Paraflagellar_rod_component_putative/GeneDB:LmjF. 33.0610

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6I1_LEIDO

TriTrypDb:

LdBPK_330660.1 , LdCL_330012100 , LDHU3_33.0950

Length:

168

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 10
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 28
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	3
GO:0031514	motile cilium	5	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

A0A3S7X6I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6I1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	158	162	PF00082	0.384
DEG_Nend_Nbox_1	1	3	PF02207	0.415
DEG_SPOP_SBC_1	140	144	PF00917	0.355
DEG_SPOP_SBC_1	77	81	PF00917	0.396
DOC_MAPK_gen_1	5	12	PF00069	0.426
DOC_PP1_RVXF_1	156	162	PF00149	0.371
DOC_PP2B_PxIxI_1	55	61	PF00149	0.348
DOC_PP4_FxxP_1	53	56	PF00568	0.364
DOC_USP7_MATH_1	140	144	PF00917	0.492
DOC_USP7_MATH_1	26	30	PF00917	0.447
DOC_USP7_UBL2_3	30	34	PF12436	0.412
DOC_WW_Pin1_4	14	19	PF00397	0.440
LIG_14-3-3_CanoR_1	5	11	PF00244	0.415
LIG_FHA_1	7	13	PF00498	0.443
LIG_FHA_1	81	87	PF00498	0.535
LIG_LIR_Apic_2	52	56	PF02991	0.353
LIG_LIR_Gen_1	107	116	PF02991	0.451
LIG_LIR_Gen_1	130	140	PF02991	0.348
LIG_LIR_Gen_1	29	39	PF02991	0.412
LIG_LIR_Nem_3	107	113	PF02991	0.466
LIG_LIR_Nem_3	130	136	PF02991	0.404
LIG_LIR_Nem_3	155	160	PF02991	0.424
LIG_LIR_Nem_3	29	35	PF02991	0.419
LIG_NRBOX	118	124	PF00104	0.355
LIG_PTB_Apo_2	47	54	PF02174	0.394
LIG_REV1ctd_RIR_1	158	167	PF16727	0.428
LIG_SH2_PTP2	32	35	PF00017	0.413
LIG_SH2_STAT5	32	35	PF00017	0.467
LIG_SH2_STAT5	95	98	PF00017	0.436
LIG_SUMO_SIM_anti_2	117	123	PF11976	0.360
LIG_SUMO_SIM_par_1	119	125	PF11976	0.407
LIG_SUMO_SIM_par_1	8	14	PF11976	0.435
LIG_TRAF2_1	126	129	PF00917	0.423
LIG_TRAF2_1	63	66	PF00917	0.485
MOD_CDC14_SPxK_1	17	20	PF00782	0.422
MOD_CDK_SPxK_1	14	20	PF00069	0.423
MOD_CK1_1	138	144	PF00069	0.457
MOD_CK1_1	79	85	PF00069	0.491
MOD_CK2_1	64	70	PF00069	0.504
MOD_GSK3_1	1	8	PF00069	0.441
MOD_GSK3_1	10	17	PF00069	0.473
MOD_GSK3_1	131	138	PF00069	0.447
MOD_GSK3_1	37	44	PF00069	0.602
MOD_GSK3_1	76	83	PF00069	0.419
MOD_N-GLC_1	49	54	PF02516	0.357
MOD_NEK2_1	1	6	PF00069	0.425
MOD_NEK2_1	10	15	PF00069	0.419
MOD_NEK2_1	135	140	PF00069	0.466
MOD_NEK2_1	159	164	PF00069	0.512
MOD_NEK2_1	41	46	PF00069	0.438
MOD_PIKK_1	135	141	PF00454	0.528
MOD_PKA_2	6	12	PF00069	0.411
MOD_Plk_1	49	55	PF00069	0.334
MOD_Plk_1	65	71	PF00069	0.419
MOD_Plk_4	6	12	PF00069	0.411
MOD_ProDKin_1	14	20	PF00069	0.439
MOD_SUMO_for_1	91	94	PF00179	0.537
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.260
TRG_ENDOCYTIC_2	157	160	PF00928	0.477
TRG_ENDOCYTIC_2	32	35	PF00928	0.413
TRG_NES_CRM1_1	112	125	PF08389	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C7	Leptomonas seymouri	82%	100%
A0A0N1HW96	Leptomonas seymouri	33%	100%
A0A0N1IHI7	Leptomonas seymouri	41%	100%
A0A0S4IPF2	Bodo saltans	36%	100%
A0A0S4IRP9	Bodo saltans	42%	100%
A0A0S4JBB4	Bodo saltans	35%	100%
A0A1X0P0Q8	Trypanosomatidae	56%	100%
A0A1X0P760	Trypanosomatidae	42%	100%
A0A3Q8IB96	Leishmania donovani	39%	97%
A0A3R7K0R9	Trypanosoma rangeli	33%	100%
A0A3S7X3W3	Leishmania donovani	40%	100%
A0A422N867	Trypanosoma rangeli	50%	100%
A0A422NFX4	Trypanosoma rangeli	32%	100%
A4H9R6	Leishmania braziliensis	38%	98%
A4HIL9	Leishmania braziliensis	36%	100%
A4HLA1	Leishmania braziliensis	82%	100%
A4HY35	Leishmania infantum	39%	97%
A4I5W4	Leishmania infantum	40%	100%
A4I8S7	Leishmania infantum	100%	100%
D0A4S3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ARU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	99%
E9B159	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B3P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4Q4E4	Leishmania major	88%	100%
Q4Q707	Leishmania major	40%	100%
Q4QDM4	Leishmania major	39%	98%
V5BMX8	Trypanosoma cruzi	35%	100%