Serine_peptidase_Clan_SC_Family_S9D/GeneDB:LmjF.3 3.0400

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X6G6_LEIDO

TriTrypDb:

LdBPK_330410.1 , LdCL_330009500 , LDHU3_33.0620

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X6G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6G6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0008474	palmitoyl-(protein) hydrolase activity	3	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016790	thiolester hydrolase activity	4	1
GO:0098599	palmitoyl hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.394
CLV_NRD_NRD_1	240	242	PF00675	0.355
CLV_NRD_NRD_1	27	29	PF00675	0.461
CLV_NRD_NRD_1	309	311	PF00675	0.459
CLV_NRD_NRD_1	320	322	PF00675	0.383
CLV_PCSK_KEX2_1	204	206	PF00082	0.353
CLV_PCSK_KEX2_1	240	242	PF00082	0.368
CLV_PCSK_KEX2_1	251	253	PF00082	0.467
CLV_PCSK_KEX2_1	261	263	PF00082	0.463
CLV_PCSK_KEX2_1	29	31	PF00082	0.438
CLV_PCSK_KEX2_1	309	311	PF00082	0.438
CLV_PCSK_KEX2_1	320	322	PF00082	0.397
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.512
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.463
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.417
CLV_PCSK_PC7_1	247	253	PF00082	0.499
CLV_PCSK_SKI1_1	247	251	PF00082	0.465
CLV_PCSK_SKI1_1	258	262	PF00082	0.458
CLV_PCSK_SKI1_1	368	372	PF00082	0.368
CLV_PCSK_SKI1_1	377	381	PF00082	0.427
CLV_PCSK_SKI1_1	384	388	PF00082	0.502
CLV_PCSK_SKI1_1	394	398	PF00082	0.459
DEG_Nend_Nbox_1	1	3	PF02207	0.435
DOC_MAPK_gen_1	164	174	PF00069	0.297
DOC_MAPK_gen_1	28	34	PF00069	0.434
DOC_MAPK_gen_1	62	72	PF00069	0.398
DOC_MAPK_MEF2A_6	65	72	PF00069	0.397
DOC_MAPK_NFAT4_5	65	73	PF00069	0.307
DOC_PP4_FxxP_1	11	14	PF00568	0.387
DOC_USP7_MATH_1	260	264	PF00917	0.597
DOC_USP7_MATH_1	332	336	PF00917	0.404
DOC_USP7_MATH_1	390	394	PF00917	0.722
DOC_USP7_UBL2_3	164	168	PF12436	0.329
DOC_USP7_UBL2_3	261	265	PF12436	0.473
DOC_WW_Pin1_4	113	118	PF00397	0.268
LIG_14-3-3_CanoR_1	183	193	PF00244	0.471
LIG_14-3-3_CanoR_1	240	249	PF00244	0.399
LIG_14-3-3_CanoR_1	30	35	PF00244	0.454
LIG_14-3-3_CanoR_1	368	375	PF00244	0.414
LIG_14-3-3_CanoR_1	42	46	PF00244	0.336
LIG_14-3-3_CanoR_1	62	72	PF00244	0.229
LIG_Actin_WH2_2	168	185	PF00022	0.307
LIG_AP2alpha_1	359	363	PF02296	0.346
LIG_BRCT_BRCA1_1	359	363	PF00533	0.413
LIG_BRCT_BRCA1_1	7	11	PF00533	0.398
LIG_FHA_1	177	183	PF00498	0.352
LIG_FHA_2	114	120	PF00498	0.318
LIG_FHA_2	356	362	PF00498	0.340
LIG_HCF-1_HBM_1	130	133	PF13415	0.375
LIG_LIR_Apic_2	8	14	PF02991	0.397
LIG_LIR_Gen_1	130	141	PF02991	0.375
LIG_LIR_Gen_1	358	367	PF02991	0.383
LIG_LIR_Nem_3	102	106	PF02991	0.307
LIG_LIR_Nem_3	130	136	PF02991	0.307
LIG_LIR_Nem_3	198	203	PF02991	0.412
LIG_LIR_Nem_3	303	308	PF02991	0.373
LIG_LIR_Nem_3	360	366	PF02991	0.376
LIG_LIR_Nem_3	44	48	PF02991	0.328
LIG_MAD2	183	191	PF02301	0.461
LIG_NRBOX	244	250	PF00104	0.479
LIG_PCNA_yPIPBox_3	240	249	PF02747	0.394
LIG_Pex14_2	339	343	PF04695	0.357
LIG_Pex14_2	359	363	PF04695	0.405
LIG_Pex14_2	369	373	PF04695	0.284
LIG_RPA_C_Fungi	236	248	PF08784	0.472
LIG_SH2_CRK	312	316	PF00017	0.389
LIG_SH2_NCK_1	126	130	PF00017	0.307
LIG_SH2_STAP1	133	137	PF00017	0.375
LIG_SH2_STAP1	86	90	PF00017	0.409
LIG_SH2_STAT5	103	106	PF00017	0.458
LIG_SH2_STAT5	160	163	PF00017	0.297
LIG_SH2_STAT5	365	368	PF00017	0.498
LIG_SH2_STAT5	45	48	PF00017	0.361
LIG_SH3_3	7	13	PF00018	0.404
LIG_SUMO_SIM_par_1	171	177	PF11976	0.307
LIG_WRC_WIRS_1	175	180	PF05994	0.307
LIG_WW_3	12	16	PF00397	0.434
MOD_CK1_1	124	130	PF00069	0.357
MOD_CK1_1	176	182	PF00069	0.307
MOD_CK1_1	33	39	PF00069	0.469
MOD_CK2_1	113	119	PF00069	0.318
MOD_GlcNHglycan	108	111	PF01048	0.307
MOD_GlcNHglycan	242	245	PF01048	0.360
MOD_GlcNHglycan	279	282	PF01048	0.607
MOD_GlcNHglycan	38	41	PF01048	0.488
MOD_GlcNHglycan	381	384	PF01048	0.530
MOD_GSK3_1	1	8	PF00069	0.399
MOD_GSK3_1	173	180	PF00069	0.307
MOD_GSK3_1	267	274	PF00069	0.621
MOD_GSK3_1	277	284	PF00069	0.765
MOD_GSK3_1	32	39	PF00069	0.469
MOD_GSK3_1	82	89	PF00069	0.424
MOD_N-GLC_1	274	279	PF02516	0.626
MOD_N-GLC_1	332	337	PF02516	0.319
MOD_NEK2_1	1	6	PF00069	0.435
MOD_NEK2_1	174	179	PF00069	0.324
MOD_NEK2_1	32	37	PF00069	0.454
MOD_NEK2_1	327	332	PF00069	0.563
MOD_OFUCOSY	181	188	PF10250	0.495
MOD_PKA_1	240	246	PF00069	0.329
MOD_PKA_1	261	267	PF00069	0.523
MOD_PKA_2	240	246	PF00069	0.350
MOD_PKA_2	261	267	PF00069	0.523
MOD_PKA_2	41	47	PF00069	0.418
MOD_PKA_2	64	70	PF00069	0.415
MOD_PKB_1	28	36	PF00069	0.407
MOD_Plk_1	121	127	PF00069	0.307
MOD_Plk_1	332	338	PF00069	0.397
MOD_Plk_2-3	300	306	PF00069	0.411
MOD_Plk_2-3	355	361	PF00069	0.419
MOD_Plk_4	1	7	PF00069	0.425
MOD_Plk_4	121	127	PF00069	0.307
MOD_Plk_4	300	306	PF00069	0.544
MOD_Plk_4	64	70	PF00069	0.361
MOD_ProDKin_1	113	119	PF00069	0.268
TRG_DiLeu_BaEn_1	211	216	PF01217	0.394
TRG_DiLeu_BaEn_1	376	381	PF01217	0.480
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.470
TRG_ENDOCYTIC_2	133	136	PF00928	0.307
TRG_ENDOCYTIC_2	203	206	PF00928	0.420
TRG_ENDOCYTIC_2	312	315	PF00928	0.383
TRG_ENDOCYTIC_2	45	48	PF00928	0.440
TRG_ER_diArg_1	203	205	PF00400	0.367
TRG_ER_diArg_1	308	310	PF00400	0.441
TRG_ER_diArg_1	319	321	PF00400	0.370
TRG_NES_CRM1_1	88	102	PF08389	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M6	Leptomonas seymouri	55%	100%
A4HL75	Leishmania braziliensis	74%	100%
A4I8Q4	Leishmania infantum	100%	100%
E9B3L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q4J7	Leishmania major	92%	100%