LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X6F7_LEIDO
TriTrypDb:
LdBPK_330490.1 * , LdCL_330010400 , LDHU3_33.0740
Length:
782

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X6F7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6F7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 100 104 PF00656 0.678
CLV_C14_Caspase3-7 176 180 PF00656 0.693
CLV_C14_Caspase3-7 435 439 PF00656 0.633
CLV_NRD_NRD_1 127 129 PF00675 0.562
CLV_NRD_NRD_1 172 174 PF00675 0.535
CLV_NRD_NRD_1 198 200 PF00675 0.505
CLV_NRD_NRD_1 260 262 PF00675 0.497
CLV_NRD_NRD_1 317 319 PF00675 0.590
CLV_NRD_NRD_1 323 325 PF00675 0.559
CLV_NRD_NRD_1 327 329 PF00675 0.508
CLV_NRD_NRD_1 344 346 PF00675 0.399
CLV_NRD_NRD_1 427 429 PF00675 0.535
CLV_NRD_NRD_1 433 435 PF00675 0.469
CLV_NRD_NRD_1 487 489 PF00675 0.574
CLV_NRD_NRD_1 583 585 PF00675 0.544
CLV_NRD_NRD_1 607 609 PF00675 0.450
CLV_PCSK_FUR_1 251 255 PF00082 0.471
CLV_PCSK_FUR_1 315 319 PF00082 0.482
CLV_PCSK_KEX2_1 126 128 PF00082 0.554
CLV_PCSK_KEX2_1 172 174 PF00082 0.537
CLV_PCSK_KEX2_1 253 255 PF00082 0.476
CLV_PCSK_KEX2_1 262 264 PF00082 0.446
CLV_PCSK_KEX2_1 289 291 PF00082 0.513
CLV_PCSK_KEX2_1 296 298 PF00082 0.506
CLV_PCSK_KEX2_1 317 319 PF00082 0.590
CLV_PCSK_KEX2_1 322 324 PF00082 0.573
CLV_PCSK_KEX2_1 344 346 PF00082 0.498
CLV_PCSK_KEX2_1 422 424 PF00082 0.572
CLV_PCSK_KEX2_1 427 429 PF00082 0.502
CLV_PCSK_KEX2_1 433 435 PF00082 0.436
CLV_PCSK_KEX2_1 448 450 PF00082 0.465
CLV_PCSK_KEX2_1 487 489 PF00082 0.478
CLV_PCSK_KEX2_1 583 585 PF00082 0.544
CLV_PCSK_PC1ET2_1 253 255 PF00082 0.476
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.446
CLV_PCSK_PC1ET2_1 289 291 PF00082 0.513
CLV_PCSK_PC1ET2_1 296 298 PF00082 0.506
CLV_PCSK_PC1ET2_1 422 424 PF00082 0.470
CLV_PCSK_PC1ET2_1 448 450 PF00082 0.542
CLV_PCSK_PC7_1 292 298 PF00082 0.531
CLV_PCSK_PC7_1 318 324 PF00082 0.512
CLV_PCSK_PC7_1 423 429 PF00082 0.464
CLV_PCSK_SKI1_1 120 124 PF00082 0.445
CLV_PCSK_SKI1_1 328 332 PF00082 0.496
CLV_PCSK_SKI1_1 423 427 PF00082 0.439
CLV_PCSK_SKI1_1 45 49 PF00082 0.411
CLV_PCSK_SKI1_1 495 499 PF00082 0.511
CLV_PCSK_SKI1_1 692 696 PF00082 0.467
DEG_APCC_DBOX_1 422 430 PF00400 0.634
DEG_SCF_FBW7_1 698 704 PF00400 0.707
DEG_SCF_FBW7_1 710 715 PF00400 0.659
DOC_CKS1_1 695 700 PF01111 0.726
DOC_CKS1_1 721 726 PF01111 0.320
DOC_CYCLIN_RxL_1 16 28 PF00134 0.600
DOC_CYCLIN_RxL_1 689 699 PF00134 0.660
DOC_CYCLIN_yCln2_LP_2 23 29 PF00134 0.595
DOC_CYCLIN_yCln2_LP_2 624 627 PF00134 0.684
DOC_MAPK_gen_1 16 25 PF00069 0.603
DOC_MAPK_MEF2A_6 147 156 PF00069 0.706
DOC_MAPK_MEF2A_6 406 413 PF00069 0.687
DOC_MAPK_MEF2A_6 597 604 PF00069 0.677
DOC_PP2B_LxvP_1 23 26 PF13499 0.599
DOC_PP2B_LxvP_1 623 626 PF13499 0.705
DOC_USP7_MATH_1 390 394 PF00917 0.729
DOC_USP7_MATH_1 432 436 PF00917 0.646
DOC_USP7_MATH_1 439 443 PF00917 0.654
DOC_USP7_MATH_1 538 542 PF00917 0.489
DOC_USP7_MATH_1 652 656 PF00917 0.722
DOC_USP7_MATH_1 680 684 PF00917 0.686
DOC_USP7_MATH_1 701 705 PF00917 0.715
DOC_USP7_MATH_1 712 716 PF00917 0.680
DOC_USP7_MATH_1 764 768 PF00917 0.470
DOC_USP7_UBL2_3 170 174 PF12436 0.696
DOC_USP7_UBL2_3 285 289 PF12436 0.737
DOC_USP7_UBL2_3 394 398 PF12436 0.730
DOC_WW_Pin1_4 194 199 PF00397 0.725
DOC_WW_Pin1_4 397 402 PF00397 0.751
DOC_WW_Pin1_4 405 410 PF00397 0.683
DOC_WW_Pin1_4 459 464 PF00397 0.696
DOC_WW_Pin1_4 666 671 PF00397 0.649
DOC_WW_Pin1_4 694 699 PF00397 0.712
DOC_WW_Pin1_4 708 713 PF00397 0.671
DOC_WW_Pin1_4 720 725 PF00397 0.434
LIG_14-3-3_CanoR_1 128 138 PF00244 0.736
LIG_14-3-3_CanoR_1 190 198 PF00244 0.729
LIG_14-3-3_CanoR_1 206 215 PF00244 0.648
LIG_14-3-3_CanoR_1 263 272 PF00244 0.679
LIG_14-3-3_CanoR_1 290 299 PF00244 0.694
LIG_14-3-3_CanoR_1 322 331 PF00244 0.673
LIG_14-3-3_CanoR_1 339 347 PF00244 0.586
LIG_14-3-3_CanoR_1 433 437 PF00244 0.623
LIG_14-3-3_CanoR_1 495 501 PF00244 0.385
LIG_14-3-3_CanoR_1 665 670 PF00244 0.661
LIG_Actin_WH2_2 563 579 PF00022 0.444
LIG_BIR_II_1 1 5 PF00653 0.620
LIG_BIR_III_4 438 442 PF00653 0.608
LIG_BRCT_BRCA1_1 53 57 PF00533 0.633
LIG_BRCT_BRCA1_1 682 686 PF00533 0.683
LIG_CtBP_PxDLS_1 548 552 PF00389 0.385
LIG_EH1_1 29 37 PF00400 0.585
LIG_eIF4E_1 772 778 PF01652 0.515
LIG_FHA_1 266 272 PF00498 0.654
LIG_FHA_1 325 331 PF00498 0.694
LIG_FHA_1 406 412 PF00498 0.688
LIG_FHA_1 463 469 PF00498 0.736
LIG_FHA_1 569 575 PF00498 0.648
LIG_FHA_1 617 623 PF00498 0.636
LIG_FHA_1 635 641 PF00498 0.593
LIG_FHA_1 75 81 PF00498 0.628
LIG_FHA_1 89 95 PF00498 0.621
LIG_FHA_2 314 320 PF00498 0.698
LIG_FHA_2 371 377 PF00498 0.707
LIG_FHA_2 589 595 PF00498 0.643
LIG_Integrin_RGD_1 449 451 PF01839 0.528
LIG_Integrin_RGD_1 656 658 PF01839 0.493
LIG_LIR_Gen_1 244 252 PF02991 0.674
LIG_LIR_Gen_1 54 64 PF02991 0.643
LIG_LIR_Gen_1 683 694 PF02991 0.675
LIG_LIR_Nem_3 17 23 PF02991 0.602
LIG_LIR_Nem_3 244 250 PF02991 0.673
LIG_LIR_Nem_3 28 32 PF02991 0.558
LIG_LIR_Nem_3 54 60 PF02991 0.641
LIG_LIR_Nem_3 683 689 PF02991 0.677
LIG_NRBOX 101 107 PF00104 0.690
LIG_NRBOX 619 625 PF00104 0.614
LIG_NRBOX 689 695 PF00104 0.672
LIG_SH2_CRK 348 352 PF00017 0.719
LIG_SH2_STAP1 616 620 PF00017 0.656
LIG_SH2_STAT5 348 351 PF00017 0.718
LIG_SH3_3 110 116 PF00018 0.688
LIG_SH3_3 181 187 PF00018 0.717
LIG_SH3_3 220 226 PF00018 0.706
LIG_SH3_3 463 469 PF00018 0.706
LIG_SH3_3 670 676 PF00018 0.655
LIG_SH3_3 695 701 PF00018 0.699
LIG_SH3_3 718 724 PF00018 0.485
LIG_SH3_CIN85_PxpxPR_1 187 192 PF14604 0.679
LIG_SUMO_SIM_anti_2 566 571 PF11976 0.543
LIG_SUMO_SIM_anti_2 685 691 PF11976 0.621
LIG_SUMO_SIM_par_1 560 566 PF11976 0.342
LIG_WRC_WIRS_1 497 502 PF05994 0.320
MOD_CDC14_SPxK_1 197 200 PF00782 0.673
MOD_CDK_SPK_2 194 199 PF00069 0.677
MOD_CDK_SPxK_1 194 200 PF00069 0.655
MOD_CK1_1 131 137 PF00069 0.692
MOD_CK1_1 202 208 PF00069 0.693
MOD_CK1_1 28 34 PF00069 0.456
MOD_CK1_1 338 344 PF00069 0.603
MOD_CK1_1 397 403 PF00069 0.664
MOD_CK1_1 482 488 PF00069 0.612
MOD_CK1_1 501 507 PF00069 0.245
MOD_CK1_1 668 674 PF00069 0.555
MOD_CK1_1 7 13 PF00069 0.479
MOD_CK1_1 715 721 PF00069 0.662
MOD_CK2_1 278 284 PF00069 0.628
MOD_CK2_1 588 594 PF00069 0.596
MOD_CK2_1 682 688 PF00069 0.597
MOD_GlcNHglycan 133 136 PF01048 0.648
MOD_GlcNHglycan 162 165 PF01048 0.630
MOD_GlcNHglycan 208 211 PF01048 0.662
MOD_GlcNHglycan 239 242 PF01048 0.575
MOD_GlcNHglycan 273 276 PF01048 0.656
MOD_GlcNHglycan 284 288 PF01048 0.563
MOD_GlcNHglycan 340 343 PF01048 0.594
MOD_GlcNHglycan 351 354 PF01048 0.547
MOD_GlcNHglycan 375 379 PF01048 0.660
MOD_GlcNHglycan 474 477 PF01048 0.637
MOD_GlcNHglycan 534 537 PF01048 0.620
MOD_GlcNHglycan 588 591 PF01048 0.646
MOD_GlcNHglycan 6 9 PF01048 0.487
MOD_GlcNHglycan 649 653 PF01048 0.523
MOD_GlcNHglycan 682 685 PF01048 0.595
MOD_GSK3_1 178 185 PF00069 0.701
MOD_GSK3_1 190 197 PF00069 0.614
MOD_GSK3_1 198 205 PF00069 0.555
MOD_GSK3_1 211 218 PF00069 0.574
MOD_GSK3_1 237 244 PF00069 0.579
MOD_GSK3_1 261 268 PF00069 0.601
MOD_GSK3_1 307 314 PF00069 0.674
MOD_GSK3_1 370 377 PF00069 0.596
MOD_GSK3_1 39 46 PF00069 0.474
MOD_GSK3_1 390 397 PF00069 0.637
MOD_GSK3_1 405 412 PF00069 0.533
MOD_GSK3_1 439 446 PF00069 0.681
MOD_GSK3_1 47 54 PF00069 0.479
MOD_GSK3_1 479 486 PF00069 0.552
MOD_GSK3_1 528 535 PF00069 0.622
MOD_GSK3_1 634 641 PF00069 0.420
MOD_GSK3_1 648 655 PF00069 0.537
MOD_GSK3_1 696 703 PF00069 0.670
MOD_GSK3_1 708 715 PF00069 0.601
MOD_LATS_1 288 294 PF00433 0.584
MOD_N-GLC_1 202 207 PF02516 0.690
MOD_N-GLC_1 416 421 PF02516 0.557
MOD_NEK2_1 178 183 PF00069 0.724
MOD_NEK2_1 307 312 PF00069 0.683
MOD_NEK2_1 404 409 PF00069 0.662
MOD_NEK2_1 43 48 PF00069 0.491
MOD_NEK2_1 453 458 PF00069 0.670
MOD_NEK2_1 498 503 PF00069 0.385
MOD_NEK2_1 528 533 PF00069 0.577
MOD_NEK2_1 576 581 PF00069 0.580
MOD_PIKK_1 217 223 PF00454 0.633
MOD_PIKK_1 440 446 PF00454 0.579
MOD_PIKK_1 518 524 PF00454 0.544
MOD_PKA_1 173 179 PF00069 0.651
MOD_PKA_1 199 205 PF00069 0.621
MOD_PKA_1 261 267 PF00069 0.620
MOD_PKA_1 323 329 PF00069 0.646
MOD_PKA_2 182 188 PF00069 0.689
MOD_PKA_2 198 204 PF00069 0.553
MOD_PKA_2 323 329 PF00069 0.607
MOD_PKA_2 338 344 PF00069 0.472
MOD_PKA_2 365 371 PF00069 0.596
MOD_PKA_2 39 45 PF00069 0.473
MOD_PKA_2 390 396 PF00069 0.614
MOD_PKA_2 432 438 PF00069 0.512
MOD_PKA_2 480 486 PF00069 0.625
MOD_PKA_2 52 58 PF00069 0.483
MOD_PKA_2 576 582 PF00069 0.626
MOD_PKA_2 74 80 PF00069 0.503
MOD_PKB_1 126 134 PF00069 0.630
MOD_PKB_1 190 198 PF00069 0.625
MOD_PKB_1 261 269 PF00069 0.623
MOD_PKB_1 322 330 PF00069 0.618
MOD_PKB_1 584 592 PF00069 0.555
MOD_Plk_1 638 644 PF00069 0.409
MOD_Plk_2-3 97 103 PF00069 0.599
MOD_Plk_4 211 217 PF00069 0.695
MOD_Plk_4 25 31 PF00069 0.462
MOD_Plk_4 409 415 PF00069 0.623
MOD_Plk_4 501 507 PF00069 0.346
MOD_Plk_4 668 674 PF00069 0.555
MOD_Plk_4 682 688 PF00069 0.467
MOD_Plk_4 97 103 PF00069 0.599
MOD_ProDKin_1 194 200 PF00069 0.655
MOD_ProDKin_1 397 403 PF00069 0.690
MOD_ProDKin_1 405 411 PF00069 0.589
MOD_ProDKin_1 459 465 PF00069 0.613
MOD_ProDKin_1 666 672 PF00069 0.553
MOD_ProDKin_1 694 700 PF00069 0.646
MOD_ProDKin_1 708 714 PF00069 0.577
MOD_ProDKin_1 720 726 PF00069 0.247
MOD_SUMO_rev_2 257 264 PF00179 0.589
MOD_SUMO_rev_2 451 459 PF00179 0.619
TRG_DiLeu_BaLyEn_6 689 694 PF01217 0.530
TRG_DiLeu_BaLyEn_6 773 778 PF01217 0.639
TRG_DiLeu_LyEn_5 659 664 PF01217 0.522
TRG_ENDOCYTIC_2 20 23 PF00928 0.485
TRG_ENDOCYTIC_2 247 250 PF00928 0.586
TRG_ENDOCYTIC_2 348 351 PF00928 0.646
TRG_ER_diArg_1 125 128 PF00400 0.630
TRG_ER_diArg_1 13 16 PF00400 0.477
TRG_ER_diArg_1 315 318 PF00400 0.628
TRG_ER_diArg_1 321 324 PF00400 0.593
TRG_ER_diArg_1 343 345 PF00400 0.612
TRG_ER_diArg_1 426 428 PF00400 0.575
TRG_ER_diArg_1 487 490 PF00400 0.579
TRG_ER_diArg_1 574 577 PF00400 0.645
TRG_ER_diArg_1 583 586 PF00400 0.553
TRG_NES_CRM1_1 515 526 PF08389 0.560
TRG_NLS_MonoExtC_3 261 267 PF00514 0.620
TRG_NLS_MonoExtC_3 288 294 PF00514 0.606
TRG_NLS_MonoExtN_4 261 266 PF00514 0.609
TRG_Pf-PMV_PEXEL_1 603 607 PF00026 0.566
TRG_Pf-PMV_PEXEL_1 642 646 PF00026 0.511

Homologs

Protein Taxonomy Sequence identity Coverage
A4HL83 Leishmania braziliensis 65% 99%
A4I8R1 Leishmania infantum 99% 100%
E9B3M6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 97%
Q4Q4G1 Leishmania major 88% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS