Beta-galactofuranosyltransferase-like_protein/Gen eDB:LmjF.33.0300

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-galactofuranosyltransferase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X6F1_LEIDO

TriTrypDb:

LdBPK_330330.1 , LdCL_330008500 , LDHU3_33.0430

Length:

460

Annotations

LeishMANIAdb annotations

A large family of glycosyltransferases expanded in parazitic kinetoplastids (and even more in T cruzi). Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 37
NetGPI	no	yes: 0, no: 37

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

A0A3S7X6F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X6F1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	38
GO:0016740	transferase activity	2	38
GO:0016757	glycosyltransferase activity	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.448
CLV_NRD_NRD_1	186	188	PF00675	0.603
CLV_NRD_NRD_1	458	460	PF00675	0.588
CLV_NRD_NRD_1	73	75	PF00675	0.489
CLV_PCSK_KEX2_1	16	18	PF00082	0.415
CLV_PCSK_KEX2_1	186	188	PF00082	0.603
CLV_PCSK_KEX2_1	2	4	PF00082	0.548
CLV_PCSK_KEX2_1	73	75	PF00082	0.507
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.367
CLV_PCSK_SKI1_1	162	166	PF00082	0.486
CLV_PCSK_SKI1_1	17	21	PF00082	0.417
CLV_PCSK_SKI1_1	282	286	PF00082	0.556
CLV_PCSK_SKI1_1	315	319	PF00082	0.438
CLV_PCSK_SKI1_1	377	381	PF00082	0.656
DEG_APCC_DBOX_1	15	23	PF00400	0.420
DEG_APCC_DBOX_1	376	384	PF00400	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.572
DEG_SCF_FBW7_1	233	240	PF00400	0.256
DOC_CYCLIN_RxL_1	14	24	PF00134	0.368
DOC_MAPK_DCC_7	167	177	PF00069	0.223
DOC_MAPK_gen_1	16	22	PF00069	0.217
DOC_MAPK_MEF2A_6	406	413	PF00069	0.369
DOC_PP1_RVXF_1	15	22	PF00149	0.209
DOC_PP2B_PxIxI_1	172	178	PF00149	0.339
DOC_PP4_FxxP_1	393	396	PF00568	0.360
DOC_USP7_MATH_1	136	140	PF00917	0.410
DOC_USP7_MATH_1	343	347	PF00917	0.474
DOC_WW_Pin1_4	10	15	PF00397	0.685
DOC_WW_Pin1_4	233	238	PF00397	0.411
DOC_WW_Pin1_4	36	41	PF00397	0.337
DOC_WW_Pin1_4	383	388	PF00397	0.352
LIG_14-3-3_CanoR_1	226	230	PF00244	0.333
LIG_14-3-3_CanoR_1	250	255	PF00244	0.399
LIG_14-3-3_CanoR_1	3	12	PF00244	0.568
LIG_14-3-3_CanoR_1	74	82	PF00244	0.420
LIG_Actin_WH2_2	119	136	PF00022	0.377
LIG_APCC_Cbox_2	190	196	PF00515	0.198
LIG_BRCT_BRCA1_1	320	324	PF00533	0.246
LIG_deltaCOP1_diTrp_1	301	307	PF00928	0.397
LIG_deltaCOP1_diTrp_1	370	375	PF00928	0.385
LIG_deltaCOP1_diTrp_1	97	104	PF00928	0.368
LIG_FHA_1	125	131	PF00498	0.402
LIG_FHA_1	234	240	PF00498	0.324
LIG_FHA_1	30	36	PF00498	0.331
LIG_FHA_1	424	430	PF00498	0.433
LIG_FHA_1	76	82	PF00498	0.363
LIG_FHA_2	62	68	PF00498	0.409
LIG_IRF3_LxIS_1	237	242	PF10401	0.235
LIG_LIR_Apic_2	392	396	PF02991	0.372
LIG_LIR_Gen_1	95	105	PF02991	0.316
LIG_LIR_Nem_3	171	177	PF02991	0.243
LIG_LIR_Nem_3	190	195	PF02991	0.224
LIG_LIR_Nem_3	293	299	PF02991	0.273
LIG_LIR_Nem_3	321	327	PF02991	0.371
LIG_LIR_Nem_3	386	391	PF02991	0.375
LIG_LIR_Nem_3	95	101	PF02991	0.343
LIG_Pex14_2	174	178	PF04695	0.326
LIG_Pex14_2	324	328	PF04695	0.235
LIG_PTB_Apo_2	308	315	PF02174	0.209
LIG_REV1ctd_RIR_1	325	334	PF16727	0.256
LIG_SH2_NCK_1	349	353	PF00017	0.232
LIG_SH2_NCK_1	37	41	PF00017	0.347
LIG_SH2_PTP2	192	195	PF00017	0.201
LIG_SH2_SRC	114	117	PF00017	0.357
LIG_SH2_SRC	192	195	PF00017	0.208
LIG_SH2_STAP1	153	157	PF00017	0.249
LIG_SH2_STAP1	197	201	PF00017	0.340
LIG_SH2_STAP1	251	255	PF00017	0.256
LIG_SH2_STAP1	303	307	PF00017	0.228
LIG_SH2_STAP1	349	353	PF00017	0.385
LIG_SH2_STAT3	116	119	PF00017	0.378
LIG_SH2_STAT3	146	149	PF00017	0.254
LIG_SH2_STAT3	303	306	PF00017	0.222
LIG_SH2_STAT5	114	117	PF00017	0.352
LIG_SH2_STAT5	183	186	PF00017	0.384
LIG_SH2_STAT5	188	191	PF00017	0.353
LIG_SH2_STAT5	192	195	PF00017	0.322
LIG_SH2_STAT5	299	302	PF00017	0.299
LIG_SH3_3	52	58	PF00018	0.533
LIG_SH3_3	87	93	PF00018	0.376
LIG_SH3_5	364	368	PF00018	0.381
LIG_SUMO_SIM_anti_2	281	287	PF11976	0.375
LIG_SUMO_SIM_anti_2	30	35	PF11976	0.334
LIG_SUMO_SIM_par_1	124	131	PF11976	0.383
LIG_SUMO_SIM_par_1	32	39	PF11976	0.402
LIG_SUMO_SIM_par_1	409	415	PF11976	0.252
LIG_SUMO_SIM_par_1	92	97	PF11976	0.268
LIG_TRAF2_1	122	125	PF00917	0.233
LIG_TRAF2_1	209	212	PF00917	0.380
LIG_TRAF2_1	64	67	PF00917	0.258
LIG_TYR_ITIM	195	200	PF00017	0.213
LIG_WRC_WIRS_1	251	256	PF05994	0.251
MOD_CDC14_SPxK_1	13	16	PF00782	0.651
MOD_CDK_SPxK_1	10	16	PF00069	0.666
MOD_CDK_SPxxK_3	10	17	PF00069	0.516
MOD_CK1_1	232	238	PF00069	0.317
MOD_CK1_1	430	436	PF00069	0.268
MOD_CK2_1	250	256	PF00069	0.271
MOD_CK2_1	61	67	PF00069	0.312
MOD_GlcNHglycan	320	323	PF01048	0.487
MOD_GlcNHglycan	383	386	PF01048	0.587
MOD_GlcNHglycan	448	451	PF01048	0.553
MOD_GSK3_1	124	131	PF00069	0.415
MOD_GSK3_1	225	232	PF00069	0.403
MOD_GSK3_1	233	240	PF00069	0.347
MOD_GSK3_1	341	348	PF00069	0.354
MOD_GSK3_1	417	424	PF00069	0.492
MOD_GSK3_1	427	434	PF00069	0.439
MOD_GSK3_1	446	453	PF00069	0.519
MOD_N-GLC_1	427	432	PF02516	0.570
MOD_NEK2_1	21	26	PF00069	0.298
MOD_NEK2_1	229	234	PF00069	0.349
MOD_NEK2_1	239	244	PF00069	0.260
MOD_NEK2_1	27	32	PF00069	0.286
MOD_NEK2_1	278	283	PF00069	0.264
MOD_NEK2_1	423	428	PF00069	0.446
MOD_NEK2_1	431	436	PF00069	0.408
MOD_NEK2_1	446	451	PF00069	0.510
MOD_NEK2_1	69	74	PF00069	0.403
MOD_NEK2_2	225	230	PF00069	0.416
MOD_PK_1	417	423	PF00069	0.481
MOD_PKA_1	315	321	PF00069	0.215
MOD_PKA_2	225	231	PF00069	0.353
MOD_PKA_2	249	255	PF00069	0.428
MOD_PKB_1	248	256	PF00069	0.250
MOD_Plk_1	124	130	PF00069	0.387
MOD_Plk_1	427	433	PF00069	0.283
MOD_Plk_4	124	130	PF00069	0.269
MOD_Plk_4	21	27	PF00069	0.218
MOD_Plk_4	427	433	PF00069	0.400
MOD_Plk_4	82	88	PF00069	0.225
MOD_ProDKin_1	10	16	PF00069	0.683
MOD_ProDKin_1	233	239	PF00069	0.404
MOD_ProDKin_1	36	42	PF00069	0.338
MOD_ProDKin_1	383	389	PF00069	0.355
MOD_SUMO_rev_2	367	374	PF00179	0.379
TRG_DiLeu_BaEn_1	125	130	PF01217	0.227
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.394
TRG_ENDOCYTIC_2	114	117	PF00928	0.382
TRG_ENDOCYTIC_2	192	195	PF00928	0.367
TRG_ENDOCYTIC_2	197	200	PF00928	0.364
TRG_ENDOCYTIC_2	251	254	PF00928	0.281
TRG_ER_diArg_1	111	114	PF00400	0.259
TRG_ER_diArg_1	186	188	PF00400	0.400
TRG_ER_diArg_1	248	251	PF00400	0.311
TRG_ER_diArg_1	73	75	PF00400	0.320
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P269	Leptomonas seymouri	29%	100%
A0A0N1PC27	Leptomonas seymouri	65%	100%
A0A0N1PES8	Leptomonas seymouri	31%	100%
A0A1X0NWK3	Trypanosomatidae	36%	100%
A0A1X0NWM3	Trypanosomatidae	36%	100%
A0A3Q8IHI5	Leishmania donovani	30%	70%
A0A3R7N1J7	Trypanosoma rangeli	35%	100%
A0A3S5H7D9	Leishmania donovani	32%	100%
A0A3S7WZK8	Leishmania donovani	28%	100%
A4HDU8	Leishmania braziliensis	31%	100%
A4HER0	Leishmania braziliensis	28%	69%
A4HL36	Leishmania braziliensis	33%	80%
A4I143	Leishmania infantum	31%	100%
A4I1Y7	Leishmania infantum	29%	100%
A4I8P7	Leishmania infantum	100%	100%
E9AHM5	Leishmania infantum	30%	77%
E9AXX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AY34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B3H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	78%
E9B3L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q05889	Leishmania donovani	31%	100%
Q4Q9D9	Leishmania major	28%	100%
Q6XFB5	Leishmania major	94%	100%
Q9NC61	Leishmania major	29%	100%
V5AJV9	Trypanosoma cruzi	38%	100%
V5AJW5	Trypanosoma cruzi	37%	100%
V5AM55	Trypanosoma cruzi	39%	100%
V5AR28	Trypanosoma cruzi	38%	100%
V5ASN8	Trypanosoma cruzi	36%	100%
V5AUJ2	Trypanosoma cruzi	38%	100%
V5B2H2	Trypanosoma cruzi	38%	100%
V5B4V1	Trypanosoma cruzi	37%	100%
V5B8H6	Trypanosoma cruzi	37%	100%
V5BB47	Trypanosoma cruzi	38%	100%
V5BRK8	Trypanosoma cruzi	38%	100%
V5BXG8	Trypanosoma cruzi	36%	100%
V5DD11	Trypanosoma cruzi	38%	100%