Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6K5_LEIDO

TriTrypDb:

LdBPK_330980.1 , LdCL_330015900 , LDHU3_33.1510

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6K5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.595
CLV_NRD_NRD_1	153	155	PF00675	0.532
CLV_NRD_NRD_1	19	21	PF00675	0.601
CLV_NRD_NRD_1	191	193	PF00675	0.629
CLV_NRD_NRD_1	204	206	PF00675	0.420
CLV_NRD_NRD_1	280	282	PF00675	0.609
CLV_NRD_NRD_1	283	285	PF00675	0.585
CLV_NRD_NRD_1	287	289	PF00675	0.572
CLV_NRD_NRD_1	293	295	PF00675	0.536
CLV_NRD_NRD_1	33	35	PF00675	0.507
CLV_NRD_NRD_1	460	462	PF00675	0.611
CLV_PCSK_FUR_1	189	193	PF00082	0.634
CLV_PCSK_FUR_1	281	285	PF00082	0.591
CLV_PCSK_FUR_1	288	292	PF00082	0.588
CLV_PCSK_KEX2_1	153	155	PF00082	0.532
CLV_PCSK_KEX2_1	19	21	PF00082	0.601
CLV_PCSK_KEX2_1	191	193	PF00082	0.750
CLV_PCSK_KEX2_1	203	205	PF00082	0.457
CLV_PCSK_KEX2_1	222	224	PF00082	0.594
CLV_PCSK_KEX2_1	280	282	PF00082	0.591
CLV_PCSK_KEX2_1	283	285	PF00082	0.593
CLV_PCSK_KEX2_1	286	288	PF00082	0.603
CLV_PCSK_KEX2_1	290	292	PF00082	0.589
CLV_PCSK_KEX2_1	293	295	PF00082	0.570
CLV_PCSK_KEX2_1	33	35	PF00082	0.507
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.594
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.623
CLV_PCSK_PC7_1	283	289	PF00082	0.594
CLV_PCSK_PC7_1	29	35	PF00082	0.582
CLV_PCSK_SKI1_1	205	209	PF00082	0.484
CLV_PCSK_SKI1_1	219	223	PF00082	0.575
CLV_PCSK_SKI1_1	229	233	PF00082	0.457
CLV_PCSK_SKI1_1	331	335	PF00082	0.631
CLV_PCSK_SKI1_1	382	386	PF00082	0.655
CLV_PCSK_SKI1_1	461	465	PF00082	0.659
CLV_PCSK_SKI1_1	504	508	PF00082	0.632
CLV_PCSK_SKI1_1	525	529	PF00082	0.633
DEG_APCC_DBOX_1	144	152	PF00400	0.562
DEG_APCC_DBOX_1	178	186	PF00400	0.619
DEG_APCC_DBOX_1	204	212	PF00400	0.552
DEG_SPOP_SBC_1	394	398	PF00917	0.535
DEG_SPOP_SBC_1	420	424	PF00917	0.690
DEG_SPOP_SBC_1	505	509	PF00917	0.516
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.542
DOC_MAPK_gen_1	191	201	PF00069	0.685
DOC_MAPK_gen_1	351	360	PF00069	0.628
DOC_MAPK_gen_1	381	387	PF00069	0.602
DOC_MAPK_JIP1_4	195	201	PF00069	0.559
DOC_MAPK_MEF2A_6	45	53	PF00069	0.572
DOC_USP7_MATH_1	241	245	PF00917	0.549
DOC_USP7_MATH_1	32	36	PF00917	0.658
DOC_USP7_MATH_1	367	371	PF00917	0.679
DOC_USP7_MATH_1	430	434	PF00917	0.629
DOC_USP7_MATH_1	463	467	PF00917	0.688
DOC_USP7_MATH_1	484	488	PF00917	0.751
DOC_USP7_MATH_1	505	509	PF00917	0.673
DOC_USP7_UBL2_3	458	462	PF12436	0.581
DOC_WW_Pin1_4	137	142	PF00397	0.621
DOC_WW_Pin1_4	2	7	PF00397	0.574
DOC_WW_Pin1_4	338	343	PF00397	0.659
DOC_WW_Pin1_4	406	411	PF00397	0.577
DOC_WW_Pin1_4	478	483	PF00397	0.675
DOC_WW_Pin1_4	51	56	PF00397	0.460
LIG_14-3-3_CanoR_1	179	183	PF00244	0.582
LIG_14-3-3_CanoR_1	223	228	PF00244	0.594
LIG_14-3-3_CanoR_1	243	247	PF00244	0.625
LIG_14-3-3_CanoR_1	26	32	PF00244	0.591
LIG_14-3-3_CanoR_1	331	337	PF00244	0.589
LIG_14-3-3_CanoR_1	338	342	PF00244	0.581
LIG_14-3-3_CanoR_1	401	407	PF00244	0.570
LIG_14-3-3_CanoR_1	45	53	PF00244	0.466
LIG_14-3-3_CanoR_1	461	471	PF00244	0.600
LIG_Actin_WH2_2	367	383	PF00022	0.795
LIG_BRCT_BRCA1_1	3	7	PF00533	0.557
LIG_BRCT_BRCA1_1	396	400	PF00533	0.556
LIG_BRCT_BRCA1_1	84	88	PF00533	0.486
LIG_eIF4E_1	143	149	PF01652	0.563
LIG_FHA_1	26	32	PF00498	0.597
LIG_FHA_1	313	319	PF00498	0.607
LIG_FHA_1	327	333	PF00498	0.707
LIG_FHA_1	338	344	PF00498	0.559
LIG_FHA_1	355	361	PF00498	0.597
LIG_FHA_1	401	407	PF00498	0.668
LIG_FHA_1	422	428	PF00498	0.687
LIG_FHA_1	455	461	PF00498	0.638
LIG_FHA_1	472	478	PF00498	0.696
LIG_FHA_2	182	188	PF00498	0.545
LIG_FHA_2	298	304	PF00498	0.545
LIG_LIR_Gen_1	10	17	PF02991	0.619
LIG_LIR_Gen_1	140	151	PF02991	0.662
LIG_LIR_Nem_3	10	15	PF02991	0.613
LIG_LIR_Nem_3	140	146	PF02991	0.667
LIG_LIR_Nem_3	85	91	PF02991	0.546
LIG_MYND_1	77	81	PF01753	0.522
LIG_PDZ_Class_2	544	549	PF00595	0.531
LIG_Pex14_2	7	11	PF04695	0.548
LIG_PTAP_UEV_1	498	503	PF05743	0.629
LIG_SH3_1	426	432	PF00018	0.608
LIG_SH3_1	75	81	PF00018	0.473
LIG_SH3_2	376	381	PF14604	0.588
LIG_SH3_2	499	504	PF14604	0.614
LIG_SH3_3	114	120	PF00018	0.542
LIG_SH3_3	135	141	PF00018	0.586
LIG_SH3_3	355	361	PF00018	0.777
LIG_SH3_3	373	379	PF00018	0.546
LIG_SH3_3	426	432	PF00018	0.606
LIG_SH3_3	490	496	PF00018	0.610
LIG_SH3_3	75	81	PF00018	0.587
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.499
LIG_WW_2	429	432	PF00397	0.602
MOD_CK1_1	165	171	PF00069	0.580
MOD_CK1_1	178	184	PF00069	0.452
MOD_CK1_1	197	203	PF00069	0.731
MOD_CK1_1	250	256	PF00069	0.587
MOD_CK1_1	312	318	PF00069	0.755
MOD_CK1_1	323	329	PF00069	0.517
MOD_CK1_1	487	493	PF00069	0.629
MOD_CK1_1	5	11	PF00069	0.583
MOD_CK1_1	82	88	PF00069	0.610
MOD_CK2_1	181	187	PF00069	0.517
MOD_CK2_1	241	247	PF00069	0.592
MOD_CK2_1	297	303	PF00069	0.668
MOD_DYRK1A_RPxSP_1	338	342	PF00069	0.591
MOD_GlcNHglycan	100	104	PF01048	0.548
MOD_GlcNHglycan	165	168	PF01048	0.550
MOD_GlcNHglycan	268	271	PF01048	0.492
MOD_GlcNHglycan	311	314	PF01048	0.655
MOD_GlcNHglycan	376	379	PF01048	0.585
MOD_GlcNHglycan	410	413	PF01048	0.604
MOD_GlcNHglycan	465	468	PF01048	0.647
MOD_GlcNHglycan	490	493	PF01048	0.642
MOD_GlcNHglycan	499	502	PF01048	0.574
MOD_GlcNHglycan	7	10	PF01048	0.525
MOD_GlcNHglycan	84	87	PF01048	0.571
MOD_GSK3_1	1	8	PF00069	0.598
MOD_GSK3_1	11	18	PF00069	0.587
MOD_GSK3_1	170	177	PF00069	0.642
MOD_GSK3_1	225	232	PF00069	0.559
MOD_GSK3_1	319	326	PF00069	0.723
MOD_GSK3_1	332	339	PF00069	0.505
MOD_GSK3_1	350	357	PF00069	0.768
MOD_GSK3_1	402	409	PF00069	0.551
MOD_GSK3_1	469	476	PF00069	0.650
MOD_GSK3_1	478	485	PF00069	0.707
MOD_GSK3_1	527	534	PF00069	0.571
MOD_GSK3_1	56	63	PF00069	0.559
MOD_N-GLC_1	223	228	PF02516	0.544
MOD_N-GLC_1	247	252	PF02516	0.559
MOD_NEK2_1	15	20	PF00069	0.643
MOD_NEK2_1	175	180	PF00069	0.552
MOD_NEK2_1	297	302	PF00069	0.492
MOD_NEK2_1	332	337	PF00069	0.563
MOD_NEK2_1	380	385	PF00069	0.769
MOD_NEK2_1	400	405	PF00069	0.488
MOD_NEK2_1	540	545	PF00069	0.573
MOD_NEK2_1	7	12	PF00069	0.643
MOD_NEK2_2	421	426	PF00069	0.593
MOD_PIKK_1	130	136	PF00454	0.593
MOD_PIKK_1	250	256	PF00454	0.537
MOD_PIKK_1	32	38	PF00454	0.693
MOD_PIKK_1	323	329	PF00454	0.747
MOD_PIKK_1	430	436	PF00454	0.607
MOD_PIKK_1	44	50	PF00454	0.545
MOD_PIKK_1	542	548	PF00454	0.479
MOD_PKA_1	286	292	PF00069	0.665
MOD_PKA_1	461	467	PF00069	0.609
MOD_PKA_1	531	537	PF00069	0.551
MOD_PKA_2	178	184	PF00069	0.575
MOD_PKA_2	194	200	PF00069	0.515
MOD_PKA_2	242	248	PF00069	0.577
MOD_PKA_2	25	31	PF00069	0.621
MOD_PKA_2	286	292	PF00069	0.595
MOD_PKA_2	32	38	PF00069	0.531
MOD_PKA_2	337	343	PF00069	0.777
MOD_PKA_2	400	406	PF00069	0.637
MOD_PKA_2	44	50	PF00069	0.456
MOD_PKB_1	284	292	PF00069	0.665
MOD_Plk_1	223	229	PF00069	0.551
MOD_Plk_1	247	253	PF00069	0.565
MOD_Plk_4	197	203	PF00069	0.499
MOD_Plk_4	247	253	PF00069	0.479
MOD_Plk_4	380	386	PF00069	0.689
MOD_Plk_4	432	438	PF00069	0.581
MOD_Plk_4	7	13	PF00069	0.563
MOD_Plk_4	89	95	PF00069	0.568
MOD_ProDKin_1	137	143	PF00069	0.618
MOD_ProDKin_1	2	8	PF00069	0.568
MOD_ProDKin_1	338	344	PF00069	0.660
MOD_ProDKin_1	406	412	PF00069	0.575
MOD_ProDKin_1	478	484	PF00069	0.669
MOD_ProDKin_1	51	57	PF00069	0.460
TRG_ENDOCYTIC_2	143	146	PF00928	0.523
TRG_ER_diArg_1	152	154	PF00400	0.540
TRG_ER_diArg_1	189	192	PF00400	0.563
TRG_ER_diArg_1	202	205	PF00400	0.507
TRG_ER_diArg_1	279	281	PF00400	0.602
TRG_ER_diArg_1	283	286	PF00400	0.586
TRG_ER_diArg_1	291	294	PF00400	0.571
TRG_ER_diArg_1	425	428	PF00400	0.570
TRG_NES_CRM1_1	41	52	PF08389	0.548
TRG_NLS_Bipartite_1	280	294	PF00514	0.604
TRG_NLS_MonoExtC_3	289	294	PF00514	0.620
TRG_NLS_MonoExtC_3	536	542	PF00514	0.564
TRG_NLS_MonoExtN_4	287	294	PF00514	0.625
TRG_PTS2	1	42	PF00400	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S3	Leptomonas seymouri	33%	100%
A4HLE8	Leishmania braziliensis	61%	100%
A4I8V7	Leishmania infantum	99%	100%
E9B3S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q498	Leishmania major	83%	100%