Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6J7_LEIDO

TriTrypDb:

LdBPK_330810.1 , LdCL_330013600 , LDHU3_33.1170

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6J7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.633
CLV_C14_Caspase3-7	246	250	PF00656	0.686
CLV_C14_Caspase3-7	265	269	PF00656	0.490
CLV_C14_Caspase3-7	87	91	PF00656	0.613
CLV_NRD_NRD_1	105	107	PF00675	0.464
CLV_NRD_NRD_1	121	123	PF00675	0.568
CLV_NRD_NRD_1	358	360	PF00675	0.541
CLV_NRD_NRD_1	40	42	PF00675	0.498
CLV_PCSK_KEX2_1	105	107	PF00082	0.522
CLV_PCSK_KEX2_1	115	117	PF00082	0.455
CLV_PCSK_KEX2_1	121	123	PF00082	0.444
CLV_PCSK_KEX2_1	358	360	PF00082	0.541
CLV_PCSK_KEX2_1	39	41	PF00082	0.503
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.579
CLV_PCSK_SKI1_1	111	115	PF00082	0.487
CLV_PCSK_SKI1_1	149	153	PF00082	0.439
CLV_PCSK_SKI1_1	215	219	PF00082	0.570
CLV_PCSK_SKI1_1	224	228	PF00082	0.480
CLV_PCSK_SKI1_1	340	344	PF00082	0.566
DEG_SCF_FBW7_1	254	261	PF00400	0.569
DEG_SCF_FBW7_2	258	265	PF00400	0.584
DOC_CDC14_PxL_1	225	233	PF14671	0.604
DOC_CKS1_1	259	264	PF01111	0.559
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.563
DOC_MAPK_MEF2A_6	136	144	PF00069	0.466
DOC_PP2B_LxvP_1	272	275	PF13499	0.631
DOC_PP2B_LxvP_1	298	301	PF13499	0.708
DOC_PP2B_LxvP_1	62	65	PF13499	0.547
DOC_USP7_MATH_1	16	20	PF00917	0.591
DOC_USP7_MATH_1	168	172	PF00917	0.630
DOC_USP7_MATH_1	211	215	PF00917	0.674
DOC_USP7_MATH_1	31	35	PF00917	0.587
DOC_USP7_MATH_1	342	346	PF00917	0.503
DOC_USP7_MATH_1	68	72	PF00917	0.664
DOC_USP7_MATH_1	74	78	PF00917	0.782
DOC_USP7_MATH_2	158	164	PF00917	0.627
DOC_USP7_UBL2_3	111	115	PF12436	0.567
DOC_WW_Pin1_4	207	212	PF00397	0.651
DOC_WW_Pin1_4	254	259	PF00397	0.760
DOC_WW_Pin1_4	289	294	PF00397	0.774
DOC_WW_Pin1_4	81	86	PF00397	0.622
LIG_14-3-3_CanoR_1	340	350	PF00244	0.453
LIG_14-3-3_CanoR_1	363	369	PF00244	0.480
LIG_BIR_III_2	208	212	PF00653	0.585
LIG_BIR_III_4	249	253	PF00653	0.595
LIG_FHA_1	255	261	PF00498	0.709
LIG_FHA_2	175	181	PF00498	0.580
LIG_FHA_2	274	280	PF00498	0.531
LIG_FHA_2	301	307	PF00498	0.619
LIG_FHA_2	85	91	PF00498	0.620
LIG_LIR_Gen_1	220	230	PF02991	0.527
LIG_LIR_Nem_3	145	151	PF02991	0.569
LIG_LIR_Nem_3	220	225	PF02991	0.515
LIG_LIR_Nem_3	367	372	PF02991	0.555
LIG_SH2_CRK	148	152	PF00017	0.505
LIG_SH2_STAP1	222	226	PF00017	0.511
LIG_SH2_STAP1	29	33	PF00017	0.572
LIG_SH2_STAT3	14	17	PF00017	0.643
LIG_SH2_STAT3	192	195	PF00017	0.503
LIG_SH2_STAT5	192	195	PF00017	0.503
LIG_SH3_3	3	9	PF00018	0.582
LIG_TRAF2_1	123	126	PF00917	0.628
MOD_CK1_1	127	133	PF00069	0.502
MOD_CK1_1	19	25	PF00069	0.569
MOD_CK1_1	207	213	PF00069	0.653
MOD_CK1_1	78	84	PF00069	0.602
MOD_CK2_1	174	180	PF00069	0.706
MOD_CK2_1	273	279	PF00069	0.533
MOD_CK2_1	300	306	PF00069	0.622
MOD_CK2_1	31	37	PF00069	0.509
MOD_GlcNHglycan	124	130	PF01048	0.613
MOD_GlcNHglycan	14	17	PF01048	0.651
MOD_GlcNHglycan	162	165	PF01048	0.616
MOD_GlcNHglycan	166	169	PF01048	0.631
MOD_GlcNHglycan	179	184	PF01048	0.486
MOD_GlcNHglycan	22	25	PF01048	0.569
MOD_GlcNHglycan	236	239	PF01048	0.667
MOD_GlcNHglycan	245	248	PF01048	0.562
MOD_GlcNHglycan	262	265	PF01048	0.676
MOD_GlcNHglycan	31	34	PF01048	0.564
MOD_GlcNHglycan	326	329	PF01048	0.469
MOD_GlcNHglycan	72	75	PF01048	0.799
MOD_GlcNHglycan	77	80	PF01048	0.595
MOD_GlcNHglycan	87	90	PF01048	0.516
MOD_GSK3_1	156	163	PF00069	0.560
MOD_GSK3_1	16	23	PF00069	0.592
MOD_GSK3_1	164	171	PF00069	0.607
MOD_GSK3_1	203	210	PF00069	0.640
MOD_GSK3_1	211	218	PF00069	0.648
MOD_GSK3_1	254	261	PF00069	0.698
MOD_GSK3_1	364	371	PF00069	0.485
MOD_GSK3_1	70	77	PF00069	0.607
MOD_GSK3_1	8	15	PF00069	0.644
MOD_GSK3_1	80	87	PF00069	0.651
MOD_N-GLC_1	174	179	PF02516	0.580
MOD_N-GLC_1	234	239	PF02516	0.672
MOD_NEK2_1	20	25	PF00069	0.587
MOD_NEK2_1	243	248	PF00069	0.642
MOD_NEK2_1	336	341	PF00069	0.468
MOD_NEK2_1	368	373	PF00069	0.514
MOD_NEK2_1	94	99	PF00069	0.499
MOD_NEK2_2	308	313	PF00069	0.557
MOD_PIKK_1	127	133	PF00454	0.502
MOD_PKA_2	156	162	PF00069	0.521
MOD_Plk_1	109	115	PF00069	0.513
MOD_Plk_1	284	290	PF00069	0.677
MOD_Plk_4	109	115	PF00069	0.510
MOD_Plk_4	31	37	PF00069	0.439
MOD_Plk_4	349	355	PF00069	0.614
MOD_Plk_4	364	370	PF00069	0.395
MOD_ProDKin_1	207	213	PF00069	0.648
MOD_ProDKin_1	254	260	PF00069	0.760
MOD_ProDKin_1	289	295	PF00069	0.775
MOD_ProDKin_1	81	87	PF00069	0.620
TRG_DiLeu_BaEn_1	279	284	PF01217	0.538
TRG_DiLeu_BaEn_2	138	144	PF01217	0.467
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.627
TRG_ENDOCYTIC_2	148	151	PF00928	0.450
TRG_ENDOCYTIC_2	222	225	PF00928	0.510
TRG_ER_diArg_1	104	106	PF00400	0.523
TRG_ER_diArg_1	39	41	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0S4	Leptomonas seymouri	39%	93%
A4HLB6	Leishmania braziliensis	65%	100%
A4I8U2	Leishmania infantum	100%	100%
E9B3Q8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q4C9	Leishmania major	83%	100%