Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6H6_LEIDO

TriTrypDb:

LdBPK_330920.1 , LdCL_330015300 , LDHU3_33.1450

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7X6H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6H6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.759
CLV_NRD_NRD_1	174	176	PF00675	0.443
CLV_NRD_NRD_1	214	216	PF00675	0.728
CLV_NRD_NRD_1	256	258	PF00675	0.541
CLV_NRD_NRD_1	46	48	PF00675	0.470
CLV_NRD_NRD_1	79	81	PF00675	0.452
CLV_PCSK_KEX2_1	174	176	PF00082	0.443
CLV_PCSK_KEX2_1	214	216	PF00082	0.728
CLV_PCSK_KEX2_1	256	258	PF00082	0.610
CLV_PCSK_KEX2_1	45	47	PF00082	0.488
CLV_PCSK_KEX2_1	79	81	PF00082	0.452
CLV_PCSK_SKI1_1	196	200	PF00082	0.530
CLV_PCSK_SKI1_1	60	64	PF00082	0.383
CLV_PCSK_SKI1_1	79	83	PF00082	0.436
DEG_APCC_DBOX_1	213	221	PF00400	0.534
DEG_SPOP_SBC_1	285	289	PF00917	0.748
DOC_CDC14_PxL_1	244	252	PF14671	0.452
DOC_CYCLIN_RxL_1	193	203	PF00134	0.525
DOC_CYCLIN_RxL_1	44	54	PF00134	0.631
DOC_CYCLIN_RxL_1	74	87	PF00134	0.712
DOC_MAPK_gen_1	121	131	PF00069	0.723
DOC_MAPK_gen_1	174	180	PF00069	0.634
DOC_MAPK_gen_1	214	220	PF00069	0.575
DOC_MAPK_gen_1	45	51	PF00069	0.594
DOC_MAPK_gen_1	76	84	PF00069	0.709
DOC_PP2B_LxvP_1	251	254	PF13499	0.521
DOC_PP4_FxxP_1	119	122	PF00568	0.718
DOC_USP7_MATH_1	286	290	PF00917	0.698
DOC_WW_Pin1_4	1	6	PF00397	0.462
DOC_WW_Pin1_4	104	109	PF00397	0.712
DOC_WW_Pin1_4	156	161	PF00397	0.744
LIG_14-3-3_CanoR_1	188	198	PF00244	0.642
LIG_14-3-3_CanoR_1	256	261	PF00244	0.688
LIG_14-3-3_CanoR_1	95	99	PF00244	0.651
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_eIF4E_1	12	18	PF01652	0.380
LIG_eIF4E_1	246	252	PF01652	0.316
LIG_eIF4E_1	330	336	PF01652	0.530
LIG_eIF4E_1	72	78	PF01652	0.624
LIG_FHA_1	190	196	PF00498	0.667
LIG_FHA_1	2	8	PF00498	0.529
LIG_FHA_1	22	28	PF00498	0.530
LIG_FHA_1	66	72	PF00498	0.737
LIG_GBD_Chelix_1	327	335	PF00786	0.452
LIG_LIR_Apic_2	117	122	PF02991	0.712
LIG_LIR_Gen_1	227	238	PF02991	0.551
LIG_LIR_Gen_1	291	300	PF02991	0.744
LIG_LIR_Nem_3	227	233	PF02991	0.556
LIG_LIR_Nem_3	24	29	PF02991	0.516
LIG_LIR_Nem_3	291	296	PF02991	0.690
LIG_Pex14_2	115	119	PF04695	0.700
LIG_SH2_GRB2like	12	15	PF00017	0.509
LIG_SH2_SRC	246	249	PF00017	0.452
LIG_SH2_SRC	334	337	PF00017	0.530
LIG_SH2_SRC	72	75	PF00017	0.653
LIG_SH2_STAP1	168	172	PF00017	0.683
LIG_SH2_STAP1	29	33	PF00017	0.530
LIG_SH2_STAP1	98	102	PF00017	0.753
LIG_SH2_STAT5	12	15	PF00017	0.433
LIG_SH2_STAT5	197	200	PF00017	0.530
LIG_SH2_STAT5	209	212	PF00017	0.331
LIG_SH2_STAT5	230	233	PF00017	0.564
LIG_SH2_STAT5	246	249	PF00017	0.216
LIG_SH2_STAT5	330	333	PF00017	0.530
LIG_SH2_STAT5	334	337	PF00017	0.464
LIG_SH2_STAT5	42	45	PF00017	0.593
LIG_SH3_3	102	108	PF00018	0.712
LIG_SH3_3	232	238	PF00018	0.435
LIG_SUMO_SIM_anti_2	203	209	PF11976	0.393
LIG_TRAF2_1	223	226	PF00917	0.486
LIG_TRAF2_2	308	313	PF00917	0.737
LIG_TYR_ITIM	228	233	PF00017	0.639
MOD_CDC14_SPxK_1	159	162	PF00782	0.585
MOD_CDK_SPxK_1	156	162	PF00069	0.588
MOD_CK1_1	111	117	PF00069	0.635
MOD_CK1_1	158	164	PF00069	0.631
MOD_CK1_1	288	294	PF00069	0.749
MOD_CK1_1	298	304	PF00069	0.525
MOD_CK2_1	220	226	PF00069	0.647
MOD_CK2_1	256	262	PF00069	0.617
MOD_CK2_1	276	282	PF00069	0.698
MOD_DYRK1A_RPxSP_1	104	108	PF00069	0.636
MOD_GlcNHglycan	110	113	PF01048	0.571
MOD_GlcNHglycan	167	171	PF01048	0.566
MOD_GlcNHglycan	181	184	PF01048	0.630
MOD_GlcNHglycan	202	205	PF01048	0.375
MOD_GlcNHglycan	288	291	PF01048	0.743
MOD_GlcNHglycan	298	301	PF01048	0.516
MOD_GSK3_1	104	111	PF00069	0.526
MOD_GSK3_1	150	157	PF00069	0.647
MOD_GSK3_1	220	227	PF00069	0.590
MOD_GSK3_1	256	263	PF00069	0.629
MOD_GSK3_1	284	291	PF00069	0.639
MOD_GSK3_1	292	299	PF00069	0.712
MOD_GSK3_1	94	101	PF00069	0.571
MOD_N-GLC_1	189	194	PF02516	0.574
MOD_NEK2_1	151	156	PF00069	0.790
MOD_NEK2_1	179	184	PF00069	0.631
MOD_NEK2_1	224	229	PF00069	0.662
MOD_NEK2_1	260	265	PF00069	0.733
MOD_NEK2_2	191	196	PF00069	0.554
MOD_NEK2_2	29	34	PF00069	0.530
MOD_PKA_1	256	262	PF00069	0.701
MOD_PKA_2	120	126	PF00069	0.761
MOD_PKA_2	256	262	PF00069	0.756
MOD_PKA_2	94	100	PF00069	0.518
MOD_Plk_1	224	230	PF00069	0.613
MOD_Plk_1	35	41	PF00069	0.656
MOD_Plk_1	72	78	PF00069	0.511
MOD_Plk_1	98	104	PF00069	0.608
MOD_Plk_4	114	120	PF00069	0.604
MOD_Plk_4	22	28	PF00069	0.369
MOD_Plk_4	256	262	PF00069	0.713
MOD_Plk_4	29	35	PF00069	0.369
MOD_Plk_4	321	327	PF00069	0.530
MOD_ProDKin_1	1	7	PF00069	0.567
MOD_ProDKin_1	104	110	PF00069	0.638
MOD_ProDKin_1	156	162	PF00069	0.686
MOD_SUMO_rev_2	57	65	PF00179	0.466
TRG_DiLeu_BaEn_1	73	78	PF01217	0.490
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.597
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.530
TRG_ENDOCYTIC_2	230	233	PF00928	0.632
TRG_ENDOCYTIC_2	334	337	PF00928	0.530
TRG_ER_diArg_1	173	175	PF00400	0.539
TRG_ER_diArg_1	44	47	PF00400	0.504
TRG_ER_diArg_1	78	80	PF00400	0.567
TRG_ER_diArg_1	82	85	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	47	52	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HLE2	Leishmania braziliensis	62%	99%
A4I8V1	Leishmania infantum	99%	100%
E9B3S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q4A4	Leishmania major	84%	100%