Iron-sulfur cluster assembly protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6M0_LEIDO

TriTrypDb:

LdBPK_331440.1 , LdCL_330020800 , LDHU3_33.2140

Length:

163

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1990221	L-cysteine desulfurase complex	3	1

Expansion

Sequence features

A0A3S7X6M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6M0

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	4
GO:0016226	iron-sulfur cluster assembly	4	4
GO:0022607	cellular component assembly	4	4
GO:0031163	metallo-sulfur cluster assembly	5	4
GO:0044237	cellular metabolic process	2	4
GO:0071840	cellular component organization or biogenesis	2	4
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0009451	RNA modification	5	1
GO:0016070	RNA metabolic process	5	1
GO:0034227	tRNA thio-modification	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.491
CLV_NRD_NRD_1	151	153	PF00675	0.622
CLV_NRD_NRD_1	20	22	PF00675	0.700
CLV_NRD_NRD_1	47	49	PF00675	0.744
CLV_NRD_NRD_1	80	82	PF00675	0.373
CLV_PCSK_KEX2_1	137	139	PF00082	0.652
CLV_PCSK_KEX2_1	151	153	PF00082	0.622
CLV_PCSK_KEX2_1	20	22	PF00082	0.700
CLV_PCSK_KEX2_1	80	82	PF00082	0.530
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.652
CLV_PCSK_SKI1_1	111	115	PF00082	0.491
CLV_PCSK_SKI1_1	127	131	PF00082	0.359
DEG_APCC_DBOX_1	118	126	PF00400	0.491
DEG_APCC_DBOX_1	19	27	PF00400	0.698
DEG_APCC_DBOX_1	4	12	PF00400	0.693
DOC_MAPK_gen_1	121	130	PF00069	0.586
DOC_MAPK_gen_1	20	28	PF00069	0.700
DOC_MAPK_RevD_3	6	21	PF00069	0.694
DOC_PP1_RVXF_1	136	143	PF00149	0.633
DOC_USP7_MATH_1	31	35	PF00917	0.562
DOC_USP7_UBL2_3	62	66	PF12436	0.549
LIG_14-3-3_CanoR_1	20	24	PF00244	0.697
LIG_14-3-3_CanoR_1	5	9	PF00244	0.583
LIG_Actin_WH2_2	4	22	PF00022	0.694
LIG_APCC_ABBAyCdc20_2	137	143	PF00400	0.640
LIG_BRCT_BRCA1_1	39	43	PF00533	0.712
LIG_FHA_1	12	18	PF00498	0.717
LIG_FHA_1	39	45	PF00498	0.736
LIG_LIR_Gen_1	97	105	PF02991	0.496
LIG_LIR_Nem_3	84	90	PF02991	0.378
LIG_LIR_Nem_3	97	102	PF02991	0.430
LIG_LYPXL_SIV_4	31	39	PF13949	0.456
LIG_Pex14_2	87	91	PF04695	0.491
LIG_PTB_Apo_2	129	136	PF02174	0.587
LIG_PTB_Phospho_1	129	135	PF10480	0.589
LIG_SH2_STAT3	90	93	PF00017	0.491
LIG_SH2_STAT5	141	144	PF00017	0.511
LIG_SH2_STAT5	90	93	PF00017	0.491
LIG_TRAF2_1	106	109	PF00917	0.491
MOD_CK1_1	27	33	PF00069	0.693
MOD_CK1_1	38	44	PF00069	0.550
MOD_CK2_1	103	109	PF00069	0.491
MOD_GlcNHglycan	33	36	PF01048	0.558
MOD_GlcNHglycan	57	60	PF01048	0.665
MOD_GSK3_1	27	34	PF00069	0.691
MOD_GSK3_1	60	67	PF00069	0.514
MOD_NEK2_1	11	16	PF00069	0.700
MOD_NEK2_1	19	24	PF00069	0.578
MOD_NEK2_1	4	9	PF00069	0.689
MOD_NEK2_1	75	80	PF00069	0.491
MOD_PKA_2	19	25	PF00069	0.696
MOD_PKA_2	4	10	PF00069	0.691
MOD_Plk_4	38	44	PF00069	0.707
TRG_DiLeu_BaEn_3	108	114	PF01217	0.491
TRG_ER_diArg_1	19	21	PF00400	0.692
TRG_ER_diArg_1	80	82	PF00400	0.512
TRG_NES_CRM1_1	120	133	PF08389	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I907	Leishmania infantum	99%	100%
Q4Q452	Leishmania major	95%	99%