404	410	PF02991	0.422
LIG_LIR_Nem_3	435	440	PF02991	0.355
LIG_LIR_Nem_3	450	455	PF02991	0.543
LIG_LIR_Nem_3	634	639	PF02991	0.407
LIG_LIR_Nem_3	673	679	PF02991	0.292
LIG_LYPXL_yS_3	319	322	PF13949	0.331
LIG_NRBOX	533	539	PF00104	0.321
LIG_NRBOX	578	584	PF00104	0.365
LIG_NRBOX	679	685	PF00104	0.286
LIG_NRBOX	726	732	PF00104	0.347
LIG_NRBOX	815	821	PF00104	0.394
LIG_PCNA_TLS_4	125	132	PF02747	0.377
LIG_Pex14_1	367	371	PF04695	0.331
LIG_Pex14_1	385	389	PF04695	0.262
LIG_Pex14_2	139	143	PF04695	0.417
LIG_SH2_CRK	23	27	PF00017	0.366
LIG_SH2_CRK	580	584	PF00017	0.254
LIG_SH2_GRB2like	7	10	PF00017	0.374
LIG_SH2_NCK_1	452	456	PF00017	0.520
LIG_SH2_SRC	260	263	PF00017	0.338
LIG_SH2_SRC	452	455	PF00017	0.581
LIG_SH2_SRC	900	903	PF00017	0.363
LIG_SH2_STAP1	616	620	PF00017	0.294
LIG_SH2_STAT5	127	130	PF00017	0.290
LIG_SH2_STAT5	260	263	PF00017	0.338
LIG_SH2_STAT5	345	348	PF00017	0.261
LIG_SH2_STAT5	390	393	PF00017	0.392
LIG_SH2_STAT5	437	440	PF00017	0.346
LIG_SH2_STAT5	499	502	PF00017	0.319
LIG_SH2_STAT5	616	619	PF00017	0.375
LIG_SH2_STAT5	676	679	PF00017	0.306
LIG_SH2_STAT5	7	10	PF00017	0.370
LIG_SH2_STAT5	735	738	PF00017	0.390
LIG_SH2_STAT5	848	851	PF00017	0.461
LIG_SH2_STAT5	893	896	PF00017	0.358
LIG_SH2_STAT5	900	903	PF00017	0.362
LIG_SH3_3	554	560	PF00018	0.392
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.418
LIG_SUMO_SIM_anti_2	453	459	PF11976	0.518
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.387
LIG_SUMO_SIM_par_1	131	136	PF11976	0.355
LIG_SUMO_SIM_par_1	238	244	PF11976	0.278
LIG_SUMO_SIM_par_1	246	252	PF11976	0.317
LIG_SUMO_SIM_par_1	263	271	PF11976	0.209
LIG_SUMO_SIM_par_1	464	470	PF11976	0.409
LIG_SUMO_SIM_par_1	876	881	PF11976	0.451
LIG_TRAF2_1	60	63	PF00917	0.458
LIG_TYR_ITIM	578	583	PF00017	0.261
LIG_TYR_ITIM	674	679	PF00017	0.285
LIG_UBA3_1	537	543	PF00899	0.365
LIG_UBA3_1	578	586	PF00899	0.376
MOD_CDK_SPxxK_3	167	174	PF00069	0.332
MOD_CK1_1	241	247	PF00069	0.462
MOD_CK1_1	337	343	PF00069	0.415
MOD_CK1_1	57	63	PF00069	0.532
MOD_CK1_1	634	640	PF00069	0.339
MOD_CK1_1	645	651	PF00069	0.365
MOD_CK1_1	659	665	PF00069	0.435
MOD_CK1_1	694	700	PF00069	0.372
MOD_CK1_1	86	92	PF00069	0.410
MOD_CK2_1	453	459	PF00069	0.671
MOD_CK2_1	57	63	PF00069	0.406
MOD_CK2_1	675	681	PF00069	0.332
MOD_CK2_1	809	815	PF00069	0.460
MOD_CK2_1	858	864	PF00069	0.345
MOD_CK2_1	880	886	PF00069	0.409
MOD_GlcNHglycan	185	188	PF01048	0.446
MOD_GlcNHglycan	327	330	PF01048	0.500
MOD_GlcNHglycan	403	406	PF01048	0.413
MOD_GlcNHglycan	633	636	PF01048	0.333
MOD_GlcNHglycan	707	710	PF01048	0.486
MOD_GlcNHglycan	832	837	PF01048	0.499
MOD_GlcNHglycan	882	885	PF01048	0.466
MOD_GSK3_1	109	116	PF00069	0.309
MOD_GSK3_1	318	325	PF00069	0.391
MOD_GSK3_1	41	48	PF00069	0.517
MOD_GSK3_1	458	465	PF00069	0.479
MOD_GSK3_1	477	484	PF00069	0.429
MOD_GSK3_1	485	492	PF00069	0.342
MOD_GSK3_1	506	513	PF00069	0.488
MOD_GSK3_1	53	60	PF00069	0.489
MOD_GSK3_1	599	606	PF00069	0.400
MOD_GSK3_1	610	617	PF00069	0.339
MOD_GSK3_1	744	751	PF00069	0.400
MOD_GSK3_1	810	817	PF00069	0.444
MOD_N-GLC_1	35	40	PF02516	0.454
MOD_N-GLC_1	462	467	PF02516	0.585
MOD_NEK2_1	11	16	PF00069	0.445
MOD_NEK2_1	176	181	PF00069	0.470
MOD_NEK2_1	322	327	PF00069	0.354
MOD_NEK2_1	334	339	PF00069	0.337
MOD_NEK2_1	383	388	PF00069	0.321
MOD_NEK2_1	481	486	PF00069	0.478
MOD_NEK2_1	537	542	PF00069	0.339
MOD_NEK2_1	750	755	PF00069	0.349
MOD_NEK2_1	880	885	PF00069	0.393
MOD_NEK2_2	113	118	PF00069	0.315
MOD_NEK2_2	485	490	PF00069	0.395
MOD_NEK2_2	614	619	PF00069	0.426
MOD_PKA_1	304	310	PF00069	0.434
MOD_PKA_2	304	310	PF00069	0.434
MOD_PKA_2	337	343	PF00069	0.343
MOD_PKA_2	65	71	PF00069	0.358
MOD_PKA_2	659	665	PF00069	0.405
MOD_PKA_2	810	816	PF00069	0.455
MOD_PKA_2	858	864	PF00069	0.394
MOD_Plk_1	360	366	PF00069	0.341
MOD_Plk_1	391	397	PF00069	0.346
MOD_Plk_1	41	47	PF00069	0.427
MOD_Plk_1	419	425	PF00069	0.360
MOD_Plk_1	453	459	PF00069	0.530
MOD_Plk_1	462	468	PF00069	0.437
MOD_Plk_1	75	81	PF00069	0.381
MOD_Plk_1	814	820	PF00069	0.483
MOD_Plk_1	852	858	PF00069	0.430
MOD_Plk_2-3	453	459	PF00069	0.497
MOD_Plk_4	238	244	PF00069	0.474
MOD_Plk_4	384	390	PF00069	0.306
MOD_Plk_4	453	459	PF00069	0.546
MOD_Plk_4	462	468	PF00069	0.412
MOD_Plk_4	477	483	PF00069	0.563
MOD_Plk_4	489	495	PF00069	0.335
MOD_Plk_4	573	579	PF00069	0.298
MOD_Plk_4	603	609	PF00069	0.314
MOD_Plk_4	75	81	PF00069	0.312
MOD_Plk_4	750	756	PF00069	0.450
MOD_Plk_4	772	778	PF00069	0.398
MOD_Plk_4	793	799	PF00069	0.364
MOD_Plk_4	83	89	PF00069	0.285
MOD_ProDKin_1	167	173	PF00069	0.393
MOD_ProDKin_1	506	512	PF00069	0.415
MOD_ProDKin_1	553	559	PF00069	0.358
MOD_ProDKin_1	824	830	PF00069	0.423
MOD_ProDKin_1	870	876	PF00069	0.386
MOD_SUMO_for_1	146	149	PF00179	0.291
MOD_SUMO_for_1	417	420	PF00179	0.425
MOD_SUMO_rev_2	159	165	PF00179	0.463
MOD_SUMO_rev_2	210	220	PF00179	0.428
TRG_DiLeu_BaEn_1	101	106	PF01217	0.307
TRG_DiLeu_BaEn_1	529	534	PF01217	0.474
TRG_DiLeu_BaEn_1	695	700	PF01217	0.387
TRG_DiLeu_BaEn_1	815	820	PF01217	0.389
TRG_DiLeu_BaLyEn_6	619	624	PF01217	0.314
TRG_DiLeu_LyEn_5	101	106	PF01217	0.307
TRG_DiLeu_LyEn_5	815	820	PF01217	0.389
TRG_ENDOCYTIC_2	127	130	PF00928	0.301
TRG_ENDOCYTIC_2	23	26	PF00928	0.325
TRG_ENDOCYTIC_2	319	322	PF00928	0.331
TRG_ENDOCYTIC_2	331	334	PF00928	0.332
TRG_ENDOCYTIC_2	407	410	PF00928	0.308
TRG_ENDOCYTIC_2	437	440	PF00928	0.323
TRG_ENDOCYTIC_2	452	455	PF00928	0.555
TRG_ENDOCYTIC_2	580	583	PF00928	0.249
TRG_ENDOCYTIC_2	676	679	PF00928	0.271
TRG_ER_diArg_1	304	306	PF00400	0.446
TRG_ER_diArg_1	808	811	PF00400	0.390
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	818	822	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2B9	Leptomonas seymouri	76%	100%
A0A0S4KNI8	Bodo saltans	44%	99%
A0A1X0NM76	Trypanosomatidae	54%	100%
A0A422N6C6	Trypanosoma rangeli	51%	100%
A0JMW2	Xenopus laevis	23%	100%
A4HLM3	Leishmania braziliensis	88%	100%
A4I934	Leishmania infantum	100%	100%
B9EJR8	Mus musculus	23%	100%
C9ZQE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B3Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q425	Leishmania major	95%	100%
Q86Y56	Homo sapiens	24%	100%
V5BDB2	Trypanosoma cruzi	53%	100%