ATPase family associated with various cellular activities (AAA)/AAA domain (Dynein-related subfamily), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6K2_LEIDO

TriTrypDb:

LdBPK_331260.1 , LdCL_330018800 , LDHU3_33.1910

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7X6K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6K2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016462	pyrophosphatase activity	5	17
GO:0016787	hydrolase activity	2	17
GO:0016817	hydrolase activity, acting on acid anhydrides	3	17
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	17
GO:0016887	ATP hydrolysis activity	7	17
GO:0017076	purine nucleotide binding	4	17
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.658
CLV_C14_Caspase3-7	381	385	PF00656	0.741
CLV_C14_Caspase3-7	410	414	PF00656	0.505
CLV_C14_Caspase3-7	455	459	PF00656	0.784
CLV_C14_Caspase3-7	58	62	PF00656	0.598
CLV_NRD_NRD_1	261	263	PF00675	0.471
CLV_NRD_NRD_1	439	441	PF00675	0.543
CLV_PCSK_FUR_1	437	441	PF00082	0.589
CLV_PCSK_KEX2_1	261	263	PF00082	0.499
CLV_PCSK_KEX2_1	351	353	PF00082	0.285
CLV_PCSK_KEX2_1	382	384	PF00082	0.401
CLV_PCSK_KEX2_1	439	441	PF00082	0.531
CLV_PCSK_KEX2_1	507	509	PF00082	0.523
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.322
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.401
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.437
CLV_PCSK_SKI1_1	244	248	PF00082	0.432
CLV_PCSK_SKI1_1	284	288	PF00082	0.353
CLV_PCSK_SKI1_1	326	330	PF00082	0.316
CLV_PCSK_SKI1_1	352	356	PF00082	0.301
CLV_PCSK_SKI1_1	370	374	PF00082	0.415
CLV_PCSK_SKI1_1	485	489	PF00082	0.593
CLV_PCSK_SKI1_1	513	517	PF00082	0.345
CLV_PCSK_SKI1_1	591	595	PF00082	0.396
CLV_PCSK_SKI1_1	83	87	PF00082	0.450
CLV_PCSK_SKI1_1	92	96	PF00082	0.477
CLV_Separin_Metazoa	645	649	PF03568	0.557
DEG_Nend_UBRbox_2	1	3	PF02207	0.405
DOC_CYCLIN_RxL_1	192	203	PF00134	0.619
DOC_CYCLIN_RxL_1	259	269	PF00134	0.597
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	399	405	PF00134	0.530
DOC_MAPK_gen_1	351	359	PF00069	0.485
DOC_PP1_RVXF_1	260	267	PF00149	0.754
DOC_PP2B_LxvP_1	106	109	PF13499	0.688
DOC_SPAK_OSR1_1	376	380	PF12202	0.578
DOC_SPAK_OSR1_1	97	101	PF12202	0.680
DOC_USP7_MATH_1	176	180	PF00917	0.772
DOC_USP7_MATH_1	200	204	PF00917	0.600
DOC_USP7_MATH_1	205	209	PF00917	0.595
DOC_USP7_MATH_1	227	231	PF00917	0.630
DOC_USP7_MATH_1	32	36	PF00917	0.365
DOC_USP7_MATH_1	599	603	PF00917	0.590
DOC_USP7_MATH_1	615	619	PF00917	0.757
DOC_USP7_UBL2_3	313	317	PF12436	0.554
DOC_USP7_UBL2_3	378	382	PF12436	0.595
DOC_USP7_UBL2_3	503	507	PF12436	0.757
DOC_WW_Pin1_4	129	134	PF00397	0.705
DOC_WW_Pin1_4	489	494	PF00397	0.787
DOC_WW_Pin1_4	623	628	PF00397	0.520
LIG_14-3-3_CanoR_1	140	147	PF00244	0.781
LIG_14-3-3_CanoR_1	148	152	PF00244	0.767
LIG_14-3-3_CanoR_1	361	369	PF00244	0.545
LIG_14-3-3_CanoR_1	52	57	PF00244	0.634
LIG_14-3-3_CanoR_1	574	584	PF00244	0.628
LIG_14-3-3_CanoR_1	83	93	PF00244	0.607
LIG_Actin_WH2_2	134	150	PF00022	0.736
LIG_Actin_WH2_2	3	19	PF00022	0.462
LIG_Actin_WH2_2	538	553	PF00022	0.637
LIG_BRCT_BRCA1_1	294	298	PF00533	0.511
LIG_BRCT_BRCA1_1	373	377	PF00533	0.636
LIG_BRCT_BRCA1_1	63	67	PF00533	0.701
LIG_CSL_BTD_1	44	47	PF09270	0.668
LIG_eIF4E_1	253	259	PF01652	0.612
LIG_FHA_1	118	124	PF00498	0.689
LIG_FHA_1	140	146	PF00498	0.713
LIG_FHA_1	16	22	PF00498	0.426
LIG_FHA_1	3	9	PF00498	0.376
LIG_FHA_1	413	419	PF00498	0.606
LIG_FHA_1	486	492	PF00498	0.801
LIG_FHA_1	519	525	PF00498	0.533
LIG_FHA_1	537	543	PF00498	0.470
LIG_FHA_1	554	560	PF00498	0.514
LIG_FHA_1	578	584	PF00498	0.609
LIG_FHA_1	605	611	PF00498	0.770
LIG_FHA_1	79	85	PF00498	0.651
LIG_FHA_1	89	95	PF00498	0.649
LIG_FHA_2	150	156	PF00498	0.759
LIG_FHA_2	202	208	PF00498	0.679
LIG_FHA_2	348	354	PF00498	0.572
LIG_FHA_2	427	433	PF00498	0.737
LIG_FHA_2	453	459	PF00498	0.821
LIG_FHA_2	495	501	PF00498	0.733
LIG_FHA_2	637	643	PF00498	0.543
LIG_LIR_Apic_2	315	321	PF02991	0.561
LIG_LIR_Gen_1	102	113	PF02991	0.615
LIG_LIR_Gen_1	125	134	PF02991	0.635
LIG_LIR_Gen_1	2	12	PF02991	0.379
LIG_LIR_Gen_1	292	300	PF02991	0.488
LIG_LIR_Nem_3	102	108	PF02991	0.581
LIG_LIR_Nem_3	125	129	PF02991	0.582
LIG_LIR_Nem_3	189	193	PF02991	0.628
LIG_LIR_Nem_3	2	7	PF02991	0.386
LIG_LIR_Nem_3	242	246	PF02991	0.670
LIG_LIR_Nem_3	292	296	PF02991	0.494
LIG_LIR_Nem_3	44	49	PF02991	0.608
LIG_LIR_Nem_3	64	70	PF02991	0.512
LIG_MLH1_MIPbox_1	294	298	PF16413	0.511
LIG_NRBOX	326	332	PF00104	0.423
LIG_NRBOX	589	595	PF00104	0.558
LIG_Pex14_2	293	297	PF04695	0.473
LIG_Pex14_2	373	377	PF04695	0.636
LIG_PTB_Apo_2	6	13	PF02174	0.399
LIG_SH2_CRK	126	130	PF00017	0.664
LIG_SH2_CRK	255	259	PF00017	0.550
LIG_SH2_CRK	318	322	PF00017	0.599
LIG_SH2_CRK	332	336	PF00017	0.408
LIG_SH2_NCK_1	318	322	PF00017	0.629
LIG_SH2_SRC	318	321	PF00017	0.623
LIG_SH2_STAP1	119	123	PF00017	0.672
LIG_SH2_STAP1	4	8	PF00017	0.359
LIG_SH2_STAT3	253	256	PF00017	0.510
LIG_SH2_STAT5	105	108	PF00017	0.582
LIG_SH2_STAT5	119	122	PF00017	0.592
LIG_SH2_STAT5	126	129	PF00017	0.658
LIG_SH2_STAT5	253	256	PF00017	0.520
LIG_SH2_STAT5	285	288	PF00017	0.608
LIG_SH2_STAT5	4	7	PF00017	0.414
LIG_SH2_STAT5	40	43	PF00017	0.547
LIG_SH2_STAT5	407	410	PF00017	0.503
LIG_SH2_STAT5	56	59	PF00017	0.545
LIG_SH2_STAT5	576	579	PF00017	0.597
LIG_SH2_STAT5	89	92	PF00017	0.593
LIG_SH3_1	318	324	PF00018	0.627
LIG_SH3_2	321	326	PF14604	0.547
LIG_SH3_3	296	302	PF00018	0.605
LIG_SH3_3	318	324	PF00018	0.543
LIG_SH3_3	90	96	PF00018	0.670
LIG_SUMO_SIM_anti_2	641	648	PF11976	0.554
LIG_TRAF2_1	175	178	PF00917	0.680
LIG_TRAF2_1	364	367	PF00917	0.511
LIG_TRAF2_1	461	464	PF00917	0.809
LIG_TRAF2_1	639	642	PF00917	0.586
LIG_TYR_ITIM	103	108	PF00017	0.648
LIG_TYR_ITIM	241	246	PF00017	0.571
LIG_UBA3_1	180	187	PF00899	0.612
LIG_UBA3_1	304	313	PF00899	0.573
MOD_CDC14_SPxK_1	132	135	PF00782	0.708
MOD_CDK_SPxK_1	129	135	PF00069	0.699
MOD_CK1_1	15	21	PF00069	0.384
MOD_CK1_1	179	185	PF00069	0.759
MOD_CK1_1	208	214	PF00069	0.653
MOD_CK1_1	394	400	PF00069	0.609
MOD_CK1_1	451	457	PF00069	0.775
MOD_CK1_1	55	61	PF00069	0.685
MOD_CK1_1	578	584	PF00069	0.635
MOD_CK2_1	200	206	PF00069	0.674
MOD_CK2_1	227	233	PF00069	0.691
MOD_CK2_1	361	367	PF00069	0.452
MOD_CK2_1	426	432	PF00069	0.740
MOD_CK2_1	454	460	PF00069	0.793
MOD_CK2_1	494	500	PF00069	0.735
MOD_CK2_1	589	595	PF00069	0.634
MOD_CK2_1	623	629	PF00069	0.551
MOD_CK2_1	636	642	PF00069	0.539
MOD_GlcNHglycan	35	38	PF01048	0.442
MOD_GlcNHglycan	373	376	PF01048	0.397
MOD_GlcNHglycan	471	474	PF01048	0.588
MOD_GlcNHglycan	597	600	PF01048	0.443
MOD_GlcNHglycan	61	64	PF01048	0.496
MOD_GlcNHglycan	616	620	PF01048	0.550
MOD_GlcNHglycan	73	76	PF01048	0.520
MOD_GSK3_1	201	208	PF00069	0.700
MOD_GSK3_1	334	341	PF00069	0.426
MOD_GSK3_1	357	364	PF00069	0.492
MOD_GSK3_1	448	455	PF00069	0.767
MOD_GSK3_1	485	492	PF00069	0.750
MOD_GSK3_1	503	510	PF00069	0.565
MOD_GSK3_1	55	62	PF00069	0.679
MOD_GSK3_1	595	602	PF00069	0.618
MOD_GSK3_1	604	611	PF00069	0.755
MOD_GSK3_1	615	622	PF00069	0.674
MOD_GSK3_1	84	91	PF00069	0.646
MOD_LATS_1	167	173	PF00433	0.610
MOD_N-GLC_1	117	122	PF02516	0.473
MOD_N-GLC_1	129	134	PF02516	0.473
MOD_N-GLC_1	469	474	PF02516	0.595
MOD_N-GLC_1	71	76	PF02516	0.486
MOD_NEK2_1	12	17	PF00069	0.443
MOD_NEK2_1	147	152	PF00069	0.727
MOD_NEK2_1	181	186	PF00069	0.715
MOD_NEK2_1	33	38	PF00069	0.369
MOD_NEK2_1	355	360	PF00069	0.492
MOD_NEK2_1	41	46	PF00069	0.476
MOD_NEK2_1	577	582	PF00069	0.637
MOD_NEK2_2	176	181	PF00069	0.620
MOD_NEK2_2	553	558	PF00069	0.535
MOD_NEK2_2	63	68	PF00069	0.561
MOD_NEK2_2	78	83	PF00069	0.686
MOD_PIKK_1	170	176	PF00454	0.656
MOD_PIKK_1	181	187	PF00454	0.720
MOD_PIKK_1	494	500	PF00454	0.790
MOD_PK_1	104	110	PF00069	0.618
MOD_PKA_1	507	513	PF00069	0.731
MOD_PKA_2	139	145	PF00069	0.724
MOD_PKA_2	147	153	PF00069	0.717
MOD_PKA_2	507	513	PF00069	0.723
MOD_Plk_1	232	238	PF00069	0.610
MOD_Plk_1	615	621	PF00069	0.648
MOD_Plk_2-3	458	464	PF00069	0.783
MOD_Plk_2-3	589	595	PF00069	0.591
MOD_Plk_2-3	636	642	PF00069	0.599
MOD_Plk_4	176	182	PF00069	0.729
MOD_Plk_4	227	233	PF00069	0.610
MOD_Plk_4	292	298	PF00069	0.472
MOD_Plk_4	52	58	PF00069	0.675
MOD_Plk_4	545	551	PF00069	0.609
MOD_Plk_4	578	584	PF00069	0.667
MOD_Plk_4	85	91	PF00069	0.643
MOD_ProDKin_1	129	135	PF00069	0.709
MOD_ProDKin_1	489	495	PF00069	0.786
MOD_ProDKin_1	623	629	PF00069	0.519
MOD_SUMO_for_1	420	423	PF00179	0.643
MOD_SUMO_rev_2	237	246	PF00179	0.670
MOD_SUMO_rev_2	309	315	PF00179	0.546
MOD_SUMO_rev_2	99	106	PF00179	0.632
TRG_DiLeu_BaEn_1	589	594	PF01217	0.631
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.612
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.612
TRG_ENDOCYTIC_2	105	108	PF00928	0.566
TRG_ENDOCYTIC_2	126	129	PF00928	0.647
TRG_ENDOCYTIC_2	243	246	PF00928	0.610
TRG_ENDOCYTIC_2	255	258	PF00928	0.504
TRG_ENDOCYTIC_2	4	7	PF00928	0.396
TRG_NES_CRM1_1	136	149	PF08389	0.684
TRG_NES_CRM1_1	367	381	PF08389	0.628
TRG_NES_CRM1_1	99	112	PF08389	0.563
TRG_NLS_MonoExtN_4	261	266	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	513	518	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V2	Leptomonas seymouri	59%	98%
A0A0S4JAD3	Bodo saltans	32%	100%
A0A1X0NTT2	Trypanosomatidae	28%	97%
A0A1X0P2Y3	Trypanosomatidae	28%	100%
A0A1X0P9I4	Trypanosomatidae	29%	81%
A0A422NUH1	Trypanosoma rangeli	29%	97%
A0A422P3P3	Trypanosoma rangeli	30%	100%
A4HLH5	Leishmania braziliensis	73%	96%
A4I8Y5	Leishmania infantum	100%	100%
C9ZQW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
D0A1W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	91%
E9B3V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q470	Leishmania major	93%	100%
V5DQN5	Trypanosoma cruzi	31%	100%