Calcium-transporting_ATPase_putative/GeneDB:LmjF. 33.1010

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcium-transporting ATPase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6H3_LEIDO

TriTrypDb:

LdBPK_331060.1 , LdCL_330016700 , LDHU3_33.1640

Length:

1197

Annotations

LeishMANIAdb annotations

Homologous to other eukaryotic P-type Ca2+ ATPases.. For some reason, this group has heavily expanded in Kinetoplastida.. Localization: Endosomal (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Show entries

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	13
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	13

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Expansion

Sequence features

A0A3S7X6H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6H3

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006816	calcium ion transport	7	1
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006874	intracellular calcium ion homeostasis	7	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	1

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005215	transporter activity	1	3
GO:0005388	P-type calcium transporter activity	4	3
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015085	calcium ion transmembrane transporter activity	6	3
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.607
CLV_C14_Caspase3-7	261	265	PF00656	0.425
CLV_C14_Caspase3-7	775	779	PF00656	0.695
CLV_NRD_NRD_1	1185	1187	PF00675	0.405
CLV_NRD_NRD_1	147	149	PF00675	0.389
CLV_NRD_NRD_1	165	167	PF00675	0.336
CLV_NRD_NRD_1	481	483	PF00675	0.442
CLV_NRD_NRD_1	50	52	PF00675	0.296
CLV_NRD_NRD_1	560	562	PF00675	0.338
CLV_NRD_NRD_1	723	725	PF00675	0.378

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8I8	Leptomonas seymouri	68%	98%
A0A1X0P0Y8	Trypanosomatidae	46%	100%
A4H903	Leishmania braziliensis	35%	100%
A4HLF4	Leishmania braziliensis	81%	100%
A4HTF0	Leishmania infantum	31%	100%
A4I8W5	Leishmania infantum	100%	100%
E9B3T4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q490	Leishmania major	95%	100%
Q4QED4	Leishmania major	35%	100%
Q5ZKB7	Gallus gallus	21%	99%

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