Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6J9_LEIDO

TriTrypDb:

LdBPK_331250.1 , LdCL_330018700 , LDHU3_33.1900

Length:

887

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6J9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.516
CLV_C14_Caspase3-7	387	391	PF00656	0.527
CLV_C14_Caspase3-7	842	846	PF00656	0.593
CLV_NRD_NRD_1	137	139	PF00675	0.487
CLV_NRD_NRD_1	257	259	PF00675	0.545
CLV_NRD_NRD_1	287	289	PF00675	0.469
CLV_NRD_NRD_1	326	328	PF00675	0.739
CLV_NRD_NRD_1	39	41	PF00675	0.565
CLV_NRD_NRD_1	441	443	PF00675	0.551
CLV_NRD_NRD_1	488	490	PF00675	0.637
CLV_NRD_NRD_1	494	496	PF00675	0.655
CLV_NRD_NRD_1	590	592	PF00675	0.648
CLV_NRD_NRD_1	63	65	PF00675	0.662
CLV_NRD_NRD_1	657	659	PF00675	0.611
CLV_PCSK_FUR_1	285	289	PF00082	0.485
CLV_PCSK_KEX2_1	137	139	PF00082	0.487
CLV_PCSK_KEX2_1	257	259	PF00082	0.659
CLV_PCSK_KEX2_1	287	289	PF00082	0.469
CLV_PCSK_KEX2_1	326	328	PF00082	0.731
CLV_PCSK_KEX2_1	39	41	PF00082	0.565
CLV_PCSK_KEX2_1	441	443	PF00082	0.551
CLV_PCSK_KEX2_1	488	490	PF00082	0.637
CLV_PCSK_KEX2_1	494	496	PF00082	0.655
CLV_PCSK_KEX2_1	590	592	PF00082	0.549
CLV_PCSK_KEX2_1	63	65	PF00082	0.670
CLV_PCSK_KEX2_1	657	659	PF00082	0.611
CLV_PCSK_SKI1_1	109	113	PF00082	0.532
CLV_PCSK_SKI1_1	137	141	PF00082	0.534
CLV_PCSK_SKI1_1	220	224	PF00082	0.517
CLV_PCSK_SKI1_1	39	43	PF00082	0.707
CLV_PCSK_SKI1_1	488	492	PF00082	0.651
CLV_PCSK_SKI1_1	63	67	PF00082	0.500
CLV_Separin_Metazoa	685	689	PF03568	0.431
DEG_APCC_DBOX_1	136	144	PF00400	0.543
DEG_APCC_DBOX_1	38	46	PF00400	0.560
DEG_APCC_DBOX_1	62	70	PF00400	0.546
DEG_APCC_DBOX_1	8	16	PF00400	0.546
DEG_SCF_FBW7_1	706	713	PF00400	0.497
DEG_SIAH_1	403	411	PF03145	0.624
DOC_CKS1_1	527	532	PF01111	0.597
DOC_CKS1_1	857	862	PF01111	0.514
DOC_CYCLIN_RxL_1	482	492	PF00134	0.573
DOC_CYCLIN_RxL_1	61	71	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	740	746	PF00134	0.415
DOC_MAPK_gen_1	14	23	PF00069	0.621
DOC_MAPK_gen_1	193	201	PF00069	0.513
DOC_MAPK_gen_1	39	47	PF00069	0.563
DOC_MAPK_gen_1	52	61	PF00069	0.433
DOC_MAPK_gen_1	63	69	PF00069	0.662
DOC_MAPK_HePTP_8	374	386	PF00069	0.426
DOC_MAPK_MEF2A_6	195	203	PF00069	0.495
DOC_MAPK_MEF2A_6	377	386	PF00069	0.441
DOC_MAPK_MEF2A_6	39	47	PF00069	0.520
DOC_MAPK_RevD_3	25	40	PF00069	0.564
DOC_PP1_RVXF_1	591	597	PF00149	0.524
DOC_PP1_RVXF_1	756	762	PF00149	0.489
DOC_PP2B_LxvP_1	156	159	PF13499	0.589
DOC_PP2B_LxvP_1	207	210	PF13499	0.464
DOC_PP2B_LxvP_1	30	33	PF13499	0.571
DOC_PP2B_LxvP_1	309	312	PF13499	0.425
DOC_PP2B_LxvP_1	43	46	PF13499	0.441
DOC_PP2B_LxvP_1	537	540	PF13499	0.523
DOC_PP2B_LxvP_1	576	579	PF13499	0.640
DOC_PP2B_LxvP_1	740	743	PF13499	0.523
DOC_USP7_MATH_1	146	150	PF00917	0.507
DOC_USP7_MATH_1	194	198	PF00917	0.584
DOC_USP7_MATH_1	25	29	PF00917	0.470
DOC_USP7_MATH_1	261	265	PF00917	0.583
DOC_USP7_MATH_1	268	272	PF00917	0.575
DOC_USP7_MATH_1	339	343	PF00917	0.560
DOC_USP7_MATH_1	398	402	PF00917	0.537
DOC_USP7_MATH_1	506	510	PF00917	0.572
DOC_USP7_MATH_1	532	536	PF00917	0.697
DOC_USP7_MATH_1	702	706	PF00917	0.521
DOC_USP7_MATH_1	771	775	PF00917	0.652
DOC_USP7_MATH_1	816	820	PF00917	0.635
DOC_USP7_MATH_1	871	875	PF00917	0.616
DOC_USP7_MATH_1	882	886	PF00917	0.526
DOC_WW_Pin1_4	176	181	PF00397	0.476
DOC_WW_Pin1_4	271	276	PF00397	0.507
DOC_WW_Pin1_4	406	411	PF00397	0.603
DOC_WW_Pin1_4	489	494	PF00397	0.563
DOC_WW_Pin1_4	515	520	PF00397	0.640
DOC_WW_Pin1_4	526	531	PF00397	0.539
DOC_WW_Pin1_4	543	548	PF00397	0.527
DOC_WW_Pin1_4	564	569	PF00397	0.607
DOC_WW_Pin1_4	673	678	PF00397	0.553
DOC_WW_Pin1_4	706	711	PF00397	0.541
DOC_WW_Pin1_4	742	747	PF00397	0.504
DOC_WW_Pin1_4	856	861	PF00397	0.660
DOC_WW_Pin1_4	877	882	PF00397	0.477
LIG_14-3-3_CanoR_1	193	203	PF00244	0.503
LIG_14-3-3_CanoR_1	225	231	PF00244	0.502
LIG_14-3-3_CanoR_1	257	266	PF00244	0.586
LIG_14-3-3_CanoR_1	523	527	PF00244	0.592
LIG_14-3-3_CanoR_1	593	603	PF00244	0.523
LIG_14-3-3_CanoR_1	622	630	PF00244	0.473
LIG_14-3-3_CanoR_1	657	666	PF00244	0.672
LIG_14-3-3_CanoR_1	734	742	PF00244	0.482
LIG_14-3-3_CanoR_1	753	757	PF00244	0.330
LIG_Actin_WH2_2	23	41	PF00022	0.517
LIG_BIR_II_1	1	5	PF00653	0.529
LIG_BIR_III_2	72	76	PF00653	0.522
LIG_BRCT_BRCA1_1	117	121	PF00533	0.590
LIG_BRCT_BRCA1_1	171	175	PF00533	0.551
LIG_BRCT_BRCA1_1	601	605	PF00533	0.538
LIG_CaM_NSCaTE_8	439	446	PF13499	0.679
LIG_DLG_GKlike_1	595	603	PF00625	0.545
LIG_FHA_1	176	182	PF00498	0.597
LIG_FHA_1	198	204	PF00498	0.438
LIG_FHA_1	210	216	PF00498	0.566
LIG_FHA_1	22	28	PF00498	0.502
LIG_FHA_1	226	232	PF00498	0.434
LIG_FHA_1	311	317	PF00498	0.510
LIG_FHA_1	338	344	PF00498	0.600
LIG_FHA_1	522	528	PF00498	0.563
LIG_FHA_1	60	66	PF00498	0.467
LIG_FHA_1	666	672	PF00498	0.428
LIG_FHA_1	784	790	PF00498	0.544
LIG_FHA_1	857	863	PF00498	0.564
LIG_FHA_1	878	884	PF00498	0.478
LIG_FHA_2	348	354	PF00498	0.487
LIG_FHA_2	458	464	PF00498	0.520
LIG_FHA_2	498	504	PF00498	0.678
LIG_FHA_2	516	522	PF00498	0.637
LIG_FHA_2	548	554	PF00498	0.618
LIG_FHA_2	575	581	PF00498	0.575
LIG_FHA_2	711	717	PF00498	0.534
LIG_GBD_Chelix_1	102	110	PF00786	0.443
LIG_LIR_Gen_1	557	563	PF02991	0.564
LIG_LIR_Gen_1	624	635	PF02991	0.486
LIG_LIR_Nem_3	274	279	PF02991	0.417
LIG_LIR_Nem_3	475	479	PF02991	0.529
LIG_LIR_Nem_3	557	562	PF02991	0.567
LIG_LIR_Nem_3	624	630	PF02991	0.505
LIG_LIR_Nem_3	71	77	PF02991	0.519
LIG_LIR_Nem_3	738	744	PF02991	0.399
LIG_LIR_Nem_3	799	804	PF02991	0.494
LIG_LYPXL_yS_3	10	13	PF13949	0.546
LIG_MLH1_MIPbox_1	171	175	PF16413	0.508
LIG_NRBOX	135	141	PF00104	0.534
LIG_NRBOX	486	492	PF00104	0.604
LIG_PCNA_yPIPBox_3	478	491	PF02747	0.634
LIG_PDZ_Class_1	882	887	PF00595	0.549
LIG_SH2_NCK_1	104	108	PF00017	0.432
LIG_SH2_STAP1	104	108	PF00017	0.410
LIG_SH2_STAP1	233	237	PF00017	0.440
LIG_SH2_STAP1	242	246	PF00017	0.422
LIG_SH2_STAT3	804	807	PF00017	0.490
LIG_SH2_STAT5	186	189	PF00017	0.455
LIG_SH2_STAT5	526	529	PF00017	0.637
LIG_SH2_STAT5	559	562	PF00017	0.566
LIG_SH2_STAT5	627	630	PF00017	0.464
LIG_SH2_STAT5	741	744	PF00017	0.397
LIG_SH2_STAT5	804	807	PF00017	0.490
LIG_SH3_2	477	482	PF14604	0.584
LIG_SH3_3	309	315	PF00018	0.462
LIG_SH3_3	432	438	PF00018	0.590
LIG_SH3_3	474	480	PF00018	0.627
LIG_SH3_3	62	68	PF00018	0.499
LIG_SH3_3	671	677	PF00018	0.423
LIG_SH3_3	721	727	PF00018	0.457
LIG_SH3_3	740	746	PF00018	0.335
LIG_SH3_3	854	860	PF00018	0.551
LIG_SUMO_SIM_anti_2	826	832	PF11976	0.411
LIG_SUMO_SIM_par_1	277	283	PF11976	0.384
LIG_SUMO_SIM_par_1	640	645	PF11976	0.522
LIG_TRAF2_1	131	134	PF00917	0.509
LIG_TRAF2_1	460	463	PF00917	0.536
LIG_TRAF2_1	578	581	PF00917	0.662
LIG_TRAF2_1	713	716	PF00917	0.576
LIG_TYR_ITIM	739	744	PF00017	0.392
LIG_UBA3_1	372	377	PF00899	0.494
LIG_WRC_WIRS_1	630	635	PF05994	0.440
MOD_CDC14_SPxK_1	492	495	PF00782	0.613
MOD_CDC14_SPxK_1	567	570	PF00782	0.582
MOD_CDK_SPK_2	406	411	PF00069	0.603
MOD_CDK_SPK_2	489	494	PF00069	0.556
MOD_CDK_SPK_2	676	681	PF00069	0.488
MOD_CDK_SPxK_1	489	495	PF00069	0.604
MOD_CDK_SPxK_1	564	570	PF00069	0.586
MOD_CK1_1	150	156	PF00069	0.622
MOD_CK1_1	176	182	PF00069	0.587
MOD_CK1_1	197	203	PF00069	0.440
MOD_CK1_1	271	277	PF00069	0.524
MOD_CK1_1	426	432	PF00069	0.599
MOD_CK1_1	497	503	PF00069	0.617
MOD_CK1_1	515	521	PF00069	0.599
MOD_CK1_1	629	635	PF00069	0.466
MOD_CK1_1	676	682	PF00069	0.411
MOD_CK1_1	705	711	PF00069	0.553
MOD_CK1_1	774	780	PF00069	0.603
MOD_CK1_1	783	789	PF00069	0.490
MOD_CK1_1	818	824	PF00069	0.675
MOD_CK1_1	836	842	PF00069	0.557
MOD_CK1_1	89	95	PF00069	0.559
MOD_CK2_1	128	134	PF00069	0.692
MOD_CK2_1	457	463	PF00069	0.531
MOD_CK2_1	515	521	PF00069	0.783
MOD_CK2_1	574	580	PF00069	0.577
MOD_CK2_1	709	715	PF00069	0.605
MOD_CK2_1	775	781	PF00069	0.616
MOD_Cter_Amidation	285	288	PF01082	0.498
MOD_GlcNHglycan	152	155	PF01048	0.620
MOD_GlcNHglycan	156	159	PF01048	0.645
MOD_GlcNHglycan	171	174	PF01048	0.391
MOD_GlcNHglycan	262	266	PF01048	0.647
MOD_GlcNHglycan	270	273	PF01048	0.556
MOD_GlcNHglycan	3	6	PF01048	0.625
MOD_GlcNHglycan	415	418	PF01048	0.731
MOD_GlcNHglycan	425	428	PF01048	0.585
MOD_GlcNHglycan	503	507	PF01048	0.669
MOD_GlcNHglycan	508	511	PF01048	0.647
MOD_GlcNHglycan	514	517	PF01048	0.576
MOD_GlcNHglycan	623	626	PF01048	0.711
MOD_GlcNHglycan	644	647	PF01048	0.497
MOD_GlcNHglycan	771	774	PF01048	0.634
MOD_GlcNHglycan	789	792	PF01048	0.735
MOD_GlcNHglycan	818	821	PF01048	0.631
MOD_GlcNHglycan	835	838	PF01048	0.617
MOD_GlcNHglycan	841	844	PF01048	0.592
MOD_GlcNHglycan	866	869	PF01048	0.735
MOD_GlcNHglycan	89	92	PF01048	0.600
MOD_GSK3_1	115	122	PF00069	0.542
MOD_GSK3_1	146	153	PF00069	0.586
MOD_GSK3_1	169	176	PF00069	0.618
MOD_GSK3_1	205	212	PF00069	0.555
MOD_GSK3_1	21	28	PF00069	0.481
MOD_GSK3_1	256	263	PF00069	0.546
MOD_GSK3_1	267	274	PF00069	0.614
MOD_GSK3_1	385	392	PF00069	0.653
MOD_GSK3_1	409	416	PF00069	0.698
MOD_GSK3_1	426	433	PF00069	0.525
MOD_GSK3_1	494	501	PF00069	0.575
MOD_GSK3_1	502	509	PF00069	0.793
MOD_GSK3_1	521	528	PF00069	0.494
MOD_GSK3_1	543	550	PF00069	0.714
MOD_GSK3_1	558	565	PF00069	0.722
MOD_GSK3_1	595	602	PF00069	0.601
MOD_GSK3_1	702	709	PF00069	0.511
MOD_GSK3_1	748	755	PF00069	0.352
MOD_GSK3_1	771	778	PF00069	0.535
MOD_GSK3_1	783	790	PF00069	0.544
MOD_GSK3_1	815	822	PF00069	0.713
MOD_GSK3_1	85	92	PF00069	0.565
MOD_GSK3_1	858	865	PF00069	0.669
MOD_GSK3_1	871	878	PF00069	0.703
MOD_N-GLC_1	418	423	PF02516	0.563
MOD_N-GLC_1	710	715	PF02516	0.512
MOD_N-GLC_1	86	91	PF02516	0.574
MOD_NEK2_1	1	6	PF00069	0.528
MOD_NEK2_1	119	124	PF00069	0.661
MOD_NEK2_1	174	179	PF00069	0.482
MOD_NEK2_1	21	26	PF00069	0.477
MOD_NEK2_1	384	389	PF00069	0.529
MOD_NEK2_1	59	64	PF00069	0.423
MOD_NEK2_1	594	599	PF00069	0.534
MOD_NEK2_1	601	606	PF00069	0.556
MOD_NEK2_1	780	785	PF00069	0.597
MOD_NEK2_1	86	91	PF00069	0.602
MOD_NEK2_1	875	880	PF00069	0.572
MOD_NEK2_2	339	344	PF00069	0.530
MOD_NEK2_2	771	776	PF00069	0.598
MOD_PIKK_1	375	381	PF00454	0.444
MOD_PK_1	494	500	PF00069	0.564
MOD_PKA_1	257	263	PF00069	0.552
MOD_PKA_1	494	500	PF00069	0.564
MOD_PKA_1	657	663	PF00069	0.581
MOD_PKA_2	194	200	PF00069	0.525
MOD_PKA_2	256	262	PF00069	0.556
MOD_PKA_2	347	353	PF00069	0.421
MOD_PKA_2	398	404	PF00069	0.562
MOD_PKA_2	494	500	PF00069	0.622
MOD_PKA_2	522	528	PF00069	0.553
MOD_PKA_2	594	600	PF00069	0.523
MOD_PKA_2	621	627	PF00069	0.496
MOD_PKA_2	656	662	PF00069	0.702
MOD_PKA_2	730	736	PF00069	0.500
MOD_PKA_2	752	758	PF00069	0.332
MOD_PKB_1	593	601	PF00069	0.543
MOD_Plk_1	146	152	PF00069	0.486
MOD_Plk_1	261	267	PF00069	0.606
MOD_Plk_1	418	424	PF00069	0.557
MOD_Plk_4	197	203	PF00069	0.511
MOD_Plk_4	226	232	PF00069	0.471
MOD_Plk_4	522	528	PF00069	0.563
MOD_Plk_4	532	538	PF00069	0.581
MOD_Plk_4	595	601	PF00069	0.543
MOD_Plk_4	626	632	PF00069	0.466
MOD_Plk_4	752	758	PF00069	0.332
MOD_Plk_4	775	781	PF00069	0.559
MOD_Plk_4	796	802	PF00069	0.537
MOD_Plk_4	823	829	PF00069	0.457
MOD_Plk_4	836	842	PF00069	0.506
MOD_Plk_4	871	877	PF00069	0.686
MOD_Plk_4	89	95	PF00069	0.668
MOD_ProDKin_1	176	182	PF00069	0.470
MOD_ProDKin_1	271	277	PF00069	0.490
MOD_ProDKin_1	406	412	PF00069	0.601
MOD_ProDKin_1	489	495	PF00069	0.566
MOD_ProDKin_1	515	521	PF00069	0.641
MOD_ProDKin_1	526	532	PF00069	0.538
MOD_ProDKin_1	543	549	PF00069	0.527
MOD_ProDKin_1	564	570	PF00069	0.608
MOD_ProDKin_1	673	679	PF00069	0.552
MOD_ProDKin_1	706	712	PF00069	0.539
MOD_ProDKin_1	742	748	PF00069	0.504
MOD_ProDKin_1	856	862	PF00069	0.662
MOD_ProDKin_1	877	883	PF00069	0.477
MOD_SUMO_for_1	718	721	PF00179	0.523
TRG_DiLeu_BaEn_4	737	743	PF01217	0.471
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.528
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.463
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.564
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.495
TRG_ENDOCYTIC_2	10	13	PF00928	0.546
TRG_ENDOCYTIC_2	559	562	PF00928	0.566
TRG_ENDOCYTIC_2	627	630	PF00928	0.464
TRG_ENDOCYTIC_2	741	744	PF00928	0.397
TRG_ER_diArg_1	13	16	PF00400	0.579
TRG_ER_diArg_1	136	138	PF00400	0.483
TRG_ER_diArg_1	284	287	PF00400	0.467
TRG_ER_diArg_1	326	328	PF00400	0.712
TRG_ER_diArg_1	331	334	PF00400	0.675
TRG_ER_diArg_1	38	40	PF00400	0.563
TRG_ER_diArg_1	441	443	PF00400	0.551
TRG_ER_diArg_1	487	489	PF00400	0.647
TRG_ER_diArg_1	493	495	PF00400	0.748
TRG_ER_diArg_1	590	593	PF00400	0.525
TRG_ER_diArg_1	63	65	PF00400	0.674
TRG_ER_diArg_1	698	701	PF00400	0.491
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	758	763	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS9	Leptomonas seymouri	37%	95%
A4HLH4	Leishmania braziliensis	70%	97%
A4I8Y4	Leishmania infantum	99%	100%
E9B3V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	98%
Q4Q471	Leishmania major	88%	100%