Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6N7_LEIDO

TriTrypDb:

LdBPK_331580.1 , LdCL_330022400 , LDHU3_33.2410

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X6N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6N7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.503
CLV_C14_Caspase3-7	506	510	PF00656	0.520
CLV_MEL_PAP_1	367	373	PF00089	0.549
CLV_NRD_NRD_1	131	133	PF00675	0.741
CLV_NRD_NRD_1	309	311	PF00675	0.587
CLV_NRD_NRD_1	436	438	PF00675	0.491
CLV_NRD_NRD_1	519	521	PF00675	0.499
CLV_NRD_NRD_1	550	552	PF00675	0.460
CLV_NRD_NRD_1	807	809	PF00675	0.568
CLV_PCSK_FUR_1	131	135	PF00082	0.702
CLV_PCSK_KEX2_1	131	133	PF00082	0.781
CLV_PCSK_KEX2_1	309	311	PF00082	0.587
CLV_PCSK_KEX2_1	436	438	PF00082	0.469
CLV_PCSK_KEX2_1	440	442	PF00082	0.452
CLV_PCSK_KEX2_1	46	48	PF00082	0.612
CLV_PCSK_KEX2_1	519	521	PF00082	0.499
CLV_PCSK_KEX2_1	552	554	PF00082	0.462
CLV_PCSK_KEX2_1	807	809	PF00082	0.545
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.700
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.500
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.564
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.604
CLV_PCSK_PC7_1	436	442	PF00082	0.498
CLV_PCSK_SKI1_1	183	187	PF00082	0.479
CLV_PCSK_SKI1_1	285	289	PF00082	0.468
CLV_PCSK_SKI1_1	310	314	PF00082	0.497
CLV_PCSK_SKI1_1	437	441	PF00082	0.585
CLV_PCSK_SKI1_1	455	459	PF00082	0.325
CLV_PCSK_SKI1_1	572	576	PF00082	0.576
CLV_PCSK_SKI1_1	74	78	PF00082	0.553
CLV_PCSK_SKI1_1	797	801	PF00082	0.463
DEG_APCC_DBOX_1	806	814	PF00400	0.570
DEG_SPOP_SBC_1	105	109	PF00917	0.461
DEG_SPOP_SBC_1	238	242	PF00917	0.723
DEG_SPOP_SBC_1	654	658	PF00917	0.620
DEG_SPOP_SBC_1	732	736	PF00917	0.567
DEG_SPOP_SBC_1	749	753	PF00917	0.493
DOC_CYCLIN_yCln2_LP_2	584	590	PF00134	0.600
DOC_MAPK_gen_1	807	813	PF00069	0.566
DOC_MAPK_MEF2A_6	12	21	PF00069	0.555
DOC_MAPK_MEF2A_6	325	333	PF00069	0.605
DOC_MAPK_MEF2A_6	355	364	PF00069	0.521
DOC_MAPK_RevD_3	31	47	PF00069	0.514
DOC_PP1_RVXF_1	344	351	PF00149	0.479
DOC_PP2B_LxvP_1	113	116	PF13499	0.731
DOC_PP2B_LxvP_1	333	336	PF13499	0.525
DOC_PP2B_LxvP_1	584	587	PF13499	0.567
DOC_PP2B_LxvP_1	605	608	PF13499	0.627
DOC_PP2B_LxvP_1	737	740	PF13499	0.603
DOC_PP4_FxxP_1	288	291	PF00568	0.606
DOC_SPAK_OSR1_1	775	779	PF12202	0.562
DOC_USP7_MATH_1	105	109	PF00917	0.614
DOC_USP7_MATH_1	238	242	PF00917	0.703
DOC_USP7_MATH_1	323	327	PF00917	0.613
DOC_USP7_MATH_1	337	341	PF00917	0.434
DOC_USP7_MATH_1	424	428	PF00917	0.632
DOC_USP7_MATH_1	503	507	PF00917	0.511
DOC_USP7_MATH_1	654	658	PF00917	0.678
DOC_USP7_MATH_1	715	719	PF00917	0.768
DOC_USP7_MATH_1	722	726	PF00917	0.662
DOC_USP7_MATH_1	742	746	PF00917	0.378
DOC_USP7_MATH_1	749	753	PF00917	0.712
DOC_USP7_UBL2_3	80	84	PF12436	0.604
DOC_WW_Pin1_4	166	171	PF00397	0.566
DOC_WW_Pin1_4	177	182	PF00397	0.629
DOC_WW_Pin1_4	246	251	PF00397	0.732
DOC_WW_Pin1_4	48	53	PF00397	0.642
LIG_14-3-3_CanoR_1	258	262	PF00244	0.449
LIG_14-3-3_CanoR_1	285	291	PF00244	0.562
LIG_14-3-3_CanoR_1	370	376	PF00244	0.584
LIG_14-3-3_CanoR_1	464	468	PF00244	0.523
LIG_14-3-3_CanoR_1	625	632	PF00244	0.790
LIG_14-3-3_CanoR_1	684	692	PF00244	0.594
LIG_14-3-3_CanoR_1	744	749	PF00244	0.728
LIG_14-3-3_CanoR_1	781	788	PF00244	0.581
LIG_14-3-3_CanoR_1	807	811	PF00244	0.563
LIG_14-3-3_CanoR_1	815	821	PF00244	0.546
LIG_14-3-3_CanoR_1	833	837	PF00244	0.571
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	276	280	PF00533	0.422
LIG_Clathr_ClatBox_1	198	202	PF01394	0.380
LIG_deltaCOP1_diTrp_1	704	708	PF00928	0.496
LIG_EVH1_1	333	337	PF00568	0.528
LIG_EVH1_1	620	624	PF00568	0.644
LIG_FHA_1	105	111	PF00498	0.673
LIG_FHA_1	26	32	PF00498	0.501
LIG_FHA_1	264	270	PF00498	0.558
LIG_FHA_1	273	279	PF00498	0.501
LIG_FHA_1	366	372	PF00498	0.478
LIG_FHA_1	660	666	PF00498	0.547
LIG_FHA_1	734	740	PF00498	0.569
LIG_FHA_1	815	821	PF00498	0.467
LIG_FHA_2	101	107	PF00498	0.574
LIG_FHA_2	18	24	PF00498	0.298
LIG_FHA_2	274	280	PF00498	0.435
LIG_FHA_2	485	491	PF00498	0.526
LIG_FHA_2	587	593	PF00498	0.580
LIG_LIR_Apic_2	347	353	PF02991	0.547
LIG_LIR_Gen_1	146	155	PF02991	0.511
LIG_LIR_Gen_1	213	224	PF02991	0.438
LIG_LIR_Gen_1	398	406	PF02991	0.665
LIG_LIR_Gen_1	536	544	PF02991	0.578
LIG_LIR_Gen_1	557	567	PF02991	0.444
LIG_LIR_Nem_3	146	150	PF02991	0.515
LIG_LIR_Nem_3	163	168	PF02991	0.540
LIG_LIR_Nem_3	212	217	PF02991	0.469
LIG_LIR_Nem_3	398	403	PF02991	0.633
LIG_LIR_Nem_3	536	540	PF02991	0.543
LIG_LIR_Nem_3	557	562	PF02991	0.453
LIG_LIR_Nem_3	564	570	PF02991	0.383
LIG_LIR_Nem_3	657	663	PF02991	0.524
LIG_LIR_Nem_3	704	708	PF02991	0.613
LIG_NRBOX	361	367	PF00104	0.510
LIG_Pex14_2	96	100	PF04695	0.518
LIG_SH2_CRK	420	424	PF00017	0.580
LIG_SH2_NCK_1	4	8	PF00017	0.663
LIG_SH2_PTP2	147	150	PF00017	0.503
LIG_SH2_SRC	400	403	PF00017	0.611
LIG_SH2_SRC	420	423	PF00017	0.611
LIG_SH2_STAP1	274	278	PF00017	0.438
LIG_SH2_STAP1	578	582	PF00017	0.441
LIG_SH2_STAT5	147	150	PF00017	0.503
LIG_SH2_STAT5	268	271	PF00017	0.522
LIG_SH2_STAT5	274	277	PF00017	0.420
LIG_SH2_STAT5	533	536	PF00017	0.473
LIG_SH2_STAT5	537	540	PF00017	0.488
LIG_SH2_STAT5	573	576	PF00017	0.411
LIG_SH3_3	164	170	PF00018	0.552
LIG_SH3_3	288	294	PF00018	0.611
LIG_SH3_3	317	323	PF00018	0.550
LIG_SH3_3	326	332	PF00018	0.443
LIG_SH3_3	378	384	PF00018	0.592
LIG_SH3_3	410	416	PF00018	0.588
LIG_SH3_3	618	624	PF00018	0.739
LIG_SUMO_SIM_anti_2	222	227	PF11976	0.598
LIG_SUMO_SIM_par_1	148	154	PF11976	0.386
LIG_SUMO_SIM_par_1	363	368	PF11976	0.557
LIG_SUMO_SIM_par_1	586	593	PF11976	0.570
LIG_SUMO_SIM_par_1	845	850	PF11976	0.466
LIG_SxIP_EBH_1	804	815	PF03271	0.452
LIG_TRAF2_1	395	398	PF00917	0.423
LIG_TRAF2_1	527	530	PF00917	0.540
LIG_TRAF2_1	68	71	PF00917	0.574
LIG_TRAF2_1	759	762	PF00917	0.624
LIG_TYR_ITIM	145	150	PF00017	0.522
LIG_TYR_ITIM	535	540	PF00017	0.477
LIG_UBA3_1	365	374	PF00899	0.592
LIG_UBA3_1	688	694	PF00899	0.402
LIG_WW_3	622	626	PF00397	0.644
MOD_CDC14_SPxK_1	180	183	PF00782	0.474
MOD_CDK_SPxK_1	177	183	PF00069	0.611
MOD_CK1_1	108	114	PF00069	0.686
MOD_CK1_1	138	144	PF00069	0.652
MOD_CK1_1	15	21	PF00069	0.572
MOD_CK1_1	242	248	PF00069	0.701
MOD_CK1_1	303	309	PF00069	0.508
MOD_CK1_1	316	322	PF00069	0.585
MOD_CK1_1	479	485	PF00069	0.556
MOD_CK1_1	51	57	PF00069	0.643
MOD_CK1_1	752	758	PF00069	0.682
MOD_CK1_1	814	820	PF00069	0.546
MOD_CK2_1	100	106	PF00069	0.557
MOD_CK2_1	136	142	PF00069	0.585
MOD_CK2_1	17	23	PF00069	0.309
MOD_CK2_1	273	279	PF00069	0.446
MOD_CK2_1	479	485	PF00069	0.451
MOD_CK2_1	586	592	PF00069	0.543
MOD_GlcNHglycan	126	129	PF01048	0.737
MOD_GlcNHglycan	174	177	PF01048	0.651
MOD_GlcNHglycan	241	244	PF01048	0.755
MOD_GlcNHglycan	302	305	PF01048	0.581
MOD_GlcNHglycan	339	342	PF01048	0.676
MOD_GlcNHglycan	376	379	PF01048	0.697
MOD_GlcNHglycan	478	481	PF01048	0.522
MOD_GlcNHglycan	609	612	PF01048	0.621
MOD_GlcNHglycan	642	645	PF01048	0.703
MOD_GlcNHglycan	708	711	PF01048	0.683
MOD_GlcNHglycan	718	721	PF01048	0.424
MOD_GlcNHglycan	740	743	PF01048	0.660
MOD_GlcNHglycan	754	757	PF01048	0.724
MOD_GlcNHglycan	842	845	PF01048	0.599
MOD_GSK3_1	104	111	PF00069	0.584
MOD_GSK3_1	136	143	PF00069	0.638
MOD_GSK3_1	151	158	PF00069	0.489
MOD_GSK3_1	238	245	PF00069	0.710
MOD_GSK3_1	253	260	PF00069	0.427
MOD_GSK3_1	365	372	PF00069	0.513
MOD_GSK3_1	48	55	PF00069	0.626
MOD_GSK3_1	586	593	PF00069	0.574
MOD_GSK3_1	631	638	PF00069	0.686
MOD_GSK3_1	649	656	PF00069	0.630
MOD_GSK3_1	72	79	PF00069	0.616
MOD_GSK3_1	727	734	PF00069	0.576
MOD_GSK3_1	738	745	PF00069	0.520
MOD_GSK3_1	748	755	PF00069	0.683
MOD_GSK3_1	816	823	PF00069	0.594
MOD_GSK3_1	96	103	PF00069	0.529
MOD_N-GLC_1	124	129	PF02516	0.755
MOD_N-GLC_1	15	20	PF02516	0.567
MOD_N-GLC_1	246	251	PF02516	0.529
MOD_N-GLC_1	96	101	PF02516	0.488
MOD_NEK2_1	239	244	PF00069	0.759
MOD_NEK2_1	25	30	PF00069	0.572
MOD_NEK2_1	257	262	PF00069	0.332
MOD_NEK2_1	295	300	PF00069	0.489
MOD_NEK2_1	313	318	PF00069	0.443
MOD_NEK2_1	365	370	PF00069	0.455
MOD_NEK2_1	474	479	PF00069	0.535
MOD_NEK2_1	659	664	PF00069	0.577
MOD_NEK2_1	675	680	PF00069	0.408
MOD_NEK2_1	731	736	PF00069	0.599
MOD_NEK2_1	750	755	PF00069	0.595
MOD_NEK2_1	96	101	PF00069	0.502
MOD_NEK2_2	816	821	PF00069	0.539
MOD_PIKK_1	407	413	PF00454	0.753
MOD_PIKK_1	424	430	PF00454	0.463
MOD_PIKK_1	637	643	PF00454	0.691
MOD_PK_1	673	679	PF00069	0.485
MOD_PKA_2	257	263	PF00069	0.449
MOD_PKA_2	369	375	PF00069	0.556
MOD_PKA_2	463	469	PF00069	0.548
MOD_PKA_2	624	630	PF00069	0.785
MOD_PKA_2	683	689	PF00069	0.596
MOD_PKA_2	806	812	PF00069	0.588
MOD_PKA_2	814	820	PF00069	0.546
MOD_PKA_2	832	838	PF00069	0.574
MOD_Plk_1	105	111	PF00069	0.571
MOD_Plk_1	15	21	PF00069	0.445
MOD_Plk_1	540	546	PF00069	0.553
MOD_Plk_1	590	596	PF00069	0.650
MOD_Plk_1	96	102	PF00069	0.482
MOD_Plk_4	140	146	PF00069	0.616
MOD_Plk_4	155	161	PF00069	0.553
MOD_Plk_4	257	263	PF00069	0.449
MOD_Plk_4	316	322	PF00069	0.585
MOD_Plk_4	655	661	PF00069	0.564
MOD_Plk_4	727	733	PF00069	0.625
MOD_ProDKin_1	166	172	PF00069	0.576
MOD_ProDKin_1	177	183	PF00069	0.629
MOD_ProDKin_1	246	252	PF00069	0.720
MOD_ProDKin_1	48	54	PF00069	0.650
MOD_SUMO_for_1	698	701	PF00179	0.623
MOD_SUMO_rev_2	202	211	PF00179	0.553
MOD_SUMO_rev_2	545	554	PF00179	0.595
MOD_SUMO_rev_2	701	708	PF00179	0.402
TRG_DiLeu_BaEn_1	550	555	PF01217	0.587
TRG_DiLeu_BaEn_3	529	535	PF01217	0.509
TRG_ENDOCYTIC_2	147	150	PF00928	0.504
TRG_ENDOCYTIC_2	165	168	PF00928	0.580
TRG_ENDOCYTIC_2	400	403	PF00928	0.641
TRG_ENDOCYTIC_2	420	423	PF00928	0.568
TRG_ENDOCYTIC_2	537	540	PF00928	0.540
TRG_ENDOCYTIC_2	567	570	PF00928	0.424
TRG_ENDOCYTIC_2	839	842	PF00928	0.530
TRG_ER_diArg_1	131	134	PF00400	0.664
TRG_ER_diArg_1	308	310	PF00400	0.587
TRG_ER_diArg_1	518	520	PF00400	0.457
TRG_ER_diArg_1	551	554	PF00400	0.454
TRG_ER_diArg_1	743	746	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	437	442	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW62	Leptomonas seymouri	64%	99%
A0A1X0P2J7	Trypanosomatidae	40%	100%
A0A422NG65	Trypanosoma rangeli	42%	100%
A4HLL0	Leishmania braziliensis	84%	100%
A4I922	Leishmania infantum	100%	100%
D0A522	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B3Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q438	Leishmania major	96%	100%
V5AXC5	Trypanosoma cruzi	41%	100%