Beta tubulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Beta tubulin

Gene product:

beta tubulin

Species:

Leishmania donovani

UniProt:

A0A3S7X6J0_LEIDO

TriTrypDb:

LdCL_330014400 , LDHU3_21.2650

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	4
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7X6J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6J0

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	4
GO:0009987	cellular process	1	4

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0003824	catalytic activity	1	4
GO:0003924	GTPase activity	7	4
GO:0005198	structural molecule activity	1	4
GO:0005200	structural constituent of cytoskeleton	2	4
GO:0005488	binding	1	4
GO:0005525	GTP binding	5	4
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0017076	purine nucleotide binding	4	4
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	4
GO:0019001	guanyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032561	guanyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.396
CLV_NRD_NRD_1	191	193	PF00675	0.410
CLV_NRD_NRD_1	51	53	PF00675	0.431
CLV_PCSK_KEX2_1	180	182	PF00082	0.396
CLV_PCSK_KEX2_1	191	193	PF00082	0.410
CLV_PCSK_SKI1_1	110	114	PF00082	0.396
CLV_PCSK_SKI1_1	14	18	PF00082	0.270
CLV_PCSK_SKI1_1	160	164	PF00082	0.285
CLV_PCSK_SKI1_1	192	196	PF00082	0.580
DEG_Nend_UBRbox_4	1	3	PF02207	0.331
DOC_CKS1_1	18	23	PF01111	0.277
DOC_CYCLIN_RxL_1	11	22	PF00134	0.263
DOC_MAPK_gen_1	160	168	PF00069	0.557
DOC_MAPK_gen_1	52	58	PF00069	0.397
DOC_MAPK_MEF2A_6	160	168	PF00069	0.557
DOC_PP1_RVXF_1	61	67	PF00149	0.326
DOC_USP7_MATH_1	32	36	PF00917	0.290
DOC_USP7_MATH_1	73	77	PF00917	0.460
DOC_WW_Pin1_4	17	22	PF00397	0.287
LIG_14-3-3_CanoR_1	110	118	PF00244	0.491
LIG_14-3-3_CanoR_1	119	127	PF00244	0.497
LIG_14-3-3_CanoR_1	83	88	PF00244	0.519
LIG_Actin_WH2_2	147	165	PF00022	0.596
LIG_Actin_WH2_2	4	19	PF00022	0.256
LIG_BRCT_BRCA1_1	114	118	PF00533	0.596
LIG_BRCT_BRCA1_1	138	142	PF00533	0.485
LIG_BRCT_BRCA1_1	164	168	PF00533	0.596
LIG_CAP-Gly_1	236	244	PF01302	0.771
LIG_FHA_1	122	128	PF00498	0.596
LIG_FHA_1	13	19	PF00498	0.299
LIG_FHA_1	36	42	PF00498	0.387
LIG_FHA_2	20	26	PF00498	0.267
LIG_FHA_2	208	214	PF00498	0.610
LIG_FHA_2	228	234	PF00498	0.358
LIG_LIR_Nem_3	10	16	PF02991	0.256
LIG_LIR_Nem_3	177	182	PF02991	0.596
LIG_LIR_Nem_3	20	26	PF02991	0.287
LIG_LIR_Nem_3	221	226	PF02991	0.596
LIG_LIR_Nem_3	79	85	PF02991	0.482
LIG_MLH1_MIPbox_1	138	142	PF16413	0.596
LIG_PCNA_yPIPBox_3	172	181	PF02747	0.596
LIG_Pex14_2	186	190	PF04695	0.558
LIG_Pex14_2	67	71	PF04695	0.480
LIG_SH2_CRK	82	86	PF00017	0.519
LIG_SH2_SRC	226	229	PF00017	0.603
LIG_SH2_STAP1	9	13	PF00017	0.245
LIG_SH2_STAT5	111	114	PF00017	0.546
LIG_SH2_STAT5	141	144	PF00017	0.596
LIG_SH2_STAT5	199	202	PF00017	0.445
LIG_SH3_3	56	62	PF00018	0.403
LIG_TRAF2_1	230	233	PF00917	0.706
MOD_CK1_1	35	41	PF00069	0.397
MOD_CK1_1	76	82	PF00069	0.460
MOD_CK2_1	120	126	PF00069	0.596
MOD_CK2_1	207	213	PF00069	0.612
MOD_CK2_1	227	233	PF00069	0.341
MOD_CK2_1	83	89	PF00069	0.519
MOD_GlcNHglycan	114	117	PF01048	0.396
MOD_GlcNHglycan	34	37	PF01048	0.371
MOD_GSK3_1	12	19	PF00069	0.267
MOD_GSK3_1	207	214	PF00069	0.612
MOD_GSK3_1	72	79	PF00069	0.473
MOD_LATS_1	108	114	PF00433	0.596
MOD_N-GLC_1	137	142	PF02516	0.396
MOD_N-GLC_1	170	175	PF02516	0.396
MOD_N-GLC_2	172	174	PF02516	0.396
MOD_NEK2_1	112	117	PF00069	0.596
MOD_NEK2_1	16	21	PF00069	0.271
MOD_NEK2_1	162	167	PF00069	0.596
MOD_NEK2_2	12	17	PF00069	0.279
MOD_PIKK_1	76	82	PF00454	0.519
MOD_PIKK_1	88	94	PF00454	0.426
MOD_PK_1	83	89	PF00069	0.519
MOD_PKA_2	120	126	PF00069	0.596
MOD_PKA_2	76	82	PF00069	0.519
MOD_PKB_1	119	127	PF00069	0.596
MOD_Plk_1	137	143	PF00069	0.596
MOD_Plk_1	170	176	PF00069	0.596
MOD_Plk_1	227	233	PF00069	0.664
MOD_Plk_4	137	143	PF00069	0.596
MOD_Plk_4	164	170	PF00069	0.596
MOD_ProDKin_1	17	23	PF00069	0.290
TRG_ENDOCYTIC_2	82	85	PF00928	0.519
TRG_ER_diArg_1	118	121	PF00400	0.596
TRG_ER_diArg_1	179	181	PF00400	0.596
TRG_ER_diArg_1	190	192	PF00400	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IVQ1	Bodo saltans	31%	100%
A0A0S4KMQ2	Bodo saltans	35%	100%
A0AAL4	Dictyostelium purpureum	35%	73%
A4HHS1	Leishmania braziliensis	34%	100%
A4HLD1	Leishmania braziliensis	100%	100%
A4HLD6	Leishmania braziliensis	100%	100%
C9ZIG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZIG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	81%
P09642	Gallus gallus	36%	76%
P09643	Gallus gallus	37%	76%
P09645	Gallus gallus	36%	75%
P18700	Strongylocentrotus purpuratus	87%	84%
P20364	Daucus carota	86%	77%
P24635	Octopus vulgaris	36%	100%
P33624	Anemia phyllitidis	38%	67%
P33632	Anemia phyllitidis	85%	100%
P41386	Haliotis discus	86%	72%
P86221	Mesocricetus auratus	59%	84%
Q07972	Pneumocystis carinii	39%	100%