Scaffold protein Nfu/NifU N terminal/NifU-like domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Scaffold protein Nfu/NifU N terminal/NifU-like domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6H5_LEIDO

TriTrypDb:

LdBPK_330560.1 , LdCL_330011100 , LDHU3_33.0840

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X6H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6H5

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0016226	iron-sulfur cluster assembly	4	10
GO:0022607	cellular component assembly	4	10
GO:0031163	metallo-sulfur cluster assembly	5	10
GO:0044237	cellular metabolic process	2	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005506	iron ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0051536	iron-sulfur cluster binding	3	10
GO:0051540	metal cluster binding	2	10
GO:0051539	4 iron, 4 sulfur cluster binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.524
CLV_NRD_NRD_1	427	429	PF00675	0.632
CLV_NRD_NRD_1	44	46	PF00675	0.632
CLV_NRD_NRD_1	9	11	PF00675	0.572
CLV_PCSK_KEX2_1	135	137	PF00082	0.290
CLV_PCSK_KEX2_1	44	46	PF00082	0.632
CLV_PCSK_KEX2_1	9	11	PF00082	0.567
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.360
CLV_PCSK_SKI1_1	67	71	PF00082	0.465
DEG_Nend_UBRbox_1	1	4	PF02207	0.510
DOC_CKS1_1	74	79	PF01111	0.344
DOC_MAPK_gen_1	330	339	PF00069	0.530
DOC_MAPK_MEF2A_6	24	32	PF00069	0.575
DOC_MAPK_RevD_3	120	136	PF00069	0.284
DOC_PP1_RVXF_1	305	312	PF00149	0.490
DOC_PP4_FxxP_1	91	94	PF00568	0.400
DOC_USP7_MATH_1	168	172	PF00917	0.476
DOC_USP7_MATH_1	231	235	PF00917	0.566
DOC_USP7_MATH_1	349	353	PF00917	0.597
DOC_USP7_MATH_1	369	373	PF00917	0.481
DOC_USP7_MATH_2	276	282	PF00917	0.502
DOC_USP7_UBL2_3	425	429	PF12436	0.594
DOC_WW_Pin1_4	106	111	PF00397	0.284
DOC_WW_Pin1_4	202	207	PF00397	0.758
DOC_WW_Pin1_4	216	221	PF00397	0.680
DOC_WW_Pin1_4	382	387	PF00397	0.627
DOC_WW_Pin1_4	396	401	PF00397	0.774
DOC_WW_Pin1_4	406	411	PF00397	0.690
DOC_WW_Pin1_4	73	78	PF00397	0.293
LIG_14-3-3_CanoR_1	327	337	PF00244	0.449
LIG_14-3-3_CanoR_1	359	367	PF00244	0.597
LIG_14-3-3_CanoR_1	4	9	PF00244	0.728
LIG_14-3-3_CanoR_1	50	59	PF00244	0.716
LIG_FHA_1	1	7	PF00498	0.504
LIG_FHA_1	127	133	PF00498	0.312
LIG_FHA_1	251	257	PF00498	0.398
LIG_FHA_1	332	338	PF00498	0.528
LIG_FHA_1	386	392	PF00498	0.783
LIG_FHA_2	112	118	PF00498	0.397
LIG_FHA_2	160	166	PF00498	0.533
LIG_FHA_2	186	192	PF00498	0.657
LIG_FHA_2	272	278	PF00498	0.615
LIG_FHA_2	333	339	PF00498	0.432
LIG_FHA_2	74	80	PF00498	0.284
LIG_GBD_Chelix_1	111	119	PF00786	0.284
LIG_LIR_Apic_2	104	110	PF02991	0.308
LIG_LIR_Apic_2	88	94	PF02991	0.379
LIG_LIR_Gen_1	129	137	PF02991	0.347
LIG_LIR_Gen_1	238	248	PF02991	0.422
LIG_LIR_Gen_1	361	369	PF02991	0.549
LIG_LIR_Nem_3	129	134	PF02991	0.347
LIG_LIR_Nem_3	238	244	PF02991	0.406
LIG_LIR_Nem_3	305	311	PF02991	0.447
LIG_LIR_Nem_3	361	367	PF02991	0.546
LIG_LIR_Nem_3	421	427	PF02991	0.680
LIG_LIR_Nem_3	79	85	PF02991	0.312
LIG_MYND_1	202	206	PF01753	0.594
LIG_PTAP_UEV_1	264	269	PF05743	0.506
LIG_SH2_CRK	424	428	PF00017	0.684
LIG_SH2_PTP2	107	110	PF00017	0.227
LIG_SH2_STAT5	107	110	PF00017	0.360
LIG_SH2_STAT5	148	151	PF00017	0.490
LIG_SH2_STAT5	85	88	PF00017	0.386
LIG_SH3_3	200	206	PF00018	0.576
LIG_SH3_3	262	268	PF00018	0.519
LIG_SH3_3	34	40	PF00018	0.667
LIG_SUMO_SIM_anti_2	280	287	PF11976	0.422
LIG_SUMO_SIM_anti_2	334	341	PF11976	0.507
LIG_SUMO_SIM_par_1	280	289	PF11976	0.420
LIG_SUMO_SIM_par_1	334	341	PF11976	0.523
LIG_TRAF2_1	162	165	PF00917	0.585
MOD_CK1_1	103	109	PF00069	0.329
MOD_CK1_1	130	136	PF00069	0.400
MOD_CK1_1	219	225	PF00069	0.695
MOD_CK1_1	331	337	PF00069	0.432
MOD_CK1_1	358	364	PF00069	0.616
MOD_CK1_1	385	391	PF00069	0.658
MOD_CK1_1	411	417	PF00069	0.595
MOD_CK1_1	49	55	PF00069	0.574
MOD_CK1_1	57	63	PF00069	0.655
MOD_CK2_1	111	117	PF00069	0.397
MOD_CK2_1	159	165	PF00069	0.533
MOD_CK2_1	185	191	PF00069	0.578
MOD_CK2_1	219	225	PF00069	0.556
MOD_CK2_1	271	277	PF00069	0.562
MOD_CK2_1	359	365	PF00069	0.634
MOD_CK2_1	431	437	PF00069	0.664
MOD_GlcNHglycan	248	251	PF01048	0.395
MOD_GlcNHglycan	257	260	PF01048	0.434
MOD_GlcNHglycan	264	268	PF01048	0.497
MOD_GlcNHglycan	350	354	PF01048	0.273
MOD_GlcNHglycan	361	364	PF01048	0.461
MOD_GlcNHglycan	415	418	PF01048	0.769
MOD_GlcNHglycan	420	423	PF01048	0.715
MOD_GlcNHglycan	433	436	PF01048	0.502
MOD_GlcNHglycan	442	445	PF01048	0.674
MOD_GSK3_1	123	130	PF00069	0.428
MOD_GSK3_1	214	221	PF00069	0.620
MOD_GSK3_1	246	253	PF00069	0.555
MOD_GSK3_1	325	332	PF00069	0.457
MOD_GSK3_1	355	362	PF00069	0.577
MOD_GSK3_1	381	388	PF00069	0.657
MOD_GSK3_1	402	409	PF00069	0.698
MOD_GSK3_1	46	53	PF00069	0.652
MOD_N-GLC_1	101	106	PF02516	0.336
MOD_N-GLC_1	402	407	PF02516	0.512
MOD_NEK2_1	101	106	PF00069	0.346
MOD_NEK2_1	111	116	PF00069	0.353
MOD_NEK2_1	246	251	PF00069	0.447
MOD_NEK2_1	290	295	PF00069	0.447
MOD_NEK2_2	325	330	PF00069	0.490
MOD_PIKK_1	168	174	PF00454	0.585
MOD_PIKK_1	219	225	PF00454	0.687
MOD_PKA_2	341	347	PF00069	0.459
MOD_PKA_2	358	364	PF00069	0.467
MOD_PKA_2	49	55	PF00069	0.657
MOD_PKB_1	2	10	PF00069	0.540
MOD_Plk_1	123	129	PF00069	0.289
MOD_Plk_1	349	355	PF00069	0.598
MOD_Plk_4	103	109	PF00069	0.400
MOD_Plk_4	111	117	PF00069	0.313
MOD_Plk_4	127	133	PF00069	0.442
MOD_Plk_4	231	237	PF00069	0.524
MOD_Plk_4	332	338	PF00069	0.530
MOD_Plk_4	54	60	PF00069	0.651
MOD_Plk_4	95	101	PF00069	0.400
MOD_ProDKin_1	106	112	PF00069	0.284
MOD_ProDKin_1	202	208	PF00069	0.756
MOD_ProDKin_1	216	222	PF00069	0.681
MOD_ProDKin_1	382	388	PF00069	0.627
MOD_ProDKin_1	396	402	PF00069	0.773
MOD_ProDKin_1	406	412	PF00069	0.687
MOD_ProDKin_1	73	79	PF00069	0.293
MOD_SUMO_rev_2	238	246	PF00179	0.381
TRG_ENDOCYTIC_2	148	151	PF00928	0.425
TRG_ENDOCYTIC_2	424	427	PF00928	0.680
TRG_ER_diArg_1	1	4	PF00400	0.568
TRG_ER_diArg_1	43	45	PF00400	0.627
TRG_ER_diArg_1	8	10	PF00400	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M8	Leptomonas seymouri	63%	95%
A0A0S4J2M4	Bodo saltans	40%	99%
A4HL91	Leishmania braziliensis	75%	100%
A4I8R7	Leishmania infantum	100%	100%
D0A4Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B3N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4F4	Leishmania major	92%	100%
V5B2F6	Trypanosoma cruzi	52%	99%