Mitochondrial_RNA_binding_protein_putative/GeneDB:LmjF.33.1250

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6N8_LEIDO

TriTrypDb:

LdBPK_331320.1 , LdCL_330019400 , LDHU3_33.1970

Length:

327

Annotations

Annotations by Jardim et al.

Nucleic acid binding, mitochondrial RNA binding Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X6N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6N8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.541
CLV_PCSK_SKI1_1	154	158	PF00082	0.464
CLV_PCSK_SKI1_1	34	38	PF00082	0.355
DEG_Nend_UBRbox_1	1	4	PF02207	0.651
DOC_CYCLIN_RxL_1	150	161	PF00134	0.438
DOC_MAPK_DCC_7	291	299	PF00069	0.339
DOC_MAPK_gen_1	176	185	PF00069	0.391
DOC_MAPK_MEF2A_6	291	299	PF00069	0.356
DOC_PP1_RVXF_1	32	39	PF00149	0.511
DOC_PP2B_LxvP_1	83	86	PF13499	0.389
DOC_USP7_MATH_1	3	7	PF00917	0.564
DOC_WW_Pin1_4	170	175	PF00397	0.761
DOC_WW_Pin1_4	249	254	PF00397	0.376
DOC_WW_Pin1_4	299	304	PF00397	0.437
LIG_14-3-3_CanoR_1	2	8	PF00244	0.563
LIG_14-3-3_CanoR_1	93	101	PF00244	0.345
LIG_BIR_III_2	190	194	PF00653	0.334
LIG_BRCT_BRCA1_1	93	97	PF00533	0.501
LIG_Clathr_ClatBox_1	215	219	PF01394	0.369
LIG_eIF4E_1	251	257	PF01652	0.330
LIG_FHA_1	2	8	PF00498	0.633
LIG_FHA_1	250	256	PF00498	0.398
LIG_FHA_1	304	310	PF00498	0.685
LIG_FHA_2	224	230	PF00498	0.579
LIG_FHA_2	50	56	PF00498	0.473
LIG_FHA_2	86	92	PF00498	0.448
LIG_LIR_Gen_1	177	185	PF02991	0.433
LIG_LIR_Nem_3	177	183	PF02991	0.452
LIG_LIR_Nem_3	196	200	PF02991	0.322
LIG_LIR_Nem_3	245	249	PF02991	0.428
LIG_LIR_Nem_3	35	41	PF02991	0.399
LIG_LIR_Nem_3	43	48	PF02991	0.298
LIG_PAM2_1	271	283	PF00658	0.300
LIG_SH2_CRK	45	49	PF00017	0.345
LIG_SH2_SRC	236	239	PF00017	0.331
LIG_SH2_STAT5	103	106	PF00017	0.355
LIG_SH2_STAT5	116	119	PF00017	0.350
LIG_SH2_STAT5	197	200	PF00017	0.347
LIG_SH2_STAT5	236	239	PF00017	0.355
LIG_SH2_STAT5	251	254	PF00017	0.471
LIG_SH3_3	11	17	PF00018	0.374
LIG_SH3_3	128	134	PF00018	0.385
LIG_SH3_3	168	174	PF00018	0.762
LIG_SH3_3	21	27	PF00018	0.453
LIG_SH3_5	193	197	PF00018	0.334
LIG_SUMO_SIM_par_1	181	186	PF11976	0.400
LIG_SUMO_SIM_par_1	214	219	PF11976	0.328
LIG_WRC_WIRS_1	243	248	PF05994	0.325
MOD_CDC14_SPxK_1	173	176	PF00782	0.513
MOD_CDK_SPxK_1	170	176	PF00069	0.511
MOD_CK1_1	264	270	PF00069	0.396
MOD_CK1_1	289	295	PF00069	0.346
MOD_CK1_1	302	308	PF00069	0.557
MOD_CK2_1	175	181	PF00069	0.642
MOD_CK2_1	223	229	PF00069	0.369
MOD_CK2_1	85	91	PF00069	0.436
MOD_GlcNHglycan	113	116	PF01048	0.469
MOD_GlcNHglycan	126	129	PF01048	0.334
MOD_GlcNHglycan	158	161	PF01048	0.562
MOD_GlcNHglycan	27	30	PF01048	0.469
MOD_GlcNHglycan	291	294	PF01048	0.355
MOD_GSK3_1	170	177	PF00069	0.685
MOD_GSK3_1	18	25	PF00069	0.521
MOD_GSK3_1	299	306	PF00069	0.657
MOD_GSK3_1	320	327	PF00069	0.644
MOD_GSK3_1	44	51	PF00069	0.357
MOD_NEK2_1	1	6	PF00069	0.572
MOD_NEK2_1	286	291	PF00069	0.310
MOD_NEK2_1	310	315	PF00069	0.654
MOD_NEK2_1	44	49	PF00069	0.345
MOD_NEK2_1	97	102	PF00069	0.362
MOD_NEK2_2	3	8	PF00069	0.618
MOD_NEK2_2	65	70	PF00069	0.470
MOD_PIKK_1	223	229	PF00454	0.551
MOD_PIKK_1	320	326	PF00454	0.653
MOD_PKA_2	1	7	PF00069	0.587
MOD_PKA_2	175	181	PF00069	0.477
MOD_PKA_2	92	98	PF00069	0.352
MOD_Plk_1	261	267	PF00069	0.384
MOD_Plk_2-3	181	187	PF00069	0.471
MOD_Plk_4	49	55	PF00069	0.384
MOD_ProDKin_1	170	176	PF00069	0.762
MOD_ProDKin_1	249	255	PF00069	0.364
MOD_ProDKin_1	299	305	PF00069	0.445
TRG_ENDOCYTIC_2	197	200	PF00928	0.317
TRG_ENDOCYTIC_2	45	48	PF00928	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y0	Leptomonas seymouri	33%	77%
A0A0N1PDA3	Leptomonas seymouri	77%	100%
A0A0S4INL4	Bodo saltans	38%	76%
A0A0S4JAJ5	Bodo saltans	62%	100%
A0A1X0NQR5	Trypanosomatidae	36%	82%
A0A1X0P2H5	Trypanosomatidae	69%	100%
A0A3Q8IH71	Leishmania donovani	33%	100%
A0A3R7M1X1	Trypanosoma rangeli	34%	89%
A0A3R7MCA7	Trypanosoma rangeli	69%	100%
A4H647	Leishmania braziliensis	33%	100%
A4HLI1	Leishmania braziliensis	92%	100%
A4HUG7	Leishmania infantum	33%	100%
A4I8Z1	Leishmania infantum	100%	100%
D0A4Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AN65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B3W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q464	Leishmania major	97%	100%
Q4QHG0	Leishmania major	33%	100%
V5B205	Trypanosoma cruzi	36%	78%
V5BLV5	Trypanosoma cruzi	69%	100%