Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X6H2_LEIDO

TriTrypDb:

LdBPK_330740.1 , LdCL_330012900 , LDHU3_33.1050

Length:

154

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6H2

PDB structure(s): 7aih_BB , 7am2_BB , 7ane_BB

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.548
CLV_PCSK_FUR_1	86	90	PF00082	0.581
CLV_PCSK_KEX2_1	23	25	PF00082	0.548
CLV_PCSK_KEX2_1	32	34	PF00082	0.456
CLV_PCSK_KEX2_1	88	90	PF00082	0.474
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.579
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.476
CLV_PCSK_SKI1_1	128	132	PF00082	0.454
CLV_PCSK_SKI1_1	24	28	PF00082	0.437
CLV_PCSK_SKI1_1	29	33	PF00082	0.459
DEG_APCC_DBOX_1	88	96	PF00400	0.479
DEG_APCC_KENBOX_2	96	100	PF00400	0.471
DEG_Nend_Nbox_1	1	3	PF02207	0.562
DOC_MAPK_gen_1	86	94	PF00069	0.551
DOC_PP4_FxxP_1	108	111	PF00568	0.444
DOC_PP4_FxxP_1	129	132	PF00568	0.447
DOC_USP7_UBL2_3	40	44	PF12436	0.600
LIG_14-3-3_CanoR_1	89	93	PF00244	0.565
LIG_deltaCOP1_diTrp_1	98	108	PF00928	0.460
LIG_FHA_1	105	111	PF00498	0.416
LIG_FHA_1	125	131	PF00498	0.275
LIG_FHA_1	143	149	PF00498	0.455
LIG_FHA_1	89	95	PF00498	0.583
LIG_LIR_Apic_2	107	111	PF02991	0.428
LIG_LIR_Apic_2	126	132	PF02991	0.452
LIG_LIR_Apic_2	98	104	PF02991	0.441
LIG_LIR_Gen_1	14	22	PF02991	0.416
LIG_LIR_Nem_3	107	112	PF02991	0.409
LIG_LIR_Nem_3	14	19	PF02991	0.421
LIG_MAD2	117	125	PF02301	0.468
LIG_Pex14_2	108	112	PF04695	0.419
LIG_Pex14_2	72	76	PF04695	0.523
LIG_SH2_CRK	16	20	PF00017	0.418
LIG_SH3_1	144	150	PF00018	0.435
LIG_SH3_3	108	114	PF00018	0.462
LIG_SH3_3	130	136	PF00018	0.439
LIG_SH3_3	144	150	PF00018	0.435
LIG_SH3_3	16	22	PF00018	0.441
LIG_SH3_3	76	82	PF00018	0.455
LIG_WRC_WIRS_1	9	14	PF05994	0.527
MOD_CK2_1	8	14	PF00069	0.490
MOD_NEK2_1	142	147	PF00069	0.436
MOD_NEK2_1	2	7	PF00069	0.603
MOD_NEK2_1	8	13	PF00069	0.550
MOD_NEK2_2	104	109	PF00069	0.482
MOD_PKA_1	88	94	PF00069	0.551
MOD_PKA_2	36	42	PF00069	0.574
MOD_PKA_2	88	94	PF00069	0.551
MOD_Plk_4	104	110	PF00069	0.445
MOD_SUMO_for_1	31	34	PF00179	0.588
MOD_SUMO_rev_2	120	130	PF00179	0.457
TRG_ENDOCYTIC_2	16	19	PF00928	0.407
TRG_ER_diArg_1	22	24	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN7	Leptomonas seymouri	92%	99%
A0A0S4IVK6	Bodo saltans	64%	100%
A0A1X0P0U6	Trypanosomatidae	70%	100%
A0A422P2L4	Trypanosoma rangeli	68%	100%
A4HLA9	Leishmania braziliensis	92%	100%
A4I8T5	Leishmania infantum	100%	100%
D0A4T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9B3Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q4D6	Leishmania major	95%	100%