Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6L5_LEIDO

TriTrypDb:

LdBPK_330950.1 , LdCL_330015600 , LDHU3_33.1480

Length:

117

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X6L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6L5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	110	114	PF00082	0.350
CLV_PCSK_SKI1_1	34	38	PF00082	0.494
CLV_PCSK_SKI1_1	50	54	PF00082	0.539
CLV_PCSK_SKI1_1	62	66	PF00082	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.344
DOC_MAPK_HePTP_8	80	92	PF00069	0.459
DOC_MAPK_MEF2A_6	83	92	PF00069	0.456
DOC_PP4_FxxP_1	9	12	PF00568	0.362
DOC_USP7_MATH_1	30	34	PF00917	0.490
DOC_USP7_MATH_1	99	103	PF00917	0.447
LIG_14-3-3_CanoR_1	110	116	PF00244	0.367
LIG_14-3-3_CanoR_1	97	107	PF00244	0.446
LIG_APCC_ABBA_1	3	8	PF00400	0.347
LIG_FHA_2	35	41	PF00498	0.465
LIG_FHA_2	67	73	PF00498	0.526
LIG_LIR_Apic_2	8	12	PF02991	0.358
LIG_PDZ_Class_2	112	117	PF00595	0.416
LIG_SH2_STAT5	2	5	PF00017	0.357
LIG_TRAF2_1	37	40	PF00917	0.445
MOD_CK2_1	34	40	PF00069	0.449
MOD_CK2_1	66	72	PF00069	0.491
MOD_GlcNHglycan	101	104	PF01048	0.455
MOD_GSK3_1	30	37	PF00069	0.450
MOD_N-GLC_1	56	61	PF02516	0.570
MOD_PKA_2	99	105	PF00069	0.533
MOD_Plk_2-3	66	72	PF00069	0.522
MOD_SUMO_for_1	18	21	PF00179	0.594
TRG_DiLeu_BaEn_4	40	46	PF01217	0.427
TRG_ENDOCYTIC_2	2	5	PF00928	0.357
TRG_NES_CRM1_1	82	96	PF08389	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU21	Leptomonas seymouri	75%	99%
A0A1X0P0S3	Trypanosomatidae	50%	100%
A0A3R7MVH5	Trypanosoma rangeli	50%	100%
A4HLE5	Leishmania braziliensis	87%	100%
A4I8V4	Leishmania infantum	100%	100%
E9B3S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q4A1	Leishmania major	96%	100%