POT family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

POT family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6J4_LEIDO

TriTrypDb:

LdBPK_330760.1 , LdCL_330013100 , LDHU3_33.1070

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X6J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6J4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	10
GO:0022857	transmembrane transporter activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.697
CLV_PCSK_SKI1_1	114	118	PF00082	0.561
CLV_PCSK_SKI1_1	148	152	PF00082	0.419
CLV_PCSK_SKI1_1	232	236	PF00082	0.336
CLV_PCSK_SKI1_1	312	316	PF00082	0.304
DEG_APCC_DBOX_1	147	155	PF00400	0.639
DEG_MDM2_SWIB_1	472	480	PF02201	0.485
DEG_Nend_UBRbox_4	1	3	PF02207	0.697
DEG_SPOP_SBC_1	393	397	PF00917	0.508
DOC_AGCK_PIF_1	30	35	PF00069	0.444
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	543	549	PF00134	0.344
DOC_MAPK_gen_1	421	431	PF00069	0.561
DOC_MAPK_gen_1	572	580	PF00069	0.561
DOC_MAPK_MEF2A_6	312	320	PF00069	0.522
DOC_MAPK_MEF2A_6	424	431	PF00069	0.369
DOC_MAPK_NFAT4_5	424	432	PF00069	0.401
DOC_PP2B_LxvP_1	450	453	PF13499	0.331
DOC_PP2B_LxvP_1	454	457	PF13499	0.331
DOC_PP2B_LxvP_1	5	8	PF13499	0.616
DOC_PP2B_LxvP_1	543	546	PF13499	0.344
DOC_PP4_FxxP_1	255	258	PF00568	0.355
DOC_PP4_FxxP_1	556	559	PF00568	0.437
DOC_USP7_MATH_1	165	169	PF00917	0.718
DOC_USP7_MATH_1	393	397	PF00917	0.535
DOC_USP7_MATH_1	407	411	PF00917	0.398
DOC_WW_Pin1_4	593	598	PF00397	0.321
DOC_WW_Pin1_4	95	100	PF00397	0.527
LIG_14-3-3_CanoR_1	181	187	PF00244	0.653
LIG_14-3-3_CanoR_1	317	321	PF00244	0.536
LIG_14-3-3_CanoR_1	417	421	PF00244	0.600
LIG_14-3-3_CanoR_1	77	86	PF00244	0.488
LIG_Actin_WH2_2	25	43	PF00022	0.349
LIG_Actin_WH2_2	316	333	PF00022	0.539
LIG_BIR_III_4	405	409	PF00653	0.555
LIG_BRCT_BRCA1_1	235	239	PF00533	0.490
LIG_BRCT_BRCA1_1	618	622	PF00533	0.429
LIG_Clathr_ClatBox_1	14	18	PF01394	0.558
LIG_eIF4E_1	279	285	PF01652	0.331
LIG_eIF4E_1	86	92	PF01652	0.434
LIG_FHA_1	133	139	PF00498	0.524
LIG_FHA_1	178	184	PF00498	0.733
LIG_FHA_1	220	226	PF00498	0.551
LIG_FHA_1	35	41	PF00498	0.424
LIG_FHA_1	417	423	PF00498	0.517
LIG_FHA_1	466	472	PF00498	0.403
LIG_FHA_1	85	91	PF00498	0.405
LIG_FHA_1	96	102	PF00498	0.458
LIG_FHA_2	154	160	PF00498	0.723
LIG_FHA_2	215	221	PF00498	0.684
LIG_FHA_2	453	459	PF00498	0.398
LIG_FHA_2	558	564	PF00498	0.490
LIG_LIR_Apic_2	477	482	PF02991	0.557
LIG_LIR_Apic_2	554	559	PF02991	0.427
LIG_LIR_Gen_1	34	40	PF02991	0.366
LIG_LIR_Gen_1	458	469	PF02991	0.291
LIG_LIR_Gen_1	539	549	PF02991	0.302
LIG_LIR_Gen_1	9	20	PF02991	0.537
LIG_LIR_Nem_3	277	283	PF02991	0.290
LIG_LIR_Nem_3	34	38	PF02991	0.385
LIG_LIR_Nem_3	349	353	PF02991	0.490
LIG_LIR_Nem_3	458	464	PF02991	0.291
LIG_LIR_Nem_3	506	512	PF02991	0.369
LIG_LIR_Nem_3	588	593	PF02991	0.396
LIG_LIR_Nem_3	619	625	PF02991	0.338
LIG_LIR_Nem_3	9	15	PF02991	0.607
LIG_Pex14_2	472	476	PF04695	0.439
LIG_Pex14_2	552	556	PF04695	0.419
LIG_PTB_Apo_2	49	56	PF02174	0.344
LIG_PTB_Phospho_1	49	55	PF10480	0.344
LIG_SH2_CRK	281	285	PF00017	0.401
LIG_SH2_CRK	35	39	PF00017	0.401
LIG_SH2_CRK	487	491	PF00017	0.508
LIG_SH2_NCK_1	26	30	PF00017	0.444
LIG_SH2_PTP2	55	58	PF00017	0.444
LIG_SH2_STAP1	241	245	PF00017	0.405
LIG_SH2_STAP1	26	30	PF00017	0.444
LIG_SH2_STAP1	281	285	PF00017	0.437
LIG_SH2_STAP1	86	90	PF00017	0.397
LIG_SH2_STAT3	547	550	PF00017	0.344
LIG_SH2_STAT5	102	105	PF00017	0.412
LIG_SH2_STAT5	35	38	PF00017	0.344
LIG_SH2_STAT5	529	532	PF00017	0.313
LIG_SH2_STAT5	547	550	PF00017	0.217
LIG_SH2_STAT5	55	58	PF00017	0.155
LIG_SH2_STAT5	86	89	PF00017	0.444
LIG_SH3_3	591	597	PF00018	0.383
LIG_SH3_3	70	76	PF00018	0.603
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.444
LIG_SUMO_SIM_par_1	36	42	PF11976	0.472
LIG_SUMO_SIM_par_1	451	459	PF11976	0.266
LIG_TRFH_1	55	59	PF08558	0.369
LIG_TRFH_1	593	597	PF08558	0.408
LIG_TYR_ITIM	23	28	PF00017	0.424
LIG_TYR_ITIM	53	58	PF00017	0.424
LIG_WRC_WIRS_1	280	285	PF05994	0.437
LIG_WRC_WIRS_1	608	613	PF05994	0.485
MOD_CDK_SPxxK_3	593	600	PF00069	0.321
MOD_CK1_1	168	174	PF00069	0.613
MOD_CK1_1	31	37	PF00069	0.444
MOD_CK1_1	360	366	PF00069	0.537
MOD_CK1_1	383	389	PF00069	0.584
MOD_CK1_1	394	400	PF00069	0.518
MOD_CK1_1	516	522	PF00069	0.266
MOD_CK1_1	585	591	PF00069	0.344
MOD_CK1_1	610	616	PF00069	0.408
MOD_CK2_1	221	227	PF00069	0.567
MOD_CK2_1	452	458	PF00069	0.327
MOD_CK2_1	557	563	PF00069	0.344
MOD_CMANNOS	476	479	PF00535	0.357
MOD_GlcNHglycan	167	170	PF01048	0.412
MOD_GlcNHglycan	332	335	PF01048	0.343
MOD_GlcNHglycan	368	371	PF01048	0.340
MOD_GlcNHglycan	490	493	PF01048	0.391
MOD_GlcNHglycan	538	541	PF01048	0.506
MOD_GlcNHglycan	553	556	PF01048	0.266
MOD_GlcNHglycan	585	588	PF01048	0.351
MOD_GlcNHglycan	65	68	PF01048	0.376
MOD_GlcNHglycan	95	98	PF01048	0.480
MOD_GSK3_1	208	215	PF00069	0.754
MOD_GSK3_1	262	269	PF00069	0.322
MOD_GSK3_1	362	369	PF00069	0.499
MOD_GSK3_1	379	386	PF00069	0.519
MOD_GSK3_1	391	398	PF00069	0.531
MOD_GSK3_1	616	623	PF00069	0.404
MOD_NEK2_1	212	217	PF00069	0.686
MOD_NEK2_1	330	335	PF00069	0.551
MOD_NEK2_1	39	44	PF00069	0.332
MOD_NEK2_1	503	508	PF00069	0.334
MOD_NEK2_1	513	518	PF00069	0.309
MOD_NEK2_1	573	578	PF00069	0.546
MOD_NEK2_1	607	612	PF00069	0.357
MOD_NEK2_1	616	621	PF00069	0.309
MOD_NEK2_1	63	68	PF00069	0.432
MOD_NEK2_1	93	98	PF00069	0.379
MOD_NEK2_2	127	132	PF00069	0.444
MOD_NEK2_2	208	213	PF00069	0.699
MOD_NEK2_2	416	421	PF00069	0.561
MOD_PIKK_1	266	272	PF00454	0.238
MOD_PK_1	357	363	PF00069	0.536
MOD_PKA_2	266	272	PF00069	0.314
MOD_PKA_2	316	322	PF00069	0.587
MOD_PKA_2	330	336	PF00069	0.527
MOD_PKA_2	416	422	PF00069	0.561
MOD_PKB_1	486	494	PF00069	0.508
MOD_Plk_1	208	214	PF00069	0.768
MOD_Plk_1	383	389	PF00069	0.440
MOD_Plk_4	153	159	PF00069	0.723
MOD_Plk_4	208	214	PF00069	0.698
MOD_Plk_4	221	227	PF00069	0.563
MOD_Plk_4	279	285	PF00069	0.306
MOD_Plk_4	316	322	PF00069	0.510
MOD_Plk_4	34	40	PF00069	0.375
MOD_Plk_4	407	413	PF00069	0.508
MOD_Plk_4	465	471	PF00069	0.370
MOD_Plk_4	503	509	PF00069	0.390
MOD_Plk_4	557	563	PF00069	0.344
MOD_Plk_4	573	579	PF00069	0.490
MOD_Plk_4	616	622	PF00069	0.355
MOD_Plk_4	7	13	PF00069	0.635
MOD_Plk_4	86	92	PF00069	0.408
MOD_ProDKin_1	593	599	PF00069	0.321
MOD_ProDKin_1	95	101	PF00069	0.527
MOD_SUMO_rev_2	224	234	PF00179	0.438
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.343
TRG_ENDOCYTIC_2	102	105	PF00928	0.345
TRG_ENDOCYTIC_2	128	131	PF00928	0.344
TRG_ENDOCYTIC_2	25	28	PF00928	0.420
TRG_ENDOCYTIC_2	280	283	PF00928	0.344
TRG_ENDOCYTIC_2	298	301	PF00928	0.344
TRG_ENDOCYTIC_2	35	38	PF00928	0.369
TRG_ENDOCYTIC_2	432	435	PF00928	0.344
TRG_ENDOCYTIC_2	55	58	PF00928	0.155
TRG_ER_diArg_1	75	78	PF00400	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C4	Leptomonas seymouri	58%	96%
A0A1X0P0R8	Trypanosomatidae	40%	95%
A0A422P2J5	Trypanosoma rangeli	38%	99%
A4HLB1	Leishmania braziliensis	75%	100%
A4I8T7	Leishmania infantum	100%	100%
E9B3Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q4D4	Leishmania major	91%	100%
V5BPE7	Trypanosoma cruzi	38%	100%