Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X6H4_LEIDO

TriTrypDb:

LdBPK_330890.1 , LdCL_330015000 , LDHU3_33.1420

Length:

916

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6H4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.736
CLV_C14_Caspase3-7	405	409	PF00656	0.635
CLV_C14_Caspase3-7	574	578	PF00656	0.778
CLV_C14_Caspase3-7	584	588	PF00656	0.481
CLV_NRD_NRD_1	11	13	PF00675	0.636
CLV_NRD_NRD_1	160	162	PF00675	0.749
CLV_NRD_NRD_1	171	173	PF00675	0.645
CLV_NRD_NRD_1	322	324	PF00675	0.542
CLV_NRD_NRD_1	4	6	PF00675	0.676
CLV_NRD_NRD_1	412	414	PF00675	0.683
CLV_NRD_NRD_1	442	444	PF00675	0.734
CLV_NRD_NRD_1	466	468	PF00675	0.663
CLV_NRD_NRD_1	47	49	PF00675	0.593
CLV_NRD_NRD_1	774	776	PF00675	0.722
CLV_NRD_NRD_1	783	785	PF00675	0.785
CLV_PCSK_FUR_1	45	49	PF00082	0.594
CLV_PCSK_KEX2_1	11	13	PF00082	0.636
CLV_PCSK_KEX2_1	160	162	PF00082	0.741
CLV_PCSK_KEX2_1	171	173	PF00082	0.597
CLV_PCSK_KEX2_1	322	324	PF00082	0.538
CLV_PCSK_KEX2_1	4	6	PF00082	0.676
CLV_PCSK_KEX2_1	441	443	PF00082	0.734
CLV_PCSK_KEX2_1	47	49	PF00082	0.593
CLV_PCSK_KEX2_1	783	785	PF00082	0.790
CLV_PCSK_SKI1_1	445	449	PF00082	0.703
CLV_PCSK_SKI1_1	809	813	PF00082	0.694
CLV_PCSK_SKI1_1	820	824	PF00082	0.541
CLV_PCSK_SKI1_1	836	840	PF00082	0.470
CLV_PCSK_SKI1_1	875	879	PF00082	0.608
DEG_APCC_DBOX_1	808	816	PF00400	0.694
DEG_Nend_Nbox_1	1	3	PF02207	0.691
DEG_SCF_FBW7_1	300	307	PF00400	0.547
DEG_SCF_FBW7_1	482	489	PF00400	0.732
DEG_SCF_FBW7_1	897	903	PF00400	0.773
DEG_SPOP_SBC_1	547	551	PF00917	0.703
DEG_SPOP_SBC_1	581	585	PF00917	0.681
DOC_CDC14_PxL_1	153	161	PF14671	0.733
DOC_CKS1_1	301	306	PF01111	0.499
DOC_CKS1_1	824	829	PF01111	0.734
DOC_CKS1_1	897	902	PF01111	0.680
DOC_CYCLIN_yCln2_LP_2	695	701	PF00134	0.702
DOC_CYCLIN_yCln2_LP_2	824	830	PF00134	0.691
DOC_MAPK_DCC_7	322	331	PF00069	0.382
DOC_MAPK_DCC_7	689	697	PF00069	0.634
DOC_MAPK_gen_1	11	18	PF00069	0.584
DOC_MAPK_gen_1	319	329	PF00069	0.513
DOC_MAPK_gen_1	423	432	PF00069	0.776
DOC_MAPK_HePTP_8	215	227	PF00069	0.508
DOC_MAPK_MEF2A_6	146	153	PF00069	0.469
DOC_MAPK_MEF2A_6	218	227	PF00069	0.514
DOC_MAPK_MEF2A_6	322	331	PF00069	0.382
DOC_MAPK_MEF2A_6	689	697	PF00069	0.634
DOC_PP1_RVXF_1	251	258	PF00149	0.490
DOC_PP2B_LxvP_1	227	230	PF13499	0.457
DOC_PP2B_LxvP_1	500	503	PF13499	0.762
DOC_PP2B_LxvP_1	695	698	PF13499	0.698
DOC_PP2B_LxvP_1	895	898	PF13499	0.695
DOC_PP4_FxxP_1	177	180	PF00568	0.705
DOC_PP4_FxxP_1	257	260	PF00568	0.482
DOC_PP4_FxxP_1	721	724	PF00568	0.664
DOC_USP7_MATH_1	109	113	PF00917	0.614
DOC_USP7_MATH_1	173	177	PF00917	0.725
DOC_USP7_MATH_1	270	274	PF00917	0.780
DOC_USP7_MATH_1	3	7	PF00917	0.670
DOC_USP7_MATH_1	392	396	PF00917	0.682
DOC_USP7_MATH_1	398	402	PF00917	0.767
DOC_USP7_MATH_1	449	453	PF00917	0.702
DOC_USP7_MATH_1	486	490	PF00917	0.630
DOC_USP7_MATH_1	548	552	PF00917	0.683
DOC_USP7_MATH_1	702	706	PF00917	0.727
DOC_USP7_MATH_1	796	800	PF00917	0.699
DOC_WW_Pin1_4	130	135	PF00397	0.668
DOC_WW_Pin1_4	300	305	PF00397	0.460
DOC_WW_Pin1_4	382	387	PF00397	0.790
DOC_WW_Pin1_4	445	450	PF00397	0.704
DOC_WW_Pin1_4	470	475	PF00397	0.727
DOC_WW_Pin1_4	482	487	PF00397	0.763
DOC_WW_Pin1_4	543	548	PF00397	0.751
DOC_WW_Pin1_4	603	608	PF00397	0.675
DOC_WW_Pin1_4	688	693	PF00397	0.556
DOC_WW_Pin1_4	823	828	PF00397	0.745
DOC_WW_Pin1_4	896	901	PF00397	0.617
LIG_14-3-3_CanoR_1	160	170	PF00244	0.673
LIG_14-3-3_CanoR_1	171	180	PF00244	0.503
LIG_14-3-3_CanoR_1	232	240	PF00244	0.400
LIG_14-3-3_CanoR_1	253	258	PF00244	0.487
LIG_14-3-3_CanoR_1	399	403	PF00244	0.672
LIG_14-3-3_CanoR_1	523	533	PF00244	0.768
LIG_14-3-3_CanoR_1	57	65	PF00244	0.661
LIG_14-3-3_CterR_2	912	916	PF00244	0.581
LIG_Actin_WH2_2	700	718	PF00022	0.733
LIG_APCC_ABBA_1	145	150	PF00400	0.506
LIG_APCC_ABBA_1	813	818	PF00400	0.674
LIG_BIR_III_2	501	505	PF00653	0.726
LIG_BIR_III_4	577	581	PF00653	0.580
LIG_BRCT_BRCA1_1	235	239	PF00533	0.449
LIG_BRCT_BRCA1_1	253	257	PF00533	0.487
LIG_BRCT_BRCA1_1	834	838	PF00533	0.718
LIG_CSL_BTD_1	738	741	PF09270	0.655
LIG_deltaCOP1_diTrp_1	250	257	PF00928	0.591
LIG_FHA_1	229	235	PF00498	0.465
LIG_FHA_1	260	266	PF00498	0.630
LIG_FHA_1	897	903	PF00498	0.622
LIG_FHA_2	131	137	PF00498	0.622
LIG_FHA_2	22	28	PF00498	0.667
LIG_FHA_2	403	409	PF00498	0.830
LIG_FHA_2	446	452	PF00498	0.746
LIG_FHA_2	530	536	PF00498	0.726
LIG_FHA_2	584	590	PF00498	0.614
LIG_FHA_2	845	851	PF00498	0.584
LIG_Integrin_RGD_1	803	805	PF01839	0.472
LIG_LIR_Apic_2	175	180	PF02991	0.718
LIG_LIR_Apic_2	254	260	PF02991	0.476
LIG_LIR_Apic_2	651	657	PF02991	0.513
LIG_LIR_Apic_2	750	756	PF02991	0.429
LIG_LIR_Gen_1	100	110	PF02991	0.569
LIG_LIR_Gen_1	292	301	PF02991	0.542
LIG_LIR_Nem_3	100	106	PF02991	0.667
LIG_LIR_Nem_3	250	255	PF02991	0.481
LIG_LIR_Nem_3	27	32	PF02991	0.571
LIG_LIR_Nem_3	292	298	PF02991	0.551
LIG_LIR_Nem_3	303	308	PF02991	0.479
LIG_LIR_Nem_3	908	914	PF02991	0.583
LIG_NRBOX	242	248	PF00104	0.468
LIG_NRBOX	567	573	PF00104	0.759
LIG_Pex14_1	667	671	PF04695	0.562
LIG_SH2_CRK	700	704	PF00017	0.723
LIG_SH2_CRK	753	757	PF00017	0.602
LIG_SH2_SRC	103	106	PF00017	0.584
LIG_SH2_SRC	816	819	PF00017	0.553
LIG_SH2_STAP1	103	107	PF00017	0.550
LIG_SH2_STAP1	266	270	PF00017	0.733
LIG_SH2_STAP1	333	337	PF00017	0.484
LIG_SH2_STAT3	113	116	PF00017	0.601
LIG_SH2_STAT5	113	116	PF00017	0.577
LIG_SH2_STAT5	367	370	PF00017	0.762
LIG_SH2_STAT5	517	520	PF00017	0.570
LIG_SH2_STAT5	598	601	PF00017	0.668
LIG_SH3_1	383	389	PF00018	0.749
LIG_SH3_2	684	689	PF14604	0.585
LIG_SH3_3	103	109	PF00018	0.685
LIG_SH3_3	131	137	PF00018	0.783
LIG_SH3_3	274	280	PF00018	0.680
LIG_SH3_3	383	389	PF00018	0.770
LIG_SH3_3	681	687	PF00018	0.614
LIG_SH3_3	78	84	PF00018	0.636
LIG_SH3_3	894	900	PF00018	0.644
LIG_SUMO_SIM_anti_2	347	355	PF11976	0.530
LIG_SUMO_SIM_par_1	643	648	PF11976	0.417
LIG_TRAF2_1	359	362	PF00917	0.766
LIG_TRAF2_1	377	380	PF00917	0.498
LIG_TRAF2_1	532	535	PF00917	0.760
LIG_TRAF2_1	729	732	PF00917	0.665
LIG_TRAF2_1	847	850	PF00917	0.537
LIG_TRAF2_1	869	872	PF00917	0.728
LIG_TRAF2_1	903	906	PF00917	0.661
LIG_TRAF2_2	389	394	PF00917	0.766
LIG_TRFH_1	823	827	PF08558	0.648
LIG_WRC_WIRS_1	29	34	PF05994	0.569
LIG_WRC_WIRS_1	343	348	PF05994	0.534
MOD_CDK_SPxxK_3	603	610	PF00069	0.713
MOD_CK1_1	118	124	PF00069	0.704
MOD_CK1_1	130	136	PF00069	0.630
MOD_CK1_1	251	257	PF00069	0.493
MOD_CK1_1	281	287	PF00069	0.664
MOD_CK1_1	489	495	PF00069	0.638
MOD_CK1_1	541	547	PF00069	0.781
MOD_CK1_1	603	609	PF00069	0.761
MOD_CK1_1	624	630	PF00069	0.621
MOD_CK1_1	97	103	PF00069	0.593
MOD_CK2_1	130	136	PF00069	0.659
MOD_CK2_1	21	27	PF00069	0.669
MOD_CK2_1	374	380	PF00069	0.775
MOD_CK2_1	445	451	PF00069	0.707
MOD_CK2_1	529	535	PF00069	0.720
MOD_CK2_1	548	554	PF00069	0.670
MOD_CK2_1	583	589	PF00069	0.648
MOD_CK2_1	726	732	PF00069	0.670
MOD_CK2_1	784	790	PF00069	0.802
MOD_CK2_1	844	850	PF00069	0.557
MOD_CK2_1	900	906	PF00069	0.677
MOD_CK2_1	98	104	PF00069	0.579
MOD_DYRK1A_RPxSP_1	445	449	PF00069	0.701
MOD_GlcNHglycan	117	120	PF01048	0.723
MOD_GlcNHglycan	129	132	PF01048	0.733
MOD_GlcNHglycan	268	271	PF01048	0.676
MOD_GlcNHglycan	280	283	PF01048	0.712
MOD_GlcNHglycan	376	379	PF01048	0.773
MOD_GlcNHglycan	40	43	PF01048	0.685
MOD_GlcNHglycan	444	448	PF01048	0.749
MOD_GlcNHglycan	475	478	PF01048	0.778
MOD_GlcNHglycan	489	492	PF01048	0.651
MOD_GlcNHglycan	5	8	PF01048	0.695
MOD_GlcNHglycan	540	543	PF01048	0.846
MOD_GlcNHglycan	577	581	PF01048	0.604
MOD_GlcNHglycan	59	62	PF01048	0.652
MOD_GlcNHglycan	623	626	PF01048	0.628
MOD_GlcNHglycan	631	634	PF01048	0.581
MOD_GlcNHglycan	704	707	PF01048	0.661
MOD_GlcNHglycan	74	77	PF01048	0.510
MOD_GlcNHglycan	809	812	PF01048	0.724
MOD_GlcNHglycan	96	99	PF01048	0.604
MOD_GSK3_1	160	167	PF00069	0.710
MOD_GSK3_1	266	273	PF00069	0.758
MOD_GSK3_1	28	35	PF00069	0.658
MOD_GSK3_1	300	307	PF00069	0.586
MOD_GSK3_1	342	349	PF00069	0.535
MOD_GSK3_1	370	377	PF00069	0.705
MOD_GSK3_1	398	405	PF00069	0.731
MOD_GSK3_1	445	452	PF00069	0.694
MOD_GSK3_1	473	480	PF00069	0.763
MOD_GSK3_1	482	489	PF00069	0.777
MOD_GSK3_1	534	541	PF00069	0.758
MOD_GSK3_1	543	550	PF00069	0.711
MOD_GSK3_1	576	583	PF00069	0.678
MOD_GSK3_1	596	603	PF00069	0.779
MOD_GSK3_1	648	655	PF00069	0.443
MOD_GSK3_1	68	75	PF00069	0.765
MOD_GSK3_1	731	738	PF00069	0.698
MOD_GSK3_1	896	903	PF00069	0.705
MOD_GSK3_1	94	101	PF00069	0.563
MOD_N-GLC_1	470	475	PF02516	0.711
MOD_N-GLC_1	557	562	PF02516	0.646
MOD_N-GLC_1	862	867	PF02516	0.657
MOD_NEK2_1	233	238	PF00069	0.456
MOD_NEK2_1	314	319	PF00069	0.555
MOD_NEK2_1	32	37	PF00069	0.572
MOD_NEK2_1	346	351	PF00069	0.494
MOD_NEK2_1	487	492	PF00069	0.710
MOD_NEK2_1	59	64	PF00069	0.730
MOD_NEK2_1	652	657	PF00069	0.545
MOD_NEK2_1	748	753	PF00069	0.654
MOD_NEK2_1	79	84	PF00069	0.522
MOD_NEK2_1	855	860	PF00069	0.654
MOD_NEK2_1	907	912	PF00069	0.572
MOD_PIKK_1	21	27	PF00454	0.669
MOD_PIKK_1	233	239	PF00454	0.453
MOD_PIKK_1	524	530	PF00454	0.778
MOD_PIKK_1	59	65	PF00454	0.735
MOD_PIKK_1	671	677	PF00454	0.708
MOD_PK_1	48	54	PF00069	0.573
MOD_PK_1	784	790	PF00069	0.802
MOD_PKA_1	160	166	PF00069	0.758
MOD_PKA_1	467	473	PF00069	0.614
MOD_PKA_2	160	166	PF00069	0.711
MOD_PKA_2	173	179	PF00069	0.717
MOD_PKA_2	3	9	PF00069	0.671
MOD_PKA_2	392	398	PF00069	0.798
MOD_PKA_2	422	428	PF00069	0.676
MOD_PKA_2	524	530	PF00069	0.742
MOD_PKA_2	596	602	PF00069	0.663
MOD_PKB_1	441	449	PF00069	0.820
MOD_PKB_1	465	473	PF00069	0.610
MOD_Plk_1	149	155	PF00069	0.565
MOD_Plk_1	291	297	PF00069	0.456
MOD_Plk_1	346	352	PF00069	0.508
MOD_Plk_1	494	500	PF00069	0.746
MOD_Plk_1	511	517	PF00069	0.654
MOD_Plk_1	557	563	PF00069	0.577
MOD_Plk_1	762	768	PF00069	0.675
MOD_Plk_1	855	861	PF00069	0.654
MOD_Plk_1	862	868	PF00069	0.564
MOD_Plk_1	907	913	PF00069	0.656
MOD_Plk_4	109	115	PF00069	0.596
MOD_Plk_4	173	179	PF00069	0.702
MOD_Plk_4	28	34	PF00069	0.665
MOD_Plk_4	346	352	PF00069	0.508
MOD_Plk_4	511	517	PF00069	0.756
MOD_Plk_4	648	654	PF00069	0.501
MOD_Plk_4	68	74	PF00069	0.553
MOD_Plk_4	735	741	PF00069	0.666
MOD_Plk_4	748	754	PF00069	0.633
MOD_ProDKin_1	130	136	PF00069	0.660
MOD_ProDKin_1	300	306	PF00069	0.464
MOD_ProDKin_1	382	388	PF00069	0.793
MOD_ProDKin_1	445	451	PF00069	0.707
MOD_ProDKin_1	470	476	PF00069	0.731
MOD_ProDKin_1	482	488	PF00069	0.759
MOD_ProDKin_1	543	549	PF00069	0.756
MOD_ProDKin_1	603	609	PF00069	0.675
MOD_ProDKin_1	688	694	PF00069	0.542
MOD_ProDKin_1	823	829	PF00069	0.741
MOD_ProDKin_1	896	902	PF00069	0.612
MOD_SUMO_for_1	561	564	PF00179	0.770
MOD_SUMO_rev_2	831	838	PF00179	0.603
TRG_DiLeu_BaEn_1	567	572	PF01217	0.647
TRG_DiLeu_BaEn_1	710	715	PF01217	0.623
TRG_DiLeu_BaEn_1	763	768	PF01217	0.749
TRG_DiLeu_BaEn_4	731	737	PF01217	0.688
TRG_DiLeu_BaEn_4	850	856	PF01217	0.525
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.500
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.468
TRG_DiLeu_BaLyEn_6	890	895	PF01217	0.679
TRG_DiLeu_LyEn_5	567	572	PF01217	0.719
TRG_DiLeu_LyEn_5	710	715	PF01217	0.623
TRG_DiLeu_LyEn_5	722	727	PF01217	0.670
TRG_DiLeu_LyEn_5	763	768	PF01217	0.749
TRG_ENDOCYTIC_2	103	106	PF00928	0.641
TRG_ENDOCYTIC_2	29	32	PF00928	0.571
TRG_ENDOCYTIC_2	700	703	PF00928	0.728
TRG_ER_diArg_1	10	12	PF00400	0.684
TRG_ER_diArg_1	159	161	PF00400	0.706
TRG_ER_diArg_1	170	172	PF00400	0.669
TRG_ER_diArg_1	321	323	PF00400	0.532
TRG_ER_diArg_1	44	47	PF00400	0.674
TRG_ER_diArg_1	440	443	PF00400	0.761
TRG_ER_diArg_1	464	467	PF00400	0.645
TRG_ER_diArg_1	523	526	PF00400	0.727
TRG_ER_diArg_1	764	767	PF00400	0.650
TRG_NES_CRM1_1	238	250	PF08389	0.569
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.759
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	766	770	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH80	Leptomonas seymouri	39%	92%
A4HLD9	Leishmania braziliensis	64%	100%
A4I8U8	Leishmania infantum	99%	100%
E9B3R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q4A7	Leishmania major	87%	100%