2,4-dienoyl-coa reductase fadh1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2,4-dienoyl-coa reductase fadh1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6G9_LEIDO

TriTrypDb:

LdBPK_330870.1 , LdCL_330014800 , LDHU3_33.1390

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X6G9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6G9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	5	6
GO:0010181	FMN binding	4	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	6
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	6
GO:0032553	ribonucleotide binding	3	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.521
CLV_C14_Caspase3-7	559	563	PF00656	0.382
CLV_MEL_PAP_1	225	231	PF00089	0.298
CLV_NRD_NRD_1	294	296	PF00675	0.319
CLV_NRD_NRD_1	521	523	PF00675	0.348
CLV_NRD_NRD_1	566	568	PF00675	0.457
CLV_PCSK_KEX2_1	294	296	PF00082	0.365
CLV_PCSK_KEX2_1	435	437	PF00082	0.403
CLV_PCSK_KEX2_1	466	468	PF00082	0.343
CLV_PCSK_KEX2_1	521	523	PF00082	0.348
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.403
CLV_PCSK_PC1ET2_1	466	468	PF00082	0.246
CLV_PCSK_PC7_1	290	296	PF00082	0.365
CLV_PCSK_SKI1_1	216	220	PF00082	0.365
CLV_PCSK_SKI1_1	330	334	PF00082	0.264
CLV_PCSK_SKI1_1	384	388	PF00082	0.524
CLV_PCSK_SKI1_1	466	470	PF00082	0.430
CLV_PCSK_SKI1_1	605	609	PF00082	0.348
CLV_PCSK_SKI1_1	613	617	PF00082	0.302
CLV_PCSK_SKI1_1	693	697	PF00082	0.511
CLV_PCSK_SKI1_1	96	100	PF00082	0.290
CLV_Separin_Metazoa	210	214	PF03568	0.498
DEG_APCC_DBOX_1	205	213	PF00400	0.464
DEG_APCC_DBOX_1	227	235	PF00400	0.535
DEG_Nend_UBRbox_1	1	4	PF02207	0.548
DEG_SPOP_SBC_1	542	546	PF00917	0.418
DEG_SPOP_SBC_1	584	588	PF00917	0.304
DOC_ANK_TNKS_1	521	528	PF00023	0.403
DOC_CKS1_1	606	611	PF01111	0.382
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.505
DOC_CYCLIN_yCln2_LP_2	603	609	PF00134	0.459
DOC_MAPK_DCC_7	295	305	PF00069	0.527
DOC_MAPK_gen_1	204	211	PF00069	0.464
DOC_MAPK_gen_1	294	302	PF00069	0.493
DOC_MAPK_gen_1	455	462	PF00069	0.474
DOC_MAPK_gen_1	59	68	PF00069	0.482
DOC_MAPK_gen_1	667	676	PF00069	0.425
DOC_MAPK_gen_1	712	720	PF00069	0.488
DOC_MAPK_MEF2A_6	140	149	PF00069	0.492
DOC_MAPK_MEF2A_6	294	302	PF00069	0.466
DOC_MAPK_MEF2A_6	455	464	PF00069	0.455
DOC_MAPK_MEF2A_6	6	15	PF00069	0.343
DOC_PP1_RVXF_1	202	208	PF00149	0.505
DOC_PP2B_LxvP_1	387	390	PF13499	0.502
DOC_PP2B_PxIxI_1	300	306	PF00149	0.535
DOC_USP7_MATH_1	130	134	PF00917	0.510
DOC_USP7_MATH_1	236	240	PF00917	0.448
DOC_USP7_MATH_1	288	292	PF00917	0.552
DOC_USP7_MATH_1	37	41	PF00917	0.541
DOC_USP7_MATH_1	403	407	PF00917	0.376
DOC_USP7_MATH_1	584	588	PF00917	0.424
DOC_USP7_MATH_1	590	594	PF00917	0.466
DOC_USP7_MATH_1	675	679	PF00917	0.382
DOC_USP7_MATH_1	82	86	PF00917	0.482
DOC_USP7_UBL2_3	2	6	PF12436	0.561
DOC_USP7_UBL2_3	569	573	PF12436	0.418
DOC_USP7_UBL2_3	689	693	PF12436	0.362
DOC_USP7_UBL2_3	713	717	PF12436	0.495
DOC_WW_Pin1_4	126	131	PF00397	0.480
DOC_WW_Pin1_4	133	138	PF00397	0.490
DOC_WW_Pin1_4	30	35	PF00397	0.535
DOC_WW_Pin1_4	538	543	PF00397	0.379
DOC_WW_Pin1_4	594	599	PF00397	0.440
DOC_WW_Pin1_4	605	610	PF00397	0.230
DOC_WW_Pin1_4	693	698	PF00397	0.544
DOC_WW_Pin1_4	70	75	PF00397	0.482
LIG_14-3-3_CanoR_1	118	126	PF00244	0.517
LIG_14-3-3_CanoR_1	228	232	PF00244	0.472
LIG_14-3-3_CanoR_1	279	285	PF00244	0.482
LIG_14-3-3_CanoR_1	330	336	PF00244	0.475
LIG_14-3-3_CanoR_1	467	471	PF00244	0.461
LIG_14-3-3_CanoR_1	96	104	PF00244	0.538
LIG_Actin_WH2_2	198	215	PF00022	0.505
LIG_BIR_III_4	217	221	PF00653	0.565
LIG_Clathr_ClatBox_1	662	666	PF01394	0.382
LIG_CtBP_PxDLS_1	10	14	PF00389	0.482
LIG_CtBP_PxDLS_1	142	146	PF00389	0.535
LIG_FHA_1	136	142	PF00498	0.565
LIG_FHA_1	284	290	PF00498	0.534
LIG_FHA_1	449	455	PF00498	0.358
LIG_FHA_1	459	465	PF00498	0.318
LIG_FHA_1	508	514	PF00498	0.465
LIG_FHA_1	631	637	PF00498	0.318
LIG_FHA_1	658	664	PF00498	0.443
LIG_FHA_1	671	677	PF00498	0.383
LIG_FHA_1	681	687	PF00498	0.413
LIG_FHA_1	694	700	PF00498	0.504
LIG_FHA_1	709	715	PF00498	0.324
LIG_FHA_1	97	103	PF00498	0.490
LIG_FHA_2	151	157	PF00498	0.464
LIG_FHA_2	238	244	PF00498	0.482
LIG_FHA_2	27	33	PF00498	0.482
LIG_FHA_2	408	414	PF00498	0.379
LIG_FHA_2	417	423	PF00498	0.222
LIG_FHA_2	467	473	PF00498	0.352
LIG_FHA_2	483	489	PF00498	0.394
LIG_FHA_2	554	560	PF00498	0.455
LIG_IBAR_NPY_1	47	49	PF08397	0.535
LIG_LIR_Gen_1	12	23	PF02991	0.507
LIG_LIR_Gen_1	155	164	PF02991	0.535
LIG_LIR_Gen_1	475	484	PF02991	0.369
LIG_LIR_Nem_3	12	18	PF02991	0.520
LIG_LIR_Nem_3	155	160	PF02991	0.507
LIG_LIR_Nem_3	475	481	PF02991	0.411
LIG_LIR_Nem_3	501	506	PF02991	0.356
LIG_LIR_Nem_3	653	657	PF02991	0.343
LIG_LYPXL_yS_3	503	506	PF13949	0.382
LIG_OCRL_FandH_1	184	196	PF00620	0.510
LIG_PDZ_Class_2	725	730	PF00595	0.362
LIG_Pex14_2	223	227	PF04695	0.482
LIG_Pex14_2	566	570	PF04695	0.299
LIG_PTB_Apo_2	685	692	PF02174	0.432
LIG_SH2_CRK	4	8	PF00017	0.437
LIG_SH2_CRK	49	53	PF00017	0.535
LIG_SH2_SRC	478	481	PF00017	0.375
LIG_SH2_STAP1	4	8	PF00017	0.375
LIG_SH2_STAP1	478	482	PF00017	0.375
LIG_SH2_STAP1	49	53	PF00017	0.535
LIG_SH2_STAP1	509	513	PF00017	0.382
LIG_SH2_STAT5	180	183	PF00017	0.464
LIG_SH2_STAT5	282	285	PF00017	0.495
LIG_SH2_STAT5	337	340	PF00017	0.527
LIG_SH2_STAT5	509	512	PF00017	0.318
LIG_SH2_STAT5	555	558	PF00017	0.425
LIG_SH2_STAT5	664	667	PF00017	0.375
LIG_SH3_3	603	609	PF00018	0.459
LIG_SH3_3	76	82	PF00018	0.499
LIG_SH3_3	83	89	PF00018	0.478
LIG_SUMO_SIM_anti_2	170	178	PF11976	0.464
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.464
LIG_SUMO_SIM_par_1	671	678	PF11976	0.459
LIG_TRAF2_1	469	472	PF00917	0.382
LIG_TRAF2_1	578	581	PF00917	0.288
LIG_UBA3_1	496	502	PF00899	0.403
LIG_WRC_WIRS_1	654	659	PF05994	0.308
MOD_CDK_SPK_2	605	610	PF00069	0.343
MOD_CDK_SPxxK_3	133	140	PF00069	0.207
MOD_CK1_1	133	139	PF00069	0.352
MOD_CK1_1	26	32	PF00069	0.369
MOD_CK1_1	541	547	PF00069	0.415
MOD_CK2_1	237	243	PF00069	0.344
MOD_CK2_1	26	32	PF00069	0.343
MOD_CK2_1	416	422	PF00069	0.318
MOD_CK2_1	466	472	PF00069	0.460
MOD_CK2_1	482	488	PF00069	0.276
MOD_CK2_1	505	511	PF00069	0.459
MOD_CK2_1	553	559	PF00069	0.455
MOD_CK2_1	684	690	PF00069	0.459
MOD_Cter_Amidation	519	522	PF01082	0.358
MOD_GlcNHglycan	115	118	PF01048	0.383
MOD_GlcNHglycan	253	256	PF01048	0.350
MOD_GlcNHglycan	260	263	PF01048	0.318
MOD_GlcNHglycan	343	346	PF01048	0.418
MOD_GlcNHglycan	39	42	PF01048	0.382
MOD_GlcNHglycan	405	408	PF01048	0.329
MOD_GlcNHglycan	492	495	PF01048	0.382
MOD_GlcNHglycan	545	548	PF01048	0.415
MOD_GlcNHglycan	573	576	PF01048	0.368
MOD_GlcNHglycan	590	593	PF01048	0.375
MOD_GlcNHglycan	74	77	PF01048	0.362
MOD_GSK3_1	113	120	PF00069	0.388
MOD_GSK3_1	126	133	PF00069	0.259
MOD_GSK3_1	187	194	PF00069	0.392
MOD_GSK3_1	26	33	PF00069	0.408
MOD_GSK3_1	265	272	PF00069	0.333
MOD_GSK3_1	403	410	PF00069	0.408
MOD_GSK3_1	458	465	PF00069	0.418
MOD_GSK3_1	537	544	PF00069	0.382
MOD_GSK3_1	584	591	PF00069	0.455
MOD_GSK3_1	653	660	PF00069	0.330
MOD_GSK3_1	66	73	PF00069	0.343
MOD_GSK3_1	680	687	PF00069	0.418
MOD_GSK3_1	693	700	PF00069	0.534
MOD_N-GLC_1	236	241	PF02516	0.297
MOD_N-GLC_1	458	463	PF02516	0.406
MOD_N-GLC_1	708	713	PF02516	0.506
MOD_N-GLC_2	351	353	PF02516	0.334
MOD_N-GLC_2	594	596	PF02516	0.382
MOD_NEK2_1	113	118	PF00069	0.403
MOD_NEK2_1	227	232	PF00069	0.343
MOD_NEK2_1	462	467	PF00069	0.352
MOD_NEK2_1	618	623	PF00069	0.376
MOD_NEK2_1	629	634	PF00069	0.295
MOD_NEK2_1	657	662	PF00069	0.419
MOD_NEK2_1	66	71	PF00069	0.343
MOD_NEK2_2	450	455	PF00069	0.398
MOD_NEK2_2	458	463	PF00069	0.385
MOD_PIKK_1	130	136	PF00454	0.443
MOD_PIKK_1	237	243	PF00454	0.375
MOD_PKA_1	466	472	PF00069	0.343
MOD_PKA_2	117	123	PF00069	0.393
MOD_PKA_2	187	193	PF00069	0.394
MOD_PKA_2	227	233	PF00069	0.312
MOD_PKA_2	466	472	PF00069	0.465
MOD_Plk_1	143	149	PF00069	0.388
MOD_Plk_1	458	464	PF00069	0.406
MOD_Plk_1	613	619	PF00069	0.375
MOD_Plk_1	670	676	PF00069	0.459
MOD_Plk_4	227	233	PF00069	0.310
MOD_Plk_4	416	422	PF00069	0.314
MOD_Plk_4	613	619	PF00069	0.343
MOD_Plk_4	675	681	PF00069	0.334
MOD_Plk_4	82	88	PF00069	0.410
MOD_ProDKin_1	126	132	PF00069	0.340
MOD_ProDKin_1	133	139	PF00069	0.355
MOD_ProDKin_1	30	36	PF00069	0.418
MOD_ProDKin_1	538	544	PF00069	0.379
MOD_ProDKin_1	594	600	PF00069	0.440
MOD_ProDKin_1	605	611	PF00069	0.230
MOD_ProDKin_1	693	699	PF00069	0.538
MOD_ProDKin_1	70	76	PF00069	0.343
MOD_SUMO_rev_2	580	584	PF00179	0.440
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.411
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.418
TRG_ENDOCYTIC_2	4	7	PF00928	0.396
TRG_ENDOCYTIC_2	478	481	PF00928	0.375
TRG_ENDOCYTIC_2	49	52	PF00928	0.418
TRG_ENDOCYTIC_2	503	506	PF00928	0.323
TRG_ENDOCYTIC_2	555	558	PF00928	0.459
TRG_ENDOCYTIC_2	612	615	PF00928	0.459
TRG_ENDOCYTIC_2	654	657	PF00928	0.318
TRG_ER_diArg_1	18	21	PF00400	0.343
TRG_ER_diArg_1	204	207	PF00400	0.318
TRG_ER_diArg_1	293	295	PF00400	0.459
TRG_ER_diArg_1	521	523	PF00400	0.348
TRG_NES_CRM1_1	93	105	PF08389	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P302	Leptomonas seymouri	73%	100%
A0A0N0P5L6	Leptomonas seymouri	31%	100%
A0A0S4JCH5	Bodo saltans	29%	100%
A0A0S4JST7	Bodo saltans	48%	100%
A0A1X0NKW1	Trypanosomatidae	29%	100%
A0A1X0NU55	Trypanosomatidae	54%	100%
A0A3S5H5T4	Leishmania donovani	31%	100%
A4H4Q6	Leishmania braziliensis	31%	100%
A4HLD7	Leishmania braziliensis	87%	100%
A4HSY5	Leishmania infantum	31%	100%
A4I8U6	Leishmania infantum	100%	100%
A4J778	Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)	32%	100%
C9ZTL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AKX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B3R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
G9F1Y9	Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679)	31%	100%
O87278	Rhizobium meliloti (strain 1021)	29%	100%
P16099	Methylophilus methylotrophus	27%	100%
P19410	Clostridium scindens (strain JCM 10418 / VPI 12708)	30%	100%
P32370	Clostridium scindens (strain JCM 10418 / VPI 12708)	30%	100%
P32382	Thermoanaerobacter brockii	35%	100%
P42593	Escherichia coli (strain K12)	44%	100%
Q48303	Hyphomicrobium sp. (strain x)	26%	99%
Q4Q4A9	Leishmania major	97%	100%
Q4QIY4	Leishmania major	32%	100%
V5AR23	Trypanosoma cruzi	53%	100%
V5BNI9	Trypanosoma cruzi	31%	100%