Dnaj chaperone-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dnaj chaperone-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X6M9_LEIDO

TriTrypDb:

LdBPK_330940.1 , LdCL_330015500 , LDHU3_33.1470

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7X6M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6M9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.461
CLV_C14_Caspase3-7	383	387	PF00656	0.589
CLV_NRD_NRD_1	191	193	PF00675	0.383
CLV_NRD_NRD_1	225	227	PF00675	0.610
CLV_NRD_NRD_1	24	26	PF00675	0.530
CLV_NRD_NRD_1	345	347	PF00675	0.711
CLV_NRD_NRD_1	360	362	PF00675	0.707
CLV_NRD_NRD_1	542	544	PF00675	0.558
CLV_NRD_NRD_1	563	565	PF00675	0.568
CLV_PCSK_FUR_1	189	193	PF00082	0.377
CLV_PCSK_FUR_1	56	60	PF00082	0.411
CLV_PCSK_KEX2_1	12	14	PF00082	0.565
CLV_PCSK_KEX2_1	191	193	PF00082	0.383
CLV_PCSK_KEX2_1	20	22	PF00082	0.529
CLV_PCSK_KEX2_1	225	227	PF00082	0.610
CLV_PCSK_KEX2_1	24	26	PF00082	0.523
CLV_PCSK_KEX2_1	345	347	PF00082	0.711
CLV_PCSK_KEX2_1	359	361	PF00082	0.707
CLV_PCSK_KEX2_1	541	543	PF00082	0.571
CLV_PCSK_KEX2_1	58	60	PF00082	0.461
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.565
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.529
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.461
CLV_PCSK_SKI1_1	12	16	PF00082	0.594
CLV_PCSK_SKI1_1	225	229	PF00082	0.629
CLV_PCSK_SKI1_1	25	29	PF00082	0.482
CLV_PCSK_SKI1_1	294	298	PF00082	0.621
DEG_APCC_DBOX_1	293	301	PF00400	0.419
DOC_ANK_TNKS_1	540	547	PF00023	0.762
DOC_CDC14_PxL_1	138	146	PF14671	0.411
DOC_MAPK_gen_1	20	28	PF00069	0.346
DOC_MAPK_MEF2A_6	459	468	PF00069	0.436
DOC_MAPK_NFAT4_5	459	467	PF00069	0.436
DOC_PP1_RVXF_1	241	247	PF00149	0.405
DOC_USP7_MATH_1	340	344	PF00917	0.595
DOC_USP7_MATH_1	396	400	PF00917	0.598
DOC_WW_Pin1_4	12	17	PF00397	0.363
DOC_WW_Pin1_4	127	132	PF00397	0.577
DOC_WW_Pin1_4	151	156	PF00397	0.624
DOC_WW_Pin1_4	344	349	PF00397	0.521
DOC_WW_Pin1_4	563	568	PF00397	0.769
LIG_14-3-3_CanoR_1	121	126	PF00244	0.626
LIG_14-3-3_CanoR_1	189	198	PF00244	0.640
LIG_14-3-3_CanoR_1	294	300	PF00244	0.389
LIG_14-3-3_CanoR_1	359	366	PF00244	0.506
LIG_14-3-3_CanoR_1	395	401	PF00244	0.502
LIG_BRCT_BRCA1_1	129	133	PF00533	0.546
LIG_Clathr_ClatBox_1	132	136	PF01394	0.474
LIG_FHA_1	172	178	PF00498	0.411
LIG_FHA_1	191	197	PF00498	0.627
LIG_FHA_1	286	292	PF00498	0.411
LIG_FHA_1	423	429	PF00498	0.405
LIG_FHA_1	433	439	PF00498	0.410
LIG_FHA_1	472	478	PF00498	0.338
LIG_FHA_1	86	92	PF00498	0.438
LIG_FHA_1	98	104	PF00498	0.411
LIG_FHA_2	46	52	PF00498	0.346
LIG_FHA_2	564	570	PF00498	0.783
LIG_GBD_Chelix_1	422	430	PF00786	0.455
LIG_IBAR_NPY_1	405	407	PF08397	0.537
LIG_LIR_Gen_1	122	133	PF02991	0.590
LIG_LIR_Gen_1	209	218	PF02991	0.411
LIG_LIR_Gen_1	3	10	PF02991	0.346
LIG_LIR_Nem_3	122	128	PF02991	0.598
LIG_LIR_Nem_3	209	214	PF02991	0.411
LIG_LIR_Nem_3	272	278	PF02991	0.416
LIG_LIR_Nem_3	3	8	PF02991	0.346
LIG_LIR_Nem_3	450	454	PF02991	0.546
LIG_LIR_Nem_3	48	53	PF02991	0.346
LIG_LIR_Nem_3	60	65	PF02991	0.345
LIG_NRBOX	163	169	PF00104	0.507
LIG_NRBOX	426	432	PF00104	0.436
LIG_Pex14_2	111	115	PF04695	0.515
LIG_Pex14_2	129	133	PF04695	0.422
LIG_SH2_CRK	23	27	PF00017	0.346
LIG_SH2_CRK	241	245	PF00017	0.419
LIG_SH2_CRK	451	455	PF00017	0.546
LIG_SH2_GRB2like	445	448	PF00017	0.660
LIG_SH2_NCK_1	241	245	PF00017	0.419
LIG_SH2_PTP2	125	128	PF00017	0.572
LIG_SH2_STAT3	407	410	PF00017	0.522
LIG_SH2_STAT5	125	128	PF00017	0.622
LIG_SH2_STAT5	195	198	PF00017	0.645
LIG_SH2_STAT5	206	209	PF00017	0.366
LIG_SH2_STAT5	241	244	PF00017	0.389
LIG_SH2_STAT5	275	278	PF00017	0.411
LIG_SH2_STAT5	303	306	PF00017	0.452
LIG_SH3_1	519	525	PF00018	0.714
LIG_SH3_3	125	131	PF00018	0.582
LIG_SH3_3	136	142	PF00018	0.411
LIG_SH3_3	519	525	PF00018	0.814
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.436
LIG_SUMO_SIM_par_1	226	232	PF11976	0.376
LIG_SUMO_SIM_par_1	295	302	PF11976	0.396
LIG_SUMO_SIM_par_1	452	458	PF11976	0.416
LIG_SUMO_SIM_par_1	6	11	PF11976	0.326
LIG_TYR_ITIM	273	278	PF00017	0.436
LIG_UBA3_1	227	231	PF00899	0.508
LIG_WRC_WIRS_1	112	117	PF05994	0.436
LIG_WRC_WIRS_1	82	87	PF05994	0.686
MOD_CDK_SPK_2	563	568	PF00069	0.762
MOD_CDK_SPxxK_3	563	570	PF00069	0.741
MOD_CK1_1	154	160	PF00069	0.606
MOD_CK1_1	220	226	PF00069	0.597
MOD_CK1_1	302	308	PF00069	0.571
MOD_CK2_1	45	51	PF00069	0.411
MOD_CK2_1	507	513	PF00069	0.707
MOD_CK2_1	556	562	PF00069	0.746
MOD_CK2_1	563	569	PF00069	0.679
MOD_CMANNOS	198	201	PF00535	0.486
MOD_Cter_Amidation	357	360	PF01082	0.627
MOD_GlcNHglycan	548	551	PF01048	0.784
MOD_GlcNHglycan	558	561	PF01048	0.679
MOD_GSK3_1	216	223	PF00069	0.490
MOD_GSK3_1	295	302	PF00069	0.520
MOD_GSK3_1	340	347	PF00069	0.677
MOD_GSK3_1	396	403	PF00069	0.683
MOD_GSK3_1	443	450	PF00069	0.527
MOD_GSK3_1	552	559	PF00069	0.668
MOD_GSK3_1	571	578	PF00069	0.703
MOD_GSK3_1	81	88	PF00069	0.601
MOD_N-GLC_1	239	244	PF02516	0.517
MOD_NEK2_1	111	116	PF00069	0.389
MOD_NEK2_1	285	290	PF00069	0.513
MOD_NEK2_1	295	300	PF00069	0.450
MOD_NEK2_1	431	436	PF00069	0.394
MOD_NEK2_1	455	460	PF00069	0.499
MOD_NEK2_1	85	90	PF00069	0.591
MOD_NEK2_2	206	211	PF00069	0.436
MOD_PIKK_1	471	477	PF00454	0.392
MOD_PKA_1	359	365	PF00069	0.641
MOD_PKA_2	190	196	PF00069	0.449
MOD_PKA_2	359	365	PF00069	0.641
MOD_PKA_2	575	581	PF00069	0.828
MOD_Plk_1	239	245	PF00069	0.534
MOD_Plk_1	572	578	PF00069	0.834
MOD_Plk_4	111	117	PF00069	0.393
MOD_Plk_4	160	166	PF00069	0.463
MOD_Plk_4	171	177	PF00069	0.350
MOD_Plk_4	285	291	PF00069	0.411
MOD_Plk_4	295	301	PF00069	0.517
MOD_Plk_4	422	428	PF00069	0.486
MOD_ProDKin_1	12	18	PF00069	0.436
MOD_ProDKin_1	127	133	PF00069	0.456
MOD_ProDKin_1	151	157	PF00069	0.622
MOD_ProDKin_1	344	350	PF00069	0.653
MOD_ProDKin_1	563	569	PF00069	0.723
MOD_SUMO_rev_2	224	233	PF00179	0.551
MOD_SUMO_rev_2	499	508	PF00179	0.666
TRG_ENDOCYTIC_2	125	128	PF00928	0.469
TRG_ENDOCYTIC_2	23	26	PF00928	0.411
TRG_ENDOCYTIC_2	241	244	PF00928	0.493
TRG_ENDOCYTIC_2	275	278	PF00928	0.411
TRG_ENDOCYTIC_2	451	454	PF00928	0.411
TRG_ENDOCYTIC_2	5	8	PF00928	0.411
TRG_ENDOCYTIC_2	50	53	PF00928	0.411
TRG_ER_diArg_1	189	192	PF00400	0.451
TRG_ER_diArg_1	225	227	PF00400	0.505
TRG_ER_diArg_1	23	25	PF00400	0.389
TRG_ER_diArg_1	344	346	PF00400	0.640
TRG_ER_diArg_1	359	361	PF00400	0.636
TRG_ER_diArg_1	540	543	PF00400	0.720
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.675
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.222

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P4	Leptomonas seymouri	51%	100%
A4HLE4	Leishmania braziliensis	67%	100%
A4I8V3	Leishmania infantum	100%	100%
E9B3S2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q4A2	Leishmania major	91%	100%