Hypothetical_protein_conserved

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6J5_LEIDO

TriTrypDb:

LdBPK_331090.1 , LdCL_330017000 , LDHU3_33.1690

Length:

177

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 91, 92
Promastigote: 64, 69
Promastigote/Amastigote: 66, 67, 86, 87

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7X6J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6J5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.658
CLV_C14_Caspase3-7	87	91	PF00656	0.791
CLV_NRD_NRD_1	12	14	PF00675	0.655
CLV_PCSK_KEX2_1	12	14	PF00082	0.655
DOC_PP4_FxxP_1	143	146	PF00568	0.489
DOC_PP4_FxxP_1	150	153	PF00568	0.469
DOC_USP7_MATH_1	17	21	PF00917	0.671
DOC_USP7_MATH_1	22	26	PF00917	0.641
DOC_USP7_MATH_1	5	9	PF00917	0.702
DOC_WW_Pin1_4	128	133	PF00397	0.516
DOC_WW_Pin1_4	23	28	PF00397	0.771
DOC_WW_Pin1_4	61	66	PF00397	0.707
LIG_BRCT_BRCA1_1	146	150	PF00533	0.496
LIG_FHA_2	85	91	PF00498	0.792
LIG_LIR_Apic_2	139	145	PF02991	0.468
LIG_LIR_Apic_2	147	153	PF02991	0.486
LIG_LIR_Apic_2	156	161	PF02991	0.487
LIG_LIR_Nem_3	131	137	PF02991	0.492
LIG_PDZ_Class_3	172	177	PF00595	0.692
LIG_SH2_STAT5	135	138	PF00017	0.560
LIG_SH2_STAT5	142	145	PF00017	0.463
LIG_SH3_3	115	121	PF00018	0.604
LIG_SH3_3	43	49	PF00018	0.802
LIG_SH3_3	67	73	PF00018	0.729
MOD_CK1_1	20	26	PF00069	0.664
MOD_CK1_1	64	70	PF00069	0.674
MOD_CK2_1	169	175	PF00069	0.664
MOD_GlcNHglycan	13	16	PF01048	0.748
MOD_GlcNHglycan	19	22	PF01048	0.683
MOD_GlcNHglycan	3	6	PF01048	0.722
MOD_GlcNHglycan	30	33	PF01048	0.619
MOD_GlcNHglycan	73	76	PF01048	0.673
MOD_GSK3_1	1	8	PF00069	0.757
MOD_GSK3_1	84	91	PF00069	0.776
MOD_N-GLC_1	54	59	PF02516	0.677
MOD_N-GLC_1	61	66	PF02516	0.642
MOD_N-GLC_1	83	88	PF02516	0.622
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NMyristoyl	1	7	PF02799	0.675
MOD_PKA_2	11	17	PF00069	0.624
MOD_Plk_2-3	169	175	PF00069	0.675
MOD_ProDKin_1	128	134	PF00069	0.506
MOD_ProDKin_1	23	29	PF00069	0.773
MOD_ProDKin_1	61	67	PF00069	0.704
MOD_SPalmitoyl_4	1	7	PF01529	0.675
MOD_SUMO_for_1	126	129	PF00179	0.503
MOD_SUMO_rev_2	79	87	PF00179	0.735
TRG_ENDOCYTIC_2	134	137	PF00928	0.384
TRG_ER_diArg_1	11	13	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I074	Leptomonas seymouri	54%	100%
A4HLF7	Leishmania braziliensis	49%	100%
A4I8W8	Leishmania infantum	100%	100%
D0A4W3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B3T7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q487	Leishmania major	84%	100%