Geranylgeranyl transferase type-2 subunit alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein prenyltransferase alpha subunit repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6L4_LEIDO

TriTrypDb:

LdBPK_331080.1 , LdCL_330016900 , LDHU3_33.1680

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005968	Rab-protein geranylgeranyltransferase complex	4	11
GO:0032991	protein-containing complex	1	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X6L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6L4

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0018342	protein prenylation	4	11
GO:0018344	protein geranylgeranylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0097354	prenylation	3	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004659	prenyltransferase activity	4	11
GO:0004661	protein geranylgeranyltransferase activity	4	11
GO:0004663	Rab geranylgeranyltransferase activity	5	11
GO:0008318	protein prenyltransferase activity	3	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.531
CLV_NRD_NRD_1	174	176	PF00675	0.345
CLV_NRD_NRD_1	198	200	PF00675	0.221
CLV_NRD_NRD_1	345	347	PF00675	0.476
CLV_NRD_NRD_1	457	459	PF00675	0.459
CLV_NRD_NRD_1	474	476	PF00675	0.466
CLV_NRD_NRD_1	68	70	PF00675	0.308
CLV_PCSK_KEX2_1	198	200	PF00082	0.235
CLV_PCSK_KEX2_1	345	347	PF00082	0.469
CLV_PCSK_KEX2_1	425	427	PF00082	0.519
CLV_PCSK_KEX2_1	456	458	PF00082	0.469
CLV_PCSK_KEX2_1	474	476	PF00082	0.423
CLV_PCSK_KEX2_1	68	70	PF00082	0.308
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.323
CLV_PCSK_SKI1_1	117	121	PF00082	0.256
CLV_PCSK_SKI1_1	199	203	PF00082	0.241
CLV_PCSK_SKI1_1	32	36	PF00082	0.411
CLV_PCSK_SKI1_1	426	430	PF00082	0.512
CLV_PCSK_SKI1_1	69	73	PF00082	0.312
CLV_PCSK_SKI1_1	9	13	PF00082	0.599
DEG_APCC_DBOX_1	68	76	PF00400	0.333
DEG_SPOP_SBC_1	231	235	PF00917	0.582
DEG_SPOP_SBC_1	89	93	PF00917	0.566
DOC_CKS1_1	292	297	PF01111	0.422
DOC_MAPK_MEF2A_6	50	58	PF00069	0.490
DOC_PP2B_LxvP_1	56	59	PF13499	0.403
DOC_PP4_FxxP_1	335	338	PF00568	0.434
DOC_PP4_FxxP_1	413	416	PF00568	0.433
DOC_USP7_MATH_1	100	104	PF00917	0.549
DOC_USP7_MATH_1	221	225	PF00917	0.650
DOC_USP7_MATH_1	231	235	PF00917	0.700
DOC_USP7_MATH_1	273	277	PF00917	0.422
DOC_USP7_MATH_1	74	78	PF00917	0.427
DOC_USP7_MATH_1	82	86	PF00917	0.559
DOC_USP7_MATH_1	89	93	PF00917	0.509
DOC_USP7_UBL2_3	113	117	PF12436	0.484
DOC_USP7_UBL2_3	5	9	PF12436	0.639
DOC_WW_Pin1_4	10	15	PF00397	0.593
DOC_WW_Pin1_4	217	222	PF00397	0.558
DOC_WW_Pin1_4	233	238	PF00397	0.647
DOC_WW_Pin1_4	291	296	PF00397	0.507
DOC_WW_Pin1_4	96	101	PF00397	0.694
LIG_14-3-3_CanoR_1	230	237	PF00244	0.488
LIG_14-3-3_CanoR_1	377	386	PF00244	0.541
LIG_14-3-3_CanoR_1	419	425	PF00244	0.437
LIG_14-3-3_CanoR_1	426	435	PF00244	0.368
LIG_Actin_WH2_2	306	323	PF00022	0.314
LIG_APCC_ABBAyCdc20_2	321	327	PF00400	0.417
LIG_APCC_ABBAyCdc20_2	474	480	PF00400	0.461
LIG_BRCT_BRCA1_1	237	241	PF00533	0.554
LIG_BRCT_BRCA1_1	331	335	PF00533	0.416
LIG_Clathr_ClatBox_1	184	188	PF01394	0.435
LIG_FHA_1	164	170	PF00498	0.486
LIG_FHA_1	245	251	PF00498	0.311
LIG_FHA_1	252	258	PF00498	0.411
LIG_FHA_1	407	413	PF00498	0.520
LIG_FHA_1	49	55	PF00498	0.454
LIG_FHA_2	292	298	PF00498	0.624
LIG_FHA_2	378	384	PF00498	0.501
LIG_FHA_2	89	95	PF00498	0.530
LIG_LIR_Apic_2	332	338	PF02991	0.330
LIG_LIR_Apic_2	410	416	PF02991	0.441
LIG_LIR_Gen_1	166	174	PF02991	0.446
LIG_LIR_Nem_3	166	170	PF02991	0.455
LIG_LIR_Nem_3	259	264	PF02991	0.498
LIG_LIR_Nem_3	60	65	PF02991	0.311
LIG_MLH1_MIPbox_1	238	242	PF16413	0.420
LIG_NRBOX	169	175	PF00104	0.447
LIG_OCRL_FandH_1	128	140	PF00620	0.514
LIG_OCRL_FandH_1	459	471	PF00620	0.447
LIG_PCNA_yPIPBox_3	17	31	PF02747	0.455
LIG_Pex14_2	335	339	PF04695	0.434
LIG_SH2_CRK	31	35	PF00017	0.348
LIG_SH2_STAP1	478	482	PF00017	0.437
LIG_SH2_STAT5	252	255	PF00017	0.503
LIG_SH2_STAT5	325	328	PF00017	0.345
LIG_SH2_STAT5	389	392	PF00017	0.337
LIG_SH2_STAT5	462	465	PF00017	0.517
LIG_SH2_STAT5	62	65	PF00017	0.349
LIG_SH3_3	289	295	PF00018	0.445
LIG_SH3_3	8	14	PF00018	0.614
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.501
LIG_SUMO_SIM_par_1	51	60	PF11976	0.460
LIG_TRAF2_1	243	246	PF00917	0.544
LIG_TRAF2_1	359	362	PF00917	0.332
LIG_UBA3_1	135	144	PF00899	0.509
LIG_UBA3_1	169	176	PF00899	0.452
MOD_CDK_SPxxK_3	10	17	PF00069	0.581
MOD_CK1_1	232	238	PF00069	0.597
MOD_CK1_1	259	265	PF00069	0.434
MOD_CK1_1	402	408	PF00069	0.506
MOD_CK1_1	420	426	PF00069	0.292
MOD_CK1_1	84	90	PF00069	0.631
MOD_CK2_1	240	246	PF00069	0.429
MOD_CK2_1	273	279	PF00069	0.493
MOD_CK2_1	377	383	PF00069	0.491
MOD_CK2_1	84	90	PF00069	0.579
MOD_GlcNHglycan	223	226	PF01048	0.595
MOD_GlcNHglycan	238	241	PF01048	0.536
MOD_GlcNHglycan	242	245	PF01048	0.488
MOD_GlcNHglycan	264	267	PF01048	0.229
MOD_GlcNHglycan	275	278	PF01048	0.353
MOD_GlcNHglycan	330	334	PF01048	0.273
MOD_GlcNHglycan	420	423	PF01048	0.419
MOD_GlcNHglycan	83	87	PF01048	0.617
MOD_GSK3_1	159	166	PF00069	0.650
MOD_GSK3_1	217	224	PF00069	0.662
MOD_GSK3_1	226	233	PF00069	0.700
MOD_GSK3_1	236	243	PF00069	0.572
MOD_GSK3_1	30	37	PF00069	0.359
MOD_GSK3_1	402	409	PF00069	0.566
MOD_GSK3_1	44	51	PF00069	0.350
MOD_GSK3_1	84	91	PF00069	0.747
MOD_GSK3_1	96	103	PF00069	0.522
MOD_N-GLC_1	159	164	PF02516	0.609
MOD_N-GLC_1	259	264	PF02516	0.233
MOD_N-GLC_1	43	48	PF02516	0.464
MOD_NEK2_1	169	174	PF00069	0.414
MOD_NEK2_1	206	211	PF00069	0.457
MOD_NEK2_1	250	255	PF00069	0.435
MOD_NEK2_1	30	35	PF00069	0.393
MOD_NEK2_1	360	365	PF00069	0.476
MOD_PIKK_1	206	212	PF00454	0.373
MOD_PIKK_1	278	284	PF00454	0.368
MOD_PIKK_1	399	405	PF00454	0.444
MOD_PKA_2	206	212	PF00069	0.373
MOD_PKA_2	229	235	PF00069	0.495
MOD_PKA_2	418	424	PF00069	0.450
MOD_Plk_1	262	268	PF00069	0.445
MOD_Plk_1	329	335	PF00069	0.313
MOD_Plk_1	360	366	PF00069	0.392
MOD_Plk_1	43	49	PF00069	0.404
MOD_Plk_4	169	175	PF00069	0.429
MOD_Plk_4	30	36	PF00069	0.368
MOD_Plk_4	360	366	PF00069	0.461
MOD_Plk_4	434	440	PF00069	0.485
MOD_Plk_4	60	66	PF00069	0.357
MOD_ProDKin_1	10	16	PF00069	0.585
MOD_ProDKin_1	217	223	PF00069	0.563
MOD_ProDKin_1	233	239	PF00069	0.636
MOD_ProDKin_1	291	297	PF00069	0.501
MOD_ProDKin_1	96	102	PF00069	0.676
MOD_SUMO_for_1	143	146	PF00179	0.423
MOD_SUMO_for_1	49	52	PF00179	0.286
MOD_SUMO_rev_2	13	19	PF00179	0.477
TRG_DiLeu_BaEn_2	314	320	PF01217	0.414
TRG_DiLeu_BaEn_4	245	251	PF01217	0.345
TRG_ENDOCYTIC_2	126	129	PF00928	0.421
TRG_ENDOCYTIC_2	167	170	PF00928	0.419
TRG_ENDOCYTIC_2	31	34	PF00928	0.364
TRG_ENDOCYTIC_2	336	339	PF00928	0.293
TRG_ENDOCYTIC_2	389	392	PF00928	0.334
TRG_ENDOCYTIC_2	478	481	PF00928	0.329
TRG_ER_diArg_1	197	199	PF00400	0.421
TRG_ER_diArg_1	344	346	PF00400	0.453
TRG_ER_diArg_1	456	458	PF00400	0.457
TRG_ER_diArg_1	473	475	PF00400	0.550
TRG_ER_diArg_1	68	70	PF00400	0.329
TRG_NES_CRM1_1	137	149	PF08389	0.496
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	68	73	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6W4	Leptomonas seymouri	53%	100%
A0A0S4JI96	Bodo saltans	30%	100%
A0A1X0P0V1	Trypanosomatidae	26%	88%
A0A422P2I9	Trypanosoma rangeli	33%	97%
A4HLF6	Leishmania braziliensis	75%	99%
A4I8W7	Leishmania infantum	100%	100%
A5A779	Sus scrofa	26%	87%
D0A4W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B3T6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O93829	Candida albicans	25%	100%
Q08602	Rattus norvegicus	26%	87%
Q4Q488	Leishmania major	89%	100%
Q5EA80	Bos taurus	26%	87%
Q5NVK5	Pongo abelii	28%	87%
Q92696	Homo sapiens	28%	87%
Q9FJ32	Arabidopsis thaliana	25%	71%
Q9JHK4	Mus musculus	27%	87%
V5BJU9	Trypanosoma cruzi	35%	100%