Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6M7_LEIDO

TriTrypDb:

LdBPK_331180.1 , LdCL_330017900 , LDHU3_33.1790

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6M7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.512
CLV_C14_Caspase3-7	27	31	PF00656	0.565
CLV_NRD_NRD_1	217	219	PF00675	0.681
CLV_NRD_NRD_1	23	25	PF00675	0.575
CLV_NRD_NRD_1	294	296	PF00675	0.527
CLV_PCSK_FUR_1	21	25	PF00082	0.572
CLV_PCSK_KEX2_1	154	156	PF00082	0.499
CLV_PCSK_KEX2_1	217	219	PF00082	0.681
CLV_PCSK_KEX2_1	23	25	PF00082	0.575
CLV_PCSK_KEX2_1	294	296	PF00082	0.527
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.496
CLV_PCSK_SKI1_1	247	251	PF00082	0.602
CLV_PCSK_SKI1_1	319	323	PF00082	0.550
CLV_PCSK_SKI1_1	84	88	PF00082	0.521
CLV_PCSK_SKI1_1	96	100	PF00082	0.441
DEG_APCC_DBOX_1	111	119	PF00400	0.436
DEG_APCC_DBOX_1	318	326	PF00400	0.473
DEG_SPOP_SBC_1	190	194	PF00917	0.634
DEG_SPOP_SBC_1	225	229	PF00917	0.532
DOC_USP7_MATH_1	190	194	PF00917	0.774
DOC_USP7_MATH_1	200	204	PF00917	0.622
DOC_USP7_MATH_1	40	44	PF00917	0.657
DOC_USP7_MATH_1	45	49	PF00917	0.749
DOC_WW_Pin1_4	13	18	PF00397	0.770
DOC_WW_Pin1_4	192	197	PF00397	0.805
DOC_WW_Pin1_4	47	52	PF00397	0.785
DOC_WW_Pin1_4	68	73	PF00397	0.671
LIG_14-3-3_CanoR_1	101	109	PF00244	0.591
LIG_14-3-3_CanoR_1	23	33	PF00244	0.638
LIG_14-3-3_CanoR_1	294	298	PF00244	0.526
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_BRCT_BRCA1_1	241	245	PF00533	0.501
LIG_BRCT_BRCA1_1	42	46	PF00533	0.548
LIG_BRCT_BRCA1_1	82	86	PF00533	0.523
LIG_BRCT_BRCA1_2	241	247	PF00533	0.592
LIG_CaM_IQ_9	88	103	PF13499	0.438
LIG_LIR_Nem_3	43	49	PF02991	0.561
LIG_SH2_CRK	253	257	PF00017	0.582
LIG_SH2_STAT5	265	268	PF00017	0.667
LIG_SH3_3	48	54	PF00018	0.756
LIG_SH3_3	66	72	PF00018	0.556
LIG_SUMO_SIM_par_1	127	134	PF11976	0.498
LIG_TRAF2_1	149	152	PF00917	0.521
LIG_TYR_ITIM	251	256	PF00017	0.621
LIG_UBA3_1	115	121	PF00899	0.522
LIG_UBA3_1	321	326	PF00899	0.504
MOD_CK1_1	195	201	PF00069	0.643
MOD_CK1_1	238	244	PF00069	0.554
MOD_CK1_1	269	275	PF00069	0.666
MOD_CK1_1	61	67	PF00069	0.624
MOD_CK1_1	8	14	PF00069	0.730
MOD_CK2_1	121	127	PF00069	0.478
MOD_CK2_1	185	191	PF00069	0.579
MOD_GlcNHglycan	1	4	PF01048	0.721
MOD_GlcNHglycan	176	179	PF01048	0.571
MOD_GlcNHglycan	207	210	PF01048	0.708
MOD_GlcNHglycan	228	231	PF01048	0.571
MOD_GlcNHglycan	26	29	PF01048	0.536
MOD_GlcNHglycan	271	274	PF01048	0.660
MOD_GlcNHglycan	34	37	PF01048	0.619
MOD_GlcNHglycan	42	45	PF01048	0.614
MOD_GlcNHglycan	60	63	PF01048	0.718
MOD_GlcNHglycan	66	69	PF01048	0.722
MOD_GlcNHglycan	8	11	PF01048	0.699
MOD_GSK3_1	180	187	PF00069	0.698
MOD_GSK3_1	191	198	PF00069	0.652
MOD_GSK3_1	220	227	PF00069	0.578
MOD_GSK3_1	234	241	PF00069	0.553
MOD_GSK3_1	54	61	PF00069	0.693
MOD_GSK3_1	64	71	PF00069	0.639
MOD_GSK3_1	8	15	PF00069	0.702
MOD_N-GLC_1	12	17	PF02516	0.593
MOD_N-GLC_1	225	230	PF02516	0.542
MOD_N-GLC_1	6	11	PF02516	0.636
MOD_PIKK_1	121	127	PF00454	0.435
MOD_PKA_2	100	106	PF00069	0.521
MOD_PKA_2	269	275	PF00069	0.666
MOD_PKA_2	293	299	PF00069	0.526
MOD_Plk_1	238	244	PF00069	0.566
MOD_Plk_4	142	148	PF00069	0.375
MOD_Plk_4	220	226	PF00069	0.614
MOD_ProDKin_1	13	19	PF00069	0.770
MOD_ProDKin_1	192	198	PF00069	0.803
MOD_ProDKin_1	47	53	PF00069	0.779
MOD_ProDKin_1	68	74	PF00069	0.666
MOD_SUMO_rev_2	27	34	PF00179	0.560
MOD_SUMO_rev_2	302	311	PF00179	0.506
TRG_DiLeu_BaEn_1	111	116	PF01217	0.504
TRG_DiLeu_BaEn_1	317	322	PF01217	0.476
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.508
TRG_ENDOCYTIC_2	253	256	PF00928	0.617
TRG_ER_diArg_1	293	295	PF00400	0.531
TRG_NES_CRM1_1	127	142	PF08389	0.514
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE12	Leptomonas seymouri	58%	100%
A0A1X0P0W7	Trypanosomatidae	39%	100%
A4HLG6	Leishmania braziliensis	76%	100%
A4I8X7	Leishmania infantum	98%	100%
D0A4X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B3U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
Q4Q478	Leishmania major	91%	100%