Tubulin C-terminal domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin C-terminal domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6K6_LEIDO

TriTrypDb:

LdCL_330014600 , LDHU3_21.2650

Length:

123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	5
GO:0099080	supramolecular complex	2	5
GO:0099081	supramolecular polymer	3	5
GO:0099512	supramolecular fiber	4	5
GO:0099513	polymeric cytoskeletal fiber	5	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7X6K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6K6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	5
GO:0009987	cellular process	1	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0005198	structural molecule activity	1	5
GO:0005200	structural constituent of cytoskeleton	2	5
GO:0005488	binding	1	5
GO:0005525	GTP binding	5	5
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0019001	guanyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032561	guanyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	59	61	PF00675	0.257
CLV_NRD_NRD_1	70	72	PF00675	0.351
CLV_PCSK_KEX2_1	59	61	PF00082	0.237
CLV_PCSK_KEX2_1	70	72	PF00082	0.392
CLV_PCSK_SKI1_1	39	43	PF00082	0.224
CLV_PCSK_SKI1_1	71	75	PF00082	0.366
DOC_MAPK_gen_1	39	47	PF00069	0.402
DOC_MAPK_MEF2A_6	39	47	PF00069	0.402
LIG_Actin_WH2_2	26	44	PF00022	0.423
LIG_BIR_II_1	1	5	PF00653	0.157
LIG_BRCT_BRCA1_1	17	21	PF00533	0.423
LIG_BRCT_BRCA1_1	43	47	PF00533	0.466
LIG_CAP-Gly_1	115	123	PF01302	0.611
LIG_FHA_1	1	7	PF00498	0.251
LIG_FHA_2	107	113	PF00498	0.464
LIG_FHA_2	87	93	PF00498	0.385
LIG_LIR_Nem_3	100	105	PF02991	0.389
LIG_LIR_Nem_3	56	61	PF02991	0.423
LIG_MLH1_MIPbox_1	17	21	PF16413	0.423
LIG_PCNA_yPIPBox_3	51	60	PF02747	0.423
LIG_Pex14_2	65	69	PF04695	0.326
LIG_SH2_SRC	105	108	PF00017	0.404
LIG_SH2_STAT5	20	23	PF00017	0.423
LIG_SH2_STAT5	78	81	PF00017	0.374
LIG_TRAF2_1	109	112	PF00917	0.485
MOD_CK2_1	106	112	PF00069	0.455
MOD_CK2_1	86	92	PF00069	0.404
MOD_GSK3_1	86	93	PF00069	0.402
MOD_N-GLC_1	16	21	PF02516	0.223
MOD_N-GLC_1	49	54	PF02516	0.223
MOD_N-GLC_2	51	53	PF02516	0.223
MOD_NEK2_1	41	46	PF00069	0.426
MOD_Plk_1	106	112	PF00069	0.465
MOD_Plk_1	16	22	PF00069	0.423
MOD_Plk_1	49	55	PF00069	0.423
MOD_Plk_4	16	22	PF00069	0.423
MOD_Plk_4	43	49	PF00069	0.423
TRG_ER_diArg_1	58	60	PF00400	0.457
TRG_ER_diArg_1	69	71	PF00400	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IVQ1	Bodo saltans	28%	67%
A0A0S4J902	Bodo saltans	97%	82%
A0A1X0NW87	Trypanosomatidae	34%	81%
A4HLD6	Leishmania braziliensis	100%	100%
E8NHQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
P02553	Lytechinus pictus	31%	76%
P02556	Lytechinus pictus	85%	69%
P18699	Lymnaea stagnalis	85%	100%
V5AN49	Trypanosoma cruzi	96%	82%