Skp1 family, dimerization domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SKP1-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X6K8_LEIDO

TriTrypDb:

LdBPK_331030.1 , LdCL_330016400 , LDHU3_33.1600

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6K8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	4
GO:0006511	ubiquitin-dependent protein catabolic process	7	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009056	catabolic process	2	4
GO:0009057	macromolecule catabolic process	4	4
GO:0009987	cellular process	1	4
GO:0019538	protein metabolic process	3	4
GO:0019941	modification-dependent protein catabolic process	6	4
GO:0043170	macromolecule metabolic process	3	4
GO:0043632	modification-dependent macromolecule catabolic process	5	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044248	cellular catabolic process	3	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	4
GO:0044265	obsolete cellular macromolecule catabolic process	4	4
GO:0051603	proteolysis involved in protein catabolic process	5	4
GO:0071704	organic substance metabolic process	2	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901575	organic substance catabolic process	3	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.664
CLV_C14_Caspase3-7	270	274	PF00656	0.354
CLV_C14_Caspase3-7	47	51	PF00656	0.416
CLV_C14_Caspase3-7	96	100	PF00656	0.587
CLV_PCSK_KEX2_1	34	36	PF00082	0.415
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.415
CLV_PCSK_PC7_1	30	36	PF00082	0.414
CLV_PCSK_SKI1_1	262	266	PF00082	0.418
CLV_PCSK_SKI1_1	293	297	PF00082	0.537
CLV_PCSK_SKI1_1	324	328	PF00082	0.372
CLV_PCSK_SKI1_1	46	50	PF00082	0.393
DEG_APCC_DBOX_1	63	71	PF00400	0.637
DEG_MDM2_SWIB_1	279	287	PF02201	0.341
DOC_MAPK_JIP1_4	262	268	PF00069	0.392
DOC_MAPK_RevD_3	20	35	PF00069	0.412
DOC_PP2B_LxvP_1	3	6	PF13499	0.561
DOC_PP4_FxxP_1	110	113	PF00568	0.515
DOC_PP4_FxxP_1	95	98	PF00568	0.565
DOC_PP4_MxPP_1	209	212	PF00568	0.535
DOC_USP7_MATH_1	103	107	PF00917	0.656
DOC_USP7_MATH_1	77	81	PF00917	0.614
DOC_USP7_MATH_1	82	86	PF00917	0.576
DOC_USP7_UBL2_3	129	133	PF12436	0.564
DOC_WW_Pin1_4	163	168	PF00397	0.631
DOC_WW_Pin1_4	169	174	PF00397	0.536
DOC_WW_Pin1_4	183	188	PF00397	0.620
DOC_WW_Pin1_4	197	202	PF00397	0.510
DOC_WW_Pin1_4	6	11	PF00397	0.528
DOC_WW_Pin1_4	73	78	PF00397	0.584
DOC_WW_Pin1_4	99	104	PF00397	0.632
LIG_14-3-3_CanoR_1	174	181	PF00244	0.729
LIG_14-3-3_CanoR_1	232	237	PF00244	0.334
LIG_14-3-3_CanoR_1	239	244	PF00244	0.411
LIG_14-3-3_CanoR_1	262	267	PF00244	0.401
LIG_14-3-3_CanoR_1	35	45	PF00244	0.371
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BRCT_BRCA1_1	171	175	PF00533	0.648
LIG_BRCT_BRCA1_1	234	238	PF00533	0.335
LIG_FHA_1	186	192	PF00498	0.621
LIG_FHA_1	221	227	PF00498	0.335
LIG_FHA_1	263	269	PF00498	0.418
LIG_FHA_1	9	15	PF00498	0.570
LIG_FHA_2	114	120	PF00498	0.610
LIG_FHA_2	184	190	PF00498	0.568
LIG_FHA_2	211	217	PF00498	0.486
LIG_FHA_2	87	93	PF00498	0.580
LIG_IRF3_LxIS_1	151	156	PF10401	0.571
LIG_LIR_Apic_2	92	98	PF02991	0.565
LIG_LIR_Gen_1	282	291	PF02991	0.337
LIG_LIR_Nem_3	141	145	PF02991	0.547
LIG_LIR_Nem_3	216	222	PF02991	0.370
LIG_LIR_Nem_3	247	253	PF02991	0.450
LIG_LIR_Nem_3	282	286	PF02991	0.356
LIG_MYND_1	208	212	PF01753	0.603
LIG_MYND_1	6	10	PF01753	0.589
LIG_NRBOX	44	50	PF00104	0.383
LIG_Pex14_2	279	283	PF04695	0.370
LIG_SH2_SRC	271	274	PF00017	0.345
LIG_SH2_STAP1	181	185	PF00017	0.569
LIG_SH2_STAP1	253	257	PF00017	0.400
LIG_SH2_STAP1	300	304	PF00017	0.328
LIG_SH2_STAT5	221	224	PF00017	0.396
LIG_SH2_STAT5	271	274	PF00017	0.524
LIG_SH2_STAT5	314	317	PF00017	0.379
LIG_SH3_3	109	115	PF00018	0.657
LIG_SH3_3	141	147	PF00018	0.553
LIG_SH3_3	198	204	PF00018	0.595
LIG_SH3_3	205	211	PF00018	0.563
LIG_SH3_3	212	218	PF00018	0.416
LIG_SH3_3	26	32	PF00018	0.509
LIG_SH3_3	76	82	PF00018	0.645
LIG_SUMO_SIM_par_1	150	156	PF11976	0.622
LIG_SUMO_SIM_par_1	20	27	PF11976	0.350
LIG_TYR_ITIM	298	303	PF00017	0.328
LIG_UBA3_1	303	310	PF00899	0.364
LIG_WRC_WIRS_1	240	245	PF05994	0.424
LIG_WW_3	111	115	PF00397	0.652
MOD_CDC14_SPxK_1	200	203	PF00782	0.646
MOD_CDK_SPK_2	169	174	PF00069	0.563
MOD_CDK_SPK_2	78	83	PF00069	0.599
MOD_CDK_SPxK_1	197	203	PF00069	0.652
MOD_CK1_1	169	175	PF00069	0.578
MOD_CK1_1	202	208	PF00069	0.630
MOD_CK1_1	242	248	PF00069	0.454
MOD_CK1_1	9	15	PF00069	0.518
MOD_CK2_1	113	119	PF00069	0.608
MOD_CK2_1	183	189	PF00069	0.724
MOD_CK2_1	210	216	PF00069	0.517
MOD_CK2_1	86	92	PF00069	0.576
MOD_GlcNHglycan	105	108	PF01048	0.667
MOD_GlcNHglycan	15	18	PF01048	0.467
MOD_GlcNHglycan	154	158	PF01048	0.642
MOD_GlcNHglycan	175	178	PF01048	0.681
MOD_GlcNHglycan	307	310	PF01048	0.307
MOD_GSK3_1	159	166	PF00069	0.720
MOD_GSK3_1	169	176	PF00069	0.659
MOD_GSK3_1	195	202	PF00069	0.636
MOD_GSK3_1	238	245	PF00069	0.410
MOD_GSK3_1	6	13	PF00069	0.535
MOD_GSK3_1	73	80	PF00069	0.616
MOD_GSK3_1	82	89	PF00069	0.563
MOD_GSK3_1	99	106	PF00069	0.675
MOD_N-GLC_1	169	174	PF02516	0.619
MOD_N-GLC_1	6	11	PF02516	0.523
MOD_NEK2_1	194	199	PF00069	0.661
MOD_NEK2_1	238	243	PF00069	0.449
MOD_PIKK_1	113	119	PF00454	0.582
MOD_PKA_2	113	119	PF00069	0.608
MOD_PKA_2	173	179	PF00069	0.559
MOD_PKA_2	238	244	PF00069	0.399
MOD_PKB_1	237	245	PF00069	0.401
MOD_Plk_1	39	45	PF00069	0.354
MOD_Plk_4	122	128	PF00069	0.649
MOD_Plk_4	293	299	PF00069	0.331
MOD_Plk_4	310	316	PF00069	0.344
MOD_Plk_4	39	45	PF00069	0.354
MOD_ProDKin_1	163	169	PF00069	0.630
MOD_ProDKin_1	183	189	PF00069	0.622
MOD_ProDKin_1	197	203	PF00069	0.509
MOD_ProDKin_1	6	12	PF00069	0.524
MOD_ProDKin_1	73	79	PF00069	0.586
MOD_ProDKin_1	99	105	PF00069	0.637
MOD_SUMO_for_1	341	344	PF00179	0.393
TRG_DiLeu_BaEn_4	301	307	PF01217	0.323
TRG_ENDOCYTIC_2	300	303	PF00928	0.326
TRG_NES_CRM1_1	319	332	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF05	Leptomonas seymouri	54%	100%
A4I8W2	Leishmania infantum	100%	100%