Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6N2_LEIDO

TriTrypDb:

LdBPK_331450.1 , LdCL_330021100 , LDHU3_33.2180

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6N2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.565
CLV_C14_Caspase3-7	257	261	PF00656	0.505
CLV_C14_Caspase3-7	51	55	PF00656	0.650
CLV_NRD_NRD_1	137	139	PF00675	0.541
CLV_NRD_NRD_1	221	223	PF00675	0.613
CLV_NRD_NRD_1	286	288	PF00675	0.452
CLV_PCSK_KEX2_1	137	139	PF00082	0.541
CLV_PCSK_KEX2_1	219	221	PF00082	0.634
CLV_PCSK_KEX2_1	286	288	PF00082	0.452
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.634
CLV_PCSK_PC7_1	216	222	PF00082	0.625
CLV_PCSK_SKI1_1	252	256	PF00082	0.427
CLV_PCSK_SKI1_1	341	345	PF00082	0.642
DEG_APCC_DBOX_1	249	257	PF00400	0.503
DEG_SCF_FBW7_1	20	26	PF00400	0.572
DEG_SCF_FBW7_1	396	402	PF00400	0.665
DEG_SPOP_SBC_1	227	231	PF00917	0.616
DEG_SPOP_SBC_1	79	83	PF00917	0.559
DOC_CKS1_1	20	25	PF01111	0.569
DOC_CKS1_1	305	310	PF01111	0.652
DOC_CKS1_1	396	401	PF01111	0.595
DOC_CYCLIN_RxL_1	247	260	PF00134	0.456
DOC_CYCLIN_yCln2_LP_2	385	391	PF00134	0.563
DOC_MAPK_gen_1	247	256	PF00069	0.517
DOC_MAPK_gen_1	286	293	PF00069	0.461
DOC_PP2B_LxvP_1	107	110	PF13499	0.567
DOC_USP7_MATH_1	110	114	PF00917	0.489
DOC_USP7_MATH_1	184	188	PF00917	0.602
DOC_USP7_MATH_1	227	231	PF00917	0.632
DOC_USP7_MATH_1	300	304	PF00917	0.571
DOC_USP7_MATH_1	317	321	PF00917	0.525
DOC_USP7_MATH_1	368	372	PF00917	0.641
DOC_USP7_MATH_1	397	401	PF00917	0.619
DOC_USP7_MATH_1	407	411	PF00917	0.568
DOC_USP7_MATH_1	77	81	PF00917	0.728
DOC_USP7_MATH_1	91	95	PF00917	0.558
DOC_WW_Pin1_4	153	158	PF00397	0.426
DOC_WW_Pin1_4	19	24	PF00397	0.569
DOC_WW_Pin1_4	220	225	PF00397	0.829
DOC_WW_Pin1_4	232	237	PF00397	0.474
DOC_WW_Pin1_4	304	309	PF00397	0.647
DOC_WW_Pin1_4	313	318	PF00397	0.646
DOC_WW_Pin1_4	395	400	PF00397	0.621
DOC_WW_Pin1_4	56	61	PF00397	0.632
DOC_WW_Pin1_4	89	94	PF00397	0.641
LIG_14-3-3_CanoR_1	225	234	PF00244	0.599
LIG_14-3-3_CanoR_1	24	30	PF00244	0.621
LIG_14-3-3_CanoR_1	295	299	PF00244	0.524
LIG_14-3-3_CanoR_1	408	416	PF00244	0.599
LIG_14-3-3_CanoR_1	417	423	PF00244	0.685
LIG_14-3-3_CanoR_1	447	453	PF00244	0.727
LIG_BIR_III_2	183	187	PF00653	0.583
LIG_Clathr_ClatBox_1	253	257	PF01394	0.427
LIG_FHA_1	243	249	PF00498	0.594
LIG_FHA_1	380	386	PF00498	0.540
LIG_FHA_1	430	436	PF00498	0.569
LIG_FHA_1	449	455	PF00498	0.584
LIG_FHA_1	81	87	PF00498	0.671
LIG_FHA_2	178	184	PF00498	0.599
LIG_FHA_2	26	32	PF00498	0.705
LIG_FHA_2	49	55	PF00498	0.644
LIG_FHA_2	60	66	PF00498	0.527
LIG_LIR_Apic_2	260	266	PF02991	0.457
LIG_LIR_Apic_2	400	406	PF02991	0.630
LIG_LIR_Gen_1	320	331	PF02991	0.524
LIG_LIR_Gen_1	68	77	PF02991	0.445
LIG_LIR_Nem_3	320	326	PF02991	0.552
LIG_LIR_Nem_3	65	70	PF02991	0.462
LIG_Pex14_2	237	241	PF04695	0.546
LIG_SH2_CRK	323	327	PF00017	0.583
LIG_SH2_NCK_1	310	314	PF00017	0.602
LIG_SH2_PTP2	403	406	PF00017	0.608
LIG_SH2_PTP2	70	73	PF00017	0.421
LIG_SH2_STAP1	29	33	PF00017	0.630
LIG_SH2_STAP1	310	314	PF00017	0.611
LIG_SH2_STAP1	327	331	PF00017	0.438
LIG_SH2_STAT3	144	147	PF00017	0.718
LIG_SH2_STAT5	403	406	PF00017	0.662
LIG_SH2_STAT5	70	73	PF00017	0.421
LIG_SH3_3	122	128	PF00018	0.678
LIG_SH3_3	151	157	PF00018	0.492
LIG_SH3_3	17	23	PF00018	0.586
LIG_SH3_3	187	193	PF00018	0.685
LIG_SH3_3	288	294	PF00018	0.503
LIG_SH3_3	302	308	PF00018	0.507
LIG_SH3_3	385	391	PF00018	0.537
LIG_SH3_3	87	93	PF00018	0.671
LIG_SUMO_SIM_anti_2	436	443	PF11976	0.614
LIG_SUMO_SIM_par_1	252	257	PF11976	0.429
LIG_SUMO_SIM_par_1	392	398	PF11976	0.653
LIG_TRAF2_1	63	66	PF00917	0.581
LIG_TYR_ITSM	323	330	PF00017	0.525
MOD_CDC14_SPxK_1	235	238	PF00782	0.573
MOD_CDK_SPK_2	19	24	PF00069	0.569
MOD_CDK_SPK_2	220	225	PF00069	0.616
MOD_CDK_SPxK_1	232	238	PF00069	0.580
MOD_CDK_SPxxK_3	94	101	PF00069	0.597
MOD_CK1_1	113	119	PF00069	0.515
MOD_CK1_1	176	182	PF00069	0.620
MOD_CK1_1	207	213	PF00069	0.768
MOD_CK1_1	223	229	PF00069	0.574
MOD_CK1_1	230	236	PF00069	0.627
MOD_CK1_1	25	31	PF00069	0.589
MOD_CK1_1	309	315	PF00069	0.562
MOD_CK1_1	316	322	PF00069	0.535
MOD_CK1_1	395	401	PF00069	0.627
MOD_CK1_1	434	440	PF00069	0.627
MOD_CK1_1	59	65	PF00069	0.751
MOD_CK1_1	80	86	PF00069	0.569
MOD_CK1_1	94	100	PF00069	0.675
MOD_CK2_1	153	159	PF00069	0.426
MOD_CK2_1	41	47	PF00069	0.613
MOD_CK2_1	59	65	PF00069	0.470
MOD_CK2_1	99	105	PF00069	0.508
MOD_GlcNHglycan	167	170	PF01048	0.436
MOD_GlcNHglycan	175	178	PF01048	0.569
MOD_GlcNHglycan	302	305	PF01048	0.530
MOD_GlcNHglycan	370	373	PF01048	0.634
MOD_GlcNHglycan	74	77	PF01048	0.435
MOD_GSK3_1	173	180	PF00069	0.605
MOD_GSK3_1	19	26	PF00069	0.587
MOD_GSK3_1	200	207	PF00069	0.719
MOD_GSK3_1	223	230	PF00069	0.701
MOD_GSK3_1	294	301	PF00069	0.658
MOD_GSK3_1	309	316	PF00069	0.657
MOD_GSK3_1	322	329	PF00069	0.478
MOD_GSK3_1	395	402	PF00069	0.643
MOD_GSK3_1	423	430	PF00069	0.737
MOD_GSK3_1	48	55	PF00069	0.657
MOD_GSK3_1	80	87	PF00069	0.630
MOD_N-GLC_1	336	341	PF02516	0.568
MOD_N-GLC_2	270	272	PF02516	0.505
MOD_N-GLC_2	334	336	PF02516	0.596
MOD_NEK2_1	111	116	PF00069	0.616
MOD_NEK2_1	194	199	PF00069	0.595
MOD_NEK2_1	204	209	PF00069	0.518
MOD_NEK2_1	326	331	PF00069	0.552
MOD_NEK2_1	416	421	PF00069	0.654
MOD_NEK2_1	423	428	PF00069	0.601
MOD_NEK2_2	322	327	PF00069	0.554
MOD_PIKK_1	194	200	PF00454	0.628
MOD_PKA_2	23	29	PF00069	0.658
MOD_PKA_2	294	300	PF00069	0.495
MOD_PKA_2	368	374	PF00069	0.629
MOD_PKA_2	407	413	PF00069	0.594
MOD_PKA_2	416	422	PF00069	0.718
MOD_Plk_2-3	99	105	PF00069	0.519
MOD_Plk_4	184	190	PF00069	0.639
MOD_Plk_4	322	328	PF00069	0.550
MOD_Plk_4	399	405	PF00069	0.638
MOD_Plk_4	434	440	PF00069	0.582
MOD_Plk_4	448	454	PF00069	0.556
MOD_Plk_4	91	97	PF00069	0.629
MOD_ProDKin_1	153	159	PF00069	0.426
MOD_ProDKin_1	19	25	PF00069	0.568
MOD_ProDKin_1	220	226	PF00069	0.827
MOD_ProDKin_1	232	238	PF00069	0.472
MOD_ProDKin_1	304	310	PF00069	0.649
MOD_ProDKin_1	313	319	PF00069	0.641
MOD_ProDKin_1	395	401	PF00069	0.619
MOD_ProDKin_1	56	62	PF00069	0.629
MOD_ProDKin_1	89	95	PF00069	0.638
TRG_DiLeu_BaEn_2	158	164	PF01217	0.418
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.444
TRG_ENDOCYTIC_2	323	326	PF00928	0.584
TRG_ENDOCYTIC_2	327	330	PF00928	0.537
TRG_ENDOCYTIC_2	70	73	PF00928	0.421
TRG_ER_diArg_1	220	222	PF00400	0.628
TRG_ER_diArg_1	250	253	PF00400	0.515
TRG_ER_diArg_1	286	289	PF00400	0.461
TRG_NLS_MonoCore_2	218	223	PF00514	0.623
TRG_NLS_MonoExtN_4	216	223	PF00514	0.616
TRG_Pf-PMV_PEXEL_1	252	257	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L8	Leptomonas seymouri	35%	81%
A4HLJ8	Leishmania braziliensis	68%	100%
A4I908	Leishmania infantum	99%	100%
E9B3X3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q451	Leishmania major	90%	100%